BRPI0717098B8 - análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparação - Google Patents
análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparaçãoInfo
- Publication number
- BRPI0717098B8 BRPI0717098B8 BRPI0717098A BRPI0717098A BRPI0717098B8 BR PI0717098 B8 BRPI0717098 B8 BR PI0717098B8 BR PI0717098 A BRPI0717098 A BR PI0717098A BR PI0717098 A BRPI0717098 A BR PI0717098A BR PI0717098 B8 BRPI0717098 B8 BR PI0717098B8
- Authority
- BR
- Brazil
- Prior art keywords
- insulin analogues
- protease
- preparation
- pharmaceutical composition
- human insulin
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 108091005804 Peptidases Proteins 0.000 title abstract 3
- 239000004365 Protease Substances 0.000 title abstract 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 8
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06121113 | 2006-09-22 | ||
| EP06121113.2 | 2006-09-22 | ||
| EP061211132 | 2006-09-22 | ||
| PCT/EP2007/059990 WO2008034881A1 (en) | 2006-09-22 | 2007-09-20 | Protease resistant insulin analogues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0717098A2 BRPI0717098A2 (pt) | 2013-10-08 |
| BRPI0717098B1 BRPI0717098B1 (pt) | 2018-08-07 |
| BRPI0717098B8 true BRPI0717098B8 (pt) | 2021-05-25 |
Family
ID=38754488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0717098A BRPI0717098B8 (pt) | 2006-09-22 | 2007-09-20 | análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparação |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9018161B2 (enExample) |
| EP (2) | EP2074141B1 (enExample) |
| JP (2) | JP5864834B2 (enExample) |
| KR (2) | KR101729986B1 (enExample) |
| CN (1) | CN101541830A (enExample) |
| AU (1) | AU2007298919C1 (enExample) |
| BR (1) | BRPI0717098B8 (enExample) |
| CA (1) | CA2663074A1 (enExample) |
| DK (1) | DK2074141T3 (enExample) |
| ES (1) | ES2601839T3 (enExample) |
| HU (1) | HUE029512T2 (enExample) |
| IL (1) | IL197609A (enExample) |
| MX (1) | MX2009002999A (enExample) |
| NO (1) | NO20091563L (enExample) |
| PL (1) | PL2074141T3 (enExample) |
| PT (1) | PT2074141T (enExample) |
| RU (1) | RU2524150C2 (enExample) |
| TW (1) | TW200829600A (enExample) |
| WO (1) | WO2008034881A1 (enExample) |
| ZA (1) | ZA200901838B (enExample) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101389650B (zh) | 2005-12-28 | 2012-10-10 | 诺沃-诺迪斯克有限公司 | 包含酰化胰岛素和锌的组合物以及制备所述组合物的方法 |
| BRPI0717098B8 (pt) | 2006-09-22 | 2021-05-25 | Novo Nordisk As | análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparação |
| US9387176B2 (en) | 2007-04-30 | 2016-07-12 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
| JP2011504871A (ja) | 2007-06-01 | 2011-02-17 | ノボ・ノルデイスク・エー／エス | 固体又は半固体担体中にペプチド薬剤を含む自然に分散可能なプレコンセントレイト |
| KR20100017667A (ko) | 2007-06-01 | 2010-02-16 | 노보 노르디스크 에이/에스 | 안정한 비-수성의 약학 조성물 |
| CN101677947B (zh) | 2007-06-13 | 2013-07-17 | 诺沃-诺迪斯克有限公司 | 包含胰岛素衍生物的药物制剂 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| MY152979A (en) | 2008-01-09 | 2014-12-15 | Sanofi Aventis Deutschland | Novel insulin derivatives having an extremely delayed time-action profile |
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| US8691759B2 (en) | 2008-03-18 | 2014-04-08 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| WO2009133099A2 (en) * | 2008-04-28 | 2009-11-05 | Novo Nordisk A/S | Insulin precursors for diabetes treatment |
| BRPI0920881B1 (pt) | 2008-10-17 | 2021-09-21 | Sanofi-Aventis Deutschland Gmbh | Composição farmacêutica, seu uso e método de preparação da mesma, kit e dispositivo |
