WO2009019868A1 - 10a、12位架橋型10a-アザライド化合物 - Google Patents
10a、12位架橋型10a-アザライド化合物 Download PDFInfo
- Publication number
- WO2009019868A1 WO2009019868A1 PCT/JP2008/002129 JP2008002129W WO2009019868A1 WO 2009019868 A1 WO2009019868 A1 WO 2009019868A1 JP 2008002129 W JP2008002129 W JP 2008002129W WO 2009019868 A1 WO2009019868 A1 WO 2009019868A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound crosslinked
- azalide compound
- bacterium
- erythromycin
- azalide
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 4
- 241000894006 Bacteria Species 0.000 abstract 3
- 229960003276 erythromycin Drugs 0.000 abstract 2
- 206010022000 influenza Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
インフルエンザ菌又はエリスロマイシン耐性菌(例えば耐性肺炎球菌及び連鎖球菌)に対しても有効な下記式で表される10a及び12位で架橋された新規な10a-アザライド化合物。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/671,813 US8293715B2 (en) | 2007-08-06 | 2008-08-06 | 10a-Azalide compound crosslinked at 10a- and 12-positions |
EP08790393A EP2177526A4 (en) | 2007-08-06 | 2008-08-06 | 10A-AZALIDE COMPOUND CROSS-LINKED IN POSITION 10A AND POSITION 12 |
JP2009526338A JPWO2009019868A1 (ja) | 2007-08-06 | 2008-08-06 | 10a、12位架橋型10a−アザライド化合物 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-203769 | 2007-08-06 | ||
JP2007203769 | 2007-08-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009019868A1 true WO2009019868A1 (ja) | 2009-02-12 |
Family
ID=40341109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/002129 WO2009019868A1 (ja) | 2007-08-06 | 2008-08-06 | 10a、12位架橋型10a-アザライド化合物 |
Country Status (4)
Country | Link |
---|---|
US (1) | US8293715B2 (ja) |
EP (1) | EP2177526A4 (ja) |
JP (1) | JPWO2009019868A1 (ja) |
WO (1) | WO2009019868A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009139181A1 (ja) * | 2008-05-15 | 2009-11-19 | 大正製薬株式会社 | 4員環構造を有する10a-アザライド化合物 |
CN110590547A (zh) * | 2012-12-07 | 2019-12-20 | 开曼化学股份有限公司 | 前列环素衍生物的合成方法 |
Citations (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54154724A (en) | 1978-04-25 | 1979-12-06 | Boots Co Ltd | Novel optically active base and its manufacture |
US4474768A (en) | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
US4517359A (en) | 1981-03-06 | 1985-05-14 | Sour Pliva Farmaceutska, Kemijska Prehrambena I Kozmeticka Industrija, N.Sol.O. | 11-Methyl-11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one and derivatives thereof |
EP0284203A2 (en) | 1987-02-24 | 1988-09-28 | Beecham Group Plc | Erythromycin derivatives, process for their preparation and their pharmaceutical use |
EP0508726A1 (en) | 1991-04-11 | 1992-10-14 | Merck & Co. Inc. | Novel process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives |
WO1993013116A1 (en) | 1991-12-27 | 1993-07-08 | Taisho Pharmaceutical Co., Ltd. | 5-o-desosaminylerythronolide derivative |
WO1994017088A1 (en) | 1993-01-26 | 1994-08-04 | Taisho Pharmaceutical Co., Ltd. | 5-o-desosaminylerythronolide derivative |
EP0680967A1 (fr) | 1994-05-03 | 1995-11-08 | Roussel-Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments |
WO1997042204A1 (en) | 1996-05-07 | 1997-11-13 | Abbott Laboratories | 6-o-substituted erythromycins and method for making them |
WO1998009978A1 (en) | 1996-09-04 | 1998-03-12 | Abbott Laboratories | 6-o-substituted ketolides having antibacterial activity |
WO1998018807A1 (fr) | 1996-10-31 | 1998-05-07 | Taisho Pharmaceutical Co., Ltd. | Derives de l'erythromycine a |
WO1998056801A1 (en) | 1997-06-11 | 1998-12-17 | Pfizer Products Inc. | C-4''-substituted macrolide derivatives |
EP0895999A1 (en) | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | C-4" substituted macrolide antibiotics |
WO1999028332A1 (en) | 1997-12-01 | 1999-06-10 | Abbott Laboratories | 6-o-alkyl erythromycin b oxime |
WO2000069875A1 (en) | 1999-05-14 | 2000-11-23 | Abbott Laboratories | C-2 modified erythromycin derivatives |
US6191118B1 (en) | 1996-11-27 | 2001-02-20 | Taisho Pharmaceutical Co., Ltd. | Erythromycin A derivatives |
