DK1025125T3 - Aggregater for humane insulinderivater - Google Patents

Aggregater for humane insulinderivater

Info

Publication number
DK1025125T3
DK1025125T3 DK98949960T DK98949960T DK1025125T3 DK 1025125 T3 DK1025125 T3 DK 1025125T3 DK 98949960 T DK98949960 T DK 98949960T DK 98949960 T DK98949960 T DK 98949960T DK 1025125 T3 DK1025125 T3 DK 1025125T3
Authority
DK
Denmark
Prior art keywords
aggregates
derivatives
human insulin
soluble
insulin derivatives
Prior art date
Application number
DK98949960T
Other languages
English (en)
Inventor
Ib Jonassen
Svend Havelund
Per Balschmidt
Thomas Hoeg-Jensen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of DK1025125T3 publication Critical patent/DK1025125T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK98949960T 1997-10-24 1998-10-23 Aggregater for humane insulinderivater DK1025125T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK121897 1997-10-24
US6417097P 1997-11-04 1997-11-04
PCT/DK1998/000461 WO1999021888A1 (en) 1997-10-24 1998-10-23 Aggregates of human insulin derivatives

Publications (1)

Publication Number Publication Date
DK1025125T3 true DK1025125T3 (da) 2003-10-06

Family

ID=26065414

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98949960T DK1025125T3 (da) 1997-10-24 1998-10-23 Aggregater for humane insulinderivater

Country Status (20)

Country Link
EP (1) EP1025125B1 (da)
JP (1) JP2003525846A (da)
KR (1) KR100539193B1 (da)
CN (1) CN1240718C (da)
AT (1) ATE243711T1 (da)
AU (1) AU757933B2 (da)
BR (1) BR9813128A (da)
CA (1) CA2308705A1 (da)
DE (1) DE69815877T2 (da)
DK (1) DK1025125T3 (da)
ES (1) ES2202899T3 (da)
HU (1) HUP0004096A3 (da)
IL (2) IL135400A0 (da)
NO (1) NO20002050L (da)
PL (1) PL195845B1 (da)
PT (1) PT1025125E (da)
RU (1) RU2218349C2 (da)
UA (1) UA69393C2 (da)
WO (1) WO1999021888A1 (da)
ZA (1) ZA989722B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
MY137181A (en) 2001-05-21 2009-01-30 Nektar Therapeutics Pulmonary administration of chemically modified insulin
US7317000B2 (en) 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
PT2275439E (pt) * 2003-08-05 2014-06-25 Novo Nordisk As Novos derivados de insulina
EP1660531A2 (en) * 2003-08-05 2006-05-31 Novo Nordisk A/S Novel insulin derivatives
EP2626368B1 (en) * 2004-07-19 2016-12-21 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
EP1888104A2 (en) * 2005-05-26 2008-02-20 Novo Nordisk A/S Acylated insulin with high purity
DK1969004T3 (da) 2005-12-28 2011-11-28 Novo Nordisk As Insulinsammensætninger og metode til at lave en sammensætning
ES2387955T3 (es) * 2006-02-27 2012-10-04 Novo Nordisk A/S Derivados de insulina
JP2009539778A (ja) * 2006-06-08 2009-11-19 ダイアベコア メディカル インコーポレイテッド インスリンオリゴマー誘導体
EP2049149B1 (en) 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
PT2074141T (pt) 2006-09-22 2016-11-10 Novo Nordisk As Análogos de insulina resistentes a proteases
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9034818B2 (en) 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
US9260502B2 (en) 2008-03-14 2016-02-16 Novo Nordisk A/S Protease-stabilized insulin analogues
PL2254906T3 (pl) 2008-03-18 2017-04-28 Novo Nordisk A/S Stabilizowane względem proteaz, acylowane analogi insuliny
CA2738615A1 (en) 2008-10-30 2010-05-06 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
BR112013010345A2 (pt) 2010-10-27 2017-07-25 Novo Nordisk As tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
CN103191416A (zh) * 2012-01-05 2013-07-10 四川大学 一种猪胰岛素超分子聚集体及其制备方法
MX2014012096A (es) 2012-04-11 2014-11-21 Novo Nordisk As Formulaciones de insulina.
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
CA2926701A1 (en) 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
EP3554534B1 (en) 2016-12-16 2021-06-23 Novo Nordisk A/S Insulin containing pharmaceutical compositions
WO2019038412A1 (en) 2017-08-24 2019-02-28 Novo Nordisk A/S GLP-1 COMPOSITIONS AND USES THEREOF
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
AU2021207313A1 (en) 2020-02-18 2022-07-28 Novo Nordisk A/S Pharmaceutical formulations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559094A (en) * 1994-08-02 1996-09-24 Eli Lilly And Company AspB1 insulin analogs
US6451970B1 (en) * 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives

Also Published As

Publication number Publication date
KR100539193B1 (ko) 2005-12-27
ES2202899T3 (es) 2004-04-01
PL340032A1 (en) 2001-01-15
NO20002050D0 (no) 2000-04-18
IL135400A (en) 2007-08-19
ATE243711T1 (de) 2003-07-15
IL135400A0 (en) 2001-05-20
EP1025125A1 (en) 2000-08-09
CN1240718C (zh) 2006-02-08
RU2218349C2 (ru) 2003-12-10
PL195845B1 (pl) 2007-10-31
CA2308705A1 (en) 1999-05-06
CN1281466A (zh) 2001-01-24
DE69815877T2 (de) 2004-05-19
HUP0004096A3 (en) 2001-12-28
NO20002050L (no) 2000-06-23
KR20010031247A (ko) 2001-04-16
JP2003525846A (ja) 2003-09-02
HUP0004096A2 (hu) 2001-05-28
ZA989722B (en) 1999-04-26
UA69393C2 (uk) 2004-09-15
BR9813128A (pt) 2000-08-15
PT1025125E (pt) 2003-11-28
AU757933B2 (en) 2003-03-13
DE69815877D1 (de) 2003-07-31
EP1025125B1 (en) 2003-06-25
WO1999021888A1 (en) 1999-05-06
AU9622198A (en) 1999-05-17

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