| JP4959005B2 (ja) | 2008-10-30 | 2012-06-20 | ノボ・ノルデイスク・エー／エス | 毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療 |
| JP2012511506A (ja) * | 2008-12-09 | 2012-05-24 | ノヴォ・ノルディスク・アー／エス | 新規インスリンアナログ |
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| US20120184487A1 (en) * | 2009-06-30 | 2012-07-19 | Novo Nordisk A/S | Insulin derivatives |
| WO2011003823A1 (de) * | 2009-07-06 | 2011-01-13 | Sanofi-Aventis Deutschland Gmbh | Langsamwirkende insulinzubereitungen |
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| NZ599847A (en) | 2009-11-13 | 2013-09-27 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist and methionine |
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| KR20120117013A (ko) * | 2010-01-12 | 2012-10-23 | 노보 노르디스크 에이/에스 | 인슐린 펩티드의 경구 투여를 위한 약학적 조성물 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
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| JP5931857B2 (ja) * | 2010-06-23 | 2016-06-08 | ノヴォ ノルディスク アー／エス | 追加のジスルフィド結合を含有するインスリン誘導体 |
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- 2007-09-20 WO PCT/EP2007/059990 patent/WO2008034881A1/en not_active Ceased
- 2007-09-20 EP EP07820423.7A patent/EP2074141B1/en not_active Revoked
- 2007-09-20 RU RU2009114324/10A patent/RU2524150C2/ru not_active IP Right Cessation
- 2007-09-20 DK DK07820423.7T patent/DK2074141T3/en active
- 2007-09-20 PL PL07820423T patent/PL2074141T3/pl unknown
- 2007-09-20 KR KR1020097005790A patent/KR101699370B1/ko not_active Expired - Fee Related
- 2007-09-20 HU HUE07820423A patent/HUE029512T2/en unknown
- 2007-09-20 US US12/442,190 patent/US9018161B2/en active Active
- 2007-09-20 EP EP11173251A patent/EP2404934A1/en not_active Withdrawn
- 2007-09-20 PT PT78204237T patent/PT2074141T/pt unknown
- 2007-09-20 ES ES07820423.7T patent/ES2601839T3/es active Active
- 2007-09-21 TW TW096135252A patent/TW200829600A/zh unknown
-
2009
- 2009-03-16 IL IL197609A patent/IL197609A/en active IP Right Grant
- 2009-03-16 ZA ZA2009/01838A patent/ZA200901838B/en unknown
- 2009-04-20 NO NO20091563A patent/NO20091563L/no not_active Application Discontinuation
-
2014
- 2014-01-24 JP JP2014011829A patent/JP2014129355A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PL2074141T3 (pl) | 2017-02-28 |
| IL197609A (en) | 2017-04-30 |
| JP2010504087A (ja) | 2010-02-12 |
| ES2601839T3 (es) | 2017-02-16 |
| KR101729986B1 (ko) | 2017-04-25 |
| JP2014129355A (ja) | 2014-07-10 |
| MX2009002999A (es) | 2009-04-01 |
| ZA200901838B (en) | 2010-02-24 |
| JP5864834B2 (ja) | 2016-02-17 |
| RU2009114324A (ru) | 2010-10-27 |
| AU2007298919C1 (en) | 2014-02-06 |
| BRPI0717098A2 (pt) | 2013-10-08 |
| DK2074141T3 (en) | 2016-11-28 |
| IL197609A0 (en) | 2011-08-01 |
| PT2074141T (pt) | 2016-11-10 |
| WO2008034881A1 (en) | 2008-03-27 |
| NO20091563L (no) | 2009-04-20 |
| CA2663074A1 (en) | 2008-03-27 |
| KR101699370B1 (ko) | 2017-02-14 |
| EP2074141B1 (en) | 2016-08-10 |
| EP2074141A1 (en) | 2009-07-01 |
| AU2007298919A1 (en) | 2008-03-27 |
| TW200829600A (en) | 2008-07-16 |
| EP2404934A1 (en) | 2012-01-11 |
| KR20150031494A (ko) | 2015-03-24 |
| BRPI0717098B1 (pt) | 2018-08-07 |
| US9018161B2 (en) | 2015-04-28 |
| KR20090071561A (ko) | 2009-07-01 |
| HUE029512T2 (en) | 2017-03-28 |
| RU2524150C2 (ru) | 2014-07-27 |
| US20100009898A1 (en) | 2010-01-14 |
| CN101541830A (zh) | 2009-09-23 |
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