WO2001077134A2 (en) | 2000-03-23 | 2001-10-18 | Abbott Laboratories | Process for the preparation of 6-o-propargyl erythromycin derivatives |
WO2002032919A2 (en) | 2000-10-16 | 2002-04-25 | Abbott Laboratories | 6-o-substituted erythromycin derivatives having improved gastrointestinal tolerance |
US6420535B1 (en) | 1999-06-07 | 2002-07-16 | Abbott Laboratories | 6-O-carbamate ketolide derivatives |
JP2002530422A (ja) * | 1998-11-20 | 2002-09-17 | ファイザー・プロダクツ・インク | 13員アザリド類および抗生物質としてのそれらの使用 |
WO2002096922A1 (en) | 2001-05-30 | 2002-12-05 | Abbott Laboratories | An arylation method for the functionalization of o-allyl erythromycin derivatives |
WO2003014136A1 (en) | 2001-08-08 | 2003-02-20 | Taisho Pharmaceutical Co., Ltd. | 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME |
WO2003014116A1 (en) | 2001-08-06 | 2003-02-20 | Bayer Corporation | Pyrrolo[2.1-a]isoquinoline derivatives |
WO2004078770A1 (en) | 2003-03-05 | 2004-09-16 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using the same |
WO2004101584A1 (en) | 2003-05-13 | 2004-11-25 | Glaxo Group Limited | Macrolides substituted at the 3-position having antimicrobial activity |
WO2005019238A1 (ja) | 2003-08-22 | 2005-03-03 | Meiji Seika Kaisha, Ltd. | 新規アザライド及びアザラクタム誘導体とその製造法 |
WO2005030786A1 (en) | 2003-09-25 | 2005-04-07 | Ranbaxy Laboratories Limited | 3'-n-substituted-3-o-substituted erythronolide a derivatives |
US20060142214A1 (en) | 2004-12-07 | 2006-06-29 | Or Yat S | 3,6-bicyclolides |
WO2007091393A1 (ja) | 2006-02-07 | 2007-08-16 | Taisho Pharmaceutical Co., Ltd. | 10a-アザライド化合物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2077271A4 (en) * | 2006-05-01 | 2010-09-15 | Taisho Pharmaceutical Co Ltd | MACROLIDE DERIVATIVE |
US8299035B2 (en) | 2008-05-15 | 2012-10-30 | Taisho Pharmaceutucal Co., Ltd. | 10a-azalide compound having 4-membered ring structure |
-
2008
- 2008-08-06 US US12/671,813 patent/US8293715B2/en not_active Expired - Fee Related
- 2008-08-06 JP JP2009526338A patent/JPWO2009019868A1/ja active Pending
- 2008-08-06 WO PCT/JP2008/002129 patent/WO2009019868A1/ja active Application Filing
- 2008-08-06 EP EP08790393A patent/EP2177526A4/en not_active Withdrawn
Patent Citations (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54154724A (en) | 1978-04-25 | 1979-12-06 | Boots Co Ltd | Novel optically active base and its manufacture |
US4517359A (en) | 1981-03-06 | 1985-05-14 | Sour Pliva Farmaceutska, Kemijska Prehrambena I Kozmeticka Industrija, N.Sol.O. | 11-Methyl-11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one and derivatives thereof |
US4474768A (en) | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
EP0284203A2 (en) | 1987-02-24 | 1988-09-28 | Beecham Group Plc | Erythromycin derivatives, process for their preparation and their pharmaceutical use |
EP0508726A1 (en) | 1991-04-11 | 1992-10-14 | Merck & Co. Inc. | Novel process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives |
US5523399A (en) | 1991-12-27 | 1996-06-04 | Taisho Pharmaceutical Co., Ltd. | 5-O-desosaminylerythronolide derivatives |
WO1993013116A1 (en) | 1991-12-27 | 1993-07-08 | Taisho Pharmaceutical Co., Ltd. | 5-o-desosaminylerythronolide derivative |
WO1994017088A1 (en) | 1993-01-26 | 1994-08-04 | Taisho Pharmaceutical Co., Ltd. | 5-o-desosaminylerythronolide derivative |
EP0680967A1 (fr) | 1994-05-03 | 1995-11-08 | Roussel-Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments |
WO1997042204A1 (en) | 1996-05-07 | 1997-11-13 | Abbott Laboratories | 6-o-substituted erythromycins and method for making them |
WO1998009978A1 (en) | 1996-09-04 | 1998-03-12 | Abbott Laboratories | 6-o-substituted ketolides having antibacterial activity |
WO1998018807A1 (fr) | 1996-10-31 | 1998-05-07 | Taisho Pharmaceutical Co., Ltd. | Derives de l'erythromycine a |
US6191118B1 (en) | 1996-11-27 | 2001-02-20 | Taisho Pharmaceutical Co., Ltd. | Erythromycin A derivatives |
WO1998056801A1 (en) | 1997-06-11 | 1998-12-17 | Pfizer Products Inc. | C-4''-substituted macrolide derivatives |
EP0895999A1 (en) | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | C-4" substituted macrolide antibiotics |
WO1999028332A1 (en) | 1997-12-01 | 1999-06-10 | Abbott Laboratories | 6-o-alkyl erythromycin b oxime |
JP2002530422A (ja) * | 1998-11-20 | 2002-09-17 | ファイザー・プロダクツ・インク | 13員アザリド類および抗生物質としてのそれらの使用 |
WO2000069875A1 (en) | 1999-05-14 | 2000-11-23 | Abbott Laboratories | C-2 modified erythromycin derivatives |
US6420535B1 (en) | 1999-06-07 | 2002-07-16 | Abbott Laboratories | 6-O-carbamate ketolide derivatives |
WO2001077134A2 (en) | 2000-03-23 | 2001-10-18 | Abbott Laboratories | Process for the preparation of 6-o-propargyl erythromycin derivatives |
WO2002032919A2 (en) | 2000-10-16 | 2002-04-25 | Abbott Laboratories | 6-o-substituted erythromycin derivatives having improved gastrointestinal tolerance |
WO2002096922A1 (en) | 2001-05-30 | 2002-12-05 | Abbott Laboratories | An arylation method for the functionalization of o-allyl erythromycin derivatives |
WO2003014116A1 (en) | 2001-08-06 | 2003-02-20 | Bayer Corporation | Pyrrolo[2.1-a]isoquinoline derivatives |
WO2003014136A1 (en) | 2001-08-08 | 2003-02-20 | Taisho Pharmaceutical Co., Ltd. | 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME |
WO2004078770A1 (en) | 2003-03-05 | 2004-09-16 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using the same |
WO2004101584A1 (en) | 2003-05-13 | 2004-11-25 | Glaxo Group Limited | Macrolides substituted at the 3-position having antimicrobial activity |
WO2005019238A1 (ja) | 2003-08-22 | 2005-03-03 | Meiji Seika Kaisha, Ltd. | 新規アザライド及びアザラクタム誘導体とその製造法 |
WO2005030786A1 (en) | 2003-09-25 | 2005-04-07 | Ranbaxy Laboratories Limited | 3'-n-substituted-3-o-substituted erythronolide a derivatives |
US20060142214A1 (en) | 2004-12-07 | 2006-06-29 | Or Yat S | 3,6-bicyclolides |
WO2007091393A1 (ja) | 2006-02-07 | 2007-08-16 | Taisho Pharmaceutical Co., Ltd. | 10a-アザライド化合物 |
Non-Patent Citations (23)
Title |
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BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, 2006, pages 3697 - 3711 |
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 94, 1972, pages 7586 |
JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 12, 1975, pages 1723 |
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LA. PAQUETTE ET AL.: "Compendium of Organic Synthetic Methods", 1995, article "Encyclopedia of Reagents for Organic Synthesis" |
P.G.M. WUTS, T. GREEN: "Protective Groups in Organic Syntheses(Third Edition,)", 1999 |
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S.R. SANDLER ET AL.: "Organic Functional Group Preparations", 1968, ACADEMIC PRESS INC. |
S.R. WAGNER ET AL.: "Synthetic Organic Chemistry", 1961, JOHN WILEY |
See also references of EP2177526A4 |
TETRAHEDRON ASYMMETRY, vol. 7, 1996, pages 3371 |
TETRAHEDRON LETTERS, vol. 1, 1972, pages 29 |
TETRAHEDRON LETTERS, vol. 2, 1971, pages 195 |
TETRAHEDRON LETTERS, vol. 25, 1984, pages 1587 |
TETRAHEDRON LETTERS, vol. 41, 2000, pages 2659 |
TETRAHEDRON LETTERS, vol. 42, 2001, pages 315 |
TETRAHEDRON, vol. 34, 1978, pages 1651 |
TETRAHEDRON, vol. 36, 1980, pages 87 |
THE JOURNAL OF ANTIBIOTICS, vol. 43, no. 10, 1990, pages 1334 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009139181A1 (ja) * | 2008-05-15 | 2009-11-19 | 大正製薬株式会社 | 4員環構造を有する10a-アザライド化合物 |
US8299035B2 (en) | 2008-05-15 | 2012-10-30 | Taisho Pharmaceutucal Co., Ltd. | 10a-azalide compound having 4-membered ring structure |
CN110590547A (zh) * | 2012-12-07 | 2019-12-20 | 开曼化学股份有限公司 | 前列环素衍生物的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
US20110237784A1 (en) | 2011-09-29 |
EP2177526A4 (en) | 2012-08-22 |
JPWO2009019868A1 (ja) | 2010-10-28 |
US8293715B2 (en) | 2012-10-23 |
EP2177526A1 (en) | 2010-04-21 |
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