BG100951A - Производни на еритромицина, метод за тяхното получаване и използването им като лекарствени средства - Google Patents

Производни на еритромицина, метод за тяхното получаване и използването им като лекарствени средства

Info

Publication number
BG100951A
BG100951A BG100951A BG10095196A BG100951A BG 100951 A BG100951 A BG 100951A BG 100951 A BG100951 A BG 100951A BG 10095196 A BG10095196 A BG 10095196A BG 100951 A BG100951 A BG 100951A
Authority
BG
Bulgaria
Prior art keywords
drugs
preparation
erythromycin derivatives
novel erythromycin
compounds
Prior art date
Application number
BG100951A
Other languages
English (en)
Other versions
BG63087B1 (bg
Inventor
Constantin Agouridas
Jean-Francois Chantot
Alexis Denis
D'ambrieres Solange Gouin
Martret Odile Le
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of BG100951A publication Critical patent/BG100951A/bg
Publication of BG63087B1 publication Critical patent/BG63087B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Изобретението се отнася до съединенията с формулав която R означава (СН2)nAr, n има стойност 3, 4 или 5, Ar е евентуално заместен хетероциклен радикал, Z е водороден атом или киселинен остатък. Съединениятаимат полезни антибиотични свойства.
BG100951A 1994-05-03 1996-11-01 Производни на еритромицина, метод за тяхното получаване и използването им като лекарствени средства BG63087B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9405368A FR2719587B1 (fr) 1994-05-03 1994-05-03 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000565 WO1995029929A1 (fr) 1994-05-03 1995-05-02 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
BG100951A true BG100951A (bg) 1997-08-29
BG63087B1 BG63087B1 (bg) 2001-03-30

Family

ID=9462785

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100951A BG63087B1 (bg) 1994-05-03 1996-11-01 Производни на еритромицина, метод за тяхното получаване и използването им като лекарствени средства

Country Status (43)

