CA2395660A1 - Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use - Google Patents
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use Download PDFInfo
- Publication number
- CA2395660A1 CA2395660A1 CA002395660A CA2395660A CA2395660A1 CA 2395660 A1 CA2395660 A1 CA 2395660A1 CA 002395660 A CA002395660 A CA 002395660A CA 2395660 A CA2395660 A CA 2395660A CA 2395660 A1 CA2395660 A1 CA 2395660A1
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- Canada
- Prior art keywords
- daunorubicin
- modified
- doxorubicin
- daunorubicins
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US17349799P | 1999-12-29 | 1999-12-29 | |
| US60/173,497 | 1999-12-29 | ||
| PCT/US2000/033276 WO2001049698A1 (en) | 1999-12-29 | 2000-12-19 | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
Publications (1)
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| CA2395660A1 true CA2395660A1 (en) | 2001-07-12 |
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| CA002395660A Abandoned CA2395660A1 (en) | 1999-12-29 | 2000-12-19 | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
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| EP (1) | EP1242438B1 (enExample) |
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| NZ (1) | NZ518764A (enExample) |
| PT (1) | PT1242438E (enExample) |
| WO (1) | WO2001049698A1 (enExample) |
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|---|---|---|---|---|
| US4464529A (en) * | 1982-07-20 | 1984-08-07 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
| GB2172594B (en) * | 1985-03-22 | 1988-06-08 | Erba Farmitalia | New morpholino derivatives of daunorubicin and doxorubicin |
| US5304687A (en) | 1989-12-19 | 1994-04-19 | Farmitalia Carlo Erba S.R.L. | Morpholinyl derivatives of doxorubicin and process for their preparation |
| ES2094136T3 (es) * | 1989-12-19 | 1997-01-16 | Pharmacia Spa | Intermediarios quirales de 1,5-diyodo-2-metoxi o benciloxi. |
| GB2296495B (en) * | 1994-12-23 | 1998-04-15 | Erba Carlo Spa | Anthracycline derivatives |
| US5843903A (en) | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
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2000
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- 2000-12-19 DE DE60031793T patent/DE60031793T2/de not_active Expired - Lifetime
- 2000-12-19 WO PCT/US2000/033276 patent/WO2001049698A1/en not_active Ceased
- 2000-12-19 ES ES00993714T patent/ES2274823T3/es not_active Expired - Lifetime
- 2000-12-19 JP JP2001550238A patent/JP2003531821A/ja active Pending
- 2000-12-19 AT AT00993714T patent/ATE344801T1/de active
- 2000-12-19 EP EP00993714A patent/EP1242438B1/en not_active Expired - Lifetime
- 2000-12-19 DK DK00993714T patent/DK1242438T3/da active
- 2000-12-19 PT PT00993714T patent/PT1242438E/pt unknown
- 2000-12-19 AU AU29066/01A patent/AU767394C/en not_active Ceased
- 2000-12-19 NZ NZ518764A patent/NZ518764A/en not_active IP Right Cessation
- 2000-12-21 US US09/740,991 patent/US6630579B2/en not_active Expired - Fee Related
Also Published As
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| PT1242438E (pt) | 2007-02-28 |
| ES2274823T3 (es) | 2007-06-01 |
| ATE344801T1 (de) | 2006-11-15 |
| WO2001049698A1 (en) | 2001-07-12 |
| EP1242438B1 (en) | 2006-11-08 |
| NZ518764A (en) | 2004-02-27 |
| US6630579B2 (en) | 2003-10-07 |
| DK1242438T3 (da) | 2007-02-12 |
| AU767394B2 (en) | 2003-11-06 |
| JP2003531821A (ja) | 2003-10-28 |
| US20010036923A1 (en) | 2001-11-01 |
| AU767394C (en) | 2005-04-21 |
| DE60031793D1 (de) | 2006-12-21 |
| EP1242438A1 (en) | 2002-09-25 |
| DE60031793T2 (de) | 2007-08-23 |
| AU2906601A (en) | 2001-07-16 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20120924 |