WO2009019868A1 - 10a-azalide compound crosslinked at position-10a and position-12 - Google Patents

10a-azalide compound crosslinked at position-10a and position-12 Download PDF

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Publication number
WO2009019868A1
WO2009019868A1 PCT/JP2008/002129 JP2008002129W WO2009019868A1 WO 2009019868 A1 WO2009019868 A1 WO 2009019868A1 JP 2008002129 W JP2008002129 W JP 2008002129W WO 2009019868 A1 WO2009019868 A1 WO 2009019868A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound crosslinked
azalide compound
bacterium
erythromycin
azalide
Prior art date
Application number
PCT/JP2008/002129
Other languages
French (fr)
Japanese (ja)
Inventor
Tomohiro Sugimoto
Kanako Yamamoto
Jun Kurosaka
Naoki Sasamoto
Masato Kashimura
Tomoaki Miura
Kenichi Kanemoto
Tomohiro Ozawa
Ken Chikauchi
Eiki Shitara
Original Assignee
Taisho Pharmaceutical Co., Ltd.
Meiji Seika Kaisha, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co., Ltd., Meiji Seika Kaisha, Ltd. filed Critical Taisho Pharmaceutical Co., Ltd.
Priority to EP08790393A priority Critical patent/EP2177526A4/en
Priority to JP2009526338A priority patent/JPWO2009019868A1/en
Priority to US12/671,813 priority patent/US8293715B2/en
Publication of WO2009019868A1 publication Critical patent/WO2009019868A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Disclosed is a novel 10a-azalide compound crosslinked at position-10a and position-12, which is represented by the formula shown below and is effective against an influenza bacterium or an erythromycin-resistant bacterium (e.g., an erythromycin-resistant pneumococcal or streptococcal bacterium).
PCT/JP2008/002129 2007-08-06 2008-08-06 10a-azalide compound crosslinked at position-10a and position-12 WO2009019868A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08790393A EP2177526A4 (en) 2007-08-06 2008-08-06 10a-azalide compound crosslinked at position-10a and position-12
JP2009526338A JPWO2009019868A1 (en) 2007-08-06 2008-08-06 10a, 12-position cross-linked 10a-azalide compound
US12/671,813 US8293715B2 (en) 2007-08-06 2008-08-06 10a-Azalide compound crosslinked at 10a- and 12-positions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007203769 2007-08-06
JP2007-203769 2007-08-06

Publications (1)

Publication Number Publication Date
WO2009019868A1 true WO2009019868A1 (en) 2009-02-12

Family

ID=40341109

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/002129 WO2009019868A1 (en) 2007-08-06 2008-08-06 10a-azalide compound crosslinked at position-10a and position-12

Country Status (4)

Country Link
US (1) US8293715B2 (en)
EP (1) EP2177526A4 (en)
JP (1) JPWO2009019868A1 (en)
WO (1) WO2009019868A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009139181A1 (en) * 2008-05-15 2009-11-19 大正製薬株式会社 10a-azalide compound having 4-membered ring structure
CN110590547A (en) * 2012-12-07 2019-12-20 开曼化学股份有限公司 Method for synthesizing prostacyclin derivative

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WO1998018807A1 (en) 1996-10-31 1998-05-07 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998056801A1 (en) 1997-06-11 1998-12-17 Pfizer Products Inc. C-4''-substituted macrolide derivatives
EP0895999A1 (en) 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
WO1999028332A1 (en) 1997-12-01 1999-06-10 Abbott Laboratories 6-o-alkyl erythromycin b oxime
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WO2003014116A1 (en) 2001-08-06 2003-02-20 Bayer Corporation Pyrrolo[2.1-a]isoquinoline derivatives
WO2004078770A1 (en) 2003-03-05 2004-09-16 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using the same
WO2004101584A1 (en) 2003-05-13 2004-11-25 Glaxo Group Limited Macrolides substituted at the 3-position having antimicrobial activity
WO2005019238A1 (en) 2003-08-22 2005-03-03 Meiji Seika Kaisha, Ltd. Novel azalide and azalactam derivatives and process for the production of the same
WO2005030786A1 (en) 2003-09-25 2005-04-07 Ranbaxy Laboratories Limited 3'-n-substituted-3-o-substituted erythronolide a derivatives
US20060142214A1 (en) 2004-12-07 2006-06-29 Or Yat S 3,6-bicyclolides
WO2007091393A1 (en) 2006-02-07 2007-08-16 Taisho Pharmaceutical Co., Ltd. 10a-AZALIDE COMPOUND

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103193840A (en) * 2006-05-01 2013-07-10 大正制药株式会社 Macrolide derivative
EP2287173A4 (en) 2008-05-15 2013-06-19 Taisho Pharmaceutical Co Ltd 10a-azalide compound having 4-membered ring structure

