GB1492997A - Insulin derivatives - Google Patents

Insulin derivatives

Info

Publication number
GB1492997A
GB1492997A GB3147575A GB3147575A GB1492997A GB 1492997 A GB1492997 A GB 1492997A GB 3147575 A GB3147575 A GB 3147575A GB 3147575 A GB3147575 A GB 3147575A GB 1492997 A GB1492997 A GB 1492997A
Authority
GB
United Kingdom
Prior art keywords
group
lysine
july
amino acid
insulin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3147575A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Priority to GB3147575A priority Critical patent/GB1492997A/en
Publication of GB1492997A publication Critical patent/GB1492997A/en
Application status is Expired legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • C07K14/625Extraction from natural sources
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Abstract

1492997 Insulin derivatives NATIONAL RESEARCH DEVELOPMENT CORP 21 July 1976 [28 July 1975] 31475/75 Addition to 1408757 Heading A5B [Also in Division C3] A pharmaceutical composition comprises an N - substituted insulin wherein the primary amino group of the B 29 (lysine) amino acid unit carries a carbamoyl group, N - substitution being absent from the primary group of the A 1 (glycine) and B 1 (phenylalanine) amino acid units, together with a physiologically - acceptable diluent or carrier. The composition is preferably in a form for parenteral administration and the preferred compound is B 29 (lysine) - N - carbamylinsulin.
GB3147575A 1976-07-21 1976-07-21 Insulin derivatives Expired GB1492997A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3147575A GB1492997A (en) 1976-07-21 1976-07-21 Insulin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3147575A GB1492997A (en) 1976-07-21 1976-07-21 Insulin derivatives

Publications (1)

Publication Number Publication Date
GB1492997A true GB1492997A (en) 1977-11-23

Family

ID=10323647

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3147575A Expired GB1492997A (en) 1976-07-21 1976-07-21 Insulin derivatives

Country Status (1)

Country Link
GB (1) GB1492997A (en)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US5646242A (en) * 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US5700904A (en) * 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
WO2006082204A1 (en) 2005-02-02 2006-08-10 Novo Nordisk A/S Insulin derivatives
EP2033662A1 (en) 2004-01-21 2009-03-11 Novo Nordisk Health Care AG Transglutaminase mediated conjugation of peptides
EP2107069A2 (en) 2003-08-05 2009-10-07 Novo Nordisk A/S Novel insulin derivatives
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
EP2264066A2 (en) 2003-08-05 2010-12-22 Novo Nordisk A/S Novel insulin derivatives
EP2292653A1 (en) 2005-02-02 2011-03-09 Novo Nordisk A/S Novel insulin derivatives
US8710000B2 (en) 2007-11-08 2014-04-29 Novo Nordisk A/S Insulin derivative
US8710001B2 (en) 2006-07-31 2014-04-29 Novo Nordisk A/S PEGylated, extended insulins
US9018161B2 (en) 2006-09-22 2015-04-28 Novo Nordisk A/S Protease resistant insulin analogues
US9034818B2 (en) 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
US9260502B2 (en) 2008-03-14 2016-02-16 Novo Nordisk A/S Protease-stabilized insulin analogues
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9481721B2 (en) 2012-04-11 2016-11-01 Novo Nordisk A/S Insulin formulations
US9603904B2 (en) 2008-10-30 2017-03-28 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
US9688737B2 (en) 2008-03-18 2017-06-27 Novo Nordisk A/S Protease stabilized acylated insulin analogues
US9896496B2 (en) 2013-10-07 2018-02-20 Novo Nordisk A/S Derivative of an insulin analogue
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
US5646242A (en) * 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US5922675A (en) * 1994-11-17 1999-07-13 Eli Lilly And Company Acylated Insulin Analogs
USRE37971E1 (en) 1994-11-17 2003-01-28 Eli Lilly And Company Selective acylation of epsilon-amino groups
US6620780B2 (en) 1995-03-17 2003-09-16 Novo Nordisk A/S Insulin derivatives
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
US7229964B2 (en) 1995-03-17 2007-06-12 Novo Nordisk A/S Insulin derivatives
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US5700904A (en) * 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US8030269B2 (en) 2001-06-04 2011-10-04 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
EP2264065A2 (en) 2003-08-05 2010-12-22 Novo Nordisk A/S Novel Insulin Derivatives
US7615532B2 (en) 2003-08-05 2009-11-10 Novo Nordisk A/S Insulin derivatives
US8828923B2 (en) 2003-08-05 2014-09-09 Novo Nordisk A/S Insulin derivatives
EP2287184A2 (en) 2003-08-05 2011-02-23 Novo Nordisk A/S Novel insulin derivatives
EP2264066A2 (en) 2003-08-05 2010-12-22 Novo Nordisk A/S Novel insulin derivatives
EP2275439A2 (en) 2003-08-05 2011-01-19 Novo Nordisk A/S Novel insulin derivatives
EP2107069A2 (en) 2003-08-05 2009-10-07 Novo Nordisk A/S Novel insulin derivatives
EP2368579A1 (en) 2004-01-21 2011-09-28 Novo Nordisk Health Care AG Transglutaminase mediated conjugation of peptides
EP2033662A1 (en) 2004-01-21 2009-03-11 Novo Nordisk Health Care AG Transglutaminase mediated conjugation of peptides
WO2006082204A1 (en) 2005-02-02 2006-08-10 Novo Nordisk A/S Insulin derivatives
EP2292653A1 (en) 2005-02-02 2011-03-09 Novo Nordisk A/S Novel insulin derivatives
US8067362B2 (en) 2005-02-02 2011-11-29 Novo Nordisk As Insulin derivatives
US8476228B2 (en) 2005-02-02 2013-07-02 Novo Nordisk A/S Insulin derivatives
USRE46170E1 (en) 2005-02-02 2016-10-04 Novo Nordisk A/S Insulin derivatives
EP2256130A1 (en) 2005-02-02 2010-12-01 Novo Nordisk A/S Novel insulin derivatives
US8859493B2 (en) 2005-02-02 2014-10-14 Novo Nordisk A/S Insulin derivatives
US8710001B2 (en) 2006-07-31 2014-04-29 Novo Nordisk A/S PEGylated, extended insulins
US9018161B2 (en) 2006-09-22 2015-04-28 Novo Nordisk A/S Protease resistant insulin analogues
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9034818B2 (en) 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
US8710000B2 (en) 2007-11-08 2014-04-29 Novo Nordisk A/S Insulin derivative
US9260502B2 (en) 2008-03-14 2016-02-16 Novo Nordisk A/S Protease-stabilized insulin analogues
US9688737B2 (en) 2008-03-18 2017-06-27 Novo Nordisk A/S Protease stabilized acylated insulin analogues
US9603904B2 (en) 2008-10-30 2017-03-28 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
US9481721B2 (en) 2012-04-11 2016-11-01 Novo Nordisk A/S Insulin formulations
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
US9896496B2 (en) 2013-10-07 2018-02-20 Novo Nordisk A/S Derivative of an insulin analogue

