KR900004348A - 시클로스포린을 함유하는 약학 조성물 - Google Patents
시클로스포린을 함유하는 약학 조성물 Download PDFInfo
- Publication number
- KR900004348A KR900004348A KR1019890013380A KR890013380A KR900004348A KR 900004348 A KR900004348 A KR 900004348A KR 1019890013380 A KR1019890013380 A KR 1019890013380A KR 890013380 A KR890013380 A KR 890013380A KR 900004348 A KR900004348 A KR 900004348A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- cyclosporin
- cyclosporine
- active ingredient
- total amount
- Prior art date
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (15)
- 활성 성분으로서 시클로스포린을 함유하는 마이크로 에멀젼 예비농축액 형태의 약학적 조성물.
- 제1항에 있어서, 1)친수성성; 2)소수성상, 및 3) 계면 활성제를 함유하는 조성물.
- 제2항에 있어서, 친수성 성분으로 1ㆍ1) 저분자량의 모노-또는 폴리-옥시-알칸디올의 약학적 허용 C1-5알킨 또는 테트라히드로퍼퓨릴 디-또는 부분-에테르를 함유하거나 또는 1ㆍ2) 1, 2-프로필렌 글리콜을 함유하는 조성물.
- 제2항에 있어서, 친수성 성분으로 트랜스쿠톨(Transcutol) 또는 글리코푸롤(Glycofurol)을 함유하는 조성물.
- 제2항에 있어서, 소수성 성분으로 중급 지방산 트리글리세리드를 함유하는 조성물.
- 활성 성분으로 시클로스포린을 함유하는 마이크로 에멀젼의 약학적 조성물.
- 제6항에 있어서, 제1항의 조성물과 물을 함유하는 조성물.
- 활성성분으로 시클로스포린과, 저분자량의 모노-또는 폴리-옥시-알칸디올의 약학적 허용 C1-5알킬 또는 테트라히드로 퍼퓨릴 디-또는 부분-에테르 (1ㆍ1)을 함유하는 약학적 조성물.
- 제8항에 있어서, 지방산 사카라이드 모노에스테르(5)를 함유하는 조성물.
- 제3항에 있어서, (1ㆍ1)+(2)+(3)의 총량을 기준으로 했을 때 약 15-약85%의 (1ㆍ1), 약 2-약40%의(2), 약 15-약85%의 (3)을 함유하는 조성물.
- 제3항에 있어서, (1ㆍ2)+(2)+(3) 총량을 기준으로 했을 때 약 3-약35%의 (1ㆍ2), 약 2-약35%의 (2), 약 45-약90%의 (3)을 함유하는 조성물.
- 제10항 또는 제11항에 있어서, 시클로스포린은, [시클로스포린]+[(1ㆍ1) 또는 (1ㆍ2)]+(2)+(3) 총량을 기준으로 했을 때, 약 2- 약30중량%의 양으로 존재하는 조성물.
- 제9항에 있어서, 시클로스포린과 (1ㆍ1)은 약 1 : 0.5-200p.p.w[시클로스포린 : (1ㆍ1)]로 존재하며 시클로스포린과 (5)는 약 1 : 3-200p.p.w[시클로스포린 : (5)]의비로 존재하는 조성물.
- 제1항 또는 제8항에 있어서, 약 5-약200mg의 시클로스포린/단위 용량을 함유하는 단위 용량형태의 조성물.
