BRPI0413276A - derivado de insulina, complexo de zinco do mesmo, composição farmacêutica, e, método para tratar diabete em um paciente - Google Patents
derivado de insulina, complexo de zinco do mesmo, composição farmacêutica, e, método para tratar diabete em um pacienteInfo
- Publication number
- BRPI0413276A BRPI0413276A BRPI0413276-9A BRPI0413276A BRPI0413276A BR PI0413276 A BRPI0413276 A BR PI0413276A BR PI0413276 A BRPI0413276 A BR PI0413276A BR PI0413276 A BRPI0413276 A BR PI0413276A
- Authority
- BR
- Brazil
- Prior art keywords
- patient
- pharmaceutical composition
- treating diabetes
- zinc complex
- insulin derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200301129 | 2003-08-05 | ||
DKPA200301129 | 2003-08-05 | ||
US49545103P | 2003-08-14 | 2003-08-14 | |
US60/495,451 | 2003-08-14 | ||
PCT/DK2004/000511 WO2005012347A2 (en) | 2003-08-05 | 2004-07-22 | Novel insulin derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0413276A true BRPI0413276A (pt) | 2006-10-10 |
BRPI0413276B1 BRPI0413276B1 (pt) | 2020-03-03 |
BRPI0413276B8 BRPI0413276B8 (pt) | 2021-05-25 |
Family
ID=34117520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413276A BRPI0413276B8 (pt) | 2003-08-05 | 2004-07-22 | derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica |
Country Status (18)
Country | Link |
---|---|
US (3) | US7615532B2 (pt) |
EP (3) | EP1660531A2 (pt) |
JP (1) | JP4463814B2 (pt) |
KR (1) | KR101159559B1 (pt) |
AU (2) | AU2004261353B2 (pt) |
BE (2) | BE2013C035I2 (pt) |
BR (1) | BRPI0413276B8 (pt) |
CA (1) | CA2531988C (pt) |
CY (3) | CY1113850T1 (pt) |
FR (1) | FR13C0035I2 (pt) |
HU (1) | HUS1300033I1 (pt) |
IL (1) | IL172980A (pt) |
LU (2) | LU92213I2 (pt) |
MX (1) | MXPA06001283A (pt) |
NO (3) | NO340925B1 (pt) |
PL (1) | PL2107069T3 (pt) |
RU (1) | RU2518460C2 (pt) |
WO (1) | WO2005012347A2 (pt) |
Families Citing this family (95)
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WO2005012346A1 (en) * | 2003-07-25 | 2005-02-10 | Conjuchem, Inc. | Long lasting insulin derivatives and methods thereof |
BRPI0413276B8 (pt) | 2003-08-05 | 2021-05-25 | Novo Nordisk As | derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica |
WO2006082205A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
ES2428510T3 (es) | 2005-02-02 | 2013-11-08 | Novo Nordisk A/S | Derivados de insulina |
CN101389650B (zh) * | 2005-12-28 | 2012-10-10 | 诺沃-诺迪斯克有限公司 | 包含酰化胰岛素和锌的组合物以及制备所述组合物的方法 |
ATE482977T1 (de) * | 2006-02-27 | 2010-10-15 | Novo Nordisk As | Insulinderivate |
WO2007104736A2 (en) * | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Acylated single chain insulin |
EP2015722B1 (en) | 2006-04-28 | 2016-11-16 | Avent, Inc. | Antimicrobial site dressings |
US8933021B2 (en) * | 2006-05-09 | 2015-01-13 | Novo Nordisk A/S | Insulin derivative |
CN101437849B (zh) * | 2006-05-09 | 2015-09-30 | 诺沃-诺迪斯克有限公司 | 胰岛素衍生物 |
US8796205B2 (en) | 2006-05-09 | 2014-08-05 | Novo Nordisk A/S | Insulin derivative |
JP5097900B2 (ja) * | 2006-06-27 | 2012-12-12 | 独立行政法人物質・材料研究機構 | 有機酸又はこれらの誘導体の活性エステル体の製造方法 |
ES2542146T3 (es) * | 2006-07-31 | 2015-07-31 | Novo Nordisk A/S | Insulinas extendidas PEGiladas. |
WO2008034881A1 (en) | 2006-09-22 | 2008-03-27 | Novo Nordisk A/S | Protease resistant insulin analogues |
ES2563038T3 (es) | 2007-04-30 | 2016-03-10 | Novo Nordisk A/S | Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca |
EP2514406A1 (en) | 2007-06-01 | 2012-10-24 | Novo Nordisk A/S | Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier |
EP2164458A1 (en) * | 2007-06-01 | 2010-03-24 | Novo Nordisk A/S | Stable non-aqueous pharmaceutical compositions |
WO2008152106A1 (en) | 2007-06-13 | 2008-12-18 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
KR20100053561A (ko) | 2007-08-15 | 2010-05-20 | 노보 노르디스크 에이/에스 | 아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체 |
EP2178910B1 (en) | 2007-08-15 | 2014-10-08 | Novo Nordisk A/S | Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids |
CN101157725B (zh) * | 2007-10-24 | 2012-07-25 | 中国药科大学 | 人胰岛素类似物的制备方法及用途 |
EP2217621B1 (en) | 2007-11-08 | 2015-04-22 | Novo Nordisk A/S | Insulin derivative |
CN101861333A (zh) | 2007-11-16 | 2010-10-13 | 诺沃-诺迪斯克有限公司 | 包含glp-1肽或毒蜥外泌肽-4和基础胰岛素肽的药物组合物 |
US9260502B2 (en) | 2008-03-14 | 2016-02-16 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
US8691759B2 (en) | 2008-03-18 | 2014-04-08 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
WO2010029159A1 (en) | 2008-09-12 | 2010-03-18 | Novo Nordisk A/S | Method of acylating a peptide or protein |
CA2738615A1 (en) * | 2008-10-30 | 2010-05-06 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
CA2748593A1 (en) | 2009-01-23 | 2010-07-29 | Novo Nordisk A/S | Fgf21 derivatives with albumin binder a-b-c-d-e- and their use |
WO2011051312A1 (en) | 2009-10-30 | 2011-05-05 | Novo Nordisk A/S | Derivatives of cgrp |
CN102753150A (zh) | 2010-01-12 | 2012-10-24 | 诺沃—诺迪斯克有限公司 | 用于口服给予胰岛素肽的药物组合物 |
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WO2011141407A1 (en) | 2010-05-10 | 2011-11-17 | Novo Nordisk A/S | Process for the preparation of insulin-zinc complexes |
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CN102947331B (zh) | 2010-06-23 | 2016-08-03 | 诺沃—诺迪斯克有限公司 | 包含额外的二硫键的胰岛素类似物 |
CN104693302A (zh) | 2010-06-23 | 2015-06-10 | 诺沃—诺迪斯克有限公司 | 包含额外的二硫键的胰岛素衍生物 |
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CN103154024A (zh) | 2010-10-15 | 2013-06-12 | 诺沃—诺迪斯克有限公司 | 新型n末端修饰的胰岛素衍生物 |
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