BR9813128A - Agregado solúvel em água de derivados de insulina, derivado de insulina, preparação farmacêutica, e, processo para tratamento de diabetes mellitus - Google Patents
Agregado solúvel em água de derivados de insulina, derivado de insulina, preparação farmacêutica, e, processo para tratamento de diabetes mellitusInfo
- Publication number
- BR9813128A BR9813128A BR9813128-1A BR9813128A BR9813128A BR 9813128 A BR9813128 A BR 9813128A BR 9813128 A BR9813128 A BR 9813128A BR 9813128 A BR9813128 A BR 9813128A
- Authority
- BR
- Brazil
- Prior art keywords
- insulin
- water
- soluble
- derivatives
- diabetes mellitus
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 5
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 239000004026 insulin derivative Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 1
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Abstract
"AGREGADO SOLúVEL EM áGUA DE DERIVADOS DE INSULINA, DERIVADO DE INSULINA, PREPARAçãO FARMACêUTICA, E, PROCESSO PARA TRATAMENTO DE DIABETES MELLITUS" São divulgados agregados solúveis em água de derivados de insulina humana que possuem um perfil prolongado de ação. Um novo mecanismo está envolvido no prolongamento da ação dos derivados solúveis de insulina. Este mecanismo está baseado na formação parcial ou completa das formas agregadas solúveis dos derivados, apresentando um tamanho maior que a aldolase (Mw = 158 kDa) em um sistema definido de filtração em gel.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK121897 | 1997-10-24 | ||
US6417097P | 1997-11-04 | 1997-11-04 | |
PCT/DK1998/000461 WO1999021888A1 (en) | 1997-10-24 | 1998-10-23 | Aggregates of human insulin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9813128A true BR9813128A (pt) | 2000-08-15 |
Family
ID=26065414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9813128-1A BR9813128A (pt) | 1997-10-24 | 1998-10-23 | Agregado solúvel em água de derivados de insulina, derivado de insulina, preparação farmacêutica, e, processo para tratamento de diabetes mellitus |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1025125B1 (pt) |
JP (1) | JP2003525846A (pt) |
KR (1) | KR100539193B1 (pt) |
CN (1) | CN1240718C (pt) |
AT (1) | ATE243711T1 (pt) |
AU (1) | AU757933B2 (pt) |
BR (1) | BR9813128A (pt) |
CA (1) | CA2308705A1 (pt) |
DE (1) | DE69815877T2 (pt) |
DK (1) | DK1025125T3 (pt) |
ES (1) | ES2202899T3 (pt) |
HU (1) | HUP0004096A3 (pt) |
IL (2) | IL135400A0 (pt) |
NO (1) | NO20002050L (pt) |
PL (1) | PL195845B1 (pt) |
PT (1) | PT1025125E (pt) |
RU (1) | RU2218349C2 (pt) |
UA (1) | UA69393C2 (pt) |
WO (1) | WO1999021888A1 (pt) |
ZA (1) | ZA989722B (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7316999B2 (en) | 2000-06-02 | 2008-01-08 | Novo Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
US6838076B2 (en) | 2001-05-21 | 2005-01-04 | Nektar Therapeutics | Pulmonary administration of chemically modified insulin |
US7317000B2 (en) | 2001-12-02 | 2008-01-08 | Novo Nordisk A/S | Glucose-dependent insulins |
EP2275439B1 (en) * | 2003-08-05 | 2014-03-26 | Novo Nordisk A/S | Novel insulin derivatives |
CA2531988C (en) * | 2003-08-05 | 2016-06-28 | Novo Nordisk A/S | Novel insulin derivatives |
JP5220410B2 (ja) * | 2004-07-19 | 2013-06-26 | バイオコン・リミテッド | インスリン−オリゴマー複合体、その処方物及び使用 |
EP1888104A2 (en) * | 2005-05-26 | 2008-02-20 | Novo Nordisk A/S | Acylated insulin with high purity |
PT1969004E (pt) | 2005-12-28 | 2011-11-25 | Novo Nordisk As | Composições que compreendem uma insulina acilada e zinco e método para criar tais composições |
ES2387955T3 (es) | 2006-02-27 | 2012-10-04 | Novo Nordisk A/S | Derivados de insulina |
WO2007140619A1 (en) * | 2006-06-08 | 2007-12-13 | Diabecore Medical Inc. | Derivatized insulin oligomers |
WO2008015099A2 (en) | 2006-07-31 | 2008-02-07 | Novo Nordisk A/S | Pegylated, extended insulins |
KR101729986B1 (ko) | 2006-09-22 | 2017-04-25 | 노보 노르디스크 에이/에스 | 프로테아제 내성 인슐린 유사체 |
WO2008132224A2 (en) | 2007-04-30 | 2008-11-06 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
WO2008152106A1 (en) | 2007-06-13 | 2008-12-18 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
WO2009112583A2 (en) | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
MX2010009850A (es) | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
US9603904B2 (en) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
BR112013010345A2 (pt) | 2010-10-27 | 2017-07-25 | Novo Nordisk As | tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção |
CN103191416A (zh) * | 2012-01-05 | 2013-07-10 | 四川大学 | 一种猪胰岛素超分子聚集体及其制备方法 |
WO2013153000A2 (en) | 2012-04-11 | 2013-10-17 | Novo Nordisk A/S | Insulin formulations |
WO2014177623A1 (en) | 2013-04-30 | 2014-11-06 | Novo Nordisk A/S | Novel administration regime |
KR20160065126A (ko) | 2013-10-07 | 2016-06-08 | 노보 노르디스크 에이/에스 | 인슐린 유사체의 신규한 유도체 |
AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
SI3554534T1 (sl) | 2016-12-16 | 2021-09-30 | Novo Nordisk A/S | Farmacevtski sestavki, ki vsebujejo inzulin |
TWI783890B (zh) | 2017-08-24 | 2022-11-11 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
AU2021208601A1 (en) | 2020-02-18 | 2022-07-28 | Novo Nordisk A/S | Glp-1 compositions and uses thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5559094A (en) * | 1994-08-02 | 1996-09-24 | Eli Lilly And Company | AspB1 insulin analogs |
US6451970B1 (en) * | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
-
1998
- 1998-10-23 UA UA2000042275A patent/UA69393C2/uk unknown
- 1998-10-23 AU AU96221/98A patent/AU757933B2/en not_active Ceased
- 1998-10-23 KR KR10-2000-7004229A patent/KR100539193B1/ko not_active IP Right Cessation
- 1998-10-23 PT PT98949960T patent/PT1025125E/pt unknown
- 1998-10-23 WO PCT/DK1998/000461 patent/WO1999021888A1/en active IP Right Grant
- 1998-10-23 ES ES98949960T patent/ES2202899T3/es not_active Expired - Lifetime
- 1998-10-23 EP EP98949960A patent/EP1025125B1/en not_active Expired - Lifetime
- 1998-10-23 IL IL13540098A patent/IL135400A0/xx not_active IP Right Cessation
- 1998-10-23 JP JP2000517995A patent/JP2003525846A/ja not_active Withdrawn
- 1998-10-23 DE DE69815877T patent/DE69815877T2/de not_active Expired - Fee Related
- 1998-10-23 DK DK98949960T patent/DK1025125T3/da active
- 1998-10-23 HU HU0004096A patent/HUP0004096A3/hu unknown
- 1998-10-23 RU RU2000112882/04A patent/RU2218349C2/ru not_active IP Right Cessation
- 1998-10-23 BR BR9813128-1A patent/BR9813128A/pt not_active IP Right Cessation
- 1998-10-23 CA CA002308705A patent/CA2308705A1/en not_active Abandoned
- 1998-10-23 AT AT98949960T patent/ATE243711T1/de not_active IP Right Cessation
- 1998-10-23 CN CNB988104458A patent/CN1240718C/zh not_active Expired - Fee Related
- 1998-10-23 PL PL98340032A patent/PL195845B1/pl unknown
- 1998-10-26 ZA ZA989722A patent/ZA989722B/xx unknown
-
2000
- 2000-03-31 IL IL135400A patent/IL135400A/en unknown
- 2000-04-18 NO NO20002050A patent/NO20002050L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PT1025125E (pt) | 2003-11-28 |
ZA989722B (en) | 1999-04-26 |
HUP0004096A3 (en) | 2001-12-28 |
PL340032A1 (en) | 2001-01-15 |
EP1025125A1 (en) | 2000-08-09 |
KR100539193B1 (ko) | 2005-12-27 |
HUP0004096A2 (hu) | 2001-05-28 |
KR20010031247A (ko) | 2001-04-16 |
JP2003525846A (ja) | 2003-09-02 |
EP1025125B1 (en) | 2003-06-25 |
CN1281466A (zh) | 2001-01-24 |
NO20002050L (no) | 2000-06-23 |
UA69393C2 (uk) | 2004-09-15 |
DE69815877D1 (de) | 2003-07-31 |
ATE243711T1 (de) | 2003-07-15 |
PL195845B1 (pl) | 2007-10-31 |
RU2218349C2 (ru) | 2003-12-10 |
DE69815877T2 (de) | 2004-05-19 |
NO20002050D0 (no) | 2000-04-18 |
WO1999021888A1 (en) | 1999-05-06 |
AU757933B2 (en) | 2003-03-13 |
DK1025125T3 (da) | 2003-10-06 |
CN1240718C (zh) | 2006-02-08 |
ES2202899T3 (es) | 2004-04-01 |
CA2308705A1 (en) | 1999-05-06 |
IL135400A (en) | 2007-08-19 |
AU9622198A (en) | 1999-05-17 |
IL135400A0 (en) | 2001-05-20 |
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Legal Events
Date | Code | Title | Description |
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A,12 E 13A ANUIDADE(S). |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2125 DE 27/09/2011. |