DE69933207D1 - Verbessertes verfahren zur herstellung von makroliden - Google Patents
Verbessertes verfahren zur herstellung von makrolidenInfo
- Publication number
- DE69933207D1 DE69933207D1 DE69933207T DE69933207T DE69933207D1 DE 69933207 D1 DE69933207 D1 DE 69933207D1 DE 69933207 T DE69933207 T DE 69933207T DE 69933207 T DE69933207 T DE 69933207T DE 69933207 D1 DE69933207 D1 DE 69933207D1
- Authority
- DE
- Germany
- Prior art keywords
- makrolides
- production
- improved method
- improved
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9809939.3A GB9809939D0 (en) | 1998-05-08 | 1998-05-08 | Organic compounds |
GBGB9812743.4A GB9812743D0 (en) | 1998-06-12 | 1998-06-12 | Organic compounds |
PCT/EP1999/003134 WO1999058541A2 (en) | 1998-05-08 | 1999-05-06 | Improvements in macrolide production |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69933207D1 true DE69933207D1 (de) | 2006-10-26 |
Family
ID=26313634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69933207T Expired - Lifetime DE69933207D1 (de) | 1998-05-08 | 1999-05-06 | Verbessertes verfahren zur herstellung von makroliden |
Country Status (14)
Country | Link |
---|---|
US (1) | US6420537B1 (de) |
EP (1) | EP1077986B1 (de) |
JP (1) | JP4518670B2 (de) |
KR (1) | KR100581319B1 (de) |
CN (1) | CN1299368A (de) |
AR (1) | AR018339A1 (de) |
AT (1) | ATE339433T1 (de) |
AU (1) | AU4139799A (de) |
CA (1) | CA2330007C (de) |
DE (1) | DE69933207D1 (de) |
ES (1) | ES2272068T3 (de) |
HR (1) | HRP20000758B1 (de) |
TW (1) | TW546302B (de) |
WO (1) | WO1999058541A2 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP20020231A2 (en) * | 2002-03-18 | 2003-12-31 | Pliva D D | ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A |
ES2177373B1 (es) * | 1999-11-26 | 2003-11-01 | Astur Pharma Sa | Preparacion de azitromicina en su forma no cristalina |
WO2002010144A1 (es) | 2000-07-25 | 2002-02-07 | Laboratorio Silanes, S.A. De C.V. | PROCESO PARA LA PREPARACION EN UN SOLO PASO DE 7,16-DIOXA-2-AZA-10-O-CLADINOSIL-12-O-DESOSAMINIL-4,5-DIHIDROXI-6-ETIL-3,5,9,11,13,15-HEXAMETILBICICLO[11.2.1]HEXADECA-1(2)-EN-8-ONA Y OBTENCION DE UNA FORMA NUEVA DE 9-DESOXO-9a-AZA-9a-METIL-9a-HOMOERITROMICINA A |
WO2002009640A2 (en) * | 2000-08-01 | 2002-02-07 | Shiva Prasad Singh | Process for the preparation of anhydrous azithromycin |
EP1313749B1 (de) * | 2000-08-23 | 2005-10-12 | Wockhardt Limited | Verfahren zur herstellung von wasserfreiem azithromycin |
US6861413B2 (en) * | 2001-05-22 | 2005-03-01 | Pfizer Inc. | Stable non-dihydrate azithromycin oral suspensions |
NZ539801A (en) * | 2001-05-22 | 2006-10-27 | Pfizer Prod Inc | Crystal forms of azithromycin |
IL161398A0 (en) | 2001-10-18 | 2004-09-27 | Teva Pharma | Stabilized azithromycin compositions |
US6855813B2 (en) * | 2002-07-19 | 2005-02-15 | Alembic Limited | Process for the preparation of azithromycin monohydrate |
HRP20020614A2 (en) | 2002-07-22 | 2004-06-30 | PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. | Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a |
US7435805B2 (en) * | 2003-05-30 | 2008-10-14 | Glaxpsmithkline Istrazivacki | O-alkyl macrolide and azalide derivatives and regioselective process for their preparation |
US7384921B2 (en) * | 2004-02-20 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | Polymorphic forms of 6-11 bicyclic ketolide derivatives |
US20060116336A1 (en) * | 2004-03-17 | 2006-06-01 | American Pharmaceutical Partners, Inc. | Lyophilized azithromycin formulation |
US7468428B2 (en) * | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
US7235646B2 (en) * | 2004-06-28 | 2007-06-26 | Alembic Limited | Process for the preparation of azithromycin monohydrate isopropanol clathrate |
US7683162B2 (en) * | 2004-08-30 | 2010-03-23 | Taro Pharmaceutical Industries Limited | Process of preparing a crystalline azithromycin monohydrate |
US20090093420A1 (en) * | 2006-01-12 | 2009-04-09 | Wockhardt Limited | Processes for the preparation of azithromycin |
CN101418026B (zh) * | 2008-10-09 | 2011-05-18 | 南京工业大学 | 一种晶型和粒度可控的阿奇霉素结晶工艺 |
WO2012080050A1 (en) | 2010-12-14 | 2012-06-21 | F. Hoffmann-La Roche Ag | Solid forms of a phenoxybenzenesulfonyl compound |
CN103159811A (zh) * | 2011-12-10 | 2013-06-19 | 山东方明药业集团股份有限公司 | 一种阿齐霉素中间体9a-脱氧-9a-氮杂-9a-高红霉素A的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI8110592A8 (en) | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
PH19293A (en) * | 1982-11-15 | 1986-03-04 | Pfizer | Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof |
UA27040C2 (uk) * | 1987-07-09 | 2000-02-28 | Пфайзер Інк. | Кристалічhий дигідрат азитроміциhу та спосіб одержаhhя кристалічhого дигідрату азитроміциhу |
SI9011409A (en) * | 1990-07-18 | 1995-10-31 | Pliva Pharm & Chem Works | O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them |
CA2065222A1 (en) | 1991-04-09 | 1992-10-10 | Robert R. Wilkening | Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers |
EP0549040A1 (de) * | 1991-12-20 | 1993-06-30 | Merck & Co. Inc. | Verfahren zur Herstellung von 4"-Derivaten von 9-Deoxo-8a-Aza-8a-Alkyl-8a-Homoerythromycin A |
ATE181832T1 (de) * | 1993-04-23 | 1999-07-15 | Hoechst Ag | Pyrido-pyrimidindione, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US5500423A (en) * | 1994-09-09 | 1996-03-19 | Hoechst-Roussel Pharmaceuticals Inc. | 5,6-dihydro-4H-imidazo[4,5,1-ij]quinolines |
ES2122905B1 (es) | 1996-07-11 | 1999-11-16 | Astur Pharma Sa | Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato). |
PT102006B (pt) * | 1997-05-19 | 2000-06-30 | Hovione Sociedade Quimica S A | Novo processo de preparacao de azitromicina |
WO2000032203A1 (en) * | 1998-11-30 | 2000-06-08 | Teva Pharmaceutical Industries Ltd. | Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof |
-
1999
- 1999-05-05 TW TW088107298A patent/TW546302B/zh not_active IP Right Cessation
- 1999-05-06 JP JP2000548345A patent/JP4518670B2/ja not_active Expired - Fee Related
- 1999-05-06 CN CN99805920A patent/CN1299368A/zh active Pending
- 1999-05-06 CA CA002330007A patent/CA2330007C/en not_active Expired - Fee Related
- 1999-05-06 AT AT99924899T patent/ATE339433T1/de not_active IP Right Cessation
- 1999-05-06 EP EP99924899A patent/EP1077986B1/de not_active Expired - Lifetime
- 1999-05-06 WO PCT/EP1999/003134 patent/WO1999058541A2/en active IP Right Grant
- 1999-05-06 DE DE69933207T patent/DE69933207D1/de not_active Expired - Lifetime
- 1999-05-06 ES ES99924899T patent/ES2272068T3/es not_active Expired - Lifetime
- 1999-05-06 AR ARP990102127A patent/AR018339A1/es not_active Application Discontinuation
- 1999-05-06 AU AU41397/99A patent/AU4139799A/en not_active Abandoned
- 1999-05-06 KR KR1020007012414A patent/KR100581319B1/ko not_active IP Right Cessation
-
2000
- 2000-11-07 HR HR20000758A patent/HRP20000758B1/xx not_active IP Right Cessation
- 2000-11-07 US US09/707,566 patent/US6420537B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1999058541A3 (en) | 2000-01-20 |
TW546302B (en) | 2003-08-11 |
WO1999058541A2 (en) | 1999-11-18 |
CN1299368A (zh) | 2001-06-13 |
US6420537B1 (en) | 2002-07-16 |
JP4518670B2 (ja) | 2010-08-04 |
ES2272068T3 (es) | 2007-04-16 |
CA2330007C (en) | 2008-07-08 |
KR20010043392A (ko) | 2001-05-25 |
EP1077986B1 (de) | 2006-09-13 |
CA2330007A1 (en) | 1999-11-18 |
AU4139799A (en) | 1999-11-29 |
JP2002514653A (ja) | 2002-05-21 |
ATE339433T1 (de) | 2006-10-15 |
KR100581319B1 (ko) | 2006-05-22 |
AR018339A1 (es) | 2001-11-14 |
EP1077986A2 (de) | 2001-02-28 |
HRP20000758A2 (en) | 2001-06-30 |
HRP20000758B1 (en) | 2007-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |