TJ313B - Erythromycin's dervatives and pharmaceutical composition on their basis - Google Patents

Erythromycin's dervatives and pharmaceutical composition on their basis

Info

Publication number
TJ313B
TJ313B TJ96000417A TJ96000417A TJ313B TJ 313 B TJ313 B TJ 313B TJ 96000417 A TJ96000417 A TJ 96000417A TJ 96000417 A TJ96000417 A TJ 96000417A TJ 313 B TJ313 B TJ 313B
Authority
TJ
Tajikistan
Prior art keywords
dervatives
erythromycin
basis
pharmaceutical composition
pharmaceutical
Prior art date
Application number
TJ96000417A
Other languages
English (en)
Inventor
Constantin Agouridas
Jean-Fransua Shanto
Deni Alexsis
D Ambrier Solange Gouin
Martret Odile Le
Original Assignee
Hoechest Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechest Marion Roussel filed Critical Hoechest Marion Roussel
Publication of TJ313B publication Critical patent/TJ313B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
TJ96000417A 1994-05-03 1996-11-01 Erythromycin's dervatives and pharmaceutical composition on their basis TJ313B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9405368A FR2719587B1 (fr) 1994-05-03 1994-05-03 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (1)

Publication Number Publication Date
TJ313B true TJ313B (en) 2001-08-06

Family

ID=9462785

Family Applications (1)

Application Number Title Priority Date Filing Date
TJ96000417A TJ313B (en) 1994-05-03 1996-11-01 Erythromycin's dervatives and pharmaceutical composition on their basis

Country Status (43)

