BR0308144A - Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto - Google Patents
Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um compostoInfo
- Publication number
- BR0308144A BR0308144A BR0308144-3A BR0308144A BR0308144A BR 0308144 A BR0308144 A BR 0308144A BR 0308144 A BR0308144 A BR 0308144A BR 0308144 A BR0308144 A BR 0308144A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- hydroxy
- halo
- alkyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO, E, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO". Amidas heterocíclicas da fórmula (1) em que: é uma ligação simples ou dupla; A é fenileno ou heteroarileno; m é 0, 1 ou 2; n é 0, 1 ou 2; R^ 1^ é selecionado, por exemplo, a partir de halo, nitro, ciano, hidróxi, carbóxi; r é 1 ou 2; Y é -NR^ 2^R^ 3^ ou - OR^ 3^; R^ 2^ e R^ 3^ são selecionados a partir de, por exemplo, hidrogênio, hidróxi, arila, heterociclila e alquila C~ 1-4~ (opcionalmente substituído por 1 ou 2 grupos R^ 8^); R^ 4^ é selecionado, por exemplo, a partir de hidrogênio, halo, nitro, ciano, hidróxi, alquila C~ 1-4~ e alcanoíla; R^ 8^ é selecionado, por exemplo, a partir de hidróxi, -COCOOR^ 9^, -C(O)N(R^ 9^)(R^ 10^), -NHC(O)R^ 9^, (R^ 9^) (R^ 10^)N- e -COOR^ 9^; R^ 9^ e R^ 10^ são selecionados, por exemplo, a partir de hidrogênio, hidróxi, alquila C~ 1-4~ (opcionalmente substituido por 1 ou 2 R^ 13^); R^ 13^ é selecionado a partir de hidróxi, halo, trialometila e alcóxi C~ 1-4~; ou um sal farmaceuticamente aceitável ou pró-droga dos mesmos; possuem atividade inibitória de glicogênio foforilase e portanto possuem valor no tratamento de estados de doença associados com atividade de glicogênio fosforilase aumentada. Processos para a manufatura dos referidos derivados de amida heterocíclica e composições farmacêuticas contendo os mesmos são descritos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0205176.1A GB0205176D0 (en) | 2002-03-06 | 2002-03-06 | Chemical compounds |
PCT/GB2003/000883 WO2003074484A1 (en) | 2002-03-06 | 2003-03-04 | Indolamid derivatives which possess glycogenphosphorylase inhibitory activity |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0308144A true BR0308144A (pt) | 2004-12-07 |
Family
ID=9932340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0308144-3A BR0308144A (pt) | 2002-03-06 | 2003-03-04 | Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto |
Country Status (20)
Country | Link |
---|---|
US (1) | US7138415B2 (pt) |
EP (1) | EP1483240A1 (pt) |
JP (1) | JP2005524667A (pt) |
KR (1) | KR20040097145A (pt) |
CN (1) | CN100374420C (pt) |
AR (1) | AR038889A1 (pt) |
AU (1) | AU2003216988A1 (pt) |
BR (1) | BR0308144A (pt) |
CA (1) | CA2477717A1 (pt) |
GB (1) | GB0205176D0 (pt) |
IL (1) | IL163823A0 (pt) |
IS (1) | IS7435A (pt) |
MX (1) | MXPA04008612A (pt) |
NO (1) | NO20044032L (pt) |
NZ (1) | NZ534683A (pt) |
PL (1) | PL373872A1 (pt) |
RU (1) | RU2004125182A (pt) |
TW (1) | TW200304817A (pt) |
WO (1) | WO2003074484A1 (pt) |
ZA (1) | ZA200406681B (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0205170D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205162D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205165D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0222912D0 (en) | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
GB0222909D0 (en) | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
EP1562899A2 (en) * | 2002-11-07 | 2005-08-17 | Pfizer Products Inc. | N-(indole-2-carbonyl)amides as anti-diabetic agents |
GB0318464D0 (en) * | 2003-08-07 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
GB0319690D0 (en) * | 2003-08-22 | 2003-09-24 | Astrazeneca Ab | Chemical compounds |
