CA2409991A1 - Bispecific immunoglobulin-like antigen binding proteins and method of production - Google Patents

Bispecific immunoglobulin-like antigen binding proteins and method of production Download PDF

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Publication number
CA2409991A1
CA2409991A1 CA002409991A CA2409991A CA2409991A1 CA 2409991 A1 CA2409991 A1 CA 2409991A1 CA 002409991 A CA002409991 A CA 002409991A CA 2409991 A CA2409991 A CA 2409991A CA 2409991 A1 CA2409991 A1 CA 2409991A1
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Prior art keywords
antigen
binding protein
binding
seq
domain
Prior art date
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Abandoned
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CA002409991A
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English (en)
French (fr)
Inventor
Zhenping Zhu
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ImClone LLC
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Individual
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Publication of CA2409991A1 publication Critical patent/CA2409991A1/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002409991A 2000-05-24 2001-05-24 Bispecific immunoglobulin-like antigen binding proteins and method of production Abandoned CA2409991A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20674900P 2000-05-24 2000-05-24
US60/206,749 2000-05-24
PCT/US2001/016924 WO2001090192A2 (en) 2000-05-24 2001-05-24 Bispecific immunoglobulin-like antigen binding proteins and method of production

Publications (1)

Publication Number Publication Date
CA2409991A1 true CA2409991A1 (en) 2001-11-29

Family

ID=22767777

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002409991A Abandoned CA2409991A1 (en) 2000-05-24 2001-05-24 Bispecific immunoglobulin-like antigen binding proteins and method of production

Country Status (6)

Country Link
US (2) US20020103345A1 (cg-RX-API-DMAC7.html)
EP (1) EP1299419A2 (cg-RX-API-DMAC7.html)
JP (1) JP2004511430A (cg-RX-API-DMAC7.html)
AU (1) AU2001264946A1 (cg-RX-API-DMAC7.html)
CA (1) CA2409991A1 (cg-RX-API-DMAC7.html)
WO (1) WO2001090192A2 (cg-RX-API-DMAC7.html)

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US20020103345A1 (en) 2002-08-01
WO2001090192A2 (en) 2001-11-29
AU2001264946A1 (en) 2001-12-03
US20040259156A1 (en) 2004-12-23

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