- 제1항 또는 제8항에 있어서, 시클로스포린은 Ciclosporin인 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019970011383A KR100235524B1 (en) | 1988-09-16 | 1997-03-29 | Pharmaceutical compositions comprising cyclosporins |
KR1019990019492A KR100267149B1 (ko) | 1988-09-16 | 1999-05-28 | 사이클로스포린을 함유하는 약학 조성물 |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8821754 | 1988-09-16 | ||
GB888821754A GB8821754D0 (en) | 1988-09-16 | 1988-09-16 | Improvements in/relating to organic compounds |
GB898902900A GB8902900D0 (en) | 1989-02-09 | 1989-02-09 | Improvements in or relating to organic compounds |
GB8902900 | 1989-02-09 | ||
GB8902903 | 1989-02-09 | ||
GB898902903A GB8902903D0 (en) | 1989-02-09 | 1989-02-09 | Improvements in or relating to organic compounds |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019970054119A Division KR100446170B1 (ko) | 1988-09-16 | 1997-10-18 | 사이클로스포린을함유하는약학조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900004348A true KR900004348A (ko) | 1990-04-12 |
KR0148748B1 KR0148748B1 (ko) | 1998-08-17 |
Family
ID=27264085
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890013380A KR0148748B1 (ko) | 1988-09-16 | 1989-09-12 | 사이클로스포린을 함유하는 약학조성물 |
KR1019970054119A KR100446170B1 (ko) | 1988-09-16 | 1997-10-18 | 사이클로스포린을함유하는약학조성물 |
KR1019990035661A KR100894130B1 (ko) | 1988-09-16 | 1999-08-26 | 사이클로스포린을 함유하는 약학 조성물 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019970054119A KR100446170B1 (ko) | 1988-09-16 | 1997-10-18 | 사이클로스포린을함유하는약학조성물 |
KR1019990035661A KR100894130B1 (ko) | 1988-09-16 | 1999-08-26 | 사이클로스포린을 함유하는 약학 조성물 |
Country Status (32)
Country | Link |
---|---|
US (7) | US5741512A (ko) |
JP (1) | JPH0725690B2 (ko) |
KR (3) | KR0148748B1 (ko) |
AT (1) | AT403435B (ko) |
AU (1) | AU627220B2 (ko) |
BE (1) | BE1003105A5 (ko) |
BG (1) | BG60525B2 (ko) |
CA (1) | CA1332150C (ko) |
CH (1) | CH679118A5 (ko) |
DE (1) | DE3930928C2 (ko) |
DK (1) | DK171433B1 (ko) |
ES (1) | ES2020738A6 (ko) |
FI (1) | FI98046C (ko) |
FR (1) | FR2636534B1 (ko) |
GB (1) | GB2222770B (ko) |
GR (1) | GR1000456B (ko) |
HK (1) | HK86593A (ko) |
HU (1) | HU211685A9 (ko) |
ID (1) | ID17863A (ko) |
IE (1) | IE60764B1 (ko) |
IL (1) | IL91642A (ko) |
IT (1) | IT1232243B (ko) |
LU (1) | LU87586A1 (ko) |
LV (1) | LV5749B4 (ko) |
MY (1) | MY107381A (ko) |
NL (1) | NL194781C (ko) |
NO (1) | NO180362C (ko) |
NZ (1) | NZ230660A (ko) |
PH (1) | PH31059A (ko) |
PT (1) | PT91731B (ko) |
SE (2) | SE514303C2 (ko) |
SG (1) | SG50793G (ko) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5589455A (en) * | 1994-12-28 | 1996-12-31 | Hanmi Pharm. Ind. Co., Ltd. | Cyclosporin-containing soft capsule compositions |
US5603951A (en) * | 1994-11-09 | 1997-02-18 | Hanmi Pharm. Ind. Co., Ltd. | Cyclosporin-containing soft capsule compositions |
KR100368181B1 (ko) * | 1994-05-17 | 2003-04-10 | 알러간, 인코포레이티드 | 시각조직에의국부도포를위한누선특효유제 |
KR100446170B1 (ko) * | 1988-09-16 | 2004-11-20 | 노바티스 아게 | 사이클로스포린을함유하는약학조성물 |
Families Citing this family (178)
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US5639724A (en) * | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
GR1000466B (el) * | 1989-01-28 | 1992-07-30 | Sandoz Ag | Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης. |
CH679277A5 (ko) * | 1989-02-09 | 1992-01-31 | Sandoz Ag | |
US7081445B2 (en) * | 1989-02-20 | 2006-07-25 | Novartis Ag | Cyclosporin galenic forms |
US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
GB8916901D0 (en) | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
HU208491B (en) * | 1990-11-27 | 1993-11-29 | Gyogyszerkutato Intezet | Process for producing oral pharmaceutical composition containing cyclosporin |
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US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
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GB9113872D0 (en) * | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
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DK0589843T3 (da) * | 1992-09-25 | 2002-04-02 | Novartis Ag | Cyclosporinholdige farmaceutiske præparater |
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NZ247516A (en) * | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
DE4447972B4 (de) * | 1993-05-27 | 2007-12-27 | Novartis Ag | Galenische Formulierungen |
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
