ZA200901838B - Protease resistant insulin analogues - Google Patents
Protease resistant insulin analoguesInfo
- Publication number
- ZA200901838B ZA200901838B ZA2009/01838A ZA200901838A ZA200901838B ZA 200901838 B ZA200901838 B ZA 200901838B ZA 2009/01838 A ZA2009/01838 A ZA 2009/01838A ZA 200901838 A ZA200901838 A ZA 200901838A ZA 200901838 B ZA200901838 B ZA 200901838B
- Authority
- ZA
- South Africa
- Prior art keywords
- insulin analogues
- protease resistant
- resistant insulin
- protease
- analogues
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06121113 | 2006-09-22 | ||
| PCT/EP2007/059990 WO2008034881A1 (en) | 2006-09-22 | 2007-09-20 | Protease resistant insulin analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200901838B true ZA200901838B (en) | 2010-02-24 |
Family
ID=38754488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2009/01838A ZA200901838B (en) | 2006-09-22 | 2009-03-16 | Protease resistant insulin analogues |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9018161B2 (enExample) |
| EP (2) | EP2404934A1 (enExample) |
| JP (2) | JP5864834B2 (enExample) |
| KR (2) | KR101729986B1 (enExample) |
| CN (1) | CN101541830A (enExample) |
| AU (1) | AU2007298919C1 (enExample) |
| BR (1) | BRPI0717098B8 (enExample) |
| CA (1) | CA2663074A1 (enExample) |
| DK (1) | DK2074141T3 (enExample) |
| ES (1) | ES2601839T3 (enExample) |
| HU (1) | HUE029512T2 (enExample) |
| IL (1) | IL197609A (enExample) |
| MX (1) | MX2009002999A (enExample) |
| NO (1) | NO20091563L (enExample) |
| PL (1) | PL2074141T3 (enExample) |
| PT (1) | PT2074141T (enExample) |
| RU (1) | RU2524150C2 (enExample) |
| TW (1) | TW200829600A (enExample) |
| WO (1) | WO2008034881A1 (enExample) |
| ZA (1) | ZA200901838B (enExample) |
Families Citing this family (90)
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|---|---|---|---|---|
| PL1969004T3 (pl) | 2005-12-28 | 2012-01-31 | Novo Nordisk As | Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji |
| ES2601839T3 (es) * | 2006-09-22 | 2017-02-16 | Novo Nordisk A/S | Análogos de insulina resistentes a proteasas |
| JP5496082B2 (ja) | 2007-04-30 | 2014-05-21 | ノボ・ノルデイスク・エー/エス | タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物 |
| EP2514406A1 (en) | 2007-06-01 | 2012-10-24 | Novo Nordisk A/S | Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier |
| EP2497462A1 (en) | 2007-06-01 | 2012-09-12 | Novo Nordisk A/S | Stable non-aqueous pharmaceutical compositions |
| WO2008152106A1 (en) | 2007-06-13 | 2008-12-18 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2009203809B2 (en) | 2008-01-09 | 2013-07-25 | Sanofi-Aventis Deutschland Gmbh | Novel insulin derivatives having an extremely delayed time-action profile |
| EP2254905B1 (en) | 2008-03-14 | 2016-12-14 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
| DK2254906T3 (en) | 2008-03-18 | 2017-01-23 | Novo Nordisk As | Protease-stabilized acylated insulin analogues |
| WO2009133099A2 (en) * | 2008-04-28 | 2009-11-05 | Novo Nordisk A/S | Insulin precursors for diabetes treatment |
| HUE068164T2 (hu) | 2008-10-17 | 2024-12-28 | Sanofi Aventis Deutschland | Egy inzulin és egy GLP-1 agonista kombinációja |
| WO2010049488A1 (en) | 2008-10-30 | 2010-05-06 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
| US20110294729A1 (en) * | 2008-12-09 | 2011-12-01 | Novo Nordisk A/S | Novel Insulin Analogues |
| HUE027239T2 (en) | 2009-06-26 | 2016-10-28 | Novo Nordisk As | Preparation containing insulin, nicotinamide and arginine |
| WO2011000823A1 (en) | 2009-06-30 | 2011-01-06 | Novo Nordisk A/S | Insulin derivatives |
| US20120232002A1 (en) * | 2009-07-06 | 2012-09-13 | Sanofi-Aventis Deutschland Gmbh | Slow-acting insulin preparations |
| WO2011033019A1 (en) | 2009-09-16 | 2011-03-24 | Novo Nordisk A/S | Stable non-aqueous liquid pharmaceutical compositions comprising an insulin |
| CN102665676B (zh) | 2009-11-02 | 2015-04-01 | 诺沃-诺迪斯克有限公司 | 非共价结合的白蛋白和酰化胰岛素的药物溶液 |
| CA2780460C (en) | 2009-11-13 | 2018-09-04 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine |
| SG10201500871TA (en) | 2009-11-13 | 2015-04-29 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist and methionine |
| CA2786953A1 (en) * | 2010-01-12 | 2011-07-21 | Florian Anders Foeger | Pharmaceutical compositions for oral administration of insulin peptides |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| DE102010015123A1 (de) | 2010-04-16 | 2011-10-20 | Sanofi-Aventis Deutschland Gmbh | Benzylamidische Diphenylazetidinone, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| AU2011269000C1 (en) * | 2010-06-23 | 2015-10-08 | Novo Nordisk A/S | Insulin derivatives containing additional disulfide bonds |
| CN102947331B (zh) | 2010-06-23 | 2016-08-03 | 诺沃—诺迪斯克有限公司 | 包含额外的二硫键的胰岛素类似物 |
| EP2585483A1 (en) * | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Human insulin containing additional disulfide bonds |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| RS55378B1 (sr) | 2010-08-30 | 2017-03-31 | Sanofi Aventis Deutschland | Upotreba ave0010 za proizvodnju leka za tretman diabetes mellitus tipa 2 |
| US20140315797A1 (en) | 2010-10-15 | 2014-10-23 | Peter Madsen | Novel N-Terminally Modified Insulin Derivatives |
| RU2013123515A (ru) | 2010-10-27 | 2014-12-10 | Ново Нордиск А/С | Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами |
| CA2821613A1 (en) | 2010-12-14 | 2012-06-21 | Novo Nordisk A/S | Preparation comprising insulin, nicotinamide and an amino acid |
| CN103249427A (zh) | 2010-12-14 | 2013-08-14 | 诺沃—诺迪斯克有限公司 | 速效胰岛素联合长效胰岛素 |
| EP2696847A1 (en) | 2011-04-14 | 2014-02-19 | Novo Nordisk A/S | Fatty acid acylated amino acids for oral peptide delivery |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| JP6058646B2 (ja) | 2011-06-15 | 2017-01-11 | ノヴォ ノルディスク アー/エス | 多置換インスリン |
| BR112014004726A2 (pt) | 2011-08-29 | 2017-04-04 | Sanofi Aventis Deutschland | combinação farmacêutica para uso no controle glicêmico em pacientes de diabetes tipo 2 |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013059213A1 (en) * | 2011-10-18 | 2013-04-25 | Amidebio, Llc | Chemically and thermodynamically stable insulin analogues and improved methods for their production |
| CA2870313A1 (en) | 2012-04-11 | 2013-10-17 | Novo Nordisk A/S | Insulin formulations |
| WO2013186138A1 (en) | 2012-06-14 | 2013-12-19 | Novo Nordisk A/S | Preparation comprising insulin, nicotinamide and arginine |
| US20150265710A1 (en) | 2012-10-17 | 2015-09-24 | Novo Nordisk A/S | Fatty Acid Acylated D-Amino Acids for Oral Peptide Delivery |
| TWI641381B (zh) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
| US10376644B2 (en) | 2013-04-05 | 2019-08-13 | Novo Nordisk A/S | Dose logging device for a drug delivery device |
| WO2014172488A2 (en) | 2013-04-17 | 2014-10-23 | AmideBio LLC | Chemically and thermodynamically stable insulin analogues and improved methods for their production |
| WO2014177623A1 (en) | 2013-04-30 | 2014-11-06 | Novo Nordisk A/S | Novel administration regime |
| AU2014261336B2 (en) | 2013-05-02 | 2019-02-28 | Novo Nordisk A/S | Oral dosing of GLP-1 compounds |
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| EP3091995B1 (en) | 2014-01-09 | 2024-03-20 | Sanofi | Stabilized pharmaceutical formulations of insulin aspart |
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| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
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| IL264330B2 (en) * | 2016-07-22 | 2024-05-01 | Univ Utah Res Found | An insulin analog, pharmaceutical composition comprising it and its uses |
| AU2017332408B2 (en) * | 2016-09-23 | 2022-02-10 | Hanmi Pharm. Co., Ltd. | Insulin analogs with reduced affinity to insulin receptor and use thereof |
| WO2018077851A1 (en) * | 2016-10-24 | 2018-05-03 | Novo Nordisk A/S | Bioassay for insulin formulations |
| MA46780A (fr) | 2016-11-07 | 2019-09-11 | Novo Nordisk As | Esters à dchbs actif de composés peg et leur utilisation |
| JP2020500220A (ja) | 2016-11-15 | 2020-01-09 | クラリア ファーマ ホールディング エービー | 医薬製剤 |
| HUE060149T2 (hu) | 2016-12-16 | 2023-02-28 | Novo Nordisk As | Inzulint tartalmazó gyógyászati készítmények |
| AU2018239037B2 (en) * | 2017-03-23 | 2022-05-26 | Hanmi Pharm. Co., Ltd. | Insulin analog complex with reduced affinity for insulin receptor and use thereof |
| WO2018185131A2 (en) | 2017-04-05 | 2018-10-11 | Novo Nordisk A/S | Oligomer extended insulin-fc conjugates |
| GB201709141D0 (en) | 2017-06-08 | 2017-07-26 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| BR112020002364A2 (pt) | 2017-08-17 | 2020-09-01 | Novo Nordisk A/S | derivado de insulina, produto intermediário, uso de um derivado de insulina, e, métodos para o tratamento ou prevenção de diabetes, diabetes do tipo 1, diabetes do tipo 2, tolerância à glicose comprometida, hiperglicemia, dislipidemia, obesidade, síndrome metabólica, hipertensão, distúrbios cognitivos, aterosclerose, infarto do miocárdio, acidente vascular cerebral, distúrbios cardiovasculares, doença cardíaca coronariana, síndrome intestinal inflamatória, dispepsia, hipotensão ou úlceras gástricas, e para determinar a seletividade de um composto de insulina |
| GB201808462D0 (en) | 2018-05-23 | 2018-07-11 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| KR102646845B1 (ko) | 2018-08-08 | 2024-03-14 | 주식회사 대웅제약 | 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법 |
| KR102666154B1 (ko) | 2018-08-08 | 2024-05-20 | 주식회사 대웅제약 | 지속형 인슐린 아날로그 및 그 복합체 |
| WO2020058322A1 (en) | 2018-09-19 | 2020-03-26 | Ziylo Ltd. | Glucose sensitive insulins and uses thereof |
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| CA3122636A1 (en) | 2018-12-11 | 2020-06-18 | Sanofi | Insulin analogs having reduced insulin receptor binding affinity |
| JP7518149B2 (ja) | 2019-07-12 | 2024-07-17 | ノヴォ ノルディスク アー/エス | 高濃度インスリン製剤 |
