KR870003054A - 사이클로 알킬-치환된 4-아미노 페닐 유도체의 제조 방법 - Google Patents

사이클로 알킬-치환된 4-아미노 페닐 유도체의 제조 방법 Download PDF

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Publication number
KR870003054A
KR870003054A KR1019860007406A KR860007406A KR870003054A KR 870003054 A KR870003054 A KR 870003054A KR 1019860007406 A KR1019860007406 A KR 1019860007406A KR 860007406 A KR860007406 A KR 860007406A KR 870003054 A KR870003054 A KR 870003054A
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South Korea
Prior art keywords
formula
compound
substituted
preparing
amino phenyl
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KR1019860007406A
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English (en)
Inventor
롬바르디 파올로
크루그놀라 안젤로
디 살레 엔리코
Original Assignee
비토리노 페라리오
팔미탈리아 카를로 에르바 에스. 피. 에이.
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Application filed by 비토리노 페라리오, 팔미탈리아 카를로 에르바 에스. 피. 에이. filed Critical 비토리노 페라리오
Publication of KR870003054A publication Critical patent/KR870003054A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

사이클로 알킬-치환된 4-아미노 페닐 유도체의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 일반식(Ⅱ)의 화합물 또는 이의 반응성 유도체를 일반식(Ⅲ)의 화합물과 반응시켜, A가B는 -O- 또는 -NH-인 일반식(Ⅰ)의 화합물을 수득하거나; 일반식(Ⅳ)의 화합물을 환원시켜, A가B는 -O-, -NH- 또는 -CH2-이거나, A가 -O-, -NH- 또는 -CH2-이고 B는상응하는 일반식(Ⅰ)의 화합물을 수득하거나; R 및 n이 하기 정의한 바와 같고, A가B는 -O- 또는 NH이거나, A가 -O- 또는 NH이고 B는일반식(Ⅰ)의 화합물을 환원시켜, A가 -CH2-이고, B는 -O- 또는 NH이거나, A가 -O- 또는 NH이고 B는 -CH2-인 상응하는 일반식(Ⅰ)의 화합물을 수득하거나; A가B는 -CH2-이거나, A가 -CH2-이고 B는일반식(Ⅰ)의 화합물을 탈산소화시켜, A 및 B가 둘다 -CH2-인 일반식(Ⅰ)의 유리 화합물을 수득하고; 필요시, 일반식(Ⅰ)의 화합물을 염화시키거나, 일반식(Ⅰ)화합물의 염으로부터 일반식(Ⅰ)의 유리 화합물을 수득하고/하거나, 필요시, 일반식(Ⅰ)의 이성체 혼합물을 단일 이성체로 분리시킴을 특징으로 하여, 일반식(Ⅰ)의 화합물 및 이의 약제학적으로 허용되는 염을 제조하는 방법.
  2. 제1항에 있어서, 일반식(Ⅰa)로 표시되는 에난티오머인 일반식(Ⅰ)의 화합물을 제조하는 방법.
    상기 식에서, R, n, A 및 B는 제1항에서 정의된 바와 같다.
  3. 제1항 또는 2항에 있어서, R이 메틸 또는 에틸이고 n이 3 또는 4인, 일반식(Ⅰ)의 화합물 또는 일반식(Ⅰa)의 화합물을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860007406A 1985-09-06 1986-09-04 사이클로 알킬-치환된 4-아미노 페닐 유도체의 제조 방법 KR870003054A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8522186 1985-09-06
GB858522186A GB8522186D0 (en) 1985-09-06 1985-09-06 Cycloalkyl-substituted 4-aminophenyl derivatives

Publications (1)

Publication Number Publication Date
KR870003054A true KR870003054A (ko) 1987-04-14

Family

ID=10584835

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860007406A KR870003054A (ko) 1985-09-06 1986-09-04 사이클로 알킬-치환된 4-아미노 페닐 유도체의 제조 방법

Country Status (19)

Country Link
US (1) US4769483A (ko)
EP (1) EP0215601B1 (ko)
JP (1) JPS6259245A (ko)
KR (1) KR870003054A (ko)
CN (1) CN86105919A (ko)
AT (1) ATE50982T1 (ko)
AU (1) AU6213986A (ko)
CA (1) CA1285287C (ko)
DE (1) DE3669502D1 (ko)
DK (1) DK420586A (ko)
ES (1) ES2001405A6 (ko)
FI (1) FI863566A (ko)
GB (1) GB8522186D0 (ko)
GR (1) GR862260B (ko)
HU (1) HU198441B (ko)
IL (1) IL79897A0 (ko)
NZ (1) NZ217440A (ko)
PT (1) PT83320B (ko)
ZA (1) ZA866766B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8701080D0 (en) * 1987-01-19 1987-02-18 Erba Farmitalia Cycloalkyl-substituted 4-aminophenyl halo derivatives
GB2222589B (en) * 1988-09-09 1991-03-06 Erba Carlo Spa Cycloalkyl-substituted 4-aminophenyl derivatives and process for their preparation
GB2222588B (en) * 1988-09-09 1991-03-06 Erba Carlo Spa Cycloalkyl-substituted 4-aminophenyl derivatives and process for their preparation
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5362911A (en) * 1993-12-30 1994-11-08 American Cyanamid Company Process for the preparation of o-aminophenyl cyclo-propyl ketone
CZ290670B6 (cs) 1994-10-21 2002-09-11 Nps Pharmaceuticals, Inc. Sloučeniny modulující receptory anorganických iontů a farmaceutický prostředek, který je obsahuje
PT907631E (pt) * 1996-05-01 2003-10-31 Nps Pharma Inc Compostos inorganicos activos como receptores de ioes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2443342A1 (de) * 1974-09-11 1976-03-25 Basf Ag 1-amino-2-phenyl-propanverbindungen und verfahren zu ihrer herstellung
JPS58194814A (ja) * 1982-05-11 1983-11-12 Nippon Shinyaku Co Ltd 免疫調節作用を有する薬剤
GB8519261D0 (en) * 1985-07-31 1985-09-04 Roussel Lab Ltd Chemical compounds

Also Published As

Publication number Publication date
ATE50982T1 (de) 1990-03-15
CA1285287C (en) 1991-06-25
AU6213986A (en) 1987-03-12
CN86105919A (zh) 1987-03-04
NZ217440A (en) 1989-10-27
EP0215601B1 (en) 1990-03-14
ZA866766B (en) 1987-04-29
ES2001405A6 (es) 1988-05-16
EP0215601A2 (en) 1987-03-25
DE3669502D1 (de) 1990-04-19
HUT44755A (en) 1988-04-28
PT83320B (en) 1988-10-07
US4769483A (en) 1988-09-06
EP0215601A3 (en) 1987-09-23
JPS6259245A (ja) 1987-03-14
GB8522186D0 (en) 1985-10-09
FI863566A (fi) 1987-03-07
GR862260B (en) 1987-01-02
PT83320A (pt) 1986-10-01
DK420586D0 (da) 1986-09-03
HU198441B (en) 1989-10-30
IL79897A0 (en) 1986-12-31
FI863566A0 (fi) 1986-09-04
DK420586A (da) 1987-03-07

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