BE1003105A5 - Compositions pharmaceutiques a base de cyclosporines. - Google Patents

Compositions pharmaceutiques a base de cyclosporines. Download PDF

Info

Publication number
BE1003105A5
BE1003105A5 BE8900979A BE8900979A BE1003105A5 BE 1003105 A5 BE1003105 A5 BE 1003105A5 BE 8900979 A BE8900979 A BE 8900979A BE 8900979 A BE8900979 A BE 8900979A BE 1003105 A5 BE1003105 A5 BE 1003105A5
Authority
BE
Belgium
Prior art keywords
pharmaceutical compositions
cyclosporins
compositions based
compositions
micro
Prior art date
Application number
BE8900979A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27264085&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE1003105(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB888821754A external-priority patent/GB8821754D0/en
Priority claimed from GB898902903A external-priority patent/GB8902903D0/en
Priority claimed from GB898902900A external-priority patent/GB8902900D0/en
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1003105A5 publication Critical patent/BE1003105A5/fr

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention a pour objet des compositions pharmaceutiques comprenant une cyclosporine sous forme d'un "pré-concentré de micro-émulsion" ou de micro-émulsion. Les compositions contiennent typiquement comme composant hydrophile, (1.1) un di-éther ou éther partiel alkylique en C1-C5 ou tétrahydrofurfurylique d'un mono- ou poly-oxy-alcanediol à faible poids moléculaire. Les compositions comprennent également une cyclosporine et un composant (1.1) et également un monoester d'un saccharide, par exemple le mono-laurate de raffinose ou de saccharose.
BE8900979A 1988-09-16 1989-09-14 Compositions pharmaceutiques a base de cyclosporines. BE1003105A5 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888821754A GB8821754D0 (en) 1988-09-16 1988-09-16 Improvements in/relating to organic compounds
GB898902903A GB8902903D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds
GB898902900A GB8902900D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
BE1003105A5 true BE1003105A5 (fr) 1991-11-26

Family

ID=27264085

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8900979A BE1003105A5 (fr) 1988-09-16 1989-09-14 Compositions pharmaceutiques a base de cyclosporines.

Country Status (32)

Country Link
US (7) US5741512A (fr)
JP (1) JPH0725690B2 (fr)
KR (3) KR0148748B1 (fr)
AT (1) AT403435B (fr)
AU (1) AU627220B2 (fr)
BE (1) BE1003105A5 (fr)
BG (1) BG60525B2 (fr)
CA (1) CA1332150C (fr)
CH (1) CH679118A5 (fr)
DE (1) DE3930928C2 (fr)
DK (1) DK171433B1 (fr)
ES (1) ES2020738A6 (fr)
FI (1) FI98046C (fr)
FR (1) FR2636534B1 (fr)
GB (1) GB2222770B (fr)
GR (1) GR1000456B (fr)
HK (1) HK86593A (fr)
HU (1) HU211685A9 (fr)
ID (1) ID17863A (fr)
IE (1) IE60764B1 (fr)
IL (1) IL91642A (fr)
IT (1) IT1232243B (fr)
LU (1) LU87586A1 (fr)
LV (1) LV5749B4 (fr)
MY (1) MY107381A (fr)
NL (1) NL194781C (fr)
NO (1) NO180362C (fr)
NZ (1) NZ230660A (fr)
PH (1) PH31059A (fr)
PT (1) PT91731B (fr)
SE (2) SE8903042L (fr)
SG (1) SG50793G (fr)

Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GR1000466B (el) * 1989-01-28 1992-07-30 Sandoz Ag Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης.
GB2230440B (en) * 1989-02-09 1993-05-19 Sandoz Ltd Novel cyclosporin galenic forms
US7081445B2 (en) * 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
ATE183099T1 (de) * 1991-04-19 1999-08-15 Lds Technologies Inc Konvertierbare mikroemulsionsverbindungen
IL102236A0 (en) * 1991-06-27 1993-01-14 Ltt Inst Co Ltd Topical preparations containing cyclosporin
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
AU688920B2 (en) * 1991-06-27 1998-03-19 Novartis Ag Transesterified corn oil products
GB9208712D0 (en) * 1992-04-22 1992-06-10 Sandoz Ltd Pharmaceutical compositions containing cyclosporin derivates
EP0642332B1 (fr) 1992-05-13 1997-01-15 Sandoz Ltd. Compositions ophtalmiques contenant une cyclosporine
PT589843E (pt) * 1992-09-25 2002-04-29 Novartis Ag Composicoes farmaceuticas contendo ciclosporinas
SK283442B6 (sk) 1993-04-20 2003-07-01 Novartis Ag Farmaceutický prípravok na orálne podanie
NZ247516A (en) * 1993-04-28 1995-02-24 Bernard Charles Sherman Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
GB2278780B (en) * 1993-05-27 1998-10-14 Sandoz Ltd Macrolide formulations
DE4447972B4 (de) * 1993-05-27 2007-12-27 Novartis Ag Galenische Formulierungen
CH686761A5 (de) * 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
AT408520B (de) * 1993-05-27 2001-12-27 Novartis Erfind Verwalt Gmbh Galenische formulierungen
DE4322826A1 (de) * 1993-07-08 1995-01-12 Galenik Labor Freiburg Gmbh Pharmazeutisches Präparat
GB2281697A (en) * 1993-09-14 1995-03-15 Euro Celtique Sa Laxative compositions in capsules
ES2152281T3 (es) * 1993-09-28 2001-02-01 Scherer Gmbh R P Fabricacion de capsulas de gelatina blanda.
GB2315216B (en) * 1993-10-05 1998-10-14 Ciba Geigy Ag Microemulsion preconcentrates comprising FK506 or 33-epi-chloro-33-desoxy-ascomycin
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
US5447729A (en) * 1994-04-07 1995-09-05 Pharmavene, Inc. Multilamellar drug delivery systems
US5474979A (en) * 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
FI100692B (fi) * 1994-05-24 1998-02-13 Leiras Oy Menetelmä farmaseuttisten koostumusten valmistamiseksi, jolloin koostu mukset pohjautuvat mikroemulsiogeeleihin sekä uusia mikroemulsioihin p ohjautuvia geelejä
GB2308545B (en) * 1994-10-26 1999-06-02 Novartis Ag Pharmaceutical microemulsion preconcentrates
IL129547A (en) * 1994-10-26 2001-01-11 Novartis Ag Pharmaceutical compositions comprising a macrolide and an acid
SK164796A3 (en) 1994-11-03 1997-06-04 Dresden Arzneimittel Novel cyclosporine preparation forms for oral administration of and process for producing them
US5603951A (en) * 1994-11-09 1997-02-18 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin-containing soft capsule compositions
HU215966B (hu) * 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
KR0167613B1 (ko) * 1994-12-28 1999-01-15 한스 루돌프 하우스, 니콜 케르커 사이클로스포린-함유 연질캅셀제 조성물
WO1996036316A1 (fr) * 1995-05-19 1996-11-21 Abbott Laboratories Formulations auto-emulsifiantes de medicaments lipophiles
US6696413B2 (en) * 1995-06-16 2004-02-24 Hexal Ag Pharmaceutical preparation with cyclosporin A
EP0760237A1 (fr) * 1995-08-30 1997-03-05 Cipla Limited Microémulsions huile-dans-l'eau
DE19549852B4 (de) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin enthaltende Präparate
NZ280689A (en) * 1995-12-15 1997-08-22 Bernard Charles Sherma Sherman Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
CZ288631B6 (cs) * 1996-01-18 2001-08-15 Galena, A. S. Léčivé přípravky s obsahem cyklosporinu
GB9601120D0 (en) 1996-01-19 1996-03-20 Sandoz Ltd Organic compounds
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
US6245349B1 (en) * 1996-02-23 2001-06-12 éLAN CORPORATION PLC Drug delivery compositions suitable for intravenous injection
KR970064620A (ko) * 1996-03-05 1997-10-13 임성기 사이클로스포린-함유 외용약제 조성물
