YU46081B - Postupak za dobijanje derivata gvanidina - Google Patents

Postupak za dobijanje derivata gvanidina

Info

Publication number
YU46081B
YU46081B YU195787A YU195787A YU46081B YU 46081 B YU46081 B YU 46081B YU 195787 A YU195787 A YU 195787A YU 195787 A YU195787 A YU 195787A YU 46081 B YU46081 B YU 46081B
Authority
YU
Yugoslavia
Prior art keywords
formula
procedure
guanidine derivatives
chem
alkyl
Prior art date
Application number
YU195787A
Other languages
English (en)
Other versions
YU195787A (en
Inventor
J.M.A. Douglas
W.C. Berkeley
P. Da Vid Hill
W.M. Snyder
S.W. Walinsky
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1986/002307 external-priority patent/WO1988003140A1/en
Priority claimed from PCT/US1986/002308 external-priority patent/WO1988003141A1/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU195787A publication Critical patent/YU195787A/xx
Publication of YU46081B publication Critical patent/YU46081B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/28—Y being a hetero atom, e.g. thiobiuret

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

POSTUPAK ZA DOBIJANJE DERIVATA GVANIDINA, formule ili njegove farmaceutski prihvatljive kisele adicione soli u kojoj je R2 ili R je benzil ili (C1-C5)alkil a R1 je (C1-C5)alkil, naznačen time, što se zagreva jedinjenje formule: ili njegova kisela adiciona so i kiselinski katalizator, sa najmanje jednim molarnim ekvivalentom amina formule RNH2 u kojoj je R prethodno definisano, bez rastvarača ili u reakciono-inertnom rastvaraču, na temperaturi od 50 -150В° C, najpogodnije 95 -115В° C. Prijava sadrži još 1 zavisan zahtev.
YU195787A 1986-10-29 1987-10-26 Postupak za dobijanje derivata gvanidina YU46081B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1986/002307 WO1988003140A1 (en) 1986-10-29 1986-10-29 Crystalline 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole dihydrochloride trihydrate
PCT/US1986/002308 WO1988003141A1 (en) 1986-10-29 1986-10-29 Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and analogs

Publications (2)

Publication Number Publication Date
YU195787A YU195787A (en) 1988-12-31
YU46081B true YU46081B (sh) 1992-12-21

Family

ID=26774088

Family Applications (1)

Application Number Title Priority Date Filing Date
YU195787A YU46081B (sh) 1986-10-29 1987-10-26 Postupak za dobijanje derivata gvanidina

Country Status (14)

Country Link
EP (1) EP0269239B1 (sh)
KR (1) KR900002343B1 (sh)
CN (1) CN1022567C (sh)
AT (1) ATE106884T1 (sh)
DE (1) DE3750023T2 (sh)
DK (1) DK565187A (sh)
EG (1) EG18271A (sh)
ES (1) ES2054684T3 (sh)
IE (1) IE872897L (sh)
IL (1) IL84301A (sh)
NZ (1) NZ222306A (sh)
PL (1) PL149549B1 (sh)
PT (1) PT86011B (sh)
YU (1) YU46081B (sh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002127A1 (en) * 1988-08-30 1990-03-08 Pfizer Inc. Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino-4-imidazolyl)thiazole
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
CN100384237C (zh) * 2004-02-28 2008-04-23 鸿富锦精密工业（深圳）有限公司 音量调整装置及方法
CN100517961C (zh) * 2004-04-03 2009-07-22 鸿富锦精密工业（深圳）有限公司 音量调整装置及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US391473A (en) * 1888-10-23 Feedeeick j
US3798269A (en) * 1968-08-05 1974-03-19 R Cutler Amidinoureas and amidinothioureas
US4374843A (en) * 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
US4435396A (en) * 1982-05-10 1984-03-06 Pfizer Inc. Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents

Also Published As

Publication number Publication date
PT86011B (pt) 1990-08-31
IE872897L (en) 1988-04-29
EP0269239B1 (en) 1994-06-08
DK565187D0 (da) 1987-10-28
CN87107492A (zh) 1988-05-11
DE3750023T2 (de) 1994-09-29
IL84301A (en) 1992-08-18
EG18271A (en) 1992-12-30
ES2054684T3 (es) 1994-08-16
KR880005124A (ko) 1988-06-28
CN1022567C (zh) 1993-10-27
DE3750023D1 (de) 1994-07-14
DK565187A (da) 1988-04-30
YU195787A (en) 1988-12-31
ATE106884T1 (de) 1994-06-15
KR900002343B1 (ko) 1990-04-12
EP0269239A3 (en) 1990-03-28
EP0269239A2 (en) 1988-06-01
PL149549B1 (en) 1990-02-28
NZ222306A (en) 1989-09-27
PL268454A1 (en) 1988-09-01
PT86011A (en) 1987-11-01

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