DE60202216D1 - Verfahren zur herstellung von racemischem citalopram und/oder s oder r citalopram durch trennung einer mischung von r und s citalopram - Google Patents

Verfahren zur herstellung von racemischem citalopram und/oder s oder r citalopram durch trennung einer mischung von r und s citalopram

Info

Publication number
DE60202216D1
DE60202216D1 DE2002602216 DE60202216T DE60202216D1 DE 60202216 D1 DE60202216 D1 DE 60202216D1 DE 2002602216 DE2002602216 DE 2002602216 DE 60202216 T DE60202216 T DE 60202216T DE 60202216 D1 DE60202216 D1 DE 60202216D1
Authority
DE
Germany
Prior art keywords
citalopram
separation
mixture
production
racemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE2002602216
Other languages
English (en)
Other versions
DE60202216T2 (de
Inventor
Eva Humble
Volsgaard Christensen
Harold Rock
Ole Nielsen
Hans Petersen
Robert Dancer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of DE60202216D1 publication Critical patent/DE60202216D1/de
Publication of DE60202216T2 publication Critical patent/DE60202216T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60202216T 2001-06-25 2002-06-25 Verfahren zur herstellung von racemischem citalopram und/oder s oder r citalopram durch trennung einer mischung von r und s citalopram Expired - Lifetime DE60202216T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200100991 2001-06-25
DK200100991 2001-06-25
PCT/DK2002/000426 WO2003000672A1 (en) 2001-06-25 2002-06-25 Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram

Publications (2)

Publication Number Publication Date
DE60202216D1 true DE60202216D1 (de) 2005-01-13
DE60202216T2 DE60202216T2 (de) 2005-12-08

Family

ID=8160584

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60202216T Expired - Lifetime DE60202216T2 (de) 2001-06-25 2002-06-25 Verfahren zur herstellung von racemischem citalopram und/oder s oder r citalopram durch trennung einer mischung von r und s citalopram

Country Status (40)

Country Link
US (1) US7112686B2 (de)
EP (1) EP1412341B1 (de)
JP (2) JP4377219B2 (de)
KR (4) KR100902530B1 (de)
CN (2) CN100429208C (de)
AR (2) AR034612A1 (de)
AT (1) ATE284395T1 (de)
BG (1) BG66372B1 (de)
BR (1) BRPI0210574B8 (de)
CA (2) CA2450890C (de)
CO (1) CO5550420A2 (de)
CZ (1) CZ305034B6 (de)
DE (1) DE60202216T2 (de)
DK (1) DK1412341T3 (de)
EA (1) EA006446B1 (de)
ES (1) ES2233834T3 (de)
HK (2) HK1068627A1 (de)
HR (1) HRP20031075B1 (de)
HU (1) HU228476B1 (de)
IL (1) IL159229A0 (de)
IS (1) IS2426B (de)
JO (1) JO2389B1 (de)
MA (1) MA26260A1 (de)
ME (2) ME00027B (de)
MX (1) MXPA03011770A (de)
MY (1) MY133471A (de)
NO (2) NO329873B1 (de)
NZ (1) NZ530104A (de)
PE (1) PE20030122A1 (de)
PL (1) PL366560A1 (de)
PT (1) PT1412341E (de)
RS (1) RS50673B (de)
SI (1) SI1412341T1 (de)
SK (1) SK287696B6 (de)
TN (1) TNSN02062A1 (de)
TW (1) TWI236473B (de)
UA (1) UA75147C2 (de)
UY (2) UY27356A1 (de)
WO (1) WO2003000672A1 (de)
ZA (1) ZA200309633B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723533B2 (en) 2005-06-22 2010-05-25 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR040970A1 (es) * 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
KR101076640B1 (ko) * 2002-12-23 2011-10-27 하. 룬트벡 아크티에 셀스카브 라세미 시탈로프람 디올 및/또는 ｓ― 또는 ｒ―시탈로프람디올의 제조 방법 및 라세미 시탈로프람, ｒ―시탈로프람및/또는 ｓ―시탈로프람의 제조를 위한 상기 디올의 용도
MXPA05006783A (es) 2002-12-23 2005-09-08 Lundbeck & Co As H Un proceso para la preparacion de diol de citalopram racemico y/o dioles de citalopram s o r y el uso de tales dioles para la preparacion de citalopram racemico, citalopram r y/o citalopram s.
KR20050086933A (ko) 2002-12-23 2005-08-30 하. 룬트벡 아크티에 셀스카브 브롬화수소산에스시탈로프람 및 이의 제조방법
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20050196453A1 (en) 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
AU2005218713B2 (en) * 2004-03-05 2009-11-19 H. Lundbeck A/S Crystalline composition containing escitalopram oxalate
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
WO2006021971A2 (en) * 2004-08-23 2006-03-02 Sun Pharmaceutical Industries Limited 'process for preparation of citalopram and enantiomers'
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
EP1901714A2 (de) * 2005-05-20 2008-03-26 Aurobindo Pharma Limited Pharmazeutische dosierformen mit escitalopram in granulatform
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
EP1954257A4 (de) 2005-10-14 2009-05-20 Lundbeck & Co As H Verfahren zur behandlung von erkrankungen des zentralen nervensystems mit einer niedrigdosierten kombination aus escitalopram und bupropion
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
NZ570884A (en) 2007-09-11 2010-03-26 Lundbeck & Co As H Fractionally crystallising 4-[4-(dimethyl amino)-1-(4'-fluorophenyl)-1-hydroxybutyI]-3-(hydroxymethyl)-benzonitrile and manufacturing escitalopram therefrom
CN100548974C (zh) * 2007-10-11 2009-10-14 浙江大学 西酞普兰中间体的萃取分离方法
CN101560199B (zh) * 2008-04-16 2013-09-18 北京德众万全药物技术开发有限公司 一种依地普仑的制备方法
TWI381813B (zh) 2010-01-12 2013-01-11 Taiwan Paiho Ltd A Velcro assembly for a foamed article and a foamed article comprising the adhesive tape assembly

