BR9916590A - Derivado de pirimidina, processo para a preparação de um derivado de pirimidina, método para a produção de um efeito anti-câncer em um animal de sangue quente, uso do derivado de pirimidina, e, composição farmacêutica - Google Patents
Derivado de pirimidina, processo para a preparação de um derivado de pirimidina, método para a produção de um efeito anti-câncer em um animal de sangue quente, uso do derivado de pirimidina, e, composição farmacêuticaInfo
- Publication number
- BR9916590A BR9916590A BR9916590-2A BR9916590A BR9916590A BR 9916590 A BR9916590 A BR 9916590A BR 9916590 A BR9916590 A BR 9916590A BR 9916590 A BR9916590 A BR 9916590A
- Authority
- BR
- Brazil
- Prior art keywords
- pyrimidine derivative
- pharmaceutical composition
- formula
- cancer effect
- warm
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 150000003230 pyrimidines Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 230000001093 anti-cancer Effects 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- -1 hydroxy, nitro, amino, cyano, mercapto, carboxy, sulfamoyl Chemical group 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Liquid Crystal Substances (AREA)
Abstract
"DERIVADO DE PIRIMIDINA, PROCESSO PARA A PREPARAçãO DE UM DERIVADO DE PIRIMIDINA, MéTODO PARA A PRODUçãO DE UM EFEITO ANTI-CâNCER EM UM ANIMAL DE SANGUE QUENTE, USO DO DERIVADO DE PIRIMIDINA, E, COMPOSIçãO FARMACêUTICA". Um derivado de pirimidina de fórmula (I): em que: R^ 1^ é um substituinte opcional conforme definido interiormente; R^ x^ é selecionado de halo, hidróxi, nitro, amino, ciano, mercapto, carbóxi, sulfamoíla, formamido, ureído ou carbamoíla, ou um grupo de fórmula (Ib): A-B-C- como definido interiormente; Q~ 1~ e Q~ 2~ são independentemente selecionados de arila, uma porção monocíclica de 5 ou 6 membros; e uma porção heterocíclica bicíclica de 9 ou 10 membros; e um ou ambos de Q~ 1~ e Q~ 2~ carregam sobre qualquer átomo de carbono disponível um substituinte de fórmula (Ia) conforme definido interiormente; e Q~ 1~ e Q~ 2~ são opcionalmente ainda substituídos; ou um seu sal ou éster hidrolisável in vivo farmaceuticamente aceitável; são úteis como agentes anti-câncer; e processos para a sua fabricação e composições farmacêuticas contendo-os, como descritos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9828511.7A GB9828511D0 (en) | 1998-12-24 | 1998-12-24 | Chemical compounds |
PCT/GB1999/004325 WO2000039101A1 (en) | 1998-12-24 | 1999-12-20 | Pyrimidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9916590A true BR9916590A (pt) | 2001-10-23 |
Family
ID=10844944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9916590-2A BR9916590A (pt) | 1998-12-24 | 1999-12-20 | Derivado de pirimidina, processo para a preparação de um derivado de pirimidina, método para a produção de um efeito anti-câncer em um animal de sangue quente, uso do derivado de pirimidina, e, composição farmacêutica |
Country Status (19)
Country | Link |
---|---|
US (1) | US6593326B1 (pt) |
EP (1) | EP1140860B1 (pt) |
JP (1) | JP2002533446A (pt) |
KR (1) | KR100663773B1 (pt) |
CN (1) | CN1285580C (pt) |
AT (1) | ATE277020T1 (pt) |
AU (1) | AU763091B2 (pt) |
BR (1) | BR9916590A (pt) |
CA (1) | CA2352896A1 (pt) |
DE (1) | DE69920509T2 (pt) |
DK (1) | DK1140860T3 (pt) |
ES (1) | ES2228145T3 (pt) |
GB (1) | GB9828511D0 (pt) |
IL (2) | IL143806A0 (pt) |
NO (1) | NO319815B1 (pt) |
NZ (1) | NZ512118A (pt) |
PT (1) | PT1140860E (pt) |
WO (1) | WO2000039101A1 (pt) |
ZA (1) | ZA200104413B (pt) |
Families Citing this family (240)
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JP2002523497A (ja) * | 1998-08-29 | 2002-07-30 | アストラゼネカ・アクチエボラーグ | ピリミジン化合物 |
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EP1158985B1 (en) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
RU2260592C9 (ru) | 1999-04-15 | 2017-04-07 | Бристол-Маерс Сквибб Ко. | Циклические ингибиторы протеинтирозинкиназ |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
ES2306671T3 (es) | 1999-10-07 | 2008-11-16 | Amgen Inc. | Inhibidores de triazina quinasa. |
CA2400447C (en) | 2000-02-17 | 2008-04-22 | Amgen Inc. | Kinase inhibitors |
GB0004890D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0007371D0 (en) * | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
JP4969010B2 (ja) | 2000-05-08 | 2012-07-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Hiv複製阻害性ピリミジンのプロドラッグ |
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KR20190108080A (ko) * | 2018-03-13 | 2019-09-23 | 보로노이바이오 주식회사 | 2,4,5-치환된 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암 또는 염증질환의 예방 또는 치료용 약학적 조성물 |
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1998
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1999
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- 1999-12-20 BR BR9916590-2A patent/BR9916590A/pt not_active Application Discontinuation
- 1999-12-20 KR KR1020017007971A patent/KR100663773B1/ko not_active IP Right Cessation
- 1999-12-20 IL IL14380699A patent/IL143806A0/xx unknown
- 1999-12-20 NZ NZ512118A patent/NZ512118A/en unknown
- 1999-12-20 PT PT99962375T patent/PT1140860E/pt unknown
- 1999-12-20 DK DK99962375T patent/DK1140860T3/da active
- 1999-12-20 ES ES99962375T patent/ES2228145T3/es not_active Expired - Lifetime
- 1999-12-20 CA CA002352896A patent/CA2352896A1/en not_active Abandoned
- 1999-12-20 AU AU18743/00A patent/AU763091B2/en not_active Ceased
- 1999-12-20 WO PCT/GB1999/004325 patent/WO2000039101A1/en active IP Right Grant
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- 2001-06-17 IL IL143806A patent/IL143806A/en not_active IP Right Cessation
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JP2002533446A (ja) | 2002-10-08 |
ZA200104413B (en) | 2002-08-29 |
DE69920509T2 (de) | 2006-03-09 |
DE69920509D1 (de) | 2004-10-28 |
EP1140860B1 (en) | 2004-09-22 |
KR20010099900A (ko) | 2001-11-09 |
EP1140860A1 (en) | 2001-10-10 |
ATE277020T1 (de) | 2004-10-15 |
CN1285580C (zh) | 2006-11-22 |
NO20013038L (no) | 2001-08-22 |
CA2352896A1 (en) | 2000-07-06 |
KR100663773B1 (ko) | 2007-01-03 |
IL143806A0 (en) | 2002-04-21 |
AU1874300A (en) | 2000-07-31 |
ES2228145T3 (es) | 2005-04-01 |
AU763091B2 (en) | 2003-07-10 |
IL143806A (en) | 2009-06-15 |
CN1335838A (zh) | 2002-02-13 |
GB9828511D0 (en) | 1999-02-17 |
NZ512118A (en) | 2003-08-29 |
DK1140860T3 (da) | 2005-01-10 |
NO20013038D0 (no) | 2001-06-19 |
PT1140860E (pt) | 2005-01-31 |
NO319815B1 (no) | 2005-09-19 |
WO2000039101A1 (en) | 2000-07-06 |
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