Country Link
US (2) US5635485A (xx)
EP (1) EP0680967B1 (xx)
JP (4) JP2992540B2 (xx)
KR (1) KR100312267B1 (xx)
CN (2) CN1052984C (xx)
AP (1) AP558A (xx)
AT (1) ATE172203T1 (xx)
AU (1) AU684027B2 (xx)
BG (1) BG63087B1 (xx)
BR (1) BR9507700A (xx)
CA (1) CA2189271C (xx)
CZ (1) CZ293455B6 (xx)
DE (2) DE69505296T2 (xx)
DK (1) DK0680967T3 (xx)
DZ (1) DZ1878A1 (xx)
EE (1) EE03263B1 (xx)
ES (1) ES2122472T3 (xx)
FI (1) FI111263B (xx)
FR (1) FR2719587B1 (xx)
GE (1) GEP19991538B (xx)
HK (1) HK1010732A1 (xx)
HU (2) HU227493B1 (xx)
IL (1) IL113245A (xx)
LU (1) LU90872I2 (xx)
LV (1) LV11739B (xx)
MA (1) MA23534A1 (xx)
MD (1) MD1233C2 (xx)
NL (1) NL300077I1 (xx)
NO (2) NO308853B1 (xx)
NZ (1) NZ285416A (xx)
OA (1) OA10319A (xx)
PL (1) PL182034B1 (xx)
RO (1) RO113350B1 (xx)
RU (1) RU2144036C1 (xx)
SI (1) SI0680967T1 (xx)
SK (1) SK281707B6 (xx)
TJ (1) TJ313B (xx)
TN (1) TNSN95049A1 (xx)
TW (1) TW341573B (xx)
UA (1) UA51618C2 (xx)
WO (1) WO1995029929A1 (xx)
YU (1) YU49235B (xx)
ZA (1) ZA953501B (xx)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5708005A (en) * 1995-06-27 1998-01-13 Takeda Chemical Industries, Ltd. Quinolines, their production and use
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
CN100441591C (zh) * 1996-09-04 2008-12-10 艾博特公司 酮基内酯类化合物，其用途和制备方法以及药用组合物
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
ATE298761T1 (de) 1998-09-22 2005-07-15 Pfizer Prod Inc Carbamat- und carbazatketolidantibiotika
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TW526202B (en) * 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
DE69933897T2 (de) 1998-12-10 2007-03-15 Pfizer Products Inc., Groton Carbamat- und Carbazatketolid-Antibiotika
TR200102128T2 (tr) * 1999-01-27 2001-12-21 Pfizer Products Inc. Ketolid antibiyotikler
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
IL145976A0 (en) 1999-04-16 2002-07-25 Ortho Mcneil Pharm Inc Ketolide antibacterials
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
WO2000063225A2 (en) 1999-04-16 2000-10-26 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
WO2000071557A1 (en) * 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
FR2797875B1 (fr) * 1999-08-26 2001-10-19 Hoechst Marion Roussel Inc Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
EP1313751B1 (en) * 2000-08-22 2008-09-17 Basilea Pharmaceutica AG New macrolides with antibacterial activity
FR2821747B1 (fr) * 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques Suspension de telithromycine a gout masque
CA2451391A1 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
RU2330858C2 (ru) 2002-07-08 2008-08-10 Глаксомитклайн Истраживацки Центар Загреб Д.О.О. Новые соединения, составы и способы лечения воспалительных заболеваний и состояний
ATE429441T1 (de) 2002-07-08 2009-05-15 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
WO2004009059A1 (en) * 2002-07-19 2004-01-29 Aventis Pharma S.A. Taste masked oral composition of telithromycin
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
US6916934B2 (en) * 2003-02-11 2005-07-12 Aventis Pharma Deutschland Gmbh Process for preparing pyridine-substituted amino ketal derivatives
EP1638549A4 (en) * 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
WO2004096823A2 (en) * 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives
US20050101548A1 (en) * 2003-09-12 2005-05-12 Xiaodong Lin Antimicrobial derivatives
GB0402578D0 (en) * 2004-02-05 2004-03-10 Cambridge Theranostics Ltd Methods of treatment of atherosclerosis
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
PL1742957T3 (pl) * 2004-04-28 2008-05-30 Alembic Ltd Sposób otrzymywania telitromycyny
JP2008508322A (ja) * 2004-07-28 2008-03-21 ランバクシー ラボラトリーズ リミテッド 抗菌剤としてのケトライド誘導体
WO2006046112A2 (en) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
UA85937C2 (uk) * 2004-12-21 2009-03-10 Пфайзер Продактс Інк. Макроліди
WO2006085507A1 (ja) * 2005-02-08 2006-08-17 Murata Manufacturing Co., Ltd. 表面実装型負特性サーミスタ
FR2882522B1 (fr) 2005-02-25 2007-04-13 Aventis Pharma Sa Composition pharmaceutique solide comprenant de la telithromycine
WO2006129257A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007039914A2 (en) * 2005-10-06 2007-04-12 Alembic Limited Novel polymorphs of telithromycin
WO2007049296A2 (en) * 2005-10-28 2007-05-03 Alembic Limited Amorphous form of telithromycin
US20070167382A1 (en) * 2005-11-15 2007-07-19 Nina Finkelstein Crystalline and amorphous forms of telithromycin