SE511313C2 (sv) 1997-01-13 1999-09-06 Gs Dev Ab Komposition med reglerad frisättning innefattande fettsyraester av diacylglycerol
EP0988046B1 (fr) 1997-01-30 2004-09-15 Novartis AG Compositions pharmaceutiques exemptes d'huile, a base de cyclosporine a
US6426078B1 (en) 1997-03-17 2002-07-30 Roche Vitamins Inc. Oil in water microemulsion
SI0999838T1 (en) * 1997-07-29 2002-08-31 Pharmacia & Upjohn Company Self-emulsifying formulation for lipophilic compounds
CN1112927C (zh) 1997-07-29 2003-07-02 法玛西雅厄普约翰美国公司 自体乳化剂形式的酸性亲脂性化合物的药物组合物
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
US6346511B1 (en) 1997-09-08 2002-02-12 Panacea Biotec Limited Pharmaceutical composition comprising cyclosporin
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
NZ502362A (en) 1997-10-08 2001-05-25 Isotechnika Inc Deuterated cyclosporine A derivatives and their use as immunomodulating agents
AU1509799A (en) * 1997-12-05 1999-06-28 Chong Kun Dang Corporation Pharmaceutical composition containing cyclosporin
US6063762A (en) * 1997-12-05 2000-05-16 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
ID25908A (id) * 1998-03-06 2000-11-09 Novartis Ag Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida
GB2380673B (en) * 1998-03-06 2003-05-28 Novartis Ag Emulsion preconcentrates containing cyclosporin or a macrolide
CA2335903C (fr) 1998-07-01 2009-11-10 Debiopharm S.A. Nouvelle cyclosporine ayant un profil d'activite ameliore
DE69828962D1 (de) * 1998-07-30 2005-03-17 St Microelectronics Srl Verfahren zur Herstellung eines Aktuators für eine Festplattenvorrichtung, mit einem Lese-/Schreibkopf, einem Microaktuator und einer Aufhängung und die so erhaltene Aktuatorvorrichtung
ES2215277T3 (es) * 1998-08-18 2004-10-01 Panacea Biotec Limited Composicion de ciclosporina que comprende un vehiculo hidrofilo.
SE9804192D0 (sv) * 1998-12-03 1998-12-03 Scotia Lipidteknik Ab New formulation
GB2344520A (en) * 1998-12-08 2000-06-14 Phares Pharm Res Nv Pharmaceutical carriers comprising lipids and polymers
EP1135150B1 (fr) * 1998-12-11 2012-10-17 Tris Pharma, Inc. Compositions auto-emulsifiantes pour medicaments peu solubles dans l'eau
CA2358448C (fr) * 1998-12-30 2009-02-10 Dexcel Ltd. Concentre dispersable destine a l'administration d'une cyclosporine
GB9903547D0 (en) * 1999-02-16 1999-04-07 Novartis Ag Organic compounds
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6057289A (en) * 1999-04-30 2000-05-02 Pharmasolutions, Inc. Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system
GB9912476D0 (en) 1999-05-28 1999-07-28 Novartis Ag Organic compounds
DE19925001A1 (de) * 1999-05-31 2000-12-07 Pharma Concepts Gmbh & Co Kg Flüssiges Konzentrat
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
GB2355656B (en) * 1999-08-17 2004-04-07 Galena As Pharmaceutical compositions for oral and topical administration
JP2001122779A (ja) * 1999-10-26 2001-05-08 Toyo Capsule Kk 経口投与用シクロスポリン含有ミクロエマルジョン濃縮液
WO2001032142A1 (fr) * 1999-11-02 2001-05-10 Cipla Limited Formulation de cyclosporine
GB2362573A (en) * 2000-05-25 2001-11-28 Cipla Ltd Cyclosporin formulation
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US7919113B2 (en) * 1999-12-30 2011-04-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Dispersible concentrate lipospheres for delivery of active agents
EP1257192A1 (fr) 2000-02-18 2002-11-20 Argose, Inc. Generation de cartes d'excitation-emission spatialement moyennees dans des tissus heterogenes
GB0008785D0 (en) 2000-04-10 2000-05-31 Novartis Ag Organic compounds
DE10029404B4 (de) * 2000-06-15 2009-10-29 Jagotec Ag Arzneiformulierung enthaltend Ciclosporin und deren Verwendung
US6623765B1 (en) * 2000-08-01 2003-09-23 University Of Florida, Research Foundation, Incorporated Microemulsion and micelle systems for solubilizing drugs
SI1333851T1 (sl) * 2000-09-18 2008-02-29 Rpg Life Sciences Ltd Sestavek, ki sam po sebi tvori emulzijo, z izboljsanimi bioabsobcijskimi in imunosupresijskimi aktivnostmi
US6960563B2 (en) * 2001-08-31 2005-11-01 Morton Grove Pharmaceuticals, Inc. Spontaneous emulsions containing cyclosporine
JP4261355B2 (ja) * 2001-10-19 2009-04-30 アイソテクニカ インコーポレイテッド シクロスポリン類似体の合成法
DK1435910T3 (da) * 2001-10-19 2009-11-09 Isotechnika Inc Nye cyclosporinanaloge mikroemulsionsprækoncentrater
HUP0402318A3 (en) 2001-12-14 2012-09-28 Jagotec Ag Pharmaceutical composition comprising cyclosporin and use thereof
CA2471241A1 (fr) * 2001-12-20 2003-07-03 Bernard Charles Sherman Compositions pharmaceutiques comprenant une cyclosporine, un tensioactif hydrophile et un tensioactif lipophile
ATE374602T1 (de) * 2001-12-21 2007-10-15 Supernus Pharmaceuticals Inc Orale kapselformulierung mit verbesserter physikalischer stabilität
KR100441167B1 (ko) * 2001-12-27 2004-07-21 씨제이 주식회사 마이크로에멀젼 예비 농축액 조성물
US20040005339A1 (en) * 2002-06-28 2004-01-08 Shojaei Amir H. Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability
KR20040047056A (ko) * 2002-11-29 2004-06-05 한미약품 주식회사 비페닐디메틸디카복실레이트의 경구용 마이크로에멀젼조성물
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
KR100525234B1 (ko) * 2003-02-19 2005-10-28 한국유나이티드제약 주식회사 사이클로스포린 함유 연질캅셀제 및 그 제조방법
US20050196370A1 (en) * 2003-03-18 2005-09-08 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
US7181219B2 (en) 2003-05-22 2007-02-20 Lucent Technologies Inc. Wireless handover using anchor termination
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
EP1689390B1 (fr) 2003-11-21 2011-02-09 Zalicus Inc. Procedes et reactifs destines au traitement de troubles inflammatoires
PE20050596A1 (es) * 2003-12-19 2005-10-18 Novartis Ag Microemulsion que comprende un inhibidor renina
IL159729A0 (en) * 2004-01-06 2004-06-20 Doron I Friedman Non-aqueous composition for oral delivery of insoluble bioactive agents
US20050152968A1 (en) * 2004-01-09 2005-07-14 Brophy Kristine M. Microemulsions for pharmaceutical compositions
JPWO2005089716A1 (ja) * 2004-03-24 2008-01-31 武田薬品工業株式会社 高含量化製剤
CA2562388A1 (fr) * 2004-03-24 2005-09-29 Takeda Pharmaceutical Company Limited Preparation a base d'une emulsion stabilisee
CN101065139A (zh) * 2004-10-09 2007-10-31 扶瑞药业股份有限公司 眼用药剂递送系统
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US7151085B2 (en) * 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
EP1848541A4 (fr) * 2005-02-07 2013-01-16 Pharmalight Inc Procede et dispositif d'administration ophtalmique d'ingredients pharmaceutiquement actifs
GB0504950D0 (en) 2005-03-10 2005-04-20 Novartis Ag Organic compositions
KR20080033274A (ko) 2005-06-17 2008-04-16 노파르티스 아게 Hcv에서 상글리페린의 용도
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) * 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) * 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
GT200600411A (es) * 2005-09-13 2007-05-21 Novartis Ag Combinaciones que comprenden un inhibidor del receptor del factor de crecimiento endotelial vascular
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
JP2009514969A (ja) 2005-11-09 2009-04-09 コンビナトアールエックス インコーポレーティッド 医学的状態を治療するための方法、組成物、およびキット
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US10137083B2 (en) * 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
EP2001439A2 (fr) * 2006-03-07 2008-12-17 Novavax, Inc. Emulsions nano-structurees des agents actifs mauvais soluble et leurs procedes de fabrication
US20070221693A1 (en) * 2006-03-24 2007-09-27 Moore Howard L Multi-purpose insulating and protective cover for containers
ITMI20060618A1 (it) * 2006-03-31 2007-10-01 Enitecnologie Spa Procedimento per la preparazione di nanoemulsioni acqua ion olio e olio in acqua
BRPI0710878A2 (pt) 2006-04-11 2015-03-31 Novartis Ag Compostos orgânicos e seus usos
US20080161248A1 (en) * 2006-12-28 2008-07-03 Wendye Robbins Methods and Compositions for Therapeutic Treatment
CA2674296C (fr) 2007-01-04 2015-11-24 Debiopharm Sa Cyclosporine non immunosuppressive pour le traitement de la dystrophie musculaire congenitale d'ullrich
JP5553747B2 (ja) 2007-04-04 2014-07-16 シグモイド・ファーマ・リミテッド シクロスポリン医薬組成物
US8951570B2 (en) 2007-04-26 2015-02-10 Sigmoid Pharma Limited Manufacture of multiple minicapsules
JP2011504871A (ja) * 2007-06-01 2011-02-17 ノボ・ノルデイスク・エー/エス 固体又は半固体担体中にペプチド薬剤を含む自然に分散可能なプレコンセントレイト
WO2009018338A2 (fr) * 2007-07-31 2009-02-05 Limerick Biopharma, Inc. Analogues de pyrone phosphorylés et procédés
GB2451811A (en) 2007-08-09 2009-02-18 Ems Sa Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
CA3014633C (fr) * 2007-10-08 2022-05-17 Aurinia Pharmaceuticals Inc. Compositions ophtalmiques comprenant des inhibiteurs de la calcineurine ou des inhibiteurs de mtor
BRPI0705564B8 (pt) * 2007-10-10 2021-05-25 Embrapa Pesquisa Agropecuaria sistema do tipo cristal líquido contínuo contendo co-solvente portador de substâncias fracamente solúveis em água, seu processo de obtenção e seus usos
TW200932240A (en) * 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
WO2009106574A2 (fr) * 2008-02-28 2009-09-03 Novartis Ag Combinaisons pour traiter la douleur associée au vih
US8861813B2 (en) * 2008-03-13 2014-10-14 Mallinckrodt Llc Multi-function, foot-activated controller for imaging system
DE102008015299A1 (de) 2008-03-18 2009-09-24 Pkh Gmbh Halle Kolloidales Trägersystem
KR20110004366A (ko) 2008-03-18 2011-01-13 노보 노르디스크 에이/에스 프로테아제 안정화되고, 아실화된 인슐린 유사체
US11304960B2 (en) * 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
AU2010203609A1 (en) * 2009-01-08 2011-07-21 Allergan, Inc. Compositions for enhancing nail growth
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
PL2471518T3 (pl) 2009-05-18 2018-01-31 Sigmoid Pharma Ltd Kompozycja zawierająca kropelki oleju
WO2010144194A1 (fr) * 2009-06-09 2010-12-16 Lux Biosciences, Inc. Systèmes d'administration de médicament topique pour une utilisation ophtalmique
CA2770570A1 (fr) 2009-08-12 2011-02-17 Sigmoid Pharma Limited Compositions immunomodulatrices comprenant une matrice polymere et une phase huileuse
EP2308468A1 (fr) 2009-10-08 2011-04-13 Novaliq GmbH Nouvelle composition pharmaceutique comportant un médicament contre l'immunosuppression macrolide
US8324239B2 (en) 2010-04-21 2012-12-04 Novartis Ag Furopyridine compounds and uses thereof
US20120077778A1 (en) * 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP2624826B1 (fr) 2010-10-08 2018-07-18 Novartis AG Compositions comprenant de la vitamine e et des sulfamides inhibiteurs du ns3
GB201020032D0 (en) * 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
JO3337B1 (ar) * 2010-12-13 2019-03-13 Debiopharm Sa تركيبات صيدلية تشمل أليسبوريفير
FR2971941B1 (fr) 2011-02-24 2013-08-02 Physica Pharma Compositions pharmaceutiques administrables par voie cutanee et destinees au traitement local de la dermatite atopique canine
KR101510764B1 (ko) * 2011-10-10 2015-04-10 김용남 사이클로스포린 함유 안약 조성물 및 그 제조방법
MX2014012096A (es) 2012-04-11 2014-11-21 Novo Nordisk As Formulaciones de insulina.
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
WO2014134427A1 (fr) * 2013-02-28 2014-09-04 Precision Dermatology, Inc. Régulation de la biodisponibilité d'ingrédients actifs dans des formulations topiques
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
SI3215127T1 (sl) 2014-11-07 2021-03-31 Sublimity Therapeutics Limited DCU Alpha Innovation Campus Sestavki, obsegajoči ciklosporin
EP3187172A1 (fr) * 2016-01-04 2017-07-05 Spherium Biomed S.L. Compositions topiques de cyclosporine a
CA3078723A1 (fr) 2016-11-28 2018-05-31 Nachiappan Chidambaram Traitement oral a base d'undecanoate de testosterone
US20180169190A1 (en) 2016-12-16 2018-06-21 Novo Nordisk A/S Insulin containing pharmaceutical compositions
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
WO2019002362A1 (fr) * 2017-06-28 2019-01-03 Spherium Biomed, S.L. Compositions topiques de cyclosporine a
KR102146704B1 (ko) 2018-04-13 2020-08-21 가천대학교 산학협력단 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체
SI3886813T1 (sl) * 2018-11-26 2023-05-31 Hepion Pharmaceuticals, Inc. Farmacevtske formulacije analogov ciklosporina

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4388307A (en) * 1978-03-07 1983-06-14 Sandoz Ltd. Galenical compositions

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH246178A (de) * 1942-01-28 1946-12-15 Reichstein Tadeus Dr Prof Verfahren zur Herstellung einer neuen Verbindung der Cyclopentano-polyhydrophenanthrenreihe.
FR1274354A (fr) * 1956-03-10 1961-10-27 Agents tensio-actifs obtenus à partir de triglycérides et polyéthylène glycol
GB1171125A (en) * 1966-06-08 1969-11-19 Glaxo Lab Ltd Improvements in or relating to Injectable Preparations
JPS5114746B1 (fr) * 1970-12-31 1976-05-12
US3954967A (en) * 1971-08-05 1976-05-04 Vanguard Chemical Company, Inc. Method of producing microcolloidal aqueous emulsions of unsaturated organic insecticidal compounds
US3813345A (en) * 1971-08-05 1974-05-28 Vanguard Chem Co Inc Method of producing microcolloidal aqueous emulsions of unsaturated organic compounds
US4073943A (en) * 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US4146499A (en) * 1976-09-18 1979-03-27 Rosano Henri L Method for preparing microemulsions
JPS53107408A (en) * 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
CH636013A5 (en) * 1978-03-07 1983-05-13 Sandoz Ag More readily absorbable pharmaceutical composition
CH641356A5 (en) * 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
FR2502951B1 (fr) * 1981-04-06 1985-12-06 Sandoz Sa Compositions pharmaceutiques topiques sous forme d'une micro-emulsion
AU558155B2 (en) * 1982-02-01 1987-01-22 Sandoz Ltd. Treating multiple sclerosis with dihydro-cyclosporin d
DE3225706C2 (de) * 1982-07-09 1984-04-26 A. Nattermann & Cie GmbH, 5000 Köln Flüssige Wirkstofformulierungen in Form von Konzentraten für Mikroemulsionen
DE3235612A1 (de) * 1982-09-25 1984-03-29 Bayer Ag, 5090 Leverkusen Mikroemulsionen
DE3237814A1 (de) * 1982-10-12 1984-04-12 Warner-Lambert Co., 07950 Morris Plains, N.J. Wasserfreie emulsionen und verwendung derselben
DE3315805A1 (de) * 1983-04-30 1984-11-08 Bayer Ag, 5090 Leverkusen Wirkstoffzubereitungen
JPS6024776A (ja) * 1983-07-19 1985-02-07 Fujitsu Ltd 中間調画像圧縮方式
JPS6061535A (ja) * 1983-08-24 1985-04-09 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト 製薬学的組成物
FR2553661B1 (fr) * 1983-10-19 1985-12-20 Rhone Poulenc Sante Nouvelles microemulsions pharmaceutiquement acceptables
DE3406497A1 (de) * 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4605422A (en) 1984-03-30 1986-08-12 Union Carbide Corporation Oil-in-alcohol microemulsion
US4794000A (en) * 1987-01-08 1988-12-27 Synthetic Blood Corporation Coacervate-based oral delivery system for medically useful compositions
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
EP0365044A3 (fr) * 1984-08-02 1990-08-22 Sandoz Ag Utilisation pharmaceutique de (NVA)2-cyclosporine
CH662944A5 (it) * 1984-10-18 1987-11-13 Pier Luigi Prof Dr Luisi Procedimento per la preparazione di biocompatibili di micelle inverse di biocompatibili e loro utilizzazione.
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤
JPS61249918A (ja) * 1985-04-26 1986-11-07 Yutaka Mizushima 点眼剤
IL78929A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration
US5023271A (en) * 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions
US4797272A (en) * 1985-11-15 1989-01-10 Eli Lilly And Company Water-in-oil microemulsions for cosmetic uses
SE8601624D0 (sv) * 1986-04-11 1986-04-11 Haessle Ab New pharmaceutical preparations
SE457693B (sv) * 1986-07-01 1989-01-23 Drilletten Ab Komposition med reglerad frigoering vari ett biologiskt material aer loest eller dispergerat i en l2-fas
CA1318589C (fr) * 1986-08-14 1993-06-01 Bernard Ecanow Systeme d'administration de medicament
DE3629386A1 (de) * 1986-08-29 1988-03-03 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
NL194638C (nl) * 1986-12-19 2002-10-04 Novartis Ag Hydrosol die vaste deeltjes van een farmaceutisch actieve stof bevat en farmaceutisch preparaat dat deze hydrosol bevat.
DE3707711A1 (de) * 1987-03-11 1988-09-22 Hoechst Ag Oel-in-wasser-emulsionen, verfahren zu deren herstellung und deren verwendung
CA1301642C (fr) * 1987-03-30 1992-05-26 Howard Bernard Dawson Formulations chimiques
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
DE3884470T2 (de) * 1987-06-17 1994-03-10 Sandoz Ag Cyclosporine und deren Benutzung als Arzneimittel.
GB2206119B (en) * 1987-06-22 1990-10-31 Merck & Co Inc A new cyclosporin derivative with modified "8-amino acid"
US4835002A (en) * 1987-07-10 1989-05-30 Wolf Peter A Microemulsions of oil in water and alcohol
HU205010B (en) * 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
US5756450A (en) * 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
DK483587D0 (da) * 1987-09-15 1987-09-15 Riemann & Co Aps Claus Antiperspirant praeparat
IL88076A (en) * 1987-10-28 1993-01-14 Nippon Shinyaku Co Ltd Fat emulsions as drug carriers
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
CA1326995C (fr) * 1988-01-29 1994-02-15 Kozo Kurihara Compositions a base de cyclosporines
JPH01249918A (ja) * 1988-03-30 1989-10-05 Kubota Ltd 強制送風式エンジンの放熱器の防塵装置
CH679119A5 (fr) * 1988-05-13 1991-12-31 Sandoz Ag
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
CH679210A5 (fr) * 1988-10-26 1992-01-15 Sandoz Ag
GB2230440B (en) * 1989-02-09 1993-05-19 Sandoz Ltd Novel cyclosporin galenic forms
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
GB9208712D0 (en) * 1992-04-22 1992-06-10 Sandoz Ltd Pharmaceutical compositions containing cyclosporin derivates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4388307A (en) * 1978-03-07 1983-06-14 Sandoz Ltd. Galenical compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOSIS, accession no. 90:243314; W.A. RITSCHEL et al.: "Improvement of peroral absorption of cyclosporine A by microemulsions", & METHODS FIND EXP. CLIN. PHARMACOL. 12 (2). 1990. 127-134 *