Similar Documents

Publication Publication Date Title
GB1152977A (en) Sweetening Agents
GB1175440A (en) Phenoxyacetic Acids
AU646052B2 (en) 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
AU590618B2 (en) Stable formulation of biologically active proteins for parenteral injection
AU579467B2 (en) Synthetic peptide and process of using same for detection of antibodies to HTLV-III, diagnosis of AIDS and pre-AIDS conditions, and as a vaccine
AP471A (en) Process for the preparation of clavulanic acid.
EP0393727A3 (en) Transdermal delivery system
GB2082331A (en) System for demand-based administration of insulin
GB1496769A (en) 5-substituted ethyl-8-hydroxycarbostyril derivatives and production thereof
GB1261230A (en) Acyl-substituted insulins
GB1432576A (en) Substituted phenylacetic acids
TW466242B (en) Camptothecin derivatives
YU49477B (en) Pharmaceutical composition for topical application containing acyclovir and hydrocortisone
AU588968B2 (en) Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
AU5346179A (en) Amino acid derivatives as antihypertensives
SK39595A3 (en) Derivatives of valproic and 2-valproenoic acid amides and use as anticonvulsants
MD1233C2 (en) Erythromycin derivatives, process for their preparation and pharmaceutical composition on base thereof
SE9103572D0 (en) Organic salts of N, N'-diacetyl cystine
JPS63253097A (en) Peptide compound, its production and pharmaceutical composition containing said compound
JPH01125398A (en) Amino acid derivative and its production
EP0220957A3 (en) Platelet binding inhibitors
IL90550A (en) Amino acid derivatives, process and intermediates for their manufacture and pharmaceutical compositions containing them
OA6421A (en) Process for the preparation of derivatives N- (vinblastinoyl-23) amino acids and peptides.
AU6938591A (en) Boronic acid adducts of rhenium dioxime and technetium-99m dioxime complexes containing a biochemically active group
HUT69288A (en) Amino acid linked nitrogen mustard derivatives pharmaceutical compns. contg. them and process to prepare them

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee