CY1105381T1 - Αλατα βορονικου οξεως - Google Patents
Αλατα βορονικου οξεωςInfo
- Publication number
- CY1105381T1 CY1105381T1 CY20061100903T CY061100903T CY1105381T1 CY 1105381 T1 CY1105381 T1 CY 1105381T1 CY 20061100903 T CY20061100903 T CY 20061100903T CY 061100903 T CY061100903 T CY 061100903T CY 1105381 T1 CY1105381 T1 CY 1105381T1
- Authority
- CY
- Cyprus
- Prior art keywords
- boronic acid
- acid salts
- salts
- mpg
- counterion
- Prior art date
Links
- 150000001642 boronic acid derivatives Chemical class 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Άλατα ενός πεπτιδικού βορονικού οξέος φαρμάκου, για παράδειγμα το Cbz-(R)-Phe-(S)-Pro-(R) - Mpg-B(OH)2. Το αντι-ιόν προς το βορονικό είδος ενδέχεται να είναι αλκαλικά μέταλα ή να προέρχεται από ένα οργανικό μείγμα που να περιέχει άζωτο. Τα άλατα χρησιμοποιούνται για την κατασκευή μίας μεθόδου για την θεραπεία της θρόμβωσης.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0220764A GB0220764D0 (en) | 2002-09-09 | 2002-09-09 | Boropeptides |
GB0220822A GB0220822D0 (en) | 2002-09-09 | 2002-09-09 | Boropeptides |
GB0307817A GB0307817D0 (en) | 2003-04-04 | 2003-04-04 | Boronic acid compounds |
GB0311237A GB0311237D0 (en) | 2003-05-16 | 2003-05-16 | Boronic acid compounds |
GB0315691A GB0315691D0 (en) | 2003-07-04 | 2003-07-04 | Boropeptides |
US48578603P | 2003-07-08 | 2003-07-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105381T1 true CY1105381T1 (el) | 2010-07-28 |
Family
ID=31721886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100903T CY1105381T1 (el) | 2002-09-09 | 2006-07-03 | Αλατα βορονικου οξεως |
Country Status (20)
Country | Link |
---|---|
EP (8) | EP1695712A3 (el) |
JP (3) | JP2006503903A (el) |
KR (2) | KR20050057294A (el) |
CN (2) | CN100447151C (el) |
AT (3) | ATE325611T1 (el) |
AU (3) | AU2003263333A1 (el) |
BR (1) | BR0314450A (el) |
CA (3) | CA2536010A1 (el) |
CY (1) | CY1105381T1 (el) |
DE (3) | DE60304956T2 (el) |
DK (2) | DK1396270T3 (el) |
ES (2) | ES2263924T3 (el) |
HK (1) | HK1063154A1 (el) |
IL (1) | IL167294A (el) |
MX (2) | MXPA05002661A (el) |
NZ (2) | NZ539333A (el) |
PL (2) | PL376439A1 (el) |
PT (1) | PT1396270E (el) |
SI (2) | SI1396270T1 (el) |
WO (3) | WO2004022071A1 (el) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0405272D0 (en) * | 2004-03-09 | 2004-04-21 | Trigen Ltd | Compounds |
GB0405267D0 (en) * | 2004-03-09 | 2004-04-21 | Trigen Ltd | Compounds |
GB0405280D0 (en) * | 2004-03-09 | 2004-04-21 | Trigen Ltd | Compounds |
PE20060272A1 (es) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
WO2006059082A1 (en) * | 2004-11-30 | 2006-06-08 | Trigen Limited | Oxidised lipids as reversal agents for boronic acid drugs |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
GB0515003D0 (en) * | 2005-07-21 | 2005-08-31 | Univ Aston | Medical devices and coatings therefor |
WO2009026430A2 (en) * | 2007-08-21 | 2009-02-26 | Alza Corporation | Liposome formulations of boronic acid compounds |
KR20100095507A (ko) * | 2007-08-21 | 2010-08-31 | 알자 코퍼레이션 | 보론산 화합물의 생체내 투여를 위한 리포좀 조성물 |
WO2009139864A2 (en) * | 2008-05-13 | 2009-11-19 | The Regents Of The University Of California | Fluorescence detection of poison oak oil |
BRPI0915300C1 (pt) | 2008-06-17 | 2021-05-25 | Millennium Pharm Inc | compostos de éster boronato e composições farmacêuticas dos mesmos |
KR20110108330A (ko) * | 2008-11-21 | 2011-10-05 | 이로코 카디오, 엘엘씨 | 혈소판감소증 및 혈소판감소증-관련 사망을 감소시키기 위한 티로피반의 약학적으로 허용가능한 염 |
EP2399129B1 (en) | 2009-02-20 | 2015-11-25 | Michael P. Lisanti | A method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm |
CN101928329B (zh) * | 2009-06-19 | 2013-07-17 | 北京大学 | 三肽硼酸(酯)类化合物、其制备方法和应用 |
GB2523211B (en) | 2012-01-27 | 2020-03-18 | Univ Jefferson | MCT protein inhibitor-related prognostic and therapeutic methods |
US10022372B2 (en) | 2013-04-19 | 2018-07-17 | Thomas Jefferson University | Caveolin-1 related methods for treating glioblastoma with temozolomide |
ES2761774T3 (es) * | 2014-10-01 | 2020-05-21 | Merck Patent Gmbh | Derivados del ácido borónico |
EP4257191A3 (en) | 2016-06-21 | 2023-11-22 | Orion Ophthalmology LLC | Heterocyclic prolinamide derivatives |
JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
CN109187155B (zh) * | 2018-07-27 | 2021-08-13 | 临沂大学 | 一种水样中有效硼的提取纯化方法和一种硼同位素组成的测试方法 |
KR102104507B1 (ko) * | 2019-08-23 | 2020-04-24 | 브릿지바이오테라퓨틱스(주) | 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법 |
CN113121666B (zh) * | 2021-03-10 | 2023-09-12 | 厦门大学 | 抗菌肽Scybaumancin105-127及其应用 |
CN114106346B (zh) * | 2021-10-29 | 2023-04-18 | 重庆第二师范学院 | 一种稀土双金属电致化学发光材料及其制备方法和应用 |
Family Cites Families (40)
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JPS5856695A (ja) | 1981-09-28 | 1983-04-04 | Nitto Boseki Co Ltd | 新規なトロンビン測定用基質 |
US4499082A (en) * | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
US4935493A (en) | 1987-10-06 | 1990-06-19 | E. I. Du Pont De Nemours And Company | Protease inhibitors |
EP0315574A3 (de) | 1987-11-05 | 1990-08-22 | Hoechst Aktiengesellschaft | Renin-Inhibitoren |
US5574014A (en) | 1988-04-28 | 1996-11-12 | Thrombosis Research Institute | Inhibitors of trypsin-like enzymes |
NZ229053A (en) | 1988-05-11 | 1990-12-21 | Du Pont | Pharmaceutical compositions comprising a protein or peptide and an alpha-aminoboronic acid derivative to stabilise and improve the delivery of the protein or peptide |
US5106948A (en) | 1988-05-27 | 1992-04-21 | Mao Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
US5288707A (en) | 1990-08-13 | 1994-02-22 | Sandoz Ltd. | Borolysine peptidomimetics |
GB9017694D0 (en) * | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
GB9024129D0 (en) * | 1990-11-06 | 1990-12-19 | Thrombosis Research Trust | Inhibitors and substrates of thrombin |
US5648338A (en) | 1990-11-06 | 1997-07-15 | Thrombosis Research Institute | Inhibitors and substrates of thrombin |
WO1992019707A1 (en) | 1991-04-30 | 1992-11-12 | The Procter & Gamble Company | Liquid detergents with an aryl boronic acid |
GB9224702D0 (en) | 1992-11-25 | 1993-01-13 | Thrombosis Res Inst | Boronic ester synthesis |
FR2701951B1 (fr) * | 1993-02-24 | 1995-06-09 | Adir | Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
MY131622A (en) | 1993-03-03 | 2007-08-30 | Novartis Ag | Organic compounds |
US5563127A (en) | 1993-03-24 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Boronic acid and ester inhibitors of thrombin |