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| CN113773398B (zh) * | 2020-06-10 | 2023-05-23 | 宁波鲲鹏生物科技有限公司 | 一种德谷胰岛素衍生物及其应用 |
| WO2023144240A1 (en) | 2022-01-26 | 2023-08-03 | Novo Nordisk Research Centre Oxford Limited | Glucose sensitive insulin derivatives and uses thereof |
| CN116284433B (zh) * | 2022-07-04 | 2023-09-12 | 北京惠之衡生物科技有限公司 | 一种胰岛素和glp-1的缀合物及其应用 |
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-
2007
- 2007-09-20 ES ES07820423.7T patent/ES2601839T3/es active Active
- 2007-09-20 CA CA002663074A patent/CA2663074A1/en not_active Withdrawn
- 2007-09-20 MX MX2009002999A patent/MX2009002999A/es active IP Right Grant
- 2007-09-20 AU AU2007298919A patent/AU2007298919C1/en not_active Ceased
- 2007-09-20 EP EP11173251A patent/EP2404934A1/en not_active Withdrawn
- 2007-09-20 RU RU2009114324/10A patent/RU2524150C2/ru not_active IP Right Cessation
- 2007-09-20 DK DK07820423.7T patent/DK2074141T3/en active
- 2007-09-20 BR BRPI0717098A patent/BRPI0717098B8/pt not_active IP Right Cessation
- 2007-09-20 KR KR1020157005461A patent/KR101729986B1/ko not_active Expired - Fee Related
- 2007-09-20 US US12/442,190 patent/US9018161B2/en active Active
- 2007-09-20 KR KR1020097005790A patent/KR101699370B1/ko not_active Expired - Fee Related
- 2007-09-20 HU HUE07820423A patent/HUE029512T2/en unknown
- 2007-09-20 PT PT78204237T patent/PT2074141T/pt unknown
- 2007-09-20 CN CNA2007800431301A patent/CN101541830A/zh active Pending
- 2007-09-20 WO PCT/EP2007/059990 patent/WO2008034881A1/en not_active Ceased
- 2007-09-20 PL PL07820423T patent/PL2074141T3/pl unknown
- 2007-09-20 EP EP07820423.7A patent/EP2074141B1/en not_active Revoked
- 2007-09-20 JP JP2009528727A patent/JP5864834B2/ja active Active
- 2007-09-21 TW TW096135252A patent/TW200829600A/zh unknown
-
2009
- 2009-03-16 IL IL197609A patent/IL197609A/en active IP Right Grant
- 2009-03-16 ZA ZA2009/01838A patent/ZA200901838B/en unknown
- 2009-04-20 NO NO20091563A patent/NO20091563L/no not_active Application Discontinuation
-
2014
- 2014-01-24 JP JP2014011829A patent/JP2014129355A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NO20091563L (no) | 2009-04-20 |
| HUE029512T2 (en) | 2017-03-28 |
| AU2007298919A1 (en) | 2008-03-27 |
| EP2074141A1 (en) | 2009-07-01 |
| RU2524150C2 (ru) | 2014-07-27 |
| US20100009898A1 (en) | 2010-01-14 |
| PL2074141T3 (pl) | 2017-02-28 |
| CA2663074A1 (en) | 2008-03-27 |
| RU2009114324A (ru) | 2010-10-27 |
| JP2014129355A (ja) | 2014-07-10 |
| ES2601839T3 (es) | 2017-02-16 |
| KR101729986B1 (ko) | 2017-04-25 |
| EP2404934A1 (en) | 2012-01-11 |
| DK2074141T3 (en) | 2016-11-28 |
| AU2007298919C1 (en) | 2014-02-06 |
| BRPI0717098B1 (pt) | 2018-08-07 |
| MX2009002999A (es) | 2009-04-01 |
| KR20090071561A (ko) | 2009-07-01 |
| KR20150031494A (ko) | 2015-03-24 |
| CN101541830A (zh) | 2009-09-23 |
| TW200829600A (en) | 2008-07-16 |
| JP5864834B2 (ja) | 2016-02-17 |
| EP2074141B1 (en) | 2016-08-10 |
| US9018161B2 (en) | 2015-04-28 |
| KR101699370B1 (ko) | 2017-02-14 |
| BRPI0717098B8 (pt) | 2021-05-25 |
| IL197609A0 (en) | 2011-08-01 |
| JP2010504087A (ja) | 2010-02-12 |
| BRPI0717098A2 (pt) | 2013-10-08 |
| IL197609A (en) | 2017-04-30 |
| PT2074141T (pt) | 2016-11-10 |
| WO2008034881A1 (en) | 2008-03-27 |
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