BR0008770A - Derivado de pirimidina, processo para a preparação de um derivado de pirimidina, processo para a produção de um efeito anti-câncer em um animal de sangue quente, uso de um derivado de pirimidina, e, composição farmacêutica - Google Patents

Derivado de pirimidina, processo para a preparação de um derivado de pirimidina, processo para a produção de um efeito anti-câncer em um animal de sangue quente, uso de um derivado de pirimidina, e, composição farmacêutica

Info

Publication number
BR0008770A
BR0008770A BR0008770-0A BR0008770A BR0008770A BR 0008770 A BR0008770 A BR 0008770A BR 0008770 A BR0008770 A BR 0008770A BR 0008770 A BR0008770 A BR 0008770A
Authority
BR
Brazil
Prior art keywords
pyrimidine derivative
warm
producing
preparation
pharmaceutical composition
Prior art date
Application number
BR0008770-0A
Other languages
English (en)
Inventor
Gloria Anne Breault
Stewart Russell James
Jane Elizabeth Pease
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0008770A publication Critical patent/BR0008770A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADO DE PIRIMIDINA, PROCESSO PARA A PREPARAçãO DE UM DERIVADO DE PIRIMIDINA, PROCESSO PARA A PRODUçãO DE UM EFEITO ANTI-CâNCER EM UM ANIMAL DE SANGUE QUENTE, USO DE UM DERIVADO DE PIRIMIDINA, E, COMPOSIçãO FARMACêUTICA". Um derivado de pirimidina de fórmula (I) ou (I<39>): em que: R^ x^ é um substituinte opcional como definido interiormente; Q~ 1~ é opcionalmente substituído por fenila, e Q~ 1~ carrega um substituinte de fórmula (Ia) em que: X, Y^ 1^, Y^ 2^, Z, n e m são como definidos interiormente; -NQ~ 2~ é uma porção heterocíclica opcionalmente substituída contendo um heteroátomo de nitrogênio e opcionalmente contendo um outro heteroátomo; ou um éster hidrolisável in vivo de sal farmaceuticamente aceitável deste; são úteis como agentes anti-câncer. Processos para a sua fabricação e composições farmacêuticas contendo-os, como descritos.
BR0008770-0A 1999-03-06 2000-03-02 Derivado de pirimidina, processo para a preparação de um derivado de pirimidina, processo para a produção de um efeito anti-câncer em um animal de sangue quente, uso de um derivado de pirimidina, e, composição farmacêutica BR0008770A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9905075.9A GB9905075D0 (en) 1999-03-06 1999-03-06 Chemical compounds
PCT/GB2000/000737 WO2000053595A1 (en) 1999-03-06 2000-03-02 Pyrimidine compounds

Publications (1)

Publication Number Publication Date
BR0008770A true BR0008770A (pt) 2002-01-08

Family

ID=10849022

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008770-0A BR0008770A (pt) 1999-03-06 2000-03-02 Derivado de pirimidina, processo para a preparação de um derivado de pirimidina, processo para a produção de um efeito anti-câncer em um animal de sangue quente, uso de um derivado de pirimidina, e, composição farmacêutica

Country Status (20)

Country Link
US (1) US6716831B1 (pt)
EP (1) EP1161428B1 (pt)
JP (1) JP2002539120A (pt)
KR (1) KR100683512B1 (pt)
CN (1) CN1227249C (pt)
AT (1) ATE241617T1 (pt)
AU (1) AU754967B2 (pt)
BR (1) BR0008770A (pt)
CA (1) CA2366668A1 (pt)
DE (1) DE60003001T2 (pt)
DK (1) DK1161428T3 (pt)
ES (1) ES2200824T3 (pt)
GB (1) GB9905075D0 (pt)
IL (2) IL145192A0 (pt)
MX (1) MXPA01008960A (pt)
NO (1) NO320909B1 (pt)
NZ (1) NZ513893A (pt)
PT (1) PT1161428E (pt)
WO (1) WO2000053595A1 (pt)
ZA (1) ZA200107252B (pt)

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