BR0314450A - Sais de ácido borÈnico com adição de uma base farmaceuticamente aceitável, formulação farmacêutica, e uso dos referidos sais para preparar uma formulação farmacêutica - Google Patents

Sais de ácido borÈnico com adição de uma base farmaceuticamente aceitável, formulação farmacêutica, e uso dos referidos sais para preparar uma formulação farmacêutica

Info

Publication number
BR0314450A
BR0314450A BR0314450-0A BR0314450A BR0314450A BR 0314450 A BR0314450 A BR 0314450A BR 0314450 A BR0314450 A BR 0314450A BR 0314450 A BR0314450 A BR 0314450A
Authority
BR
Brazil
Prior art keywords
salts
pharmaceutical formulation
boronic acid
pharmaceutically acceptable
addition
Prior art date
Application number
BR0314450-0A
Other languages
English (en)
Inventor
David Jonathan Madge
Mark Dolman
Sophie Marie Combe-Marzelle
John Joseph Deadman
Anthony James Kennedy
Sanjay Kumar Kakkar
Original Assignee
Trigen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0220822A external-priority patent/GB0220822D0/en
Priority claimed from GB0220764A external-priority patent/GB0220764D0/en
Priority claimed from GB0307817A external-priority patent/GB0307817D0/en
Priority claimed from GB0311237A external-priority patent/GB0311237D0/en
Priority claimed from GB0315691A external-priority patent/GB0315691D0/en
Application filed by Trigen Ltd filed Critical Trigen Ltd
Publication of BR0314450A publication Critical patent/BR0314450A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

"SAIS DE áCIDO BORÈNICO COM ADIçãO DE UMA BASE FARMACEUTICAMENTE ACEITáVEL, FORMULAçãO FARMACêUTICA, E USO DOS REFERIDOS SAIS PARA PREPARAR UMA FORMULAçãO FARMACêUTICA". A presente invenção refere aos sais de uma droga do peptídeo de ácido borónico, por exemplo, de Cbz-(R)-Phe(S)-Pro-(R)-Mpg-B(OH)2. Os contra-íons para o boronato podem ser um metal álcali ou um derivado de um composto contendo nitrogênio orgânico. Os sais são usados no tratamento de trombose.
BR0314450-0A 2002-09-09 2003-09-09 Sais de ácido borÈnico com adição de uma base farmaceuticamente aceitável, formulação farmacêutica, e uso dos referidos sais para preparar uma formulação farmacêutica BR0314450A (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0220822A GB0220822D0 (en) 2002-09-09 2002-09-09 Boropeptides
GB0220764A GB0220764D0 (en) 2002-09-09 2002-09-09 Boropeptides
GB0307817A GB0307817D0 (en) 2003-04-04 2003-04-04 Boronic acid compounds
GB0311237A GB0311237D0 (en) 2003-05-16 2003-05-16 Boronic acid compounds
GB0315691A GB0315691D0 (en) 2003-07-04 2003-07-04 Boropeptides
US48578603P 2003-07-08 2003-07-08
PCT/GB2003/003897 WO2004022072A1 (en) 2002-09-09 2003-09-09 Boronic acid salts ant their use in the treatment of thrombosis

Publications (1)

Publication Number Publication Date
BR0314450A true BR0314450A (pt) 2005-07-26

Family

ID=31721886

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0314450-0A BR0314450A (pt) 2002-09-09 2003-09-09 Sais de ácido borÈnico com adição de uma base farmaceuticamente aceitável, formulação farmacêutica, e uso dos referidos sais para preparar uma formulação farmacêutica

Country Status (20)

Country Link
EP (8) EP1695711A3 (pt)
JP (3) JP2006509034A (pt)
KR (2) KR20050057294A (pt)
CN (2) CN100553639C (pt)
AT (3) ATE324899T1 (pt)
AU (3) AU2003263328A1 (pt)
BR (1) BR0314450A (pt)
CA (3) CA2536010A1 (pt)
CY (1) CY1105381T1 (pt)
DE (3) DE60304956T2 (pt)
DK (2) DK1400245T3 (pt)
ES (2) ES2263924T3 (pt)
HK (1) HK1063154A1 (pt)
IL (1) IL167294A (pt)
MX (2) MXPA05002661A (pt)
NZ (2) NZ539333A (pt)
PL (2) PL376535A1 (pt)
PT (1) PT1396270E (pt)
SI (2) SI1400245T1 (pt)
WO (3) WO2004022072A1 (pt)

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GB0405272D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
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GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
GB0515003D0 (en) * 2005-07-21 2005-08-31 Univ Aston Medical devices and coatings therefor
EP2190411A2 (en) * 2007-08-21 2010-06-02 Alza Corporation Liposome compositions for in vivo administration of boronic acid compounds
CN101795672A (zh) * 2007-08-21 2010-08-04 阿尔扎公司 硼酸化合物的脂质体制剂
US8389232B2 (en) * 2008-05-13 2013-03-05 The Regents Of The University Of California Fluorescence detection of poison oak oil
MX349769B (es) 2008-06-17 2017-08-11 Millennium Pharm Inc Compuestos de éster boronato y composiciones farmacéuticas de los mismos.
US20120059036A1 (en) * 2008-11-21 2012-03-08 Marco Valgimigli Method for reducing thrombocytopenia and thrombocytopenia-associated mortality
EP3021120A1 (en) 2009-02-20 2016-05-18 Michael P. Lisanti Diagnosis, prognosis, therapeutics and methods for treating neoplastic deiseases comprising determining the level of caveolin-1 in a stromal cell sample
CN101928329B (zh) * 2009-06-19 2013-07-17 北京大学 三肽硼酸(酯)类化合物、其制备方法和应用
GB2523211B (en) 2012-01-27 2020-03-18 Univ Jefferson MCT protein inhibitor-related prognostic and therapeutic methods
US10022372B2 (en) 2013-04-19 2018-07-17 Thomas Jefferson University Caveolin-1 related methods for treating glioblastoma with temozolomide
KR102457840B1 (ko) * 2014-10-01 2022-10-21 메르크 파텐트 게엠베하 보론산 유도체
EP3472151A4 (en) 2016-06-21 2020-03-04 Orion Ophthalmology LLC CARBOCYCLIC PROLINAMIDE DERIVATIVES
AU2017282651B2 (en) 2016-06-21 2021-08-12 Orion Ophthalmology LLC Heterocyclic prolinamide derivatives
CN109187155B (zh) * 2018-07-27 2021-08-13 临沂大学 一种水样中有效硼的提取纯化方法和一种硼同位素组成的测试方法
KR102104507B1 (ko) * 2019-08-23 2020-04-24 브릿지바이오테라퓨틱스(주) 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법
CN113121666B (zh) * 2021-03-10 2023-09-12 厦门大学 抗菌肽Scybaumancin105-127及其应用
CN114106346B (zh) * 2021-10-29 2023-04-18 重庆第二师范学院 一种稀土双金属电致化学发光材料及其制备方法和应用

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Also Published As

Publication number Publication date
NZ539334A (en) 2007-11-30
EP1695712A3 (en) 2008-01-09
EP1695711A2 (en) 2006-08-30
KR20050057294A (ko) 2005-06-16
JP2006509034A (ja) 2006-03-16
EP1396269A1 (en) 2004-03-10
EP1396270A1 (en) 2004-03-10
ATE376551T1 (de) 2007-11-15
EP1396270B1 (en) 2006-05-10
EP1695711A3 (en) 2008-01-02
JP2006503903A (ja) 2006-02-02
EP1695712A2 (en) 2006-08-30
ES2263924T3 (es) 2006-12-16
WO2004022070A1 (en) 2004-03-18
EP1400245A1 (en) 2004-03-24
DE60305113D1 (de) 2006-06-14
CY1105381T1 (el) 2010-07-28
EP1466916A1 (en) 2004-10-13
DE60304956T2 (de) 2007-01-25
EP1466917A1 (en) 2004-10-13
NZ539333A (en) 2007-02-23
SI1396270T1 (sl) 2006-10-31
EP1561466A2 (en) 2005-08-10
ATE324899T1 (de) 2006-06-15
AU2003263328A1 (en) 2004-03-29
DE60317039D1 (de) 2007-12-06
CN100447151C (zh) 2008-12-31
AU2003263343A1 (en) 2004-03-29
JP2006511593A (ja) 2006-04-06
CA2535788A1 (en) 2004-03-18
ES2264515T3 (es) 2007-01-01
KR20050057295A (ko) 2005-06-16
MXPA05002661A (es) 2005-08-19
DK1396270T3 (da) 2006-08-28
CA2536010A1 (en) 2004-03-18
CN1681517A (zh) 2005-10-12
WO2004022071A1 (en) 2004-03-18
PL376439A1 (en) 2005-12-27
ATE325611T1 (de) 2006-06-15
EP1400245B1 (en) 2006-05-03
IL167294A (en) 2008-11-03
DE60317039T2 (de) 2008-07-31
PT1396270E (pt) 2006-08-31
HK1063154A1 (en) 2004-12-17
WO2004022072A1 (en) 2004-03-18
AU2003263333A1 (en) 2004-03-29
DE60304956D1 (de) 2006-06-08
EP1466916B1 (en) 2007-10-24
CN100553639C (zh) 2009-10-28
DK1400245T3 (da) 2006-08-28
DE60305113T2 (de) 2006-12-07
PL376535A1 (pl) 2006-01-09
SI1400245T1 (sl) 2006-10-31
MXPA05002662A (es) 2005-09-20
EP1561466A3 (en) 2006-08-23
CA2535792A1 (en) 2004-03-18
CN1684693A (zh) 2005-10-19

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

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Ipc: A61K 31/69 (2011.01), C07F 5/02 (2011.01), C07D 20

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