PE20030122A1 - Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram - Google Patents

Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram

Info

Publication number
PE20030122A1
PE20030122A1 PE2002000551A PE2002000551A PE20030122A1 PE 20030122 A1 PE20030122 A1 PE 20030122A1 PE 2002000551 A PE2002000551 A PE 2002000551A PE 2002000551 A PE2002000551 A PE 2002000551A PE 20030122 A1 PE20030122 A1 PE 20030122A1
Authority
PE
Peru
Prior art keywords
citalopram
solvents
precipitated material
crystalline
preparation
Prior art date
Application number
PE2002000551A
Other languages
English (en)
Inventor
Rikke Eva Humble
Troels Volsgaard Christensen
Ole Nielsen
Robert Dancer
Hans Petersen
Michael Harold Rock
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of PE20030122A1 publication Critical patent/PE20030122A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE REFIERE A UN PROCESO PARA LA PREPARACION DE CITALOPRAM RACEMICO EN FORMA DE UNA BASE LIBRE OBTENIDA MEDIANTE LA ADICION DE UN ACIDO (ACIDO BROMHIDRICO) QUE COMPRENDE PRECIPITAR CITALOPRAM A PARTIR DE SOLVENTES (DE PREFERENCIA SOLVENTES PROTICOS COMO AGUA, ALCOHOLES, CETONAS, SOLVENTES APROTICOS COMO ACRILONITRILO, DIGLIMA), SEPARAR EL PRECIPITADO (ACEITE, SOLIDO AMORFO, CRISTALES) FORMADO DEL LICOR MADRE (SOLVENTE QUE QUEDA DESPUES DE LA REMOCION O SEPARACION DEL MATERIAL PRECIPITADO A PARTIR DEL SOLVENTE); SI EL MATERIAL PRECIPITADO ES CRISTALINO, ES OPCIONALMENTE RECRISTALIZADO UNO O MAS VECES PARA FORMAR CITALOPRAM RACEMICO, SI EL MATERIAL PRECIPITADO NO ES CRISTALINO SE REPITEN LOS ANTERIORES PASOS O HASTA OBTENER UN MATERIAL PRECIPITADO CRISTALINO; EL LICOR MADRE ES SOMETIDO A PURIFICACION ADICIONAL
PE2002000551A 2001-06-25 2002-06-24 Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram PE20030122A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200100991 2001-06-25

Publications (1)

Publication Number Publication Date
PE20030122A1 true PE20030122A1 (es) 2003-02-12

Family

ID=8160584

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000551A PE20030122A1 (es) 2001-06-25 2002-06-24 Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram

Country Status (40)

Country Link
US (1) US7112686B2 (es)
EP (1) EP1412341B1 (es)
JP (2) JP4377219B2 (es)
KR (4) KR100939945B1 (es)
CN (2) CN100429208C (es)
AR (2) AR034612A1 (es)
AT (1) ATE284395T1 (es)
BG (1) BG66372B1 (es)
BR (1) BRPI0210574B8 (es)
CA (2) CA2691149C (es)
CO (1) CO5550420A2 (es)
CZ (1) CZ305034B6 (es)
DE (1) DE60202216T2 (es)
DK (1) DK1412341T3 (es)
EA (1) EA006446B1 (es)
ES (1) ES2233834T3 (es)
HK (2) HK1068627A1 (es)
HR (1) HRP20031075B1 (es)
HU (1) HU228476B1 (es)
IL (1) IL159229A0 (es)
IS (1) IS2426B (es)
JO (1) JO2389B1 (es)
MA (1) MA26260A1 (es)
ME (2) ME00027B (es)
MX (1) MXPA03011770A (es)
MY (1) MY133471A (es)
NO (2) NO329873B1 (es)
NZ (1) NZ530104A (es)
PE (1) PE20030122A1 (es)
PL (1) PL366560A1 (es)
PT (1) PT1412341E (es)
RS (1) RS50673B (es)
SI (1) SI1412341T1 (es)
SK (1) SK287696B6 (es)
TN (1) TNSN02062A1 (es)
TW (1) TWI236473B (es)
UA (1) UA75147C2 (es)
UY (2) UY27356A1 (es)
WO (1) WO2003000672A1 (es)
ZA (1) ZA200309633B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EP1581483B1 (en) * 2002-12-23 2012-06-06 H. Lundbeck A/S A PROCESS FOR THE PREPARATION OF RACEMIC CITALOPRAM DIOL AND/OR i S- /i OR i R- /i CITALOPRAM DIOLS AND THE USE OF SUCH DIOLS FOR THE PREPARATION OF RACEMIC CITALOPRAM, i R- /i CITALOPRAM AND/OR i S- /i CITALOPRAM
PL378275A1 (pl) 2002-12-23 2006-03-20 H. Lundbeck A/S Bromowodorek escitalopramu i sposób jego wytwarzania
UA84859C2 (ru) * 2002-12-23 2008-12-10 Х. Луннбек А/С Способ получения свободной основы и/или кислотно-аддитивной соли рацемического циталопрамдиола и/или свободной основы и/или кислотно-аддитивной соли r- или s-циталопрамдиола
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EA200601641A1 (ru) * 2004-03-05 2006-12-29 Х. Лундбекк А/С Кристаллическая композиция, содержащая оксалат эсциталопрама
US20050196453A1 (en) 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
ES2285972T1 (es) 2004-08-23 2007-12-01 Sun Pharmaceutical Industries Limited Procedimiento de fabricacion de citalopram y enantiomeros.
EP1901714A2 (en) * 2005-05-20 2008-03-26 Aurobindo Pharma Limited Pharmaceutical dosage forms comprising escitalopram in form of granules
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7569605B2 (en) 2005-10-14 2009-08-04 Forest Laboratories Holdings Limited Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
NZ570884A (en) 2007-09-11 2010-03-26 Lundbeck & Co As H Fractionally crystallising 4-[4-(dimethyl amino)-1-(4'-fluorophenyl)-1-hydroxybutyI]-3-(hydroxymethyl)-benzonitrile and manufacturing escitalopram therefrom
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
CN100548974C (zh) * 2007-10-11 2009-10-14 浙江大学 西酞普兰中间体的萃取分离方法
CN101560199B (zh) * 2008-04-16 2013-09-18 北京德众万全药物技术开发有限公司 一种依地普仑的制备方法
TWI381813B (zh) 2010-01-12 2013-01-11 Taiwan Paiho Ltd A Velcro assembly for a foamed article and a foamed article comprising the adhesive tape assembly

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
ATE277032T1 (de) * 1999-10-25 2004-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram

Also Published As

Publication number Publication date
DE60202216D1 (de) 2005-01-13
HK1132729A1 (en) 2010-03-05
HRP20031075B1 (en) 2011-12-31
HRP20031075A2 (en) 2004-04-30
NZ530104A (en) 2006-08-31
CZ305034B6 (cs) 2015-04-08
ES2233834T3 (es) 2005-06-16
IL159229A0 (en) 2004-06-01
US7112686B2 (en) 2006-09-26
PL366560A1 (en) 2005-02-07
NO335106B1 (no) 2014-09-15
RS50673B (sr) 2010-06-30
AU2002344948B2 (en) 2007-08-16
CA2691149A1 (en) 2003-01-03
CN100429208C (zh) 2008-10-29
ZA200309633B (en) 2005-02-23
MEP1508A (xx) 2010-02-10
RS101403A (en) 2007-02-05
EA006446B1 (ru) 2005-12-29
CA2450890C (en) 2011-02-15
MXPA03011770A (es) 2004-04-02
US20040259940A1 (en) 2004-12-23
ME00027B (me) 2010-02-10
HK1068627A1 (en) 2005-04-29
KR100902530B1 (ko) 2009-06-15
SI1412341T1 (en) 2005-04-30
KR100939945B1 (ko) 2010-02-04
MA26260A1 (fr) 2004-09-01
IS2426B (is) 2008-10-15
KR20080100498A (ko) 2008-11-18
UA75147C2 (en) 2006-03-15
MY133471A (en) 2007-11-30
CO5550420A2 (es) 2005-08-31
NO329873B1 (no) 2011-01-17
HUP0400293A3 (en) 2007-05-29
CN101440079B (zh) 2011-05-25
JP4377219B2 (ja) 2009-12-02
BR0210574A (pt) 2004-08-03
DE60202216T2 (de) 2005-12-08
BRPI0210574B8 (pt) 2021-05-25
BG108532A (bg) 2005-04-30
HUP0400293A2 (hu) 2004-09-28
EP1412341B1 (en) 2004-12-08
CN101440079A (zh) 2009-05-27
CN1520405A (zh) 2004-08-11
NO20101420L (no) 2003-12-18
TNSN02062A1 (en) 2005-12-23
AR034612A1 (es) 2004-03-03
JP2004536093A (ja) 2004-12-02
DK1412341T3 (da) 2005-04-04
JP2009203233A (ja) 2009-09-10
TWI236473B (en) 2005-07-21
NO20035671D0 (no) 2003-12-18
UY27356A1 (es) 2003-01-31
JO2389B1 (en) 2007-06-17
AR083483A2 (es) 2013-02-27
CA2691149C (en) 2011-09-13
ATE284395T1 (de) 2004-12-15
EA200400082A1 (ru) 2004-06-24
UY35850A (es) 2016-06-30
EP1412341A1 (en) 2004-04-28
SK512004A3 (en) 2004-05-04
KR20100052550A (ko) 2010-05-19
WO2003000672A1 (en) 2003-01-03
JP5064436B2 (ja) 2012-10-31
CZ2004131A3 (cs) 2004-04-14
IS7068A (is) 2003-12-08
BR0210574B1 (pt) 2014-03-04
SK287696B6 (sk) 2011-06-06
CA2450890A1 (en) 2003-01-03
HU228476B1 (en) 2013-03-28
NO20035671L (no) 2003-12-18
KR20090031958A (ko) 2009-03-30
PT1412341E (pt) 2005-04-29
KR20040030702A (ko) 2004-04-09
BG66372B1 (bg) 2013-10-31

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