DE60204334D1 - Verfahren zur herstellung von repaglinide - Google Patents
Verfahren zur herstellung von repaglinideInfo
- Publication number
- DE60204334D1 DE60204334D1 DE60204334T DE60204334T DE60204334D1 DE 60204334 D1 DE60204334 D1 DE 60204334D1 DE 60204334 T DE60204334 T DE 60204334T DE 60204334 T DE60204334 T DE 60204334T DE 60204334 D1 DE60204334 D1 DE 60204334D1
- Authority
- DE
- Germany
- Prior art keywords
- repaglinides
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
INDE09832001 | 2001-09-25 | ||
IN983DE2001 IN192527B (de) | 2001-09-25 | 2001-09-25 | |
PCT/IB2002/003943 WO2003027072A1 (en) | 2001-09-25 | 2002-09-24 | Process for the preparation of repaglinide |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60204334D1 true DE60204334D1 (de) | 2005-06-30 |
DE60204334T2 DE60204334T2 (de) | 2006-03-23 |
Family
ID=11097115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60204334T Expired - Fee Related DE60204334T2 (de) | 2001-09-25 | 2002-09-24 | Verfahren zur Herstellung von Repaglinid |
Country Status (13)
Country | Link |
---|---|
US (1) | US7148355B2 (de) |
EP (1) | EP1432682B1 (de) |
JP (1) | JP2005521634A (de) |
CN (1) | CN1571769A (de) |
AR (1) | AR036623A1 (de) |
AT (1) | ATE296287T1 (de) |
BR (1) | BR0212772A (de) |
CA (1) | CA2461087A1 (de) |
DE (1) | DE60204334T2 (de) |
ES (1) | ES2242068T3 (de) |
IN (1) | IN192527B (de) |
PT (1) | PT1432682E (de) |
WO (1) | WO2003027072A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040102477A1 (en) * | 2002-08-23 | 2004-05-27 | Dr. Reddy's Laboratories Limited | Polymorphic forms of (S)-Repaglinide and the processes for preparation thereof |
WO2004101540A2 (de) * | 2003-05-14 | 2004-11-25 | Cilag Ag | Verfahren zur herstellung von phenylessigsäurederivaten |
WO2004103983A1 (en) * | 2003-05-26 | 2004-12-02 | Biocon Limited | Process for the preparation of s(+)-2-ethoxy-4-[n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl]benzoic acid derivatives |
CN100445275C (zh) * | 2006-06-21 | 2008-12-24 | 浙江大学 | 一种合成瑞格列奈的工艺 |
US8101769B2 (en) * | 2007-02-15 | 2012-01-24 | Actavis Group Ptc Ehf | Process for preparing ethyl (S)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonyl methyl]benzoate and use thereof for the preparation of Repaglinide |
US20100197732A1 (en) * | 2007-06-06 | 2010-08-05 | Actavis Group Ptc Ehf | Repaglinide Substantially Free of Dimer Impurity |
CN101481363B (zh) * | 2008-01-10 | 2011-05-04 | 江苏豪森药业股份有限公司 | 一种制备瑞格列奈的方法 |
CN101220007B (zh) * | 2008-01-16 | 2010-09-15 | 浙江耐司康药业有限公司 | 一种制备瑞格列奈的方法 |
CN102267959B (zh) * | 2011-07-06 | 2013-05-01 | 海南锦瑞制药股份有限公司 | 一种瑞格列奈晶体、其制备方法及含有该晶体的固体口服制剂 |
CN103012319B (zh) * | 2011-09-20 | 2015-06-10 | 浙江九洲药业股份有限公司 | 瑞格列奈中间体的合成工艺改进 |
CN102633750A (zh) * | 2012-03-26 | 2012-08-15 | 浙江昂利康制药有限公司 | 一锅法合成治疗糖尿病的药物瑞格列奈 |
CN102731436A (zh) * | 2012-04-09 | 2012-10-17 | 海南中化联合制药工业股份有限公司 | 一种瑞格列奈的制备及精制方法 |
CN104557778A (zh) * | 2015-01-09 | 2015-04-29 | 蔡伦 | 一种瑞格列奈的制备方法及其应用 |
CN105198838A (zh) * | 2015-10-21 | 2015-12-30 | 河南普瑞制药有限公司 | 一种瑞格列奈的制备方法 |
CN105906583B (zh) * | 2015-12-23 | 2018-03-09 | 嘉实(湖南)医药科技有限公司 | 一种瑞格列奈中间体的制备工艺 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5965094A (ja) * | 1982-10-06 | 1984-04-13 | Sumitomo Chem Co Ltd | セフアロスポリン化合物の製造法 |
US5312924A (en) * | 1983-12-30 | 1994-05-17 | Dr. Karl Thomae Gmbh | Phenylacetic acid benzylamides |
-
2001
- 2001-09-25 IN IN983DE2001 patent/IN192527B/en unknown
-
2002
- 2002-09-24 EP EP02775017A patent/EP1432682B1/de not_active Expired - Lifetime
- 2002-09-24 BR BR0212772-5A patent/BR0212772A/pt not_active Application Discontinuation
- 2002-09-24 US US10/490,275 patent/US7148355B2/en not_active Expired - Fee Related
- 2002-09-24 ES ES02775017T patent/ES2242068T3/es not_active Expired - Lifetime
- 2002-09-24 PT PT02775017T patent/PT1432682E/pt unknown
- 2002-09-24 JP JP2003530663A patent/JP2005521634A/ja active Pending
- 2002-09-24 CA CA002461087A patent/CA2461087A1/en not_active Abandoned
- 2002-09-24 DE DE60204334T patent/DE60204334T2/de not_active Expired - Fee Related
- 2002-09-24 CN CNA028204492A patent/CN1571769A/zh active Pending
- 2002-09-24 AT AT02775017T patent/ATE296287T1/de not_active IP Right Cessation
- 2002-09-24 WO PCT/IB2002/003943 patent/WO2003027072A1/en active IP Right Grant
- 2002-09-25 AR ARP020103594A patent/AR036623A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2003027072A1 (en) | 2003-04-03 |
ATE296287T1 (de) | 2005-06-15 |
EP1432682A1 (de) | 2004-06-30 |
CN1571769A (zh) | 2005-01-26 |
US20050107614A1 (en) | 2005-05-19 |
DE60204334T2 (de) | 2006-03-23 |
BR0212772A (pt) | 2004-10-13 |
US7148355B2 (en) | 2006-12-12 |
CA2461087A1 (en) | 2003-04-03 |
EP1432682B1 (de) | 2005-05-25 |
ES2242068T3 (es) | 2005-11-01 |
JP2005521634A (ja) | 2005-07-21 |
AR036623A1 (es) | 2004-09-22 |
PT1432682E (pt) | 2005-09-30 |
IN192527B (de) | 2004-04-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |