BG62488B1 - Сулфонамиди като инхибитори на hiv аспартилпротеаза - Google Patents

Сулфонамиди като инхибитори на hiv аспартилпротеаза Download PDF

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Publication number
BG62488B1
BG62488B1 BG99540A BG9954095A BG62488B1 BG 62488 B1 BG62488 B1 BG 62488B1 BG 99540 A BG99540 A BG 99540A BG 9954095 A BG9954095 A BG 9954095A BG 62488 B1 BG62488 B1 BG 62488B1
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Bulgaria
Prior art keywords
compound
syn
hydroxy
phenyl
butyl
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BG99540A
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Bulgarian (bg)
English (en)
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BG99540A (bg
Inventor
Roger D. Tung
Mark A. Murcko
Govinda R. Bhisetti
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Vertex Pharmaceuticals Incorporated
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Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of BG99540A publication Critical patent/BG99540A/bg
Publication of BG62488B1 publication Critical patent/BG62488B1/bg

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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BG99540A 1992-09-08 1995-04-03 Сулфонамиди като инхибитори на hiv аспартилпротеаза BG62488B1 (bg)

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EP0885887A3 (en) 1999-02-03
US20060189810A1 (en) 2006-08-24
CY2164B1 (en) 2002-08-23
CN1087347A (zh) 1994-06-01
GR3030719T3 (en) 1999-11-30
EP0659181A1 (en) 1995-06-28
FI120685B (fi) 2010-01-29
NO950876D0 (no) 1995-03-07
US20080293727A1 (en) 2008-11-27
ATE241602T1 (de) 2003-06-15
SK281360B6 (sk) 2001-02-12
RU2135496C1 (ru) 1999-08-27
DE10199024I1 (de) 2001-07-12
NO950876L (no) 1995-05-08
US20030069222A1 (en) 2003-04-10
JP3012002B2 (ja) 2000-02-21
BG99540A (bg) 1995-11-30
MY142901A (en) 2011-01-31
DE69324369T2 (de) 1999-08-26
DE69324369D1 (de) 1999-05-12
PT885887E (pt) 2003-10-31
CO4870779A1 (es) 1999-12-27
EP0885887B1 (en) 2003-05-28
AU691160B2 (en) 1998-05-14
TW254927B (cs) 1995-08-21
US20100210603A1 (en) 2010-08-19
DK0659181T3 (da) 1999-10-18
FI951059A0 (fi) 1995-03-07
US5585397A (en) 1996-12-17
CA2143208A1 (en) 1994-03-17
NO2001012I1 (no) 2001-07-23
IL106927A (en) 2001-01-11
US7608632B2 (en) 2009-10-27
IS4068A (is) 1994-03-09
EP0659181B1 (en) 1999-04-07
SK29395A3 (en) 1995-09-13
LTIP917A (en) 1994-11-25
UA44694C2 (uk) 2002-03-15
DE69333012T2 (de) 2004-04-01
WO1994005639A1 (en) 1994-03-17
ES2200243T3 (es) 2004-03-01
KR100262056B1 (ko) 2000-07-15
PL307858A1 (en) 1995-06-26
ATE178598T1 (de) 1999-04-15
NZ256238A (en) 1997-04-24
GEP20012579B (en) 2001-11-26
AP9300572A0 (en) 1993-10-31
BR1100824A (pt) 1999-08-31
DK0885887T3 (da) 2003-09-22
NL300039I2 (nl) 2001-09-03
PH31251A (en) 1998-05-05
FI951059L (fi) 1995-04-18
HK1012631A1 (en) 1999-08-06
NZ314376A (en) 1998-10-28
RU95109928A (ru) 1997-03-20
RO118747B1 (ro) 2003-10-30
HUT71892A (en) 1996-02-28
DE10199024I2 (de) 2006-04-06
LT3302B (en) 1995-06-26
US6372778B1 (en) 2002-04-16
CN1061339C (zh) 2001-01-31
NO303444B1 (no) 1998-07-13
HU228198B1 (en) 2013-01-28
AP390A (en) 1995-08-02
LU90736I2 (fr) 2001-05-07
CA2143208C (en) 2003-01-07
PL185635B1 (pl) 2003-06-30
EP0885887A2 (en) 1998-12-23
JPH08501299A (ja) 1996-02-13
DE69333012D1 (de) 2003-07-03
MXPA03010538A (es) 2011-12-16
HK1023561A1 (en) 2000-09-15
US5856353A (en) 1999-01-05
SG43862A1 (en) 1997-11-14
AU4852093A (en) 1994-03-29
CZ58795A3 (en) 1995-12-13
IS2334B (is) 2008-02-15
ES2131589T3 (es) 1999-08-01
HU9500685D0 (en) 1995-04-28
CZ289475B6 (cs) 2002-01-16

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