MX337549B - Derivados de insulina que contienen enlaces disulfuro adicionales. - Google Patents

Derivados de insulina que contienen enlaces disulfuro adicionales.

Info

Publication number
MX337549B
MX337549B MX2012014641A MX2012014641A MX337549B MX 337549 B MX337549 B MX 337549B MX 2012014641 A MX2012014641 A MX 2012014641A MX 2012014641 A MX2012014641 A MX 2012014641A MX 337549 B MX337549 B MX 337549B
Authority
MX
Mexico
Prior art keywords
disulfide bonds
derivatives containing
containing additional
insulin derivatives
additional disulfide
Prior art date
Application number
MX2012014641A
Other languages
English (en)
Other versions
MX2012014641A (es
Inventor
Peter Madsen
Svend Ludvigsen
Frantisek Hubalek
Thomas Børglum Kjeldsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of MX2012014641A publication Critical patent/MX2012014641A/es
Publication of MX337549B publication Critical patent/MX337549B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a derivados de insulina que contienen enlaces disulfuro adicionales y métodos para su elaboración.
MX2012014641A 2010-06-23 2011-06-21 Derivados de insulina que contienen enlaces disulfuro adicionales. MX337549B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10167033 2010-06-23
EP10167046 2010-06-23
US35915010P 2010-06-28 2010-06-28
US35950010P 2010-06-29 2010-06-29
PCT/EP2011/060383 WO2011161125A1 (en) 2010-06-23 2011-06-21 Insulin derivatives containing additional disulfide bonds

Publications (2)

Publication Number Publication Date
MX2012014641A MX2012014641A (es) 2013-02-07
MX337549B true MX337549B (es) 2016-03-10

Family

ID=44508482

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012014641A MX337549B (es) 2010-06-23 2011-06-21 Derivados de insulina que contienen enlaces disulfuro adicionales.

Country Status (13)

Country Link
US (2) US8853155B2 (es)
EP (1) EP2585485A1 (es)
JP (1) JP5931857B2 (es)
KR (1) KR20130036290A (es)
CN (2) CN104693302A (es)
AU (1) AU2011269000C1 (es)
BR (1) BR112012033107A2 (es)
CA (1) CA2802510A1 (es)
IL (1) IL223288A0 (es)
MX (1) MX337549B (es)
RU (1) RU2598273C2 (es)
WO (1) WO2011161125A1 (es)
ZA (1) ZA201209345B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2910570B1 (en) 2008-03-18 2016-10-12 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
JP2014509603A (ja) * 2011-03-15 2014-04-21 ノヴォ ノルディスク アー／エス システイン置換を含むヒトインスリン類似体およびヒトインスリン誘導体
JP2015502971A (ja) * 2011-12-21 2015-01-29 ノヴォ ノルディスク アー／エス Ｎ末端修飾インスリン誘導体
KR20150002777A (ko) 2012-04-11 2015-01-07 노보 노르디스크 에이/에스 인슐린 제제
US20150111820A1 (en) 2012-07-09 2015-04-23 Novo Nordisk A/S Novel use of insulin derivatives
AU2014333979B2 (en) * 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
AR099569A1 (es) * 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
WO2016119854A1 (en) * 2015-01-29 2016-08-04 Novo Nordisk A/S Pharmaceutical composition for oral insulin administration comprising a tablet core and a polyvinyl alcohol coating
SG11201803911PA (en) * 2015-12-23 2018-07-30 Univ Case Western Reserve Encapsulation of ultra-stable insulin analogues with polymer melts
CN107436311B (zh) * 2016-05-25 2021-11-19 正大天晴药业集团股份有限公司 一种鉴别胰岛素单体或胰岛素多聚体的方法
SI3554534T1 (sl) 2016-12-16 2021-09-30 Novo Nordisk A/S Farmacevtski sestavki, ki vsebujejo inzulin
US11566059B2 (en) 2018-08-08 2023-01-31 Daewoong Pharmaceutical Co., Ltd. Long-acting insulin analogues and derivatives thereof
CN113121649B (zh) * 2019-12-26 2022-10-04 李瑛� 一种新型两亲性蛋白、其制备方法及用途

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DK155690D0 (da) * 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
ZA954983B (en) 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
AU1111799A (en) * 1997-10-24 1999-05-17 Eli Lilly And Company Fatty acid-acylated insulin analogs
IL144989A0 (en) 1999-03-17 2002-06-30 Novo Nordisk As Method for acylating peptides and novel acylating agents
KR20030004317A (ko) 1999-12-29 2003-01-14 노보 노르디스크 에이/에스 인슐린 선구물질 및 인슐린 선구물질 유사체의 제조 방법
ATE434602T1 (de) 2002-09-25 2009-07-15 Novo Nordisk As Verfahren zur herstellung acylierter peptide
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
EP2107069B1 (en) * 2003-08-05 2013-01-16 Novo Nordisk A/S Novel insulin derivatives
JP5697831B2 (ja) 2003-12-03 2015-04-08 ノヴォ ノルディスク アー／エス 単鎖インシュリン
WO2006008238A1 (en) 2004-07-16 2006-01-26 Novo Nordisk A/S Method for selective acylation
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
JP2009527526A (ja) 2006-02-21 2009-07-30 ノボ・ノルデイスク・エー／エス 単鎖インスリンのアナログとその製薬的製剤
WO2007135117A2 (en) 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
PL2074141T3 (pl) 2006-09-22 2017-02-28 Novo Nordisk A/S Analogi insuliny oporne na proteazę
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
EP2708554A1 (en) * 2007-08-15 2014-03-19 Novo Nordisk A/S Insulin analogues with an acyl and alkylene glycol moiety
BRPI0907371A2 (pt) 2008-01-09 2015-11-24 Sanofi Aventis Deutschland derivados de insulina com um perfil de tempo-ação muito retardado
EP2254905B1 (en) 2008-03-14 2016-12-14 Novo Nordisk A/S Protease-stabilized insulin analogues
EP2910570B1 (en) 2008-03-18 2016-10-12 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
CN106317164A (zh) 2008-09-12 2017-01-11 诺沃—诺迪斯克有限公司 酰化肽或蛋白的方法
EP2376531A1 (en) 2008-12-09 2011-10-19 Novo Nordisk A/S Novel insulin analogues
WO2011028813A2 (en) 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
WO2011161083A1 (en) 2010-06-23 2011-12-29 Novo Nordisk A/S Human insulin containing additional disulfide bonds
JP5973427B2 (ja) 2010-06-23 2016-08-23 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン類似体

Also Published As

Publication number Publication date
CN102985440B (zh) 2016-10-26
EP2585485A1 (en) 2013-05-01
CN102985440A (zh) 2013-03-20
ZA201209345B (en) 2013-08-28
MX2012014641A (es) 2013-02-07
AU2011269000B2 (en) 2015-04-23
WO2011161125A1 (en) 2011-12-29
CA2802510A1 (en) 2011-12-29
RU2598273C2 (ru) 2016-09-20
JP2013530974A (ja) 2013-08-01
US20130157938A1 (en) 2013-06-20
AU2011269000C1 (en) 2015-10-08
US8853155B2 (en) 2014-10-07
KR20130036290A (ko) 2013-04-11
RU2012157683A (ru) 2014-07-27
US9512195B2 (en) 2016-12-06
AU2011269000A1 (en) 2012-12-13
CN104693302A (zh) 2015-06-10
US20140371140A1 (en) 2014-12-18
IL223288A0 (en) 2013-02-03
BR112012033107A2 (pt) 2016-10-11
JP5931857B2 (ja) 2016-06-08

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