GB2206119B - A new cyclosporin derivative with modified "8-amino acid" - Google Patents
A new cyclosporin derivative with modified "8-amino acid"Info
- Publication number
- GB2206119B GB2206119B GB8814598A GB8814598A GB2206119B GB 2206119 B GB2206119 B GB 2206119B GB 8814598 A GB8814598 A GB 8814598A GB 8814598 A GB8814598 A GB 8814598A GB 2206119 B GB2206119 B GB 2206119B
- Authority
- GB
- United Kingdom
- Prior art keywords
- modified
- amino acid
- cyclosporin derivative
- new cyclosporin
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6467487A | 1987-06-22 | 1987-06-22 |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8814598D0 GB8814598D0 (en) | 1988-07-27 |
GB2206119A GB2206119A (en) | 1988-12-29 |
GB2206119B true GB2206119B (en) | 1990-10-31 |
Family
ID=22057543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8814598A Expired - Fee Related GB2206119B (en) | 1987-06-22 | 1988-06-20 | A new cyclosporin derivative with modified "8-amino acid" |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA1338319C (en) |
GB (1) | GB2206119B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0373260B1 (en) * | 1987-06-22 | 1994-03-09 | Merck & Co. Inc. | Cyclosporin derivatives with modified "8-amino acid" |
CH679119A5 (en) * | 1988-05-13 | 1991-12-31 | Sandoz Ag | |
KR0148748B1 (en) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | A multiphase cyclosporin composition |
US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
GB2227244A (en) * | 1989-01-19 | 1990-07-25 | Merck & Co Inc | Immunosuppressive fluorinated cyclosporin analogs |
GB8916901D0 (en) | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
US5122511A (en) * | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
US5214130A (en) * | 1990-02-27 | 1993-05-25 | Merck & Co., Inc. | Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
ATE147619T1 (en) | 1992-05-13 | 1997-02-15 | Sandoz Ag | OPTHALMIC COMPOSITIONS CONTAINING A CYCLOSPORIN |
ES2168271T3 (en) | 1992-09-25 | 2002-06-16 | Novartis Ag | PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORINS. |
WO1994025606A2 (en) * | 1993-04-23 | 1994-11-10 | Sandoz Ltd. | Recombinant alanine racemase and gapdh from tolypocladium |
CA2231404C (en) | 1994-11-03 | 2009-02-17 | Arzneimittelwerk Dresden Gmbh | Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them |
DE19544507B4 (en) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin containing preparations |
DE29824679U1 (en) | 1997-01-30 | 2002-03-28 | Novartis Ag | Pharmaceutical compositions |
ES2326040T3 (en) | 2001-10-19 | 2009-09-29 | Isotechnika Inc. | SYNTHESIS OF CYCLOSPORINE ANALOGS. |
US10137083B2 (en) | 2006-03-07 | 2018-11-27 | SGN Nanopharma Inc | Ophthalmic preparations |
US11311477B2 (en) | 2006-03-07 | 2022-04-26 | Sgn Nanopharma Inc. | Ophthalmic preparations |
WO2008069917A2 (en) | 2006-11-20 | 2008-06-12 | Scynexis, Inc. | Novel cyclic peptides |
NZ594755A (en) | 2009-01-30 | 2013-12-20 | Enanta Pharm Inc | Cyclosporin analogues for preventing or treating hepatitis c infection |
US8481483B2 (en) | 2009-02-19 | 2013-07-09 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
US8349312B2 (en) | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
US8685917B2 (en) | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
US8367053B2 (en) | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
US8623814B2 (en) | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
WO2012145427A1 (en) | 2011-04-18 | 2012-10-26 | The Trustees Of Columbia University In The City Of New York | Methods to treat cancer using cyclosporine and cyclosporine derivatives |
US8906853B2 (en) | 2012-11-28 | 2014-12-09 | Enanta Pharmaceuticals, Inc. | [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection |
SG11201601274QA (en) | 2013-08-26 | 2016-03-30 | Enanta Pharm Inc | Cyclosporin analogues for preventing or treating hepatitis c |
WO2016073480A1 (en) | 2014-11-03 | 2016-05-12 | Enanta Pharmaceuticals, Inc. | Novel cyclosporin analogues for preventing or treating hepatitis c infection |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0194972A2 (en) * | 1985-03-11 | 1986-09-17 | Sandoz Ag | Novel cyclosporins |
-
1988
- 1988-06-20 GB GB8814598A patent/GB2206119B/en not_active Expired - Fee Related
- 1988-12-13 CA CA 585752 patent/CA1338319C/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0194972A2 (en) * | 1985-03-11 | 1986-09-17 | Sandoz Ag | Novel cyclosporins |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
Also Published As
Publication number | Publication date |
---|---|
CA1338319C (en) | 1996-05-07 |
GB2206119A (en) | 1988-12-29 |
GB8814598D0 (en) | 1988-07-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20020620 |