MD1233C2 - Derivaţi de eritromicină, procedeu de preparare a lor şi compoziţie farmaceutică pe baza acestora - Google Patents

Derivaţi de eritromicină, procedeu de preparare a lor şi compoziţie farmaceutică pe baza acestora Download PDF

Info

Publication number
MD1233C2
MD1233C2 MD97-0010A MD970010A MD1233C2 MD 1233 C2 MD1233 C2 MD 1233C2 MD 970010 A MD970010 A MD 970010A MD 1233 C2 MD1233 C2 MD 1233C2
Authority
MD
Moldova
Prior art keywords
preparation
base
pharmaceutical composition
erythromycin derivatives
erythromycin
Prior art date
Application number
MD97-0010A
Other languages
English (en)
Russian (ru)
Other versions
MD1233B1 (ro
Inventor
Constantin Agouridas
Jean-Francois Chantot
Alexis Denis
Solange Gouin D'ambrieres
Odile Le Martret
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD1233B1 publication Critical patent/MD1233B1/ro
Publication of MD1233C2 publication Critical patent/MD1233C2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Invenţia se referă la derivaţi de eritromicină utilizaţi ca medicamente în lupta cu infecţiile, în particular la antibiotice.Sunt revendicaţi derivaţi de eritromicină cu formula (I),în care R reprezintă un radical -(CH2)nAr, n fiind 3, 4 sau 5,Ar reprezintă un radical heterociclic, eventual substituit,Z reprezintă un atom de hidrogen sau restul unui acid,precum şi un procedeu de preparare şi compoziţie farmaceutică pe baza acestora.
MD97-0010A 1994-05-03 1995-05-02 Derivaţi de eritromicină, procedeu de preparare a lor şi compoziţie farmaceutică pe baza acestora MD1233C2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9405368A FR2719587B1 (fr) 1994-05-03 1994-05-03 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000565 WO1995029929A1 (fr) 1994-05-03 1995-05-02 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
MD1233B1 MD1233B1 (ro) 1999-05-31
MD1233C2 true MD1233C2 (ro) 2000-10-31

Family

ID=9462785

Family Applications (1)

Application Number Title Priority Date Filing Date
MD97-0010A MD1233C2 (ro) 1994-05-03 1995-05-02 Derivaţi de eritromicină, procedeu de preparare a lor şi compoziţie farmaceutică pe baza acestora

Country Status (42)