Also Published As

Publication number Publication date
IL91642A0 (en) 1990-04-29
US5741512A (en) 1998-04-21
DK171433B1 (da) 1996-10-28
PH31059A (en) 1998-02-05
DE3930928C2 (de) 1994-06-01
AU4140089A (en) 1990-03-22
DK455989D0 (da) 1989-09-15
AU627220B2 (en) 1992-08-20
IE892939L (en) 1990-03-16
JPH02121929A (ja) 1990-05-09
NL194781B (nl) 2002-11-01
BG60525B2 (bg) 1995-07-28
KR100894130B1 (ko) 2009-04-20
SE514303C2 (sv) 2001-02-05
FI894342A (fi) 1990-03-17
US7235248B2 (en) 2007-06-26
NO893678L (no) 1990-03-19
JPH0725690B2 (ja) 1995-03-22
AT403435B (de) 1998-02-25
US5866159A (en) 1999-02-02
NZ230660A (en) 1992-06-25
KR0148748B1 (ko) 1998-08-17
GR890100583A (en) 1990-10-31
CA1332150C (fr) 1994-09-27
ES2020738A6 (es) 1991-09-16
SG50793G (en) 1993-06-25
NO180362C (no) 1997-04-09
KR900004348A (ko) 1990-04-12
IL91642A (en) 1994-04-12
NO180362B (no) 1996-12-30
ID17863A (id) 1998-01-29
FI894342A0 (fi) 1989-09-14
US5962014A (en) 1999-10-05
GB2222770A (en) 1990-03-21
ATA214289A (de) 1997-07-15
FI98046B (fi) 1996-12-31
HK86593A (en) 1993-08-27
PT91731A (pt) 1990-03-30
FR2636534A1 (fr) 1990-03-23
KR20070108289A (ko) 2007-11-09
NL8902315A (nl) 1990-04-17
FI98046C (fi) 1997-04-10
DE3930928A1 (de) 1990-03-22
IT1232243B (it) 1992-01-28
GR1000456B (el) 1992-07-30
SE8903042L (sv) 1990-05-11
IE60764B1 (en) 1994-08-10
IT8948369A0 (it) 1989-09-15
LU87586A1 (fr) 1991-05-07
DK455989A (da) 1990-03-17
HU211685A9 (en) 1995-12-28
FR2636534B1 (fr) 1994-09-09
NL194781C (nl) 2003-03-04
US6024978A (en) 2000-02-15
US5962017A (en) 1999-10-05
PT91731B (pt) 1995-08-09
LV5749B4 (lv) 1997-04-20
US5916589A (en) 1999-06-29
GB2222770B (en) 1992-07-29
KR100446170B1 (ko) 2004-11-20
NO893678D0 (no) 1989-09-14
MY107381A (en) 1995-11-30
SE8903042D0 (sv) 1989-09-15
LV5749A4 (lv) 1996-12-20
GB8920597D0 (en) 1989-10-25
CH679118A5 (fr) 1991-12-31
US20030143250A1 (en) 2003-07-31

Similar Documents

Publication Publication Date Title
BE1003105A5 (fr) Compositions pharmaceutiques a base de cyclosporines.
ES2021942A6 (es) Procedimiento para preparar composiciones farmaceuticas a base de ciclosporinas.
IL102310A (en) Pharmaceutical compositions comprising cyclosporins
CA2037101A1 (fr) Compositions d'omeprazole destinees a une administration par voie rectale
MY103586A (en) Cloth-softening liquid composition
MX9304530A (es) Suministro topico mejorado de farmacos.
KR900001364A (ko) 정맥주사용 약학적 조성물 및 이를 제조하는 방법
GB8922026D0 (en) Novel anti-viral and cytotoxic agent
ES8706750A1 (es) Procedimiento para la obtencion de nuevos esteres de polioles
RU97118224A (ru) Соединения и композиции для доставки активных агентов
NO944567L (no) Cyklosporinholdige flytende preparater og fremgangsmåte ved deres fremstilling
TR199500299A2 (tr) Farmasötik bilesimler.
PL316942A1 (en) Novel pharmaceutic compositions based on taxoides
IT1238343B (it) Procedimento per la preparazione di vaccini capaci di generare non solo la risposta immune dei linfociti t helper,ma anche un'efficace risposta di linfociti t citotossici,e vaccini con queste caratteristiche
FI923347A0 (fi) Blodfaktorer producerade med rekombinant-dna-teknik och foerfarande foer expression av naemnda blodfaktorer samt i naemnda foerfarande anvaenda rekombinanta kokoppvirus.
AU596160B2 (en) Agent for the removal of nucleic acids and/or endotoxin and method for the removal thereof
CA2158543A1 (fr) Compositions de nettoyage concentrees
WO1995023586A3 (fr) Compositions cosmetiques et/ou pharmaceutiques
CA2068224A1 (fr) Nouveaux inducteurs efficaces de la phase terminale de la differenciation et methode d'utilisation
EP0058535A3 (fr) Bureau
JPS56118082A (en) Aldehyde adduct of novel 2*4*77triaminoo66phenylbutelidine
UA27055C2 (uk) Лікарський препарат імуhозаміhhої дії hа осhові клітиhhої суспеhзії та спосіб лікуваhhя сиhдрому hабутого імуhодефіциту (віл-іhфекції) з використаhhям цього препарату
IL89496A0 (en) Eglin mutants,their preparation and pharmaceutical compositions containing them
IE890275L (en) Pharmaceutical composition for 4-aroylimidazol-2-ones
FR2711370B1 (fr) Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *NOVARTIS A.G.

Effective date: 20090914