Country Link
US (2) US5635485A (bg)
EP (1) EP0680967B1 (bg)
JP (4) JP2992540B2 (bg)
KR (1) KR100312267B1 (bg)
CN (2) CN1052984C (bg)
AP (1) AP558A (bg)
AT (1) ATE172203T1 (bg)
AU (1) AU684027B2 (bg)
BG (1) BG63087B1 (bg)
BR (1) BR9507700A (bg)
CA (1) CA2189271C (bg)
CZ (1) CZ293455B6 (bg)
DE (2) DE10299001I2 (bg)
DK (1) DK0680967T3 (bg)
DZ (1) DZ1878A1 (bg)
EE (1) EE03263B1 (bg)
ES (1) ES2122472T3 (bg)
FI (1) FI111263B (bg)
FR (1) FR2719587B1 (bg)
GE (1) GEP19991538B (bg)
HK (1) HK1010732A1 (bg)
HU (2) HU227493B1 (bg)
IL (1) IL113245A (bg)
LU (1) LU90872I2 (bg)
LV (1) LV11739B (bg)
MA (1) MA23534A1 (bg)
MD (1) MD1233C2 (bg)
NL (1) NL300077I1 (bg)
NO (2) NO308853B1 (bg)
NZ (1) NZ285416A (bg)
OA (1) OA10319A (bg)
PL (1) PL182034B1 (bg)
RO (1) RO113350B1 (bg)
RU (1) RU2144036C1 (bg)
SI (1) SI0680967T1 (bg)
SK (1) SK281707B6 (bg)
TJ (1) TJ313B (bg)
TN (1) TNSN95049A1 (bg)
TW (1) TW341573B (bg)
UA (1) UA51618C2 (bg)
WO (1) WO1995029929A1 (bg)
YU (1) YU49235B (bg)
ZA (1) ZA953501B (bg)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5708005A (en) * 1995-06-27 1998-01-13 Takeda Chemical Industries, Ltd. Quinolines, their production and use
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
ATE296832T1 (de) * 1996-09-04 2005-06-15 Abbott Lab 6-o-substituierte ketoliden mit antibakteriellen wirkung
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
ES2243066T3 (es) * 1998-09-22 2005-11-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
ATE344269T1 (de) 1998-12-10 2006-11-15 Pfizer Prod Inc Carbamat und carbazat ketolid antibiotika
BR9916969A (pt) * 1999-01-27 2001-11-06 Pfizer Prod Inc Antibióticos cetólidos
FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
ES2272273T3 (es) 1999-04-16 2007-05-01 Kosan Biosciences, Inc. Agentes antiinfecciosos macrolidos.
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
AU4354900A (en) 1999-04-16 2000-11-02 Kosan Biosciences, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
WO2000071557A1 (en) * 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
FR2797875B1 (fr) * 1999-08-26 2001-10-19 Hoechst Marion Roussel Inc Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
WO2002016380A1 (en) * 2000-08-22 2002-02-28 Basilea Pharmaceutica Ag New macrolides with antibacterial activity
FR2821747B1 (fr) * 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques Suspension de telithromycine a gout masque
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
ES2325495T3 (es) 2002-07-08 2009-09-07 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas.
CN100577681C (zh) 2002-07-08 2010-01-06 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 用于治疗炎性疾病和病症的新化合物、组合物和方法
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
WO2004009059A1 (en) * 2002-07-19 2004-01-29 Aventis Pharma S.A. Taste masked oral composition of telithromycin
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
US6916934B2 (en) * 2003-02-11 2005-07-12 Aventis Pharma Deutschland Gmbh Process for preparing pyridine-substituted amino ketal derivatives
CA2529817C (en) 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
US20050101548A1 (en) * 2003-09-12 2005-05-12 Xiaodong Lin Antimicrobial derivatives
GB0402578D0 (en) * 2004-02-05 2004-03-10 Cambridge Theranostics Ltd Methods of treatment of atherosclerosis
JP5383037B2 (ja) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
AU2005238313A1 (en) * 2004-04-28 2005-11-10 Alembic Limited Process for the preparation of telithromycin
JP2008508322A (ja) * 2004-07-28 2008-03-21 ランバクシー ラボラトリーズ リミテッド 抗菌剤としてのケトライド誘導体
WO2006046112A2 (en) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
EP1836211B1 (en) * 2004-12-21 2010-03-03 Pfizer Products Inc. Macrolides
EP2546840B1 (en) * 2005-02-08 2017-04-19 Murata Manufacturing Co., Ltd. Surface-mountable negative-characteristic ceramic thermistor based on Mn, Co, Ni and Ti compounds
FR2882522B1 (fr) 2005-02-25 2007-04-13 Aventis Pharma Sa Composition pharmaceutique solide comprenant de la telithromycine
WO2006129257A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007039914A2 (en) * 2005-10-06 2007-04-12 Alembic Limited Novel polymorphs of telithromycin
WO2007049296A2 (en) * 2005-10-28 2007-05-03 Alembic Limited Amorphous form of telithromycin
WO2007059307A2 (en) * 2005-11-15 2007-05-24 Teva Pharmaceutical Industries Ltd. Crystalline and amorphous forms of telithromycin