WO2005020985A1 (en) * | 2003-08-29 | 2005-03-10 | Astrazeneca Ab | Indolamide derivatives which possess glycogen phosphorylase inhibitory activity |
US7214704B2 (en) | 2004-11-15 | 2007-05-08 | Bristol-Myers Squibb Company | 2-Amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
WO2006055462A1 (en) * | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
WO2006055435A1 (en) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors |
US7365061B2 (en) | 2004-11-15 | 2008-04-29 | Bristol-Myers Squibb Company | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
EP1848693A1 (en) * | 2005-02-05 | 2007-10-31 | AstraZeneca AB | Indan-amide derivatives with glycogen phosphorylase inhibitory activity |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
EA201790317A1 (ru) * | 2014-09-10 | 2018-07-31 | Эпизим, Инк. | Ингибиторы smyd |
CN112442022B (zh) * | 2019-09-02 | 2022-05-20 | 承德医学院 | 苯并嗪-4-酮类化合物、其制备方法及医药用途 |
CN114403150B (zh) * | 2022-02-09 | 2022-11-04 | 中国农业大学 | 一种吲哚酰胺类化合物作为海藻糖-6-磷酸合成酶抑制剂的应用 |
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WO2005020986A1 (en) | 2003-08-29 | 2005-03-10 | Astrazeneca Ab | Heterocyclic amide derivatives which posses glycogen phosphorylase inhibitory activity |
WO2005020985A1 (en) | 2003-08-29 | 2005-03-10 | Astrazeneca Ab | Indolamide derivatives which possess glycogen phosphorylase inhibitory activity |
GB0320422D0 (en) | 2003-08-30 | 2003-10-01 | Astrazeneca Ab | Chemical compounds |
-
2002
- 2002-03-06 GB GBGB0205176.1A patent/GB0205176D0/en not_active Ceased
-
2003
- 2003-03-04 PL PL03373872A patent/PL373872A1/xx not_active Application Discontinuation
- 2003-03-04 CN CNB038053098A patent/CN100374420C/zh not_active Expired - Fee Related
- 2003-03-04 AU AU2003216988A patent/AU2003216988A1/en not_active Abandoned
- 2003-03-04 EP EP03712310A patent/EP1483240A1/en not_active Withdrawn
- 2003-03-04 JP JP2003572954A patent/JP2005524667A/ja not_active Withdrawn
- 2003-03-04 WO PCT/GB2003/000883 patent/WO2003074484A1/en active Application Filing
- 2003-03-04 CA CA002477717A patent/CA2477717A1/en not_active Abandoned
- 2003-03-04 RU RU2004125182/04A patent/RU2004125182A/ru not_active Application Discontinuation
- 2003-03-04 US US10/506,554 patent/US7138415B2/en not_active Expired - Fee Related
- 2003-03-04 KR KR10-2004-7013859A patent/KR20040097145A/ko not_active Application Discontinuation
- 2003-03-04 IL IL16382303A patent/IL163823A0/xx unknown
- 2003-03-04 NZ NZ534683A patent/NZ534683A/en unknown
- 2003-03-04 BR BR0308144-3A patent/BR0308144A/pt not_active IP Right Cessation
- 2003-03-04 MX MXPA04008612A patent/MXPA04008612A/es active IP Right Grant
- 2003-03-05 TW TW092104668A patent/TW200304817A/zh unknown
- 2003-03-06 AR ARP030100769A patent/AR038889A1/es unknown
-
2004
- 2004-08-23 ZA ZA200406681A patent/ZA200406681B/en unknown
- 2004-09-02 IS IS7435A patent/IS7435A/is unknown
- 2004-09-24 NO NO20044032A patent/NO20044032L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
GB0205176D0 (en) | 2002-04-17 |
EP1483240A1 (en) | 2004-12-08 |
MXPA04008612A (es) | 2004-12-06 |
NZ534683A (en) | 2006-02-24 |
CN100374420C (zh) | 2008-03-12 |
KR20040097145A (ko) | 2004-11-17 |
TW200304817A (en) | 2003-10-16 |
IS7435A (is) | 2004-09-02 |
US7138415B2 (en) | 2006-11-21 |
CN1639120A (zh) | 2005-07-13 |
RU2004125182A (ru) | 2005-06-10 |
WO2003074484A1 (en) | 2003-09-12 |
US20050107362A1 (en) | 2005-05-19 |
CA2477717A1 (en) | 2003-09-12 |
NO20044032L (no) | 2004-10-05 |
AU2003216988A1 (en) | 2003-09-16 |
ZA200406681B (en) | 2005-09-22 |
JP2005524667A (ja) | 2005-08-18 |
IL163823A0 (en) | 2005-12-18 |
AR038889A1 (es) | 2005-02-02 |
PL373872A1 (en) | 2005-09-19 |
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