BR9507700A - Novos derivados da eritromicida proceso de preparação dos mesmos e aplicação dos mesmos como medicamentos - Google Patents

Novos derivados da eritromicida proceso de preparação dos mesmos e aplicação dos mesmos como medicamentos

Info

Publication number
BR9507700A
BR9507700A BR9507700A BR9507700A BR9507700A BR 9507700 A BR9507700 A BR 9507700A BR 9507700 A BR9507700 A BR 9507700A BR 9507700 A BR9507700 A BR 9507700A BR 9507700 A BR9507700 A BR 9507700A
Authority
BR
Brazil
Prior art keywords
erythromycide
medicines
preparing
applying
new derivatives
Prior art date
Application number
BR9507700A
Other languages
English (en)
Inventor
Constantin Agouridas
Jean Francois Chantot
Alexis Denis
Solange Gouin D Ambrieres
Martret Odile Le
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of BR9507700A publication Critical patent/BR9507700A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
BR9507700A 1994-05-03 1995-05-02 Novos derivados da eritromicida proceso de preparação dos mesmos e aplicação dos mesmos como medicamentos BR9507700A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9405368A FR2719587B1 (fr) 1994-05-03 1994-05-03 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000565 WO1995029929A1 (fr) 1994-05-03 1995-05-02 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
BR9507700A true BR9507700A (pt) 1997-08-19

Family

ID=9462785

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9507700A BR9507700A (pt) 1994-05-03 1995-05-02 Novos derivados da eritromicida proceso de preparação dos mesmos e aplicação dos mesmos como medicamentos

Country Status (43)

Country Link
US (2) US5635485A (pt)
EP (1) EP0680967B1 (pt)
JP (4) JP2992540B2 (pt)
KR (1) KR100312267B1 (pt)
CN (2) CN1052984C (pt)
AP (1) AP558A (pt)
AT (1) ATE172203T1 (pt)
AU (1) AU684027B2 (pt)
BG (1) BG63087B1 (pt)
BR (1) BR9507700A (pt)
CA (1) CA2189271C (pt)
CZ (1) CZ293455B6 (pt)
DE (2) DE10299001I1 (pt)
DK (1) DK0680967T3 (pt)
DZ (1) DZ1878A1 (pt)
EE (1) EE03263B1 (pt)
ES (1) ES2122472T3 (pt)
FI (1) FI111263B (pt)
FR (1) FR2719587B1 (pt)
GE (1) GEP19991538B (pt)
HK (1) HK1010732A1 (pt)
HU (2) HU219599B (pt)
IL (1) IL113245A (pt)
LU (1) LU90872I2 (pt)
LV (1) LV11739B (pt)
MA (1) MA23534A1 (pt)
MD (1) MD1233C2 (pt)
NL (1) NL300077I1 (pt)
NO (2) NO308853B1 (pt)
NZ (1) NZ285416A (pt)
OA (1) OA10319A (pt)
PL (1) PL182034B1 (pt)
RO (1) RO113350B1 (pt)
RU (1) RU2144036C1 (pt)
SI (1) SI0680967T1 (pt)
SK (1) SK281707B6 (pt)
TJ (1) TJ313B (pt)
TN (1) TNSN95049A1 (pt)
TW (1) TW341573B (pt)
UA (1) UA51618C2 (pt)
WO (1) WO1995029929A1 (pt)
YU (1) YU49235B (pt)
ZA (1) ZA953501B (pt)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2215178A1 (en) * 1995-06-27 1997-01-16 Takeda Chemical Industries, Ltd. 4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DK1291352T3 (da) * 1996-09-04 2005-09-19 Abbott Lab 6-O-substituerede ketolider med antibakteriel aktivitet
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
DE69926005T2 (de) * 1998-09-22 2006-05-18 Pfizer Products Inc., Groton Carbamat- und carbazatketolidantibiotika
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TW526202B (en) * 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
AU6484199A (en) 1998-12-10 2000-06-26 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
EA200100623A1 (ru) * 1999-01-27 2002-02-28 Пфайзер Продактс Инк. Кетолидные антибиотики
FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
ID30547A (id) 1999-04-16 2001-12-20 Kosan Biosciences Inc Zat anti-infeksi makrolida
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
AU4354900A (en) * 1999-04-16 2000-11-02 Kosan Biosciences, Inc. Ketolide antibacterials
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
EE200100613A (et) * 1999-05-24 2003-02-17 Pfizer Products Inc. 13-metüülerütromütsiini derivaadid
FR2797875B1 (fr) * 1999-08-26 2001-10-19 Hoechst Marion Roussel Inc Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
DE60135859D1 (de) 2000-08-22 2008-10-30 Basilea Pharmaceutica Ag Neue macrolide mit antibakterieller wirkung
FR2821747B1 (fr) * 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques Suspension de telithromycine a gout masque
JP4509553B2 (ja) * 2001-07-03 2010-07-21 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 抗菌活性を有するｃ１２修飾エリスロマイシンマクロライドおよびケトライド
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
ATE429441T1 (de) 2002-07-08 2009-05-15 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
US7091187B2 (en) 2002-07-08 2006-08-15 Pliva-Istrazivacki Institut D.O.O. Compounds, compositions and methods for treatment of inflammatory diseases and conditions
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
WO2004009059A1 (en) * 2002-07-19 2004-01-29 Aventis Pharma S.A. Taste masked oral composition of telithromycin
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
US6916934B2 (en) * 2003-02-11 2005-07-12 Aventis Pharma Deutschland Gmbh Process for preparing pyridine-substituted amino ketal derivatives
WO2004080391A2 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
WO2004096823A2 (en) * 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives
EP1670808A1 (en) * 2003-09-12 2006-06-21 Chiron Corporation Antimicrobial derivatives
GB0402578D0 (en) * 2004-02-05 2004-03-10 Cambridge Theranostics Ltd Methods of treatment of atherosclerosis
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
CA2559281A1 (en) * 2004-04-28 2005-11-10 Alembic Limited Process for the preparation of telithromycin
RU2397987C2 (ru) * 2004-07-28 2010-08-27 Рэнбакси Лабораториз Лимитед Кетолидные производные в качестве антибактериальных агентов
US20090170790A1 (en) * 2004-10-25 2009-07-02 Biswajit Das Ketolide derivatives as antibacterial agents
KR100897678B1 (ko) 2004-12-21 2009-05-14 화이자 프로덕츠 인코포레이티드 마크롤라이드
KR100894967B1 (ko) * 2005-02-08 2009-04-24 가부시키가이샤 무라타 세이사쿠쇼 표면 실장형 부특성 서미스터
FR2882522B1 (fr) 2005-02-25 2007-04-13 Aventis Pharma Sa Composition pharmaceutique solide comprenant de la telithromycine
WO2006129257A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007039914A2 (en) * 2005-10-06 2007-04-12 Alembic Limited Novel polymorphs of telithromycin
WO2007049296A2 (en) * 2005-10-28 2007-05-03 Alembic Limited Amorphous form of telithromycin
US20070167382A1 (en) * 2005-11-15 2007-07-19 Nina Finkelstein Crystalline and amorphous forms of telithromycin
WO2007060518A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
EP1960413A2 (en) * 2005-11-23 2008-08-27 Ranbaxy Laboratories Limited Macrolides derivatives as antibacterial agents
EP1954294A2 (en) * 2005-11-23 2008-08-13 Ranbaxy Laboratories Limited Use of macrolide derivatives for treating acne
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
GB0600238D0 (en) * 2006-01-06 2006-02-15 Sandoz Ag Organic compounds
JP5015016B2 (ja) * 2006-02-07 2012-08-29 大正製薬株式会社 １０ａ−アザライド化合物
CA2661538A1 (en) 2006-08-24 2008-02-28 Wockhardt Research Centre Novel macrolides and ketolides having antimicrobial activity
WO2008023383A1 (en) * 2006-08-25 2008-02-28 Alembic Limited Novel process for the preparation of telithromycin
ES2306590B1 (es) * 2006-12-15 2009-08-07 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.
WO2009019868A1 (ja) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. １０ａ、１２位架橋型１０ａ－アザライド化合物
US20090075917A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched telithromycin
US7926879B2 (en) 2007-09-20 2011-04-19 Herman Miller, Inc. Load support structure
US20110040078A1 (en) * 2007-10-25 2011-02-17 Siegfried Wolf Process for the production of telithromycin
EP2214484A4 (en) * 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
US8299035B2 (en) * 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
JP5602748B2 (ja) * 2008-10-24 2014-10-08 センプラ ファーマシューティカルズ，インコーポレイテッド トリアゾール含有マクロライドを用いた生体防御
MX2011012614A (es) 2009-05-27 2012-02-22 Wockhardt Ltd Compuestos de quetolida que tienen actividad antimicrobiana.
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
KR102006200B1 (ko) 2010-03-22 2019-08-01 셈프라 파마슈티컬스, 인크. 매크로라이드의 결정 형태들 및 그 용도들
SI2571506T1 (sl) 2010-05-20 2017-12-29 Cempra Pharmaceuticals, Inc. Postopki za pripravo makrolidov in ketolidov ter njihovih intermediatov
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
RU2601550C2 (ru) 2010-12-09 2016-11-10 Вокхардт Лимитед Кетолидные соединения
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
EP2681222B1 (en) 2011-03-01 2018-02-28 Wockhardt Limited Process for preparation of ketolide intermediates
US8993739B2 (en) 2011-03-22 2015-03-31 Wockhardt Ltd. Process for preparation of ketolide compounds
CN104470527B (zh) 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN105524132B (zh) * 2014-09-30 2019-07-02 中国医学科学院药物研究所 含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用
DE102015201783A1 (de) 2015-02-02 2016-08-04 Friedrich Baur Verfahren zur Herstellung eines Füllstoffs aus Textilfasern sowie Textil mit einem solchen Füllstoff
CN107129514B (zh) * 2016-03-02 2019-12-13 中国医学科学院药物研究所 红霉素a酮内酯类抗生素衍生物、其制备方法及应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
US4434174A (en) * 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
IE810250L (en) * 1980-02-11 1981-08-11 Berlex Lab N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
US4568687A (en) * 1983-02-28 1986-02-04 American Cyanamid Company N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
ZA84949B (en) * 1983-04-06 1984-09-26 American Cyanamid Co Substituted-n-(2-4-(1h-imidazol-1-yl)alkyl)substituted amides
US4489089A (en) * 1983-04-06 1984-12-18 American Cyanamid Company Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides
AU573828B2 (en) * 1984-05-17 1988-06-23 E.R. Squibb & Sons, Inc. Tetrahydronaphthalenols
GB8425104D0 (en) * 1984-10-04 1984-11-07 Ici America Inc Amide derivatives
DE3540376A1 (de) * 1985-11-14 1987-05-21 Bayer Ag Verfahren zur inhibierung der wasserstoffinduzierten korrosion von metallischen werkstoffen
EP0269239B1 (en) * 1986-10-29 1994-06-08 Pfizer Inc. Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and the crystalline dihydrochloride trihydrate thereof
DE3930669A1 (de) * 1989-09-14 1991-03-28 Basf Ag Verfahren zur herstellung von uretdiongruppen aufweisenden polyisocyanaten
JP2899028B2 (ja) * 1989-12-01 1999-06-02 協和醗酵工業株式会社 ジベンゾオキセピン誘導体
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
ATE157368T1 (de) * 1990-11-28 1997-09-15 Taisho Pharmaceutical Co Ltd 6-0-methylerythromycin a-derivat
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
TW444018B (en) * 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

Also Published As

Publication number Publication date
UA51618C2 (uk) 2002-12-16
GEP19991538B (en) 1999-03-05
CA2189271A1 (fr) 1995-11-09
HK1010732A1 (en) 1999-06-25
CZ293455B6 (cs) 2004-05-12
RU2144036C1 (ru) 2000-01-10
BG100951A (en) 1997-08-29
CN1229082A (zh) 1999-09-22
ES2122472T3 (es) 1998-12-16
AU2449995A (en) 1995-11-29
KR100312267B1 (ko) 2002-06-22
DE69505296D1 (de) 1998-11-19
JPH0853489A (ja) 1996-02-27
CA2189271C (fr) 2005-12-27
JP4750755B2 (ja) 2011-08-17
NO964654D0 (no) 1996-11-04
JP2992540B2 (ja) 1999-12-20
DZ1878A1 (fr) 2002-02-17
ATE172203T1 (de) 1998-10-15
NZ285416A (en) 1997-07-27
DE69505296T2 (de) 1999-04-22
SI0680967T1 (en) 1999-02-28
EE03263B1 (et) 2000-04-17
HUT75698A (en) 1997-05-28
HU9904687D0 (en) 2000-03-28
AP9500744A0 (en) 1995-07-31
PL317071A1 (en) 1997-03-03
LU90872I2 (fr) 2002-03-12
TJ313B (en) 2001-08-06
TNSN95049A1 (fr) 1996-02-06
DE10299001I2 (de) 2012-07-05
YU49235B (sh) 2004-12-31
YU27095A (sh) 1998-05-15
FR2719587B1 (fr) 1996-07-12
FI964395A0 (fi) 1996-10-31
EP0680967B1 (fr) 1998-10-14
BG63087B1 (bg) 2001-03-30
IL113245A (en) 1999-11-30
WO1995029929A1 (fr) 1995-11-09
SK281707B6 (sk) 2001-07-10
TW341573B (en) 1998-10-01
CZ321496A3 (en) 1997-08-13
US6100404A (en) 2000-08-08
PL182034B1 (pl) 2001-10-31
CN1088709C (zh) 2002-08-07
OA10319A (fr) 1997-10-07
ZA953501B (en) 1996-05-02
DK0680967T3 (da) 1999-06-23
AP558A (en) 1996-11-07
US5635485A (en) 1997-06-03
FR2719587A1 (fr) 1995-11-10
NO2001027I1 (no) 2002-01-28
JPH11152296A (ja) 1999-06-08
SK140296A3 (en) 1998-04-08
HU219599B (hu) 2001-05-28
HU227493B1 (en) 2011-07-28
HU9603038D0 (en) 1997-01-28
JP2007045847A (ja) 2007-02-22
NL300077I1 (nl) 2002-03-01
MD1233B1 (en) 1999-05-31
AU684027B2 (en) 1997-11-27
MD1233C2 (ro) 2000-10-31
FI964395A (fi) 1996-10-31
FI111263B (fi) 2003-06-30
LV11739A (lv) 1997-04-20
JP4658902B2 (ja) 2011-03-23
MA23534A1 (fr) 1995-12-31
JP3998828B2 (ja) 2007-10-31
CN1151746A (zh) 1997-06-11
RO113350B1 (ro) 1998-06-30
EP0680967A1 (fr) 1995-11-08
MX9605208A (es) 1997-09-30
CN1052984C (zh) 2000-05-31
DE10299001I1 (de) 2012-07-05
LV11739B (en) 1997-08-20
NO308853B1 (no) 2000-11-06
JP2007269810A (ja) 2007-10-18
IL113245A0 (en) 1995-07-31
NO964654L (no) 1996-11-04

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