Patent Citations (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54154724A (en) 1978-04-25 1979-12-06 Boots Co Ltd Novel optically active base and its manufacture
US4517359A (en) 1981-03-06 1985-05-14 Sour Pliva Farmaceutska, Kemijska Prehrambena I Kozmeticka Industrija, N.Sol.O. 11-Methyl-11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
EP0284203A2 (en) 1987-02-24 1988-09-28 Beecham Group Plc Erythromycin derivatives, process for their preparation and their pharmaceutical use
EP0508726A1 (en) 1991-04-11 1992-10-14 Merck & Co. Inc. Novel process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
US5523399A (en) 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
WO1993013116A1 (en) 1991-12-27 1993-07-08 Taisho Pharmaceutical Co., Ltd. 5-o-desosaminylerythronolide derivative
WO1994017088A1 (en) 1993-01-26 1994-08-04 Taisho Pharmaceutical Co., Ltd. 5-o-desosaminylerythronolide derivative
EP0680967A1 (en) 1994-05-03 1995-11-08 Roussel-Uclaf Erythromycin derivatives, their process of preparation and their use as medicaments
WO1997042204A1 (en) 1996-05-07 1997-11-13 Abbott Laboratories 6-o-substituted erythromycins and method for making them
WO1998009978A1 (en) 1996-09-04 1998-03-12 Abbott Laboratories 6-o-substituted ketolides having antibacterial activity
WO1998018807A1 (en) 1996-10-31 1998-05-07 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6191118B1 (en) 1996-11-27 2001-02-20 Taisho Pharmaceutical Co., Ltd. Erythromycin A derivatives
WO1998056801A1 (en) 1997-06-11 1998-12-17 Pfizer Products Inc. C-4''-substituted macrolide derivatives
EP0895999A1 (en) 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
WO1999028332A1 (en) 1997-12-01 1999-06-10 Abbott Laboratories 6-o-alkyl erythromycin b oxime
JP2002530422A (en) * 1998-11-20 2002-09-17 ファイザー・プロダクツ・インク 13-membered azalides and their use as antibiotics
WO2000069875A1 (en) 1999-05-14 2000-11-23 Abbott Laboratories C-2 modified erythromycin derivatives
US6420535B1 (en) 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
WO2001077134A2 (en) 2000-03-23 2001-10-18 Abbott Laboratories Process for the preparation of 6-o-propargyl erythromycin derivatives
WO2002032919A2 (en) 2000-10-16 2002-04-25 Abbott Laboratories 6-o-substituted erythromycin derivatives having improved gastrointestinal tolerance
WO2002096922A1 (en) 2001-05-30 2002-12-05 Abbott Laboratories An arylation method for the functionalization of o-allyl erythromycin derivatives
WO2003014116A1 (en) 2001-08-06 2003-02-20 Bayer Corporation Pyrrolo[2.1-a]isoquinoline derivatives
WO2003014136A1 (en) 2001-08-08 2003-02-20 Taisho Pharmaceutical Co., Ltd. 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
WO2004078770A1 (en) 2003-03-05 2004-09-16 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using the same
WO2004101584A1 (en) 2003-05-13 2004-11-25 Glaxo Group Limited Macrolides substituted at the 3-position having antimicrobial activity
WO2005019238A1 (en) 2003-08-22 2005-03-03 Meiji Seika Kaisha, Ltd. Novel azalide and azalactam derivatives and process for the production of the same
WO2005030786A1 (en) 2003-09-25 2005-04-07 Ranbaxy Laboratories Limited 3'-n-substituted-3-o-substituted erythronolide a derivatives
US20060142214A1 (en) 2004-12-07 2006-06-29 Or Yat S 3,6-bicyclolides
WO2007091393A1 (en) 2006-02-07 2007-08-16 Taisho Pharmaceutical Co., Ltd. 10a-AZALIDE COMPOUND

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See also references of EP2177526A4
TETRAHEDRON ASYMMETRY, vol. 7, 1996, pages 3371
TETRAHEDRON LETTERS, vol. 1, 1972, pages 29
TETRAHEDRON LETTERS, vol. 2, 1971, pages 195
TETRAHEDRON LETTERS, vol. 25, 1984, pages 1587
TETRAHEDRON LETTERS, vol. 41, 2000, pages 2659
TETRAHEDRON LETTERS, vol. 42, 2001, pages 315
TETRAHEDRON, vol. 34, 1978, pages 1651
TETRAHEDRON, vol. 36, 1980, pages 87
THE JOURNAL OF ANTIBIOTICS, vol. 43, no. 10, 1990, pages 1334

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009139181A1 (en) * 2008-05-15 2009-11-19 大正製薬株式会社 10a-azalide compound having 4-membered ring structure
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
CN110590547A (en) * 2012-12-07 2019-12-20 开曼化学股份有限公司 Method for synthesizing prostacyclin derivative

Also Published As

Publication number Publication date
EP2177526A1 (en) 2010-04-21
JPWO2009019868A1 (en) 2010-10-28
US20110237784A1 (en) 2011-09-29
US8293715B2 (en) 2012-10-23
EP2177526A4 (en) 2012-08-22

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