BR0210574A - Processos para a preparação de uma base livre de citalopram racêmico ou de um seu sal de adição de ácido e/ou de r- ou s-citalopram como a base livre ou um seu sal de adição de ácido e para a preparação de uma mistura de r- e s-citalopram - Google Patents
Processos para a preparação de uma base livre de citalopram racêmico ou de um seu sal de adição de ácido e/ou de r- ou s-citalopram como a base livre ou um seu sal de adição de ácido e para a preparação de uma mistura de r- e s-citalopramInfo
- Publication number
- BR0210574A BR0210574A BR0210574-8A BR0210574A BR0210574A BR 0210574 A BR0210574 A BR 0210574A BR 0210574 A BR0210574 A BR 0210574A BR 0210574 A BR0210574 A BR 0210574A
- Authority
- BR
- Brazil
- Prior art keywords
- citalopram
- acid addition
- addition salt
- free base
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
"PROCESSOS PARA A PREPARAçãO DE UMA BASE LIVRE DE CITALOPRAM RACêMICO OU DE UM SEU SAL DE ADIçãO DE áCIDO E/OU DE R- OU S-CITALOPRAM COMO A BASE LIVRE OU UM SEU SAL DE ADIçãO DE áCIDO E PARA A PREPARAçãO DE UMA MISTURA DE R- E S-CITALOPRAM". A invenção refere-se a um processo para a preparação de uma base livre de citalopram racêmico ou de um seu sal de adição de ácido e/ou de R- ou S-citalopram como a base livre ou um seu sal de adição de ácido pela separação de uma mistura de R- e S-citalopram com mais do que 50% de um dos enanciómeros em uma fração consistindo de citalopram racêmico e/ou uma fração de S-citalopram ou R-citalopram caracterizado pelo fato de que i) o citalopram é precipitado de um solvente como a base livre ou como um seu sal de adição de ácido; ii) o precipitado formado é separado do licor-mãe; iia) se o precipitado for cristalino ele será opcionalmente recristalizado uma ou mais vezes para formar citalopram racêmico, e depois opcionalmente convertido em um seu sal de adição de ácido; iib) se o precipitado não for cristalino, as etapas i) e ii) serão opcionalmente repetidas até que um precipitado cristalino seja obtido e o precipitado cristalino será recristalizado uma ou mais vezes para formar citalopram racêmico, e depois opcionalmente convertido em um seu sal de adição de ácido; iii) o licor-mãe é opcionalmente submetido à purificação adicional e S-citalopram ou R-citalopram é isolado do licor-mãe e opcionalmente convertido em um seu sal de adição de ácido.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100991 | 2001-06-25 | ||
| DKPA200100991 | 2001-06-25 | ||
| PCT/DK2002/000426 WO2003000672A1 (en) | 2001-06-25 | 2002-06-25 | Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0210574A true BR0210574A (pt) | 2004-08-03 |
| BR0210574B1 BR0210574B1 (pt) | 2014-03-04 |
| BRPI0210574B8 BRPI0210574B8 (pt) | 2021-05-25 |
Family
ID=8160584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0210574A BRPI0210574B8 (pt) | 2001-06-25 | 2002-06-25 | processo para a preparação de uma mistura de r- e s-citalopram |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US7112686B2 (pt) |
| EP (1) | EP1412341B1 (pt) |
| JP (2) | JP4377219B2 (pt) |
| KR (4) | KR20080100498A (pt) |
| CN (2) | CN100429208C (pt) |
| AR (2) | AR034612A1 (pt) |
| AT (1) | ATE284395T1 (pt) |
| BG (1) | BG66372B1 (pt) |
| BR (1) | BRPI0210574B8 (pt) |
| CA (2) | CA2450890C (pt) |
| CO (1) | CO5550420A2 (pt) |
| CZ (1) | CZ305034B6 (pt) |
| DE (1) | DE60202216T2 (pt) |
| DK (1) | DK1412341T3 (pt) |
| EA (1) | EA006446B1 (pt) |
| ES (1) | ES2233834T3 (pt) |
| HK (2) | HK1068627A1 (pt) |
| HR (1) | HRP20031075B1 (pt) |
| HU (1) | HU228476B1 (pt) |
| IL (1) | IL159229A0 (pt) |
| IS (1) | IS2426B (pt) |
| JO (1) | JO2389B1 (pt) |
| MA (1) | MA26260A1 (pt) |
| ME (2) | MEP1508A (pt) |
| MX (1) | MXPA03011770A (pt) |
| MY (1) | MY133471A (pt) |
| NO (2) | NO329873B1 (pt) |
| NZ (1) | NZ530104A (pt) |
| PE (1) | PE20030122A1 (pt) |
| PL (1) | PL366560A1 (pt) |
| PT (1) | PT1412341E (pt) |
| RS (1) | RS50673B (pt) |
| SI (1) | SI1412341T1 (pt) |
| SK (1) | SK287696B6 (pt) |
| TN (1) | TNSN02062A1 (pt) |
| TW (1) | TWI236473B (pt) |
| UA (1) | UA75147C2 (pt) |
| UY (2) | UY27356A1 (pt) |
| WO (1) | WO2003000672A1 (pt) |
| ZA (1) | ZA200309633B (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI306846B (en) | 2002-08-12 | 2009-03-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| JP4505335B2 (ja) | 2002-12-23 | 2010-07-21 | ハー・ルンドベック・アクチエゼルスカベット | ラセミ体シタロプラムジオール（ｒａｃｅｍｉｃｃｉｔａｌｏｐｒａｍｄｉｏｌ）および／またはＳ−もしくはＲ−シタロプラムジオールの製造方法、およびラセミ体シタロプラム、Ｒ−シタロプラムおよび／またはＳ−シタロプラムを製造するために、上記ジオールを使用する方法。 |
| CN100334071C (zh) * | 2002-12-23 | 2007-08-29 | H·隆德贝克有限公司 | 外消旋西酞普兰二醇和 /或 s －或 r－西酞普兰二醇的制备方法及这些二醇在制备外消旋西酞普兰二醇、 r －西酞普兰和 /或 s －西酞普兰中的用途 |
| WO2004056791A1 (en) | 2002-12-23 | 2004-07-08 | H. Lundbeck A/S | Escitalopram hydrobromide and a method for the preparation thereof |
| TR200504022T1 (tr) * | 2003-03-24 | 2006-08-21 | Hetero Drugs Limited | (S)-sitalopram oksalatın yeni sıvı kristal formları. |
| CN100569765C (zh) | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
| TWI339651B (en) * | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| US20050196453A1 (en) | 2004-03-05 | 2005-09-08 | H. Lundbeck A/S | Crystalline composition containing escitalopram |
| AU2005218713B2 (en) * | 2004-03-05 | 2009-11-19 | H. Lundbeck A/S | Crystalline composition containing escitalopram oxalate |
| ITMI20040717A1 (it) | 2004-04-09 | 2004-07-09 | Adorkem Technology Spa | Procedimento chemo-enzimatico per la preparazione dell'escitalopram |
| JP2006008603A (ja) * | 2004-06-25 | 2006-01-12 | Sumitomo Chemical Co Ltd | 光学活性シタロプラムの製造方法、その中間体およびその製造方法 |
| EP2141156A1 (en) * | 2004-08-23 | 2010-01-06 | Sun Pharma Global FZE | Process for Preparation of Citalopram and Enantiomers |
| US7989645B2 (en) * | 2004-08-23 | 2011-08-02 | Sun Pharma Global Fze | Process for preparation of citalopram and enantiomers |
| EP1901714A2 (en) * | 2005-05-20 | 2008-03-26 | Aurobindo Pharma Limited | Pharmaceutical dosage forms comprising escitalopram in form of granules |
| TWI347942B (en) * | 2005-06-22 | 2011-09-01 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| US7834201B2 (en) | 2005-06-22 | 2010-11-16 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| JP2009511606A (ja) | 2005-10-14 | 2009-03-19 | ハー・ルンドベック・アクチエゼルスカベット | エスシタロプラムおよびブプロピオンの低用量の併用を用いる中枢神経系障害の治療方法 |
| WO2008059514A2 (en) * | 2006-07-31 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing escitalopram |
| US8022232B2 (en) | 2007-09-11 | 2011-09-20 | H. Lundbeck A/S | Method for manufacture of escitalopram |
| FI121570B (fi) | 2007-09-11 | 2011-01-14 | Lundbeck & Co As H | Menetelmä essitalopraamin valmistamiseksi |
| CN100548974C (zh) * | 2007-10-11 | 2009-10-14 | 浙江大学 | 西酞普兰中间体的萃取分离方法 |
| CN101560199B (zh) * | 2008-04-16 | 2013-09-18 | 北京德众万全药物技术开发有限公司 | 一种依地普仑的制备方法 |
| TWI381813B (zh) | 2010-01-12 | 2013-01-11 | Taiwan Paiho Ltd | A Velcro assembly for a foamed article and a foamed article comprising the adhesive tape assembly |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| NZ512406A (en) * | 1999-10-25 | 2004-01-30 | H | Method for the preparation of citalopram |
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2002
- 2002-06-21 AR ARP020102350A patent/AR034612A1/es active IP Right Grant
- 2002-06-23 JO JO200265A patent/JO2389B1/en active
- 2002-06-24 TN TNTNSN02062A patent/TNSN02062A1/en unknown
- 2002-06-24 PE PE2002000551A patent/PE20030122A1/es active IP Right Grant
- 2002-06-25 NZ NZ530104A patent/NZ530104A/en not_active IP Right Cessation
- 2002-06-25 ES ES02742848T patent/ES2233834T3/es not_active Expired - Lifetime
- 2002-06-25 KR KR1020087026708A patent/KR20080100498A/ko active Application Filing
- 2002-06-25 AT AT02742848T patent/ATE284395T1/de active
- 2002-06-25 MA MA26713A patent/MA26260A1/fr unknown
- 2002-06-25 US US10/482,000 patent/US7112686B2/en not_active Expired - Lifetime
- 2002-06-25 MY MYPI20022382A patent/MY133471A/en unknown
- 2002-06-25 DE DE60202216T patent/DE60202216T2/de not_active Expired - Lifetime
- 2002-06-25 KR KR1020107006751A patent/KR20100052550A/ko not_active Application Discontinuation
- 2002-06-25 EP EP02742848A patent/EP1412341B1/en not_active Expired - Lifetime
- 2002-06-25 IL IL15922902A patent/IL159229A0/xx active IP Right Grant
- 2002-06-25 KR KR1020037016853A patent/KR100902530B1/ko active IP Right Grant
- 2002-06-25 CA CA2450890A patent/CA2450890C/en not_active Expired - Fee Related
- 2002-06-25 UA UA20031211986A patent/UA75147C2/uk unknown
- 2002-06-25 WO PCT/DK2002/000426 patent/WO2003000672A1/en active Application Filing
- 2002-06-25 RS YUP-1014/03A patent/RS50673B/sr unknown
- 2002-06-25 PT PT02742848T patent/PT1412341E/pt unknown
- 2002-06-25 JP JP2003507077A patent/JP4377219B2/ja not_active Expired - Lifetime
- 2002-06-25 TW TW091113845A patent/TWI236473B/zh not_active IP Right Cessation
- 2002-06-25 SK SK51-2004A patent/SK287696B6/sk unknown
- 2002-06-25 HU HU0400293A patent/HU228476B1/hu unknown
- 2002-06-25 PL PL02366560A patent/PL366560A1/xx not_active Application Discontinuation
- 2002-06-25 BR BRPI0210574A patent/BRPI0210574B8/pt not_active IP Right Cessation
- 2002-06-25 ME MEP-15/08A patent/MEP1508A/xx unknown
- 2002-06-25 CN CNB028126688A patent/CN100429208C/zh not_active Expired - Lifetime
- 2002-06-25 EA EA200400082A patent/EA006446B1/ru not_active IP Right Cessation
- 2002-06-25 CA CA2691149A patent/CA2691149C/en not_active Expired - Fee Related
- 2002-06-25 CZ CZ2004-131A patent/CZ305034B6/cs not_active IP Right Cessation
- 2002-06-25 UY UY27356A patent/UY27356A1/es not_active IP Right Cessation
- 2002-06-25 DK DK02742848T patent/DK1412341T3/da active
- 2002-06-25 ME MEP-2008-15A patent/ME00027B/me unknown
- 2002-06-25 KR KR1020097004586A patent/KR100939945B1/ko active IP Right Grant
- 2002-06-25 SI SI200230078T patent/SI1412341T1/xx unknown
- 2002-06-25 MX MXPA03011770A patent/MXPA03011770A/es active IP Right Grant
- 2002-06-25 CN CN2008102158851A patent/CN101440079B/zh not_active Expired - Lifetime
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2003
- 2003-12-08 IS IS7068A patent/IS2426B/is unknown
- 2003-12-11 ZA ZA2003/09633A patent/ZA200309633B/en unknown
- 2003-12-18 NO NO20035671A patent/NO329873B1/no not_active IP Right Cessation
- 2003-12-23 HR HR20031075A patent/HRP20031075B1/xx not_active IP Right Cessation
-
2004
- 2004-01-14 BG BG108532A patent/BG66372B1/bg unknown
- 2004-01-22 CO CO04004620A patent/CO5550420A2/es not_active Application Discontinuation
-
2005
- 2005-02-07 HK HK05101034.1A patent/HK1068627A1/xx not_active IP Right Cessation
-
2009
- 2009-04-17 JP JP2009101188A patent/JP5064436B2/ja not_active Expired - Lifetime
- 2009-11-12 HK HK09110569.1A patent/HK1132729A1/xx not_active IP Right Cessation
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2010
- 2010-10-13 NO NO20101420A patent/NO335106B1/no not_active IP Right Cessation
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2011
- 2011-10-19 AR ARP110103869A patent/AR083483A2/es active IP Right Grant
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2014
- 2014-11-21 UY UY0001035850A patent/UY35850A/es not_active IP Right Cessation
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