Country Link
US (2) US5635485A (ro)
EP (1) EP0680967B1 (ro)
JP (4) JP2992540B2 (ro)
KR (1) KR100312267B1 (ro)
CN (2) CN1052984C (ro)
AP (1) AP558A (ro)
AT (1) ATE172203T1 (ro)
AU (1) AU684027B2 (ro)
BG (1) BG63087B1 (ro)
BR (1) BR9507700A (ro)
CA (1) CA2189271C (ro)
CZ (1) CZ293455B6 (ro)
DE (2) DE10299001I2 (ro)
DK (1) DK0680967T3 (ro)
DZ (1) DZ1878A1 (ro)
EE (1) EE03263B1 (ro)
ES (1) ES2122472T3 (ro)
FI (1) FI111263B (ro)
FR (1) FR2719587B1 (ro)
GE (1) GEP19991538B (ro)
HU (2) HU219599B (ro)
IL (1) IL113245A (ro)
LU (1) LU90872I2 (ro)
LV (1) LV11739B (ro)
MA (1) MA23534A1 (ro)
MD (1) MD1233C2 (ro)
NL (1) NL300077I1 (ro)
NO (2) NO308853B1 (ro)
NZ (1) NZ285416A (ro)
OA (1) OA10319A (ro)
PL (1) PL182034B1 (ro)
RO (1) RO113350B1 (ro)
RU (1) RU2144036C1 (ro)
SI (1) SI0680967T1 (ro)
SK (1) SK281707B6 (ro)
TJ (1) TJ313B (ro)
TN (1) TNSN95049A1 (ro)
TW (1) TW341573B (ro)
UA (1) UA51618C2 (ro)
WO (1) WO1995029929A1 (ro)
YU (1) YU49235B (ro)
ZA (1) ZA953501B (ro)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001539A1 (en) * 1995-06-27 1997-01-16 Takeda Chemical Industries, Ltd. 4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
DE69733439T2 (de) * 1996-09-04 2006-05-04 Abbott Laboratories, Abbott Park 6-o-Substituierte Ketoliden mit antibakteriellen Wirkung
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
WO2000017218A1 (en) * 1998-09-22 2000-03-30 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TW526202B (en) * 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
ATE344269T1 (de) 1998-12-10 2006-11-15 Pfizer Prod Inc Carbamat und carbazat ketolid antibiotika
DK1147121T3 (da) * 1999-01-27 2004-04-13 Pfizer Prod Inc Ketolidantibiotika
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
AU775637B2 (en) 1999-04-16 2004-08-12 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6399582B1 (en) 1999-04-16 2002-06-04 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
EE200100613A (et) * 1999-05-24 2003-02-17 Pfizer Products Inc. 13-metüülerütromütsiini derivaadid
FR2797875B1 (fr) * 1999-08-26 2001-10-19 Hoechst Marion Roussel Inc Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
MXPA03001607A (es) * 2000-08-22 2003-06-04 Basilea Pharmaceutica Ag Nuevos macrolidos con actividad antibacteriana.
FR2821747B1 (fr) * 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques Suspension de telithromycine a gout masque
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
ES2325495T3 (es) 2002-07-08 2009-09-07 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas.
CN100577681C (zh) 2002-07-08 2010-01-06 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 用于治疗炎性疾病和病症的新化合物、组合物和方法
WO2004009059A1 (en) * 2002-07-19 2004-01-29 Aventis Pharma S.A. Taste masked oral composition of telithromycin
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
DE10305391A1 (de) * 2003-02-11 2004-08-19 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von Pyridin-substituierten Aminoketal-Derivaten
US6916934B2 (en) * 2003-02-11 2005-07-12 Aventis Pharma Deutschland Gmbh Process for preparing pyridine-substituted amino ketal derivatives
US7601695B2 (en) * 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
EP1618120A2 (en) * 2003-04-25 2006-01-25 Chiron Corporation Novel ketolide derivatives
US20050101548A1 (en) * 2003-09-12 2005-05-12 Xiaodong Lin Antimicrobial derivatives
GB0402578D0 (en) * 2004-02-05 2004-03-10 Cambridge Theranostics Ltd Methods of treatment of atherosclerosis
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
ATE373009T1 (de) * 2004-04-28 2007-09-15 Alembic Ltd Verfahren zur vorbereitung von telithromycin
WO2006080954A1 (en) * 2004-07-28 2006-08-03 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2006046112A2 (en) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
SI1836211T1 (sl) 2004-12-21 2010-04-30 Pfizer Prod Inc Makrolidi
JP4726890B2 (ja) * 2005-02-08 2011-07-20 株式会社村田製作所 表面実装型負特性サーミスタ
FR2882522B1 (fr) 2005-02-25 2007-04-13 Aventis Pharma Sa Composition pharmaceutique solide comprenant de la telithromycine
WO2006129257A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007039914A2 (en) * 2005-10-06 2007-04-12 Alembic Limited Novel polymorphs of telithromycin
WO2007049296A2 (en) * 2005-10-28 2007-05-03 Alembic Limited Amorphous form of telithromycin
US20070167382A1 (en) * 2005-11-15 2007-07-19 Nina Finkelstein Crystalline and amorphous forms of telithromycin
EP1960413A2 (en) * 2005-11-23 2008-08-27 Ranbaxy Laboratories Limited Macrolides derivatives as antibacterial agents
EP1954294A2 (en) * 2005-11-23 2008-08-13 Ranbaxy Laboratories Limited Use of macrolide derivatives for treating acne
WO2007060518A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
GB0600238D0 (en) * 2006-01-06 2006-02-15 Sandoz Ag Organic compounds
WO2007091393A1 (ja) * 2006-02-07 2007-08-16 Taisho Pharmaceutical Co., Ltd. １０ａ－アザライド化合物
CN101541331A (zh) 2006-08-24 2009-09-23 沃克哈特研究中心 具有抗微生物活性的新颖大环内酯和酮内酯
WO2008023383A1 (en) * 2006-08-25 2008-02-28 Alembic Limited Novel process for the preparation of telithromycin
ES2306590B1 (es) * 2006-12-15 2009-08-07 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.
JPWO2009019868A1 (ja) * 2007-08-06 2010-10-28 大正製薬株式会社 １０ａ、１２位架橋型１０ａ−アザライド化合物
US20090075917A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched telithromycin
US7926879B2 (en) 2007-09-20 2011-04-19 Herman Miller, Inc. Load support structure
WO2009053259A1 (en) * 2007-10-25 2009-04-30 Sandoz Ag Process for the production of telithromycin
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2009139181A1 (ja) 2008-05-15 2009-11-19 大正製薬株式会社 ４員環構造を有する１０ａ－アザライド化合物
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
EP2435460B1 (en) 2009-05-27 2015-01-07 Wockhardt Limited Ketolide compounds having antimicrobial activity
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
HRP20160168T1 (hr) 2010-03-22 2016-03-25 Cempra Pharmaceuticals Inc Kristalne forme makrolida i njihova uporaba
BR112012029586A2 (pt) 2010-05-20 2016-08-02 Cempra Pharmaceuticals Inc processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos
KR20130120458A (ko) * 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
RU2601550C2 (ru) 2010-12-09 2016-11-10 Вокхардт Лимитед Кетолидные соединения
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
CN103619849B (zh) 2011-03-01 2016-05-25 沃克哈特有限公司 酮内酯中间体的制备方法
EP2688900B1 (en) 2011-03-22 2016-09-28 Wockhardt Limited Process for preparation of ketolide compounds
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN105524132B (zh) * 2014-09-30 2019-07-02 中国医学科学院药物研究所 含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用
DE102015201783A1 (de) 2015-02-02 2016-08-04 Friedrich Baur Verfahren zur Herstellung eines Füllstoffs aus Textilfasern sowie Textil mit einem solchen Füllstoff
CN107129514B (zh) * 2016-03-02 2019-12-13 中国医学科学院药物研究所 红霉素a酮内酯类抗生素衍生物、其制备方法及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
IE810250L (en) * 1980-02-11 1981-08-11 Berlex Lab N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
US4434174A (en) * 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4568687A (en) * 1983-02-28 1986-02-04 American Cyanamid Company N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
ZA84949B (en) * 1983-04-06 1984-09-26 American Cyanamid Co Substituted-n-(2-4-(1h-imidazol-1-yl)alkyl)substituted amides
US4489089A (en) * 1983-04-06 1984-12-18 American Cyanamid Company Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides
AU573828B2 (en) * 1984-05-17 1988-06-23 E.R. Squibb & Sons, Inc. Tetrahydronaphthalenols
GB8425104D0 (en) * 1984-10-04 1984-11-07 Ici America Inc Amide derivatives
DE3540376A1 (de) * 1985-11-14 1987-05-21 Bayer Ag Verfahren zur inhibierung der wasserstoffinduzierten korrosion von metallischen werkstoffen
ATE106884T1 (de) * 1986-10-29 1994-06-15 Pfizer Verfahren zur herstellung von 2-(1-pentyl-3- guanidino)-4-(2-methyl-4-imidazolyl)thiazol und dessen kristallinisches dihydrochlorid-trihydrat.
DE3930669A1 (de) * 1989-09-14 1991-03-28 Basf Ag Verfahren zur herstellung von uretdiongruppen aufweisenden polyisocyanaten
JP2899028B2 (ja) * 1989-12-01 1999-06-02 協和醗酵工業株式会社 ジベンゾオキセピン誘導体
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
EP0559896B1 (en) * 1990-11-28 1997-08-27 Taisho Pharmaceutical Co. Ltd 6-o-methylerythromycin a derivative
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
TW370529B (en) * 1992-12-17 1999-09-21 Pfizer Pyrazolopyrimidines
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Tetrahedrom Letters, 1991,vol. 32, nr. 14, p.1699(1702 *

Also Published As

Publication number Publication date
JPH11152296A (ja) 1999-06-08
PL182034B1 (pl) 2001-10-31
ES2122472T3 (es) 1998-12-16
FI964395L (fi) 1996-10-31
EP0680967B1 (fr) 1998-10-14
FR2719587B1 (fr) 1996-07-12
JPH0853489A (ja) 1996-02-27
GEP19991538B (en) 1999-03-05
LV11739A (lv) 1997-04-20
CN1151746A (zh) 1997-06-11
ATE172203T1 (de) 1998-10-15
DE69505296T2 (de) 1999-04-22
LU90872I2 (fr) 2002-03-12
RO113350B1 (ro) 1998-06-30
HU227493B1 (en) 2011-07-28
HU9603038D0 (en) 1997-01-28
CN1088709C (zh) 2002-08-07
CZ321496A3 (en) 1997-08-13
AP9500744A0 (en) 1995-07-31
UA51618C2 (uk) 2002-12-16
FR2719587A1 (fr) 1995-11-10
DK0680967T3 (da) 1999-06-23
MA23534A1 (fr) 1995-12-31
ZA953501B (en) 1996-05-02
KR100312267B1 (ko) 2002-06-22
AP558A (en) 1996-11-07
DE10299001I1 (de) 2012-07-05
DZ1878A1 (fr) 2002-02-17
IL113245A0 (en) 1995-07-31
EE03263B1 (et) 2000-04-17
FI111263B (fi) 2003-06-30
NO2001027I1 (no) 2002-01-28
JP4750755B2 (ja) 2011-08-17
US6100404A (en) 2000-08-08
YU27095A (sh) 1998-05-15
IL113245A (en) 1999-11-30
TJ313B (en) 2001-08-06
LV11739B (en) 1997-08-20
SI0680967T1 (en) 1999-02-28
CZ293455B6 (cs) 2004-05-12
BR9507700A (pt) 1997-08-19
CA2189271A1 (fr) 1995-11-09
BG63087B1 (bg) 2001-03-30
MX9605208A (es) 1997-09-30
NO964654L (no) 1996-11-04
TW341573B (en) 1998-10-01
AU684027B2 (en) 1997-11-27
CA2189271C (fr) 2005-12-27
JP2007269810A (ja) 2007-10-18
DE10299001I2 (de) 2012-07-05
YU49235B (sh) 2004-12-31
NL300077I1 (nl) 2002-03-01
HU9904687D0 (en) 2000-03-28
HK1010732A1 (en) 1999-06-25
BG100951A (en) 1997-08-29
JP2992540B2 (ja) 1999-12-20
NO964654D0 (no) 1996-11-04
DE69505296D1 (de) 1998-11-19
FI964395A0 (fi) 1996-10-31
US5635485A (en) 1997-06-03
NZ285416A (en) 1997-07-27
WO1995029929A1 (fr) 1995-11-09
CN1052984C (zh) 2000-05-31
SK140296A3 (en) 1998-04-08
AU2449995A (en) 1995-11-29
HU219599B (hu) 2001-05-28
TNSN95049A1 (fr) 1996-02-06
SK281707B6 (sk) 2001-07-10
JP3998828B2 (ja) 2007-10-31
MD1233B1 (ro) 1999-05-31
JP4658902B2 (ja) 2011-03-23
RU2144036C1 (ru) 2000-01-10
CN1229082A (zh) 1999-09-22
OA10319A (fr) 1997-10-07
PL317071A1 (en) 1997-03-03
EP0680967A1 (fr) 1995-11-08
JP2007045847A (ja) 2007-02-22
NO308853B1 (no) 2000-11-06
HUT75698A (en) 1997-05-28

Similar Documents

Publication Publication Date Title
MD1233B1 (ro) Derivati de eritromicina, procedeu de preparare a lor si compozitie farmaceu-tica pe baza acestora
AU4869690A (en) Pyrazolopyridine compound and processes for preparation thereof
MX9803954A (es) Derivados de aminoacidos, composiciones farmaceuticas que contienen estos compuestos y procesos para prepararlos.
BG103268A (en) Propionic acid derivatives and their application
AU6194994A (en) Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
IL108382A0 (en) Amino acid derivatives, their preparation and pharmaceutical compositions containing them
MY121908A (en) 3-amidopyrazole derivatives, process for preparing these and pharmaceutical compositions containing them.
AU6194694A (en) Nor-bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
AU6194794A (en) Tetrazole derivatives of bile acids, processes for their preparation and the use of these compounds as medicaments
IL123293A (en) Piperidine derivatives, their preparation and pharmaceutical compositions containing them
IL94433A0 (en) Aminophenol derivatives,their preparation and pharmaceutical compositions containing them
BG103947A (en) Derivatives of 9-oxymerythromycin
EP0279149A3 (en) Benzimidazole derivatives, process for their production and a pharmaceutical composition containing the same
MY115211A (en) Novel amino acid derivatives, their preparation and use
HUT52040A (en) Process for producing diaryl-derivatives and pharmaceutical compositions containing them
NO971625L (no) Nye peptider med immunomodulatoriske effekter
MY105538A (en) Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them.
AU7414691A (en) New 3-aminochroman derivatives, process for preparing these and pharmaceutical compositions containing them
CA2263846A1 (en) Novel pyranoside derivatives
ES2001389A6 (es) Procedimiento para preparar derivados de o-toluidina
NZ510116A (en) Tricyclic delta-3-piperidines as pharmaceuticals
AU2067592A (en) New n-(isoquinolin-5-ylsulphonyl)azacycloalkanes, process for the preparation thereof, and pharmaceutical compositions containing them
IL134194A0 (en) Streptogramines, their preparation and compositions containing them
NO174963C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 8-fluorantracyklinglucosider
GR3021467T3 (en) New peptide derivates active in the process of cell adhesion, a method to prepare them end pharmaceutical compositions containing them.

Legal Events

Date Code Title Description
MK4A Patent for invention expired