CA2255614C - Dha-pharmaceutical agent conjugates - Google Patents

Dha-pharmaceutical agent conjugates Download PDF

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Publication number
CA2255614C
CA2255614C CA002255614A CA2255614A CA2255614C CA 2255614 C CA2255614 C CA 2255614C CA 002255614 A CA002255614 A CA 002255614A CA 2255614 A CA2255614 A CA 2255614A CA 2255614 C CA2255614 C CA 2255614C
Authority
CA
Canada
Prior art keywords
hydrochloride
tissue
sodium
taxane
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002255614A
Other languages
English (en)
French (fr)
Other versions
CA2255614A1 (en
Inventor
Matthews O. Bradley
Victor E. Shashoua
Nigel L. Webb
Charles S. Swindell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Regent Inc
Original Assignee
Luitpold Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luitpold Pharmaceuticals Inc filed Critical Luitpold Pharmaceuticals Inc
Publication of CA2255614A1 publication Critical patent/CA2255614A1/en
Application granted granted Critical
Publication of CA2255614C publication Critical patent/CA2255614C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
CA002255614A 1996-05-22 1997-05-22 Dha-pharmaceutical agent conjugates Expired - Fee Related CA2255614C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/651,312 1996-05-22
US08/651,312 US5795909A (en) 1996-05-22 1996-05-22 DHA-pharmaceutical agent conjugates of taxanes
PCT/US1997/008867 WO1997044063A2 (en) 1996-05-22 1997-05-22 Dha-pharmaceutical agent conjugates

Publications (2)

Publication Number Publication Date
CA2255614A1 CA2255614A1 (en) 1997-11-27
CA2255614C true CA2255614C (en) 2009-12-15

Family

ID=24612392

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002255614A Expired - Fee Related CA2255614C (en) 1996-05-22 1997-05-22 Dha-pharmaceutical agent conjugates

Country Status (10)

Country Link
US (3) US5795909A (US20020010208A1-20020124-C00009.png)
EP (2) EP0909183B1 (US20020010208A1-20020124-C00009.png)
JP (1) JP4402173B2 (US20020010208A1-20020124-C00009.png)
AT (1) ATE273025T1 (US20020010208A1-20020124-C00009.png)
AU (1) AU725759B2 (US20020010208A1-20020124-C00009.png)
CA (1) CA2255614C (US20020010208A1-20020124-C00009.png)
DE (1) DE69730217T2 (US20020010208A1-20020124-C00009.png)
DK (1) DK0909183T3 (US20020010208A1-20020124-C00009.png)
ES (1) ES2222514T3 (US20020010208A1-20020124-C00009.png)
WO (1) WO1997044063A2 (US20020010208A1-20020124-C00009.png)

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JP4402173B2 (ja) 2010-01-20
US5795909A (en) 1998-08-18
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CA2255614A1 (en) 1997-11-27
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WO1997044063A3 (en) 1998-02-26
AU3142597A (en) 1997-12-09
DE69730217D1 (de) 2004-09-16
US6602902B2 (en) 2003-08-05
US20040180949A1 (en) 2004-09-16
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US7199151B2 (en) 2007-04-03

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