AT408520B (de) * | 1993-05-27 | 2001-12-27 | Novartis Erfind Verwalt Gmbh | Galenische formulierungen |
GB2278780B (en) * | 1993-05-27 | 1998-10-14 | Sandoz Ltd | Macrolide formulations |
DE4322826A1 (de) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmazeutisches Präparat |
GB2281697A (en) * | 1993-09-14 | 1995-03-15 | Euro Celtique Sa | Laxative compositions in capsules |
ATE398448T1 (de) * | 1993-09-28 | 2008-07-15 | Scherer Gmbh R P | Herstellung von weichgelatinekapseln |
GB2315216B (en) * | 1993-10-05 | 1998-10-14 | Ciba Geigy Ag | Microemulsion preconcentrates comprising FK506 or 33-epi-chloro-33-desoxy-ascomycin |
DE4340781C3 (de) * | 1993-11-30 | 2000-01-27 | Novartis Ag | Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung |
KR0146671B1 (ko) * | 1994-02-25 | 1998-08-17 | 김충환 | 사이클로스포린-함유 분말 조성물 |
GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
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FI100692B (fi) * | 1994-05-24 | 1998-02-13 | Leiras Oy | Menetelmä farmaseuttisten koostumusten valmistamiseksi, jolloin koostu mukset pohjautuvat mikroemulsiogeeleihin sekä uusia mikroemulsioihin p ohjautuvia geelejä |
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EP0760237A1 (en) * | 1995-08-30 | 1997-03-05 | Cipla Limited | Oil-in-water microemulsions |
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CZ288631B6 (cs) * | 1996-01-18 | 2001-08-15 | Galena, A. S. | Léčivé přípravky s obsahem cyklosporinu |
GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
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- 1989-09-14 IE IE293989A patent/IE60764B1/en not_active IP Right Cessation
- 1989-09-14 NZ NZ230660A patent/NZ230660A/en unknown
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- 1989-09-15 FR FR898912229A patent/FR2636534B1/fr not_active Expired - Lifetime
- 1989-09-15 LU LU87586A patent/LU87586A1/fr unknown
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- 1989-09-15 IT IT8948369A patent/IT1232243B/it active
- 1989-09-15 SE SE8903042D patent/SE8903042L/xx not_active Application Discontinuation
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- 1989-09-15 DE DE3930928A patent/DE3930928C2/de not_active Expired - Lifetime
- 1989-09-15 ES ES8903141A patent/ES2020738A6/es not_active Expired - Lifetime
- 1989-09-15 PT PT91731A patent/PT91731B/pt not_active IP Right Cessation
- 1989-09-15 DK DK455989A patent/DK171433B1/da not_active IP Right Cessation
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1993
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- 1993-08-19 HK HK865/93A patent/HK86593A/xx not_active IP Right Cessation
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1994
- 1994-02-22 BG BG098510A patent/BG60525B2/bg unknown
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1995
- 1995-04-27 US US08/430,770 patent/US5741512A/en not_active Expired - Lifetime
- 1995-06-21 HU HU95P/P00318P patent/HU211685A9/hu unknown
-
1996
- 1996-07-18 LV LV960265A patent/LV5749B4/xx unknown
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1997
- 1997-03-06 US US08/811,749 patent/US5866159A/en not_active Expired - Fee Related
- 1997-03-06 US US08/812,073 patent/US5916589A/en not_active Expired - Fee Related
- 1997-03-06 US US08/812,078 patent/US5962014A/en not_active Expired - Fee Related
- 1997-10-18 KR KR1019970054119A patent/KR100446170B1/ko not_active IP Right Cessation
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1998
- 1998-02-17 US US09/024,521 patent/US5962017A/en not_active Expired - Fee Related
- 1998-11-02 US US09/184,546 patent/US6024978A/en not_active Expired - Fee Related
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1999
- 1999-08-26 KR KR1019990035661A patent/KR100894130B1/ko active IP Right Grant
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2002
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100446170B1 (ko) * | 1988-09-16 | 2004-11-20 | 노바티스 아게 | 사이클로스포린을함유하는약학조성물 |
KR100368181B1 (ko) * | 1994-05-17 | 2003-04-10 | 알러간, 인코포레이티드 | 시각조직에의국부도포를위한누선특효유제 |
US5603951A (en) * | 1994-11-09 | 1997-02-18 | Hanmi Pharm. Ind. Co., Ltd. | Cyclosporin-containing soft capsule compositions |
US5589455A (en) * | 1994-12-28 | 1996-12-31 | Hanmi Pharm. Ind. Co., Ltd. | Cyclosporin-containing soft capsule compositions |
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