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DK1228056T3 (da) * 1999-10-25 2005-01-24 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723533B2 (en) 2005-06-22 2010-05-25 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Also Published As

Publication number Publication date
CN101440079B (zh) 2011-05-25
BR0210574A (pt) 2004-08-03
HRP20031075B1 (en) 2011-12-31
KR100939945B1 (ko) 2010-02-04
DK1412341T3 (da) 2005-04-04
KR20080100498A (ko) 2008-11-18
CN1520405A (zh) 2004-08-11
BR0210574B1 (pt) 2014-03-04
KR20040030702A (ko) 2004-04-09
CN101440079A (zh) 2009-05-27
CZ305034B6 (cs) 2015-04-08
ATE284395T1 (de) 2004-12-15
EP1412341B1 (de) 2004-12-08
HK1068627A1 (en) 2005-04-29
BG108532A (bg) 2005-04-30
PL366560A1 (en) 2005-02-07
IL159229A0 (en) 2004-06-01
MEP1508A (xx) 2010-02-10
NZ530104A (en) 2006-08-31
PT1412341E (pt) 2005-04-29
JP5064436B2 (ja) 2012-10-31
HU228476B1 (en) 2013-03-28
KR20090031958A (ko) 2009-03-30
UY27356A1 (es) 2003-01-31
NO20101420L (no) 2003-12-18
CA2691149C (en) 2011-09-13
HUP0400293A2 (hu) 2004-09-28
EA200400082A1 (ru) 2004-06-24
UA75147C2 (en) 2006-03-15
WO2003000672A1 (en) 2003-01-03
ZA200309633B (en) 2005-02-23
BRPI0210574B8 (pt) 2021-05-25
AR034612A1 (es) 2004-03-03
AR083483A2 (es) 2013-02-27
US7112686B2 (en) 2006-09-26
TNSN02062A1 (en) 2005-12-23
IS2426B (is) 2008-10-15
JP2009203233A (ja) 2009-09-10
JP2004536093A (ja) 2004-12-02
KR20100052550A (ko) 2010-05-19
EA006446B1 (ru) 2005-12-29
RS50673B (sr) 2010-06-30
CA2450890A1 (en) 2003-01-03
HK1132729A1 (en) 2010-03-05
CZ2004131A3 (cs) 2004-04-14
CO5550420A2 (es) 2005-08-31
US20040259940A1 (en) 2004-12-23
NO329873B1 (no) 2011-01-17
PE20030122A1 (es) 2003-02-12
BG66372B1 (bg) 2013-10-31
RS101403A (en) 2007-02-05
DE60202216T2 (de) 2005-12-08
SK287696B6 (sk) 2011-06-06
JO2389B1 (en) 2007-06-17
AU2002344948B2 (en) 2007-08-16
HUP0400293A3 (en) 2007-05-29
EP1412341A1 (de) 2004-04-28
CA2691149A1 (en) 2003-01-03
CN100429208C (zh) 2008-10-29
SK512004A3 (en) 2004-05-04
ME00027B (me) 2010-02-10
IS7068A (is) 2003-12-08
UY35850A (es) 2016-06-30
NO20035671D0 (no) 2003-12-18
SI1412341T1 (en) 2005-04-30
JP4377219B2 (ja) 2009-12-02
KR100902530B1 (ko) 2009-06-15
HRP20031075A2 (en) 2004-04-30
CA2450890C (en) 2011-02-15
NO20035671L (no) 2003-12-18
TWI236473B (en) 2005-07-21
NO335106B1 (no) 2014-09-15
MY133471A (en) 2007-11-30
MA26260A1 (fr) 2004-09-01
MXPA03011770A (es) 2004-04-02
ES2233834T3 (es) 2005-06-16

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Legal Events

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