AU2020337938B2 - KRas G12D inhibitors - Google Patents

KRas G12D inhibitors

Info

Publication number
AU2020337938B2
AU2020337938B2 AU2020337938A AU2020337938A AU2020337938B2 AU 2020337938 B2 AU2020337938 B2 AU 2020337938B2 AU 2020337938 A AU2020337938 A AU 2020337938A AU 2020337938 A AU2020337938 A AU 2020337938A AU 2020337938 B2 AU2020337938 B2 AU 2020337938B2
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AU
Australia
Prior art keywords
alkyl
mmol
fluoro
compound
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020337938A
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English (en)
Other versions
AU2020337938A1 (en
Inventor
Shelley Allen
James Francis Blake
Aaron Craig BURNS
Mark Joseph Chicarelli
James Gail Christensen
Joshua Ryan DAHLKE
Donghua DAI
Jay Bradford Fell
John Peter Fischer
John Gaudino
Michael Christopher HILTON
Dean Russell KAHN
John Michael Ketcham
John David Lawson
Matthew Arnold Marx
Macedonio J. Mejia
Brad Newhouse
Phong Nguyen
Jacob Matthew O'LEARY
Spencer Pajk
Martha E. Rodriguez
Pavel SAVECHENKOV
Christopher Ronald Smith
Tony P. Tang
Guy P.A. Vigers
Xiaolun Wang
Qian Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Array Biopharma Inc
Mirati Therapeutics Inc
Original Assignee
Array Biopharma Inc
Mirati Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc, Mirati Therapeutics Inc filed Critical Array Biopharma Inc
Publication of AU2020337938A1 publication Critical patent/AU2020337938A1/en
Application granted granted Critical
Publication of AU2020337938B2 publication Critical patent/AU2020337938B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2020337938A 2019-08-29 2020-08-27 KRas G12D inhibitors Active AU2020337938B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962893604P 2019-08-29 2019-08-29
US62/893,604 2019-08-29
US202063052840P 2020-07-16 2020-07-16
US63/052,840 2020-07-16
US202063058188P 2020-07-29 2020-07-29
US63/058,188 2020-07-29
PCT/US2020/048194 WO2021041671A1 (en) 2019-08-29 2020-08-27 Kras g12d inhibitors

Publications (2)

Publication Number Publication Date
AU2020337938A1 AU2020337938A1 (en) 2022-03-17
AU2020337938B2 true AU2020337938B2 (en) 2025-09-25

Family

ID=74683570

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020337938A Active AU2020337938B2 (en) 2019-08-29 2020-08-27 KRas G12D inhibitors

Country Status (16)

Country Link
US (3) US11453683B1 (https=)
EP (1) EP4021444A4 (https=)
JP (2) JP7622043B2 (https=)
KR (1) KR20220071193A (https=)
CN (1) CN114615981B (https=)
AU (1) AU2020337938B2 (https=)
BR (1) BR112022003543A2 (https=)
CA (1) CA3148745A1 (https=)
CL (1) CL2022000447A1 (https=)
CO (1) CO2022003782A2 (https=)
IL (1) IL290845B1 (https=)
MX (1) MX2022002465A (https=)
PH (1) PH12022550469A1 (https=)
TW (2) TWI874443B (https=)
WO (1) WO2021041671A1 (https=)
ZA (1) ZA202202362B (https=)

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* Cited by examiner, † Cited by third party
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