FR2786486B3 - Procede de preparation du (2s)-1-[(2r,3s)-5-chloro-3-(2- chlorophenyl)-1-(3,4-dimethoxy benzenesulfonyl)-3-hydroxy- 2,3-dihydro-1h-indole-2-carbonyl]pyrrolidine-2-carboxamide, de ses solvats et/ou hydrates - Google Patents

Procede de preparation du (2s)-1-[(2r,3s)-5-chloro-3-(2- chlorophenyl)-1-(3,4-dimethoxy benzenesulfonyl)-3-hydroxy- 2,3-dihydro-1h-indole-2-carbonyl]pyrrolidine-2-carboxamide, de ses solvats et/ou hydrates

Info

Publication number
FR2786486B3
FR2786486B3 FR9814384A FR9814384A FR2786486B3 FR 2786486 B3 FR2786486 B3 FR 2786486B3 FR 9814384 A FR9814384 A FR 9814384A FR 9814384 A FR9814384 A FR 9814384A FR 2786486 B3 FR2786486 B3 FR 2786486B3
Authority
FR
France
Prior art keywords
carboxamide
solvates
pyrrolidine
hydrates
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9814384A
Other languages
English (en)
Other versions
FR2786486A1 (fr
Inventor
Dominique Chantreux
Philippe Mercey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9814384A priority Critical patent/FR2786486B3/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to US09/831,721 priority patent/US6355809B1/en
Priority to JP2000582392A priority patent/JP2002530281A/ja
Priority to PCT/FR1999/002759 priority patent/WO2000029405A1/fr
Priority to CA002348676A priority patent/CA2348676A1/fr
Priority to EP99972213A priority patent/EP1131317A1/fr
Priority to AU11659/00A priority patent/AU1165900A/en
Publication of FR2786486A1 publication Critical patent/FR2786486A1/fr
Application granted granted Critical
Publication of FR2786486B3 publication Critical patent/FR2786486B3/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FR9814384A 1998-11-16 1998-11-16 Procede de preparation du (2s)-1-[(2r,3s)-5-chloro-3-(2- chlorophenyl)-1-(3,4-dimethoxy benzenesulfonyl)-3-hydroxy- 2,3-dihydro-1h-indole-2-carbonyl]pyrrolidine-2-carboxamide, de ses solvats et/ou hydrates Expired - Lifetime FR2786486B3 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR9814384A FR2786486B3 (fr) 1998-11-16 1998-11-16 Procede de preparation du (2s)-1-[(2r,3s)-5-chloro-3-(2- chlorophenyl)-1-(3,4-dimethoxy benzenesulfonyl)-3-hydroxy- 2,3-dihydro-1h-indole-2-carbonyl]pyrrolidine-2-carboxamide, de ses solvats et/ou hydrates
JP2000582392A JP2002530281A (ja) 1998-11-16 1999-11-10 （２ｓ）−１−［（２ｒ，３ｓ）−５−クロロ−３−（２−クロロフェニル）−１−（３，４−ジメトキシベンゼンスルホニル）−３−ヒドロキシ−２，３−ジヒドロ−１ｈ−インドール−２−カルボニル］ピロリジン−２−カルボキサミドの製造法
PCT/FR1999/002759 WO2000029405A1 (fr) 1998-11-16 1999-11-10 Procede de preparation du (2s)-1-[(2r,3s)-5- chloro-3-(2- chlorophenyl) -1-(3,4-dimethoxy benzenesulfonyl) -3-hydroxy-2, 3-dihydro-1h- indole-2-carbonyl] pyrrolidine-2- carboxamide
CA002348676A CA2348676A1 (fr) 1998-11-16 1999-11-10 Procede de preparation du (2s)-1-¬(2r,3s)-5- chloro-3-(2- chlorophenyl) -1-(3,4-dimethoxy benzenesulfonyl) -3-hydroxy-2, 3-dihydro-1h- indole-2-carbonyl| pyrrolidine-2- carboxamide
US09/831,721 US6355809B1 (en) 1998-11-16 1999-11-10 Method for preparing (2s)-1-(2r3s)-5-chloro-3-(2-chlorophenyl) -1-(3,4-dimethoxy benzene-sulphonyl) 3-hydroxy-2,3-dihydro-1h-indole-2-carbonyl pyrrolidine-2-carboxamide
EP99972213A EP1131317A1 (fr) 1998-11-16 1999-11-10 Procede de preparation du (2s)-1- (2r,3s)-5- chloro-3-(2- chlorophenyl) -1-(3,4-dimethoxy benzenesulfonyl) -3-hydroxy-2, 3-dihydro-1h- indole-2-carbonyl] pyrrolidine-2- carboxamide
AU11659/00A AU1165900A (en) 1998-11-16 1999-11-10 Method for preparing (2s)-1-( (2r,3s)-5- chloro-3-(2- chlorophenyl) -1-(3,4-dimethoxy benzenesulphonyl) -3-hydroxy-2, 3-dihydro-1h- indole-2-carbonyl) pyrrolidine-2- carboxamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9814384A FR2786486B3 (fr) 1998-11-16 1998-11-16 Procede de preparation du (2s)-1-[(2r,3s)-5-chloro-3-(2- chlorophenyl)-1-(3,4-dimethoxy benzenesulfonyl)-3-hydroxy- 2,3-dihydro-1h-indole-2-carbonyl]pyrrolidine-2-carboxamide, de ses solvats et/ou hydrates

Publications (2)

Publication Number Publication Date
FR2786486A1 FR2786486A1 (fr) 2000-06-02
FR2786486B3 true FR2786486B3 (fr) 2000-12-08

Family

ID=9532788

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9814384A Expired - Lifetime FR2786486B3 (fr) 1998-11-16 1998-11-16 Procede de preparation du (2s)-1-[(2r,3s)-5-chloro-3-(2- chlorophenyl)-1-(3,4-dimethoxy benzenesulfonyl)-3-hydroxy- 2,3-dihydro-1h-indole-2-carbonyl]pyrrolidine-2-carboxamide, de ses solvats et/ou hydrates

Country Status (7)

Country Link
US (1) US6355809B1 (fr)
EP (1) EP1131317A1 (fr)
JP (1) JP2002530281A (fr)
AU (1) AU1165900A (fr)
CA (1) CA2348676A1 (fr)
FR (1) FR2786486B3 (fr)
WO (1) WO2000029405A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0205176D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
MXPA05013478A (es) * 2003-06-10 2006-03-09 Pfizer Combinaciones terapeuticas.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5481005A (en) 1990-07-31 1996-01-02 Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2679903B1 (fr) * 1991-08-02 1993-12-03 Elf Sanofi Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.
US5338755A (en) * 1990-07-31 1994-08-16 Elf Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2756736B1 (fr) * 1996-12-05 1999-03-05 Sanofi Sa Compositions pharmaceutiques contenant des derives de n-sulfonyl indoline

Also Published As

Publication number Publication date
EP1131317A1 (fr) 2001-09-12
US6355809B1 (en) 2002-03-12
CA2348676A1 (fr) 2000-05-25
WO2000029405A1 (fr) 2000-05-25
FR2786486A1 (fr) 2000-06-02
JP2002530281A (ja) 2002-09-17
AU1165900A (en) 2000-06-05

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