CA2288994C - Polyalkylene oxide-modified single chain polypeptides - Google Patents

Polyalkylene oxide-modified single chain polypeptides Download PDF

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Publication number
CA2288994C
CA2288994C CA2288994A CA2288994A CA2288994C CA 2288994 C CA2288994 C CA 2288994C CA 2288994 A CA2288994 A CA 2288994A CA 2288994 A CA2288994 A CA 2288994A CA 2288994 C CA2288994 C CA 2288994C
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CA
Canada
Prior art keywords
antigen
polypeptide
binding
chain
variable region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2288994A
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English (en)
French (fr)
Other versions
CA2288994A1 (en
Inventor
Marc D. Whitlow
Robert G. L. Shorr
David R. Filpula
Lihsyng S. Lee
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Individual
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Enzon Pharmaceuticals Inc
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Publication date
Application filed by Enzon Pharmaceuticals Inc filed Critical Enzon Pharmaceuticals Inc
Publication of CA2288994A1 publication Critical patent/CA2288994A1/en
Application granted granted Critical
Publication of CA2288994C publication Critical patent/CA2288994C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CA2288994A 1997-04-30 1998-04-30 Polyalkylene oxide-modified single chain polypeptides Expired - Lifetime CA2288994C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US4444997P 1997-04-30 1997-04-30
US5047297P 1997-06-23 1997-06-23
US6307497P 1997-10-27 1997-10-27
US6734197P 1997-12-02 1997-12-02
US60/063,074 1997-12-02
US60/067,341 1997-12-02
US60/050,472 1997-12-02
US60/044,449 1997-12-02
PCT/US1998/008654 WO1998048837A1 (en) 1997-04-30 1998-04-30 Polyalkylene oxide-modified single chain polypeptides

Publications (2)

Publication Number Publication Date
CA2288994A1 CA2288994A1 (en) 1998-11-05
CA2288994C true CA2288994C (en) 2011-07-05

Family

ID=27488916

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2288994A Expired - Lifetime CA2288994C (en) 1997-04-30 1998-04-30 Polyalkylene oxide-modified single chain polypeptides
CA2288992A Expired - Lifetime CA2288992C (en) 1997-04-30 1998-04-30 Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2288992A Expired - Lifetime CA2288992C (en) 1997-04-30 1998-04-30 Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof

Country Status (6)

Country Link
US (8) US6323322B1 (https=)
EP (2) EP0979102A4 (https=)
JP (4) JP4187277B2 (https=)
AU (2) AU7266898A (https=)
CA (2) CA2288994C (https=)
WO (2) WO1998049198A1 (https=)

Families Citing this family (399)

* Cited by examiner, † Cited by third party
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CA2288992C (en) 2012-06-12
US6872393B2 (en) 2005-03-29
EP0981548A4 (en) 2005-11-23
EP0981548A1 (en) 2000-03-01
US6743896B2 (en) 2004-06-01
AU7266898A (en) 1998-11-24
US20020061307A1 (en) 2002-05-23
US20050048064A1 (en) 2005-03-03
US20020161201A1 (en) 2002-10-31
WO1998048837A9 (en) 1999-04-22
EP0979102A1 (en) 2000-02-16
CA2288992A1 (en) 1998-11-05
US20020098192A1 (en) 2002-07-25
US6824782B2 (en) 2004-11-30
JP2002516610A (ja) 2002-06-04
US20050042680A1 (en) 2005-02-24
US20020155498A1 (en) 2002-10-24
US7632504B2 (en) 2009-12-15
JP2010051331A (ja) 2010-03-11
US6743908B2 (en) 2004-06-01
EP0979102A4 (en) 2005-11-23
JP2008115193A (ja) 2008-05-22
US7150872B2 (en) 2006-12-19
US6323322B1 (en) 2001-11-27
AU7266698A (en) 1998-11-24
CA2288994A1 (en) 1998-11-05
JP4187277B2 (ja) 2008-11-26
WO1998048837A1 (en) 1998-11-05
US20050008650A1 (en) 2005-01-13
WO1998049198A1 (en) 1998-11-05
JP2002505574A (ja) 2002-02-19

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