EP1954294A2 (en) * 2005-11-23 2008-08-13 Ranbaxy Laboratories Limited Use of macrolide derivatives for treating acne
WO2007060518A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007060618A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Macrolides derivatives as antibacterial agents
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
GB0600238D0 (en) * 2006-01-06 2006-02-15 Sandoz Ag Organic compounds
EP1985620A4 (en) * 2006-02-07 2012-08-15 Taisho Pharmaceutical Co Ltd COMPOUND 10a-AZALIDE
KR20090042971A (ko) 2006-08-24 2009-05-04 욱크하르트 리서치 센터 항미생물 활성을 갖는 신규한 마크로라이드 및 케토라이드
WO2008023383A1 (en) * 2006-08-25 2008-02-28 Alembic Limited Novel process for the preparation of telithromycin
ES2306590B1 (es) * 2006-12-15 2009-08-07 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.
WO2009019868A1 (ja) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. １０ａ、１２位架橋型１０ａ－アザライド化合物
US20090075917A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched telithromycin
CN104605647B (zh) 2007-09-20 2019-10-08 赫尔曼米勒有限公司 载荷支撑结构
US9453042B2 (en) 2007-10-25 2016-09-27 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2009053259A1 (en) * 2007-10-25 2009-04-30 Sandoz Ag Process for the production of telithromycin
US8299035B2 (en) * 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
AU2009308182B2 (en) * 2008-10-24 2016-05-19 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US8541420B2 (en) 2009-05-27 2013-09-24 Wockhardt Ltd. Ketolide compounds having antimicrobial activity
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
CA2793884C (en) 2010-03-22 2019-09-10 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
DK2571506T3 (en) 2010-05-20 2017-08-28 Cempra Pharmaceuticals Inc PROCEDURES FOR THE MANUFACTURE OF MACROLIDES AND KETOLIDES AND INTERMEDIATES
KR20130120458A (ko) * 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
DK2673285T3 (en) 2010-12-09 2017-10-16 Wockhardt Ltd Ketolide compounds
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
US9206214B2 (en) 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
US8993739B2 (en) 2011-03-22 2015-03-31 Wockhardt Ltd. Process for preparation of ketolide compounds
US10188674B2 (en) 2012-03-27 2019-01-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CA2905975A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
CN105524132B (zh) * 2014-09-30 2019-07-02 中国医学科学院药物研究所 含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用
DE102015201783A1 (de) 2015-02-02 2016-08-04 Friedrich Baur Verfahren zur Herstellung eines Füllstoffs aus Textilfasern sowie Textil mit einem solchen Füllstoff
CN107129514B (zh) * 2016-03-02 2019-12-13 中国医学科学院药物研究所 红霉素a酮内酯类抗生素衍生物、其制备方法及应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
EP0034116A3 (en) * 1980-02-11 1981-09-02 Berlex Laboratories, Inc. N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4434174A (en) * 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4568687A (en) * 1983-02-28 1986-02-04 American Cyanamid Company N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
ZA84949B (en) * 1983-04-06 1984-09-26 American Cyanamid Co Substituted-n-(2-4-(1h-imidazol-1-yl)alkyl)substituted amides
US4489089A (en) * 1983-04-06 1984-12-18 American Cyanamid Company Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides
AU573828B2 (en) * 1984-05-17 1988-06-23 E.R. Squibb & Sons, Inc. Tetrahydronaphthalenols
GB8425104D0 (en) * 1984-10-04 1984-11-07 Ici America Inc Amide derivatives
DE3540376A1 (de) * 1985-11-14 1987-05-21 Bayer Ag Verfahren zur inhibierung der wasserstoffinduzierten korrosion von metallischen werkstoffen
ES2054684T3 (es) * 1986-10-29 1994-08-16 Pfizer Procedimientos para la preparacion de 2-(1-pentil-3-guanidino)-4-(2-metil-4-imidazolil) tiazol y el dihidrocloruro trihidratado cristalino del mismo.
DE3930669A1 (de) * 1989-09-14 1991-03-28 Basf Ag Verfahren zur herstellung von uretdiongruppen aufweisenden polyisocyanaten
JP2899028B2 (ja) * 1989-12-01 1999-06-02 協和醗酵工業株式会社 ジベンゾオキセピン誘導体
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
ATE157368T1 (de) * 1990-11-28 1997-09-15 Taisho Pharmaceutical Co Ltd 6-0-methylerythromycin a-derivat
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
TW370529B (en) * 1992-12-17 1999-09-21 Pfizer Pyrazolopyrimidines
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

Also Published As

Publication number Publication date
CZ293455B6 (cs) 2004-05-12
NZ285416A (en) 1997-07-27
JP4750755B2 (ja) 2011-08-17
UA51618C2 (uk) 2002-12-16
DK0680967T3 (da) 1999-06-23
FI964395A0 (fi) 1996-10-31
NO964654D0 (no) 1996-11-04
CZ321496A3 (en) 1997-08-13
HUT75698A (en) 1997-05-28
JPH11152296A (ja) 1999-06-08
TW341573B (en) 1998-10-01
DE69505296T2 (de) 1999-04-22
KR100312267B1 (ko) 2002-06-22
FR2719587A1 (fr) 1995-11-10
NO964654L (no) 1996-11-04
BG63087B1 (bg) 2001-03-30
CN1229082A (zh) 1999-09-22
JP3998828B2 (ja) 2007-10-31
US6100404A (en) 2000-08-08
PL182034B1 (pl) 2001-10-31
AU2449995A (en) 1995-11-29
JP4658902B2 (ja) 2011-03-23
ATE172203T1 (de) 1998-10-15
IL113245A0 (en) 1995-07-31
DE10299001I1 (de) 2012-07-05
ES2122472T3 (es) 1998-12-16
CA2189271C (fr) 2005-12-27
EE03263B1 (et) 2000-04-17
MA23534A1 (fr) 1995-12-31
SK281707B6 (sk) 2001-07-10
LU90872I2 (fr) 2002-03-12
SK140296A3 (en) 1998-04-08
HU219599B (hu) 2001-05-28
PL317071A1 (en) 1997-03-03
RO113350B1 (ro) 1998-06-30
YU49235B (sh) 2004-12-31
HU227493B1 (en) 2011-07-28
HU9603038D0 (en) 1997-01-28
FR2719587B1 (fr) 1996-07-12
SI0680967T1 (en) 1999-02-28
WO1995029929A1 (fr) 1995-11-09
CA2189271A1 (fr) 1995-11-09
CN1052984C (zh) 2000-05-31
HK1010732A1 (en) 1999-06-25
DE10299001I2 (de) 2012-07-05
MX9605208A (es) 1997-09-30
HU9904687D0 (en) 2000-03-28
JP2007045847A (ja) 2007-02-22
AU684027B2 (en) 1997-11-27
GEP19991538B (en) 1999-03-05
BG100951A (en) 1997-08-29
CN1088709C (zh) 2002-08-07
AP558A (en) 1996-11-07
AP9500744A0 (en) 1995-07-31
MD1233B1 (en) 1999-05-31
NO308853B1 (no) 2000-11-06
MD1233C2 (ro) 2000-10-31
FI964395A (fi) 1996-10-31
DZ1878A1 (fr) 2002-02-17
TNSN95049A1 (fr) 1996-02-06
EP0680967A1 (fr) 1995-11-08
BR9507700A (pt) 1997-08-19
NL300077I1 (nl) 2002-03-01
FI111263B (fi) 2003-06-30
JPH0853489A (ja) 1996-02-27
DE69505296D1 (de) 1998-11-19
EP0680967B1 (fr) 1998-10-14
JP2007269810A (ja) 2007-10-18
YU27095A (sh) 1998-05-15
US5635485A (en) 1997-06-03
NO2001027I1 (no) 2002-01-28
LV11739B (en) 1997-08-20
CN1151746A (zh) 1997-06-11
JP2992540B2 (ja) 1999-12-20
ZA953501B (en) 1996-05-02
LV11739A (lv) 1997-04-20
IL113245A (en) 1999-11-30
RU2144036C1 (ru) 2000-01-10
OA10319A (fr) 1997-10-07

Similar Documents

Publication Publication Date Title
TJ313B (en) Erythromycin's dervatives and pharmaceutical composition on their basis
IL117859A (en) Isothiazolones and their uses
IL122428A0 (en) Minizymes and minribozymes and uses thereof
HU9602104D0 (en) Novel medicines and their use
IL122216A0 (en) Dolastatin derivatives their preparation and use
HUP9801819A3 (en) Synergetic phytomicrobicide compositions and use thereof
GB9525812D0 (en) Composition and use
IL118442A0 (en) Triazolymethyl-cyclopentanols their preparation and use
EP0803255A4 (en) DRUG
EP0948323A4 (en) PROTEASE-ACTIVATED RECEPTOR 3 AND THEIR USE
IL135723A (en) 1'-Ä4-Ä1-4-Fluorophenyl)-1H-indole-3-ylÜ-1-butylÜ-spiroÄisobenzofuran-1-(3H),4'-piperidineÜhydrohal ogenides and pharmaceutical compositions containing them
GB9518692D0 (en) 'Spraymate'
HUP0000460A3 (en) Imidazopyridazines and pharmaceutical compositions thereof
GB9501286D0 (en) Pharmaceutical compositions and preparations thereof
IL124415A (en) N, n'-bridged bisindolylmaleimides, their preparation and pharmaceutical compositions containing them
IL122686A0 (en) Benzylhydroxylamines their preparation and use
IL118444A0 (en) Mercapto-triazolyl-silanes their preparation and use
IL114161A0 (en) Amido- quinoxalinediones pharmaceutical compositions containing them and their use
IL117045A0 (en) Substituted 2,3-dihydro-1,4-dioxinopyridines their preparation and pharmaceutical compositions containing them
GB9515285D0 (en) "Absorbent materials"
GB9503462D0 (en) "Cleaning composition and its use"
GB9512703D0 (en) Composition and use
GB9519849D0 (en) Pharmaceutical compositions and their use
GB9503463D0 (en) "Cleaning composition and method"
HUP9602732A3 (en) Pharmaceutical composition comprising lanperisone