WO1994021650A1 (en) * | 1993-03-24 | 1994-09-29 | The Du Pont Merck Pharmaceutical Company | Boronic acid and ester inhibitors of thrombin |
US5384410A (en) * | 1993-03-24 | 1995-01-24 | The Du Pont Merck Pharmaceutical Company | Removal of boronic acid protecting groups by transesterification |
US5658885A (en) | 1993-04-27 | 1997-08-19 | The Dupont Merck Pharmaceutical Company | Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes |
IL109319A0 (en) | 1993-04-27 | 1994-07-31 | Du Pont Merck Pharma | Amidino and guanidino substituted boronic acid compounds |
SE9900043D0 (sv) | 1999-01-11 | 1999-01-11 | Astra Ab | New use |
US5681978A (en) * | 1993-07-07 | 1997-10-28 | Washington State University Research Foundation | Method for the stereocontrolled synthesis of stegobinone and useful borane intermediates |
US5462964A (en) * | 1993-10-20 | 1995-10-31 | The Du Pont Merck Pharmaceutical Company | Dipeptide boronic acid inhibitors of trypsin-like enzymes |
IL111176A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them |
IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
CA2174311A1 (en) * | 1993-10-07 | 1995-04-13 | Gregory James Pacofsky | Boropeptide inhibitors of thrombin which contain a substituted pyrrolidine ring |
US5431842A (en) | 1993-11-05 | 1995-07-11 | The Procter & Gamble Company | Liquid detergents with ortho-substituted phenylboronic acids for inhibition of proteolytic enzyme |
GB9401483D0 (en) | 1994-01-26 | 1994-03-23 | Sandoz Ltd | Organic compounds |
FR2721611B1 (fr) | 1994-06-22 | 1996-09-27 | Adir | Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent . |
US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
JPH10511957A (ja) | 1995-01-05 | 1998-11-17 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティ オブ ミシガン | 表面改質ナノ微粒子並びにその製造及び使用方法 |
GB9502985D0 (en) | 1995-02-16 | 1995-04-05 | Thrombosis Res Inst | Enzyme inhibitors |
GB9515489D0 (en) | 1995-07-28 | 1995-09-27 | Sandoz Ltd | Organic compounds |
GB9613718D0 (en) | 1996-06-29 | 1996-08-28 | Thrombosis Res Inst | Thrombin inhibitors |
GB9724786D0 (en) * | 1997-11-25 | 1998-01-21 | Danbiosyst Uk | Oral delivery system |
CA2376965A1 (en) | 1999-07-07 | 2001-01-11 | Timothy Patrick Forsyth | Peptide boronic acid inhibitors of hepatitis c virus protease |
SE9904483D0 (sv) | 1999-12-08 | 1999-12-08 | Astra Ab | New use |
US6462021B1 (en) | 2000-11-06 | 2002-10-08 | Astrazeneca Ab | Use of low molecular weight thrombin inhibitor |
JP4162491B2 (ja) * | 2001-01-25 | 2008-10-08 | アメリカ合衆国 | ボロン酸化合物製剤 |
DE10133786A1 (de) | 2001-07-16 | 2003-02-06 | Boehringer Ingelheim Pharma | Verwendung von Thrombin-Inhibitoren zur Behandlung von Arthritis |
-
2003
- 2003-09-09 DK DK03255629T patent/DK1396270T3/da active
- 2003-09-09 DE DE60304956T patent/DE60304956T2/de not_active Expired - Lifetime
- 2003-09-09 WO PCT/GB2003/003887 patent/WO2004022071A1/en active Application Filing
- 2003-09-09 CA CA002536010A patent/CA2536010A1/en not_active Abandoned
- 2003-09-09 PL PL03376439A patent/PL376439A1/xx unknown
- 2003-09-09 KR KR1020057004076A patent/KR20050057294A/ko not_active Application Discontinuation
- 2003-09-09 EP EP06113648A patent/EP1695712A3/en not_active Withdrawn
- 2003-09-09 PL PL376535A patent/PL376535A1/pl unknown
- 2003-09-09 AT AT03255629T patent/ATE325611T1/de not_active IP Right Cessation
- 2003-09-09 AU AU2003263333A patent/AU2003263333A1/en not_active Abandoned
- 2003-09-09 EP EP03255629A patent/EP1396270B1/en not_active Expired - Lifetime
- 2003-09-09 BR BR0314450-0A patent/BR0314450A/pt not_active IP Right Cessation
- 2003-09-09 SI SI200330344T patent/SI1396270T1/sl unknown
- 2003-09-09 EP EP03255590A patent/EP1400245B1/en not_active Expired - Lifetime
- 2003-09-09 CN CNB038213907A patent/CN100447151C/zh not_active Expired - Fee Related
- 2003-09-09 AT AT03255590T patent/ATE324899T1/de not_active IP Right Cessation
- 2003-09-09 EP EP06113409A patent/EP1695711A3/en not_active Withdrawn
- 2003-09-09 JP JP2004569794A patent/JP2006503903A/ja active Pending
- 2003-09-09 NZ NZ539333A patent/NZ539333A/en unknown
- 2003-09-09 MX MXPA05002661A patent/MXPA05002661A/es active IP Right Grant
- 2003-09-09 DE DE60305113T patent/DE60305113T2/de not_active Expired - Lifetime
- 2003-09-09 DE DE60317039T patent/DE60317039T2/de not_active Expired - Lifetime
- 2003-09-09 WO PCT/GB2003/003883 patent/WO2004022070A1/en active Application Filing
- 2003-09-09 AT AT04076510T patent/ATE376551T1/de not_active IP Right Cessation
- 2003-09-09 AU AU2003263343A patent/AU2003263343A1/en not_active Abandoned
- 2003-09-09 CN CNB038214032A patent/CN100553639C/zh not_active Expired - Fee Related
- 2003-09-09 DK DK03255590T patent/DK1400245T3/da active
- 2003-09-09 EP EP04076521A patent/EP1466917A1/en not_active Withdrawn
- 2003-09-09 EP EP04076510A patent/EP1466916B1/en not_active Expired - Lifetime
- 2003-09-09 EP EP04076548A patent/EP1561466A3/en not_active Withdrawn
- 2003-09-09 ES ES03255629T patent/ES2263924T3/es not_active Expired - Lifetime
- 2003-09-09 AU AU2003263328A patent/AU2003263328A1/en not_active Abandoned
- 2003-09-09 SI SI200330345T patent/SI1400245T1/sl unknown
- 2003-09-09 WO PCT/GB2003/003897 patent/WO2004022072A1/en active Application Filing
- 2003-09-09 JP JP2004569793A patent/JP2006509034A/ja active Pending
- 2003-09-09 ES ES03255590T patent/ES2264515T3/es not_active Expired - Lifetime
- 2003-09-09 MX MXPA05002662A patent/MXPA05002662A/es not_active Application Discontinuation
- 2003-09-09 KR KR1020057004077A patent/KR20050057295A/ko not_active Application Discontinuation
- 2003-09-09 PT PT03255629T patent/PT1396270E/pt unknown
- 2003-09-09 CA CA002535788A patent/CA2535788A1/en not_active Abandoned
- 2003-09-09 NZ NZ539334A patent/NZ539334A/en not_active IP Right Cessation
- 2003-09-09 JP JP2004569795A patent/JP2006511593A/ja active Pending
- 2003-09-09 CA CA002535792A patent/CA2535792A1/en not_active Abandoned
- 2003-09-09 EP EP03255604A patent/EP1396269A1/en not_active Withdrawn
-
2004
- 2004-08-09 HK HK04105939A patent/HK1063154A1/xx not_active IP Right Cessation
-
2005
- 2005-03-07 IL IL167294A patent/IL167294A/en not_active IP Right Cessation
-
2006
- 2006-07-03 CY CY20061100903T patent/CY1105381T1/el unknown
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