IT1264987B1 - Sali di un acido grasso poliinsaturo e formulazioni farmaceutiche che li contengono - Google Patents

Sali di un acido grasso poliinsaturo e formulazioni farmaceutiche che li contengono

Info

Publication number
IT1264987B1
IT1264987B1 IT93MI002612A ITMI932612A IT1264987B1 IT 1264987 B1 IT1264987 B1 IT 1264987B1 IT 93MI002612 A IT93MI002612 A IT 93MI002612A IT MI932612 A ITMI932612 A IT MI932612A IT 1264987 B1 IT1264987 B1 IT 1264987B1
Authority
IT
Italy
Prior art keywords
salts
contain
fatty acid
pharmaceutical formulations
polyunsaturated fatty
Prior art date
Application number
IT93MI002612A
Other languages
English (en)
Inventor
Tiberio Bruzzese
Original Assignee
Prospa Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prospa Bv filed Critical Prospa Bv
Publication of ITMI932612A0 publication Critical patent/ITMI932612A0/it
Priority to IT93MI002612A priority Critical patent/IT1264987B1/it
Priority to ES95903298T priority patent/ES2117390T3/es
Priority to EP95903298A priority patent/EP0734373B1/en
Priority to US08/649,707 priority patent/US5750572A/en
Priority to AU12412/95A priority patent/AU1241295A/en
Priority to JP7516492A priority patent/JPH09508619A/ja
Priority to DE69409969T priority patent/DE69409969T2/de
Priority to PCT/EP1994/003943 priority patent/WO1995016661A1/en
Publication of ITMI932612A1 publication Critical patent/ITMI932612A1/it
Application granted granted Critical
Publication of IT1264987B1 publication Critical patent/IT1264987B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids

Abstract

Sali dell'acido 4, 7, 10, 13, 16, 19-cis docosaesaenoico (DHA) con amminoacidi basici, in particolare arginina e lisina, presentano favorevoli caratteristiche terapeutiche e tecnologiche (idrosolubilità) rispetto all'acido di partenza.
IT93MI002612A 1993-12-14 1993-12-14 Sali di un acido grasso poliinsaturo e formulazioni farmaceutiche che li contengono IT1264987B1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT93MI002612A IT1264987B1 (it) 1993-12-14 1993-12-14 Sali di un acido grasso poliinsaturo e formulazioni farmaceutiche che li contengono
AU12412/95A AU1241295A (en) 1993-12-14 1994-11-28 Salts of a polyunsaturated fatty acid and pharmaceutical formulations containing them
EP95903298A EP0734373B1 (en) 1993-12-14 1994-11-28 Salts of a polyunsaturated fatty acid and pharmaceutical formulations containing them
US08/649,707 US5750572A (en) 1993-12-14 1994-11-28 Salts of a polyunsaturated fatty acid and pharmaceutical formulations containing them
ES95903298T ES2117390T3 (es) 1993-12-14 1994-11-28 Sales de un acido graso poliinsaturado y formulaciones farmaceuticas que las contienen.
JP7516492A JPH09508619A (ja) 1993-12-14 1994-11-28 ポリ不飽和脂肪酸の塩とこれらを含む医薬製剤
DE69409969T DE69409969T2 (de) 1993-12-14 1994-11-28 Salze der mehrfach ungesättigten fettsäuren und diese enthaltende pharmazeutischen zusammensetzungen
PCT/EP1994/003943 WO1995016661A1 (en) 1993-12-14 1994-11-28 Salts of a polyunsaturated fatty acid and pharmaceutical formulations containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI002612A IT1264987B1 (it) 1993-12-14 1993-12-14 Sali di un acido grasso poliinsaturo e formulazioni farmaceutiche che li contengono

Publications (3)

Publication Number Publication Date
ITMI932612A0 ITMI932612A0 (it) 1993-12-14
ITMI932612A1 ITMI932612A1 (it) 1995-06-14
IT1264987B1 true IT1264987B1 (it) 1996-10-17

Family

ID=11367322

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI002612A IT1264987B1 (it) 1993-12-14 1993-12-14 Sali di un acido grasso poliinsaturo e formulazioni farmaceutiche che li contengono

Country Status (8)

Country Link
US (1) US5750572A (it)
EP (1) EP0734373B1 (it)
JP (1) JPH09508619A (it)
AU (1) AU1241295A (it)
DE (1) DE69409969T2 (it)
ES (1) ES2117390T3 (it)
IT (1) IT1264987B1 (it)
WO (1) WO1995016661A1 (it)

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US6107499A (en) * 1988-02-26 2000-08-22 Neuromedica, Inc. Dopamine analog amide
AUPM906594A0 (en) * 1994-10-26 1994-11-17 Peptide Technology Limited Synthetic polyunsaturated fatty acid analogues
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US6197764B1 (en) 1997-11-26 2001-03-06 Protarga, Inc. Clozapine compositions and uses thereof
US5955459A (en) * 1997-11-26 1999-09-21 Neuromedica, Inc. Fatty acid-antipsychotic compositions and uses thereof
FR2781371B1 (fr) 1998-07-21 2001-04-27 Oreal Composition cosmetique aqueuse transparente a une seule phase
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
EP1423107B1 (en) * 2001-03-23 2012-05-09 Luitpold Pharmaceuticals, Inc. Fatty alcohol drug conjugates
JP2005500988A (ja) 2001-03-23 2005-01-13 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド 脂肪族アミン薬物複合体
GB0210212D0 (en) * 2002-05-03 2002-06-12 Univ Southampton Effects of dietary N-3 and N-6 pufa intake on atheromatous plaque stability
US8729124B2 (en) 2002-03-05 2014-05-20 Pronova Biopharma Norge As Use of EPA and DHA in secondary prevention
JP2003261456A (ja) * 2002-03-08 2003-09-16 Howaizu:Kk 脳の老化予防剤
US7935365B2 (en) 2003-10-22 2011-05-03 Enzymotec, Ltd. Glycerophospholipids for the improvement of cognitive functions
US8052992B2 (en) * 2003-10-22 2011-11-08 Enzymotec Ltd. Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions
US20050130937A1 (en) * 2003-10-22 2005-06-16 Enzymotec Ltd. Lipids containing omega-3 and omega-6 fatty acids
HU227588B1 (hu) * 2004-12-03 2011-09-28 Sinnex Mueszaki Fejlesztoe Es Tanacsado Kft Többszörösen telítetlen zsírsavak észtereit tartalmazó vírusellenes és immunstimuláns gyógyászati készítmény
ITMI20072142A1 (it) * 2007-11-08 2009-05-09 Yervant Zarmanian Composizioni farmaceutiche contenenti statine e derivati di acidi grassi omega-3
EP3058942B2 (en) * 2008-01-04 2023-03-22 Société des Produits Nestlé S.A. Compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and use thereof for enhancing cognitive and related functions
EP2367547B1 (en) 2008-12-12 2014-07-30 Cognite AB L-lysine for improving normal cognitive functions
WO2013103902A1 (en) 2012-01-06 2013-07-11 Omthera Pharmaceuticals, Inc. Dpa-enriched compositions of omega-3 polyunsaturated fatty acids in free acid form
AU2015277509A1 (en) * 2014-06-18 2017-01-05 Thetis Pharmaceuticals Llc Mineral amino-acid complexes of active agents
JP6861156B2 (ja) * 2014-12-23 2021-04-21 エボニック オペレーションズ ゲーエムベーハー ω−３系多価不飽和脂肪酸を含む組成物の安定性を向上させる方法
PE20171082A1 (es) * 2014-12-23 2017-08-03 Evonik Degussa Gmbh Proceso para aumentar la estabilidad de una composicion que comprende acidos grasos omega-6 poliinsaturados
FR3031451B1 (fr) * 2015-01-13 2018-03-23 Greentech Sel d'un triglyceride, preparation et utilisations
US20200315970A1 (en) * 2016-05-25 2020-10-08 Evonik Technochemie Gmbh Tablets with high active ingredient content of omega-3 fatty acid amino acid salts
EP3248467A1 (de) 2016-05-25 2017-11-29 Evonik Technochemie GmbH Verfahren zur herstellung einer zusammensetzung enthaltend omega-3-fettsäure-l-lysin-salze
CN109562186B (zh) 2016-06-03 2022-09-13 西蒂斯制药有限责任公司 与专门促消退介质的盐有关的组合物和方法
EP3648748A1 (en) 2017-07-06 2020-05-13 Evonik Operations GmbH Enteric coated solid dosage form comprising omega-3 fatty acid amino acid salts
EP3668498A1 (en) 2017-08-15 2020-06-24 Evonik Operations GmbH Tablets with high active ingredient content of omega-3 fatty acid amino acid salts
WO2019093708A1 (ko) * 2017-11-08 2019-05-16 김승수 악취 억제형 불포화오일 및 아르기닌 함유 조성물의 제조 방법
KR102172036B1 (ko) * 2017-11-08 2020-10-30 주식회사 오스테온 악취 억제형 불포화오일 및 아르기닌 함유 조성물의 제조 방법
US20220016065A1 (en) * 2018-11-30 2022-01-20 Evonik Operations Gmbh Preparation comprising a dispersion of phospholipids and fatty acid salts
EP3965755A1 (en) 2019-05-06 2022-03-16 Evonik Operations GmbH Preparation for use in weight management comprising omega-3 fatty acid salts and basic amino acids
WO2021023849A1 (en) 2019-08-08 2021-02-11 Evonik Operations Gmbh Down streaming process for the production of polyunsaturated fatty acid salts
EP4009960A1 (en) 2019-08-08 2022-06-15 Evonik Operations GmbH Method of preparing a solid dosage form and a binder
EP4009961A1 (en) * 2019-08-08 2022-06-15 Evonik Operations GmbH Solubility enhancement of poorly soluble actives
KR20220044543A (ko) 2019-08-08 2022-04-08 에보니크 오퍼레이션즈 게엠베하 고체 투여 형태를 제조하는 방법 및 윤활제
EP3804699A1 (en) 2019-10-10 2021-04-14 Evonik Operations GmbH Method of preparing a solid dosage form and a binder
US20230068687A1 (en) * 2020-01-30 2023-03-02 Silicycle Inc. Process for preparing a solid form of basic amino acid salts of polyunsaturated fatty acids
US20230037453A1 (en) 2020-04-01 2023-02-09 Evonik Operations Gmbh Preparation for use as vasorelaxant
WO2021197971A1 (en) 2020-04-01 2021-10-07 Evonik Operations Gmbh Preparation for use as antioxidant
DE102022003441A1 (de) 2022-09-17 2024-03-28 Jutta Ibrahim Nahrungsergänzungsmittel Omega3 und essentielle Aminosäure(n)

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Publication number Priority date Publication date Assignee Title
NL7405325A (it) * 1973-04-25 1974-10-29
HU209973B (en) * 1988-03-09 1995-01-30 Biorex Kutato Fejlesztoe Kft Process for production of antiviral and immunstimular pharmaceutical composition
GB8819110D0 (en) * 1988-08-11 1988-09-14 Norsk Hydro As Antihypertensive drug & method for production

Also Published As

Publication number Publication date
EP0734373A1 (en) 1996-10-02
US5750572A (en) 1998-05-12
JPH09508619A (ja) 1997-09-02
EP0734373B1 (en) 1998-04-29
ES2117390T3 (es) 1998-08-01
AU1241295A (en) 1995-07-03
DE69409969D1 (de) 1998-06-04
WO1995016661A1 (en) 1995-06-22
ITMI932612A0 (it) 1993-12-14
DE69409969T2 (de) 1998-12-10
ITMI932612A1 (it) 1995-06-14

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971223