MXPA03011770A - Proceso para la preparacion de citalopram racemico y/o s- o r-citalopram por separacion de una mezcla de r- y s- citalopram. - Google Patents

Proceso para la preparacion de citalopram racemico y/o s- o r-citalopram por separacion de una mezcla de r- y s- citalopram.

Info

Publication number
MXPA03011770A
MXPA03011770A MXPA03011770A MXPA03011770A MXPA03011770A MX PA03011770 A MXPA03011770 A MX PA03011770A MX PA03011770 A MXPA03011770 A MX PA03011770A MX PA03011770 A MXPA03011770 A MX PA03011770A MX PA03011770 A MXPA03011770 A MX PA03011770A
Authority
MX
Mexico
Prior art keywords
citalopram
acid addition
addition salt
racemic
precipitate
Prior art date
Application number
MXPA03011770A
Other languages
English (en)
Inventor
Petersen Hans
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of MXPA03011770A publication Critical patent/MXPA03011770A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La invencion se relaciona con un proceso para la preparacion de base libre de citalopram racemico o una sal de adicion de acido del mismo y/o R- o S-citalopram como la base libre o una sal de adicion del acido del mismo por separacion de una mezcla de R- y S-citalopram con mas del 50% de uno de los enantiomeros en una fraccion que consiste de citalopram racemico y/o una fraccion de S-citalopram o R-citalopram, caracterizado porque i) el citalopram es precipitado en un solvente como la base libre o como una sal de adicion de acido del mismo; ii) el precipitado formado es separado del licor madre; iia) si el precipitado es cristalino este es opcionalmente recristalizado una o mas veces para formar citalopram racemico, y entonces opcionalmente convertido en una sal de adicion de acido del mismo; iib) si el precipitado no es cristalino, los pasos i) y ii) son repetidos, opcionalmente, hasta que se obtiene un precipitado cristalino y el precipitado cristalino es recristalizado una o mas veces para formar citalopram racemico y entonces convertido opcionalmente en una sal de adicion del acido del mismo; iii) el licor madre es sometido opcionalmente a purificacion adicional y es aislado S-citalopram o R-citalopram del licor madre y convertido opcionalmente en una sal de adicion de acido del mismo.
MXPA03011770A 2001-06-25 2002-06-25 Proceso para la preparacion de citalopram racemico y/o s- o r-citalopram por separacion de una mezcla de r- y s- citalopram. MXPA03011770A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200100991 2001-06-25
PCT/DK2002/000426 WO2003000672A1 (en) 2001-06-25 2002-06-25 Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram

Publications (1)

Publication Number Publication Date
MXPA03011770A true MXPA03011770A (es) 2004-04-02

Family

ID=8160584

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03011770A MXPA03011770A (es) 2001-06-25 2002-06-25 Proceso para la preparacion de citalopram racemico y/o s- o r-citalopram por separacion de una mezcla de r- y s- citalopram.

Country Status (40)

Country Link
US (1) US7112686B2 (es)
EP (1) EP1412341B1 (es)
JP (2) JP4377219B2 (es)
KR (4) KR100939945B1 (es)
CN (2) CN100429208C (es)
AR (2) AR034612A1 (es)
AT (1) ATE284395T1 (es)
BG (1) BG66372B1 (es)
BR (1) BRPI0210574B8 (es)
CA (2) CA2691149C (es)
CO (1) CO5550420A2 (es)
CZ (1) CZ305034B6 (es)
DE (1) DE60202216T2 (es)
DK (1) DK1412341T3 (es)
EA (1) EA006446B1 (es)
ES (1) ES2233834T3 (es)
HK (2) HK1068627A1 (es)
HR (1) HRP20031075B1 (es)
HU (1) HU228476B1 (es)
IL (1) IL159229A0 (es)
IS (1) IS2426B (es)
JO (1) JO2389B1 (es)
MA (1) MA26260A1 (es)
ME (2) ME00027B (es)
MX (1) MXPA03011770A (es)
MY (1) MY133471A (es)
NO (2) NO329873B1 (es)
NZ (1) NZ530104A (es)
PE (1) PE20030122A1 (es)
PL (1) PL366560A1 (es)
PT (1) PT1412341E (es)
RS (1) RS50673B (es)
SI (1) SI1412341T1 (es)
SK (1) SK287696B6 (es)
TN (1) TNSN02062A1 (es)
TW (1) TWI236473B (es)
UA (1) UA75147C2 (es)
UY (2) UY27356A1 (es)
WO (1) WO2003000672A1 (es)
ZA (1) ZA200309633B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EP1581483B1 (en) * 2002-12-23 2012-06-06 H. Lundbeck A/S A PROCESS FOR THE PREPARATION OF RACEMIC CITALOPRAM DIOL AND/OR i S- /i OR i R- /i CITALOPRAM DIOLS AND THE USE OF SUCH DIOLS FOR THE PREPARATION OF RACEMIC CITALOPRAM, i R- /i CITALOPRAM AND/OR i S- /i CITALOPRAM
PL378275A1 (pl) 2002-12-23 2006-03-20 H. Lundbeck A/S Bromowodorek escitalopramu i sposób jego wytwarzania
UA84859C2 (ru) * 2002-12-23 2008-12-10 Х. Луннбек А/С Способ получения свободной основы и/или кислотно-аддитивной соли рацемического циталопрамдиола и/или свободной основы и/или кислотно-аддитивной соли r- или s-циталопрамдиола
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EA200601641A1 (ru) * 2004-03-05 2006-12-29 Х. Лундбекк А/С Кристаллическая композиция, содержащая оксалат эсциталопрама
US20050196453A1 (en) 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
ES2285972T1 (es) 2004-08-23 2007-12-01 Sun Pharmaceutical Industries Limited Procedimiento de fabricacion de citalopram y enantiomeros.
EP1901714A2 (en) * 2005-05-20 2008-03-26 Aurobindo Pharma Limited Pharmaceutical dosage forms comprising escitalopram in form of granules
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7569605B2 (en) 2005-10-14 2009-08-04 Forest Laboratories Holdings Limited Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
NZ570884A (en) 2007-09-11 2010-03-26 Lundbeck & Co As H Fractionally crystallising 4-[4-(dimethyl amino)-1-(4'-fluorophenyl)-1-hydroxybutyI]-3-(hydroxymethyl)-benzonitrile and manufacturing escitalopram therefrom
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
CN100548974C (zh) * 2007-10-11 2009-10-14 浙江大学 西酞普兰中间体的萃取分离方法
CN101560199B (zh) * 2008-04-16 2013-09-18 北京德众万全药物技术开发有限公司 一种依地普仑的制备方法
TWI381813B (zh) 2010-01-12 2013-01-11 Taiwan Paiho Ltd A Velcro assembly for a foamed article and a foamed article comprising the adhesive tape assembly

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
ATE277032T1 (de) * 1999-10-25 2004-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram

Also Published As

Publication number Publication date
DE60202216D1 (de) 2005-01-13
HK1132729A1 (en) 2010-03-05
HRP20031075B1 (en) 2011-12-31
HRP20031075A2 (en) 2004-04-30
NZ530104A (en) 2006-08-31
CZ305034B6 (cs) 2015-04-08
ES2233834T3 (es) 2005-06-16
IL159229A0 (en) 2004-06-01
US7112686B2 (en) 2006-09-26
PL366560A1 (en) 2005-02-07
NO335106B1 (no) 2014-09-15
RS50673B (sr) 2010-06-30
AU2002344948B2 (en) 2007-08-16
CA2691149A1 (en) 2003-01-03
CN100429208C (zh) 2008-10-29
ZA200309633B (en) 2005-02-23
MEP1508A (xx) 2010-02-10
RS101403A (en) 2007-02-05
EA006446B1 (ru) 2005-12-29
CA2450890C (en) 2011-02-15
US20040259940A1 (en) 2004-12-23
ME00027B (me) 2010-02-10
HK1068627A1 (en) 2005-04-29
KR100902530B1 (ko) 2009-06-15
SI1412341T1 (en) 2005-04-30
KR100939945B1 (ko) 2010-02-04
MA26260A1 (fr) 2004-09-01
IS2426B (is) 2008-10-15
KR20080100498A (ko) 2008-11-18
UA75147C2 (en) 2006-03-15
MY133471A (en) 2007-11-30
CO5550420A2 (es) 2005-08-31
NO329873B1 (no) 2011-01-17
HUP0400293A3 (en) 2007-05-29
CN101440079B (zh) 2011-05-25
JP4377219B2 (ja) 2009-12-02
BR0210574A (pt) 2004-08-03
DE60202216T2 (de) 2005-12-08
PE20030122A1 (es) 2003-02-12
BRPI0210574B8 (pt) 2021-05-25
BG108532A (bg) 2005-04-30
HUP0400293A2 (hu) 2004-09-28
EP1412341B1 (en) 2004-12-08
CN101440079A (zh) 2009-05-27
CN1520405A (zh) 2004-08-11
NO20101420L (no) 2003-12-18
TNSN02062A1 (en) 2005-12-23
AR034612A1 (es) 2004-03-03
JP2004536093A (ja) 2004-12-02
DK1412341T3 (da) 2005-04-04
JP2009203233A (ja) 2009-09-10
TWI236473B (en) 2005-07-21
NO20035671D0 (no) 2003-12-18
UY27356A1 (es) 2003-01-31
JO2389B1 (en) 2007-06-17
AR083483A2 (es) 2013-02-27
CA2691149C (en) 2011-09-13
ATE284395T1 (de) 2004-12-15
EA200400082A1 (ru) 2004-06-24
UY35850A (es) 2016-06-30
EP1412341A1 (en) 2004-04-28
SK512004A3 (en) 2004-05-04
KR20100052550A (ko) 2010-05-19
WO2003000672A1 (en) 2003-01-03
JP5064436B2 (ja) 2012-10-31
CZ2004131A3 (cs) 2004-04-14
IS7068A (is) 2003-12-08
BR0210574B1 (pt) 2014-03-04
SK287696B6 (sk) 2011-06-06
CA2450890A1 (en) 2003-01-03
HU228476B1 (en) 2013-03-28
NO20035671L (no) 2003-12-18
KR20090031958A (ko) 2009-03-30
PT1412341E (pt) 2005-04-29
KR20040030702A (ko) 2004-04-09
BG66372B1 (bg) 2013-10-31

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