EP1957508A2 (en) * 2005-11-23 2008-08-20 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007060627A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Use of macrolide derivatives for treating acne
US20090130225A1 (en) * 2005-11-23 2009-05-21 Anjan Chakrabarti Macrolides derivatives as antibacterial agents
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
GB0600238D0 (en) * 2006-01-06 2006-02-15 Sandoz Ag Organic compounds
JP5015016B2 (ja) * 2006-02-07 2012-08-29 大正製薬株式会社 １０ａ−アザライド化合物
WO2008023248A2 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
WO2008023383A1 (en) * 2006-08-25 2008-02-28 Alembic Limited Novel process for the preparation of telithromycin
ES2306590B1 (es) * 2006-12-15 2009-08-07 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.
US8293715B2 (en) * 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
US20090075917A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched telithromycin
EP2937019B1 (en) 2007-09-20 2017-11-08 Herman Miller, Inc. Load support structure
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
US20110040078A1 (en) * 2007-10-25 2011-02-17 Siegfried Wolf Process for the production of telithromycin
WO2009139181A1 (ja) 2008-05-15 2009-11-19 大正製薬株式会社 ４員環構造を有する１０ａ－アザライド化合物
WO2010048599A1 (en) 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Methods for treating gastrointestinal diseases
BRPI1011959A2 (pt) 2009-05-27 2016-04-26 Wockhardt Research Center compostos de cetolídeo tendo atividade antimicrobiana.
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
NZ602544A (en) 2010-03-22 2014-11-28 Cempra Pharmaceuticals Inc Crystalline forms of a macrolide, and uses therefor
US9051346B2 (en) 2010-05-20 2015-06-09 Cempra Pharmaceuticals, Inc. Process for preparing triazole-containing ketolide antibiotics
JP6042334B2 (ja) * 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
PL2673285T3 (pl) 2010-12-09 2017-12-29 Wockhardt Limited Związki ketolidowe
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
JP5718488B2 (ja) 2011-03-01 2015-05-13 ウォックハート リミテッド ケトライド中間体の調製方法
KR101795838B1 (ko) 2011-03-22 2017-11-08 욱크하르트 리미티드 케톨리드 화합물의 제조 방법
SG11201405895UA (en) 2012-03-27 2014-10-30 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
JP6675973B2 (ja) 2013-03-15 2020-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド抗菌薬を調製するための集束的な方法
CN105524132B (zh) * 2014-09-30 2019-07-02 中国医学科学院药物研究所 含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用
DE102015201783A1 (de) 2015-02-02 2016-08-04 Friedrich Baur Verfahren zur Herstellung eines Füllstoffs aus Textilfasern sowie Textil mit einem solchen Füllstoff
CN107129514B (zh) * 2016-03-02 2019-12-13 中国医学科学院药物研究所 红霉素a酮内酯类抗生素衍生物、其制备方法及应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
EP0034116A3 (en) * 1980-02-11 1981-09-02 Berlex Laboratories, Inc. N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4434174A (en) * 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4568687A (en) * 1983-02-28 1986-02-04 American Cyanamid Company N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
ZA84949B (en) * 1983-04-06 1984-09-26 American Cyanamid Co Substituted-n-(2-4-(1h-imidazol-1-yl)alkyl)substituted amides
US4489089A (en) * 1983-04-06 1984-12-18 American Cyanamid Company Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides
AU573828B2 (en) * 1984-05-17 1988-06-23 E.R. Squibb & Sons, Inc. Tetrahydronaphthalenols
GB8425104D0 (en) * 1984-10-04 1984-11-07 Ici America Inc Amide derivatives
DE3540376A1 (de) * 1985-11-14 1987-05-21 Bayer Ag Verfahren zur inhibierung der wasserstoffinduzierten korrosion von metallischen werkstoffen
DE3750023T2 (de) * 1986-10-29 1994-09-29 Pfizer, Inc., New York, N.Y. Verfahren zur Herstellung von 2-(1-Pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)Thiazol und dessen kristallinisches Dihydrochlorid-Trihydrat.
DE3930669A1 (de) * 1989-09-14 1991-03-28 Basf Ag Verfahren zur herstellung von uretdiongruppen aufweisenden polyisocyanaten
JP2899028B2 (ja) * 1989-12-01 1999-06-02 協和醗酵工業株式会社 ジベンゾオキセピン誘導体
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
EP0559896B1 (en) * 1990-11-28 1997-08-27 Taisho Pharmaceutical Co. Ltd 6-o-methylerythromycin a derivative
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
TW370529B (en) * 1992-12-17 1999-09-21 Pfizer Pyrazolopyrimidines
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

Also Published As

Publication number Publication date
HUT75698A (en) 1997-05-28
JP2007269810A (ja) 2007-10-18
DE10299001I1 (de) 2012-07-05
DE69505296T2 (de) 1999-04-22
FR2719587B1 (fr) 1996-07-12
ES2122472T3 (es) 1998-12-16
JP2992540B2 (ja) 1999-12-20
GEP19991538B (en) 1999-03-05
IL113245A0 (en) 1995-07-31
ZA953501B (en) 1996-05-02
HU9904687D0 (en) 2000-03-28
YU27095A (sh) 1998-05-15
DE69505296D1 (de) 1998-11-19
TJ313B (en) 2001-08-06
HK1010732A1 (en) 1999-06-25
JP3998828B2 (ja) 2007-10-31
CN1229082A (zh) 1999-09-22
LV11739B (en) 1997-08-20
BG63087B1 (bg) 2001-03-30
CZ293455B6 (cs) 2004-05-12
FI964395A0 (fi) 1996-10-31
SK281707B6 (sk) 2001-07-10
NO308853B1 (no) 2000-11-06
SI0680967T1 (en) 1999-02-28
RU2144036C1 (ru) 2000-01-10
SK140296A3 (en) 1998-04-08
AP9500744A0 (en) 1995-07-31
US5635485A (en) 1997-06-03
CA2189271C (fr) 2005-12-27
MD1233B1 (en) 1999-05-31
HU219599B (hu) 2001-05-28
PL182034B1 (pl) 2001-10-31
RO113350B1 (ro) 1998-06-30
CN1052984C (zh) 2000-05-31
NO964654D0 (no) 1996-11-04
AU684027B2 (en) 1997-11-27
MX9605208A (es) 1997-09-30
JP4658902B2 (ja) 2011-03-23
DK0680967T3 (da) 1999-06-23
TNSN95049A1 (fr) 1996-02-06
TW341573B (en) 1998-10-01
FI964395A (fi) 1996-10-31
LU90872I2 (fr) 2002-03-12
NZ285416A (en) 1997-07-27
UA51618C2 (uk) 2002-12-16
YU49235B (sh) 2004-12-31
IL113245A (en) 1999-11-30
EP0680967A1 (fr) 1995-11-08
NL300077I1 (nl) 2002-03-01
JP4750755B2 (ja) 2011-08-17
CA2189271A1 (fr) 1995-11-09
US6100404A (en) 2000-08-08
DE10299001I2 (de) 2012-07-05
CN1151746A (zh) 1997-06-11
KR100312267B1 (ko) 2002-06-22
FI111263B (fi) 2003-06-30
MA23534A1 (fr) 1995-12-31
LV11739A (lv) 1997-04-20
CZ321496A3 (en) 1997-08-13
WO1995029929A1 (fr) 1995-11-09
OA10319A (fr) 1997-10-07
HU227493B1 (en) 2011-07-28
HU9603038D0 (en) 1997-01-28
JPH0853489A (ja) 1996-02-27
DZ1878A1 (fr) 2002-02-17
EE03263B1 (et) 2000-04-17
PL317071A1 (en) 1997-03-03
AP558A (en) 1996-11-07
BR9507700A (pt) 1997-08-19
AU2449995A (en) 1995-11-29
JPH11152296A (ja) 1999-06-08
CN1088709C (zh) 2002-08-07
ATE172203T1 (de) 1998-10-15
JP2007045847A (ja) 2007-02-22
NO964654L (no) 1996-11-04
NO2001027I1 (no) 2002-01-28
EP0680967B1 (fr) 1998-10-14
FR2719587A1 (fr) 1995-11-10
MD1233C2 (ro) 2000-10-31

Similar Documents

Publication Publication Date Title
BG100951A (bg) Производни на еритромицина, метод за тяхното получаване и използването им като лекарствени средства
AU5047793A (en) New derivatives of erythromycin, their preparation process, their use as medicaments
IL127296A (en) Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them
IL124537A0 (en) Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
HUP9902576A1 (hu) Új eritromicinszármazékok, eljárás előállításukra és alkalmazásuk gyógyászati készítményekben
IL112622A (en) Iminoalkylamino or aminoalkylideneamino camptothecin derivatives, process for their preparation and pharmaceutical compositions containing them
AU4627097A (en) Aminothiazole derivatives, method of preparation and pharmaceutical compositions containing same
IL102093A0 (en) 1-methylcarbapenem derivatives,processes for the preparation thereof,and pharmaceutical compositions containing the same
HU9203761D0 (en) Method for producing substituted pyridine derivatives
PL309874A1 (en) Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
MY105538A (en) Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them.
BG101220A (bg) N-заместени 3-азабицикло(3.2.0) хептанови производни, метод за получаване и използването им
TW336235B (en) 3'-aziridino-anthracycline derivatives, process for preparating them and pharmaceutical composition containing them
AU7414691A (en) New 3-aminochroman derivatives, process for preparing these and pharmaceutical compositions containing them
IE901314L (en) 2- substituted-n,n'-di(trimethoxybenzoyl)piperazines
CA2030732A1 (fr) Nouveaux derives du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant
UA41871C2 (uk) Похідні еритроміцину, спосіб їх одержання та фармацевтична композиція на їх основі
BG103271A (bg) Производни на n-(бензотиазол-2-ил) пиперидин-1-етанамин, метод за тяхното получаване и използванетоим като терапевтични средства
GR3023757T3 (en) Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents.
YU25699A (sh) Novi derivati eritromicina, postupak za njihovu izradu i njihova primena
PL314794A1 (en) Crystalline polymorphous form of (s,s,s)-n-(1-[2-carbocy-3-(n2-mezilolysilamino)propyl]-1-cyclopentylocabonyl)thyrosine
IL115085A0 (en) Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
ES2049186A1 (es) Procedimiento para la preparacion de nuevos derivados de benzofuranil-imidazol.
AU1234488A (en) New 2-(2,3-dihydro-2-oxo-3-benzofuranyl) acetic acid derivatives, processes for preparing them and the pharmaceutical compositions which contain them
HU9600300D0 (en) Thiocarbamoyl derivatives using as antimicrobial agents and process for producing of these