ES2054684T3 - Procedimientos para la preparacion de 2-(1-pentil-3-guanidino)-4-(2-metil-4-imidazolil) tiazol y el dihidrocloruro trihidratado cristalino del mismo. - Google Patents

Procedimientos para la preparacion de 2-(1-pentil-3-guanidino)-4-(2-metil-4-imidazolil) tiazol y el dihidrocloruro trihidratado cristalino del mismo.

Info

Publication number
ES2054684T3
ES2054684T3 ES87309159T ES87309159T ES2054684T3 ES 2054684 T3 ES2054684 T3 ES 2054684T3 ES 87309159 T ES87309159 T ES 87309159T ES 87309159 T ES87309159 T ES 87309159T ES 2054684 T3 ES2054684 T3 ES 2054684T3
Authority
ES
Spain
Prior art keywords
imidazolyl
methyl
preparation
pentil
guanidino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87309159T
Other languages
English (en)
Inventor
Douglas John Meldrum Allen
William Michael Snyder
Berkeley Wendell Cue Jr
Stanley Walter Walinsky
Paul David Hill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1986/002307 external-priority patent/WO1988003140A1/en
Priority claimed from PCT/US1986/002308 external-priority patent/WO1988003141A1/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2054684T3 publication Critical patent/ES2054684T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/28—Y being a hetero atom, e.g. thiobiuret

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN COMPUESTO DE FORMULA (I) EN LA QUE X ES EL GRUPO (II) O (III); R ES BENCILO O ALQUILO DE 1 A 5 C Y R1 ES UN GRUPO ALQUILO DE 1 A 5; QUE COMPRENDE CALENTAR UN COMPUESTO DE FORMULA (IV), EN FORMA DE UNA SAL DE ADICION DE ACIDO, O EN PRESENCIA DE UN CATALIZADOR ACIDO, CON POR LO MENOS UN EQUIVALENTE MOLAR DE UNA AMINA R-NH2, BIEN PURA O EN UN DISOLVENTE INERTE. TAMBIEN SE REFIERE LA INVENCION AL DIHIDROCLORURO TRIHIDRATO CRATALINO DE 2-(1-PENTIL-3- GUANIDINO)-4(2-METIL-4-IMIDAZOLIL) TIAZOL, PREPARADO POR EL PROCEDIMIENTO INDICADO.
ES87309159T 1986-10-29 1987-10-16 Procedimientos para la preparacion de 2-(1-pentil-3-guanidino)-4-(2-metil-4-imidazolil) tiazol y el dihidrocloruro trihidratado cristalino del mismo. Expired - Lifetime ES2054684T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1986/002307 WO1988003140A1 (en) 1986-10-29 1986-10-29 Crystalline 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole dihydrochloride trihydrate
PCT/US1986/002308 WO1988003141A1 (en) 1986-10-29 1986-10-29 Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and analogs

Publications (1)

Publication Number Publication Date
ES2054684T3 true ES2054684T3 (es) 1994-08-16

Family

ID=26774088

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87309159T Expired - Lifetime ES2054684T3 (es) 1986-10-29 1987-10-16 Procedimientos para la preparacion de 2-(1-pentil-3-guanidino)-4-(2-metil-4-imidazolil) tiazol y el dihidrocloruro trihidratado cristalino del mismo.

Country Status (14)

Country Link
EP (1) EP0269239B1 (es)
KR (1) KR900002343B1 (es)
CN (1) CN1022567C (es)
AT (1) ATE106884T1 (es)
DE (1) DE3750023T2 (es)
DK (1) DK565187A (es)
EG (1) EG18271A (es)
ES (1) ES2054684T3 (es)
IE (1) IE872897L (es)
IL (1) IL84301A (es)
NZ (1) NZ222306A (es)
PL (1) PL149549B1 (es)
PT (1) PT86011B (es)
YU (1) YU46081B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002127A1 (en) * 1988-08-30 1990-03-08 Pfizer Inc. Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino-4-imidazolyl)thiazole
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
CN100384237C (zh) * 2004-02-28 2008-04-23 鸿富锦精密工业（深圳）有限公司 音量调整装置及方法
CN100517961C (zh) * 2004-04-03 2009-07-22 鸿富锦精密工业（深圳）有限公司 音量调整装置及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US391473A (en) * 1888-10-23 Feedeeick j
US3798269A (en) * 1968-08-05 1974-03-19 R Cutler Amidinoureas and amidinothioureas
US4374843A (en) * 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
US4435396A (en) * 1982-05-10 1984-03-06 Pfizer Inc. Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents

Also Published As

Publication number Publication date
CN87107492A (zh) 1988-05-11
KR900002343B1 (ko) 1990-04-12
KR880005124A (ko) 1988-06-28
PL268454A1 (en) 1988-09-01
ATE106884T1 (de) 1994-06-15
EP0269239B1 (en) 1994-06-08
PT86011A (en) 1987-11-01
DE3750023D1 (de) 1994-07-14
DK565187A (da) 1988-04-30
NZ222306A (en) 1989-09-27
EG18271A (en) 1992-12-30
CN1022567C (zh) 1993-10-27
YU195787A (en) 1988-12-31
YU46081B (sh) 1992-12-21
DK565187D0 (da) 1987-10-28
IE872897L (en) 1988-04-29
DE3750023T2 (de) 1994-09-29
EP0269239A3 (en) 1990-03-28
PT86011B (pt) 1990-08-31
EP0269239A2 (en) 1988-06-01
IL84301A (en) 1992-08-18
PL149549B1 (en) 1990-02-28

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