ZA202202362B - Kras g12d inhibitors - Google Patents
Kras g12d inhibitorsInfo
- Publication number
- ZA202202362B ZA202202362B ZA2022/02362A ZA202202362A ZA202202362B ZA 202202362 B ZA202202362 B ZA 202202362B ZA 2022/02362 A ZA2022/02362 A ZA 2022/02362A ZA 202202362 A ZA202202362 A ZA 202202362A ZA 202202362 B ZA202202362 B ZA 202202362B
- Authority
- ZA
- South Africa
- Prior art keywords
- kras
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962893604P | 2019-08-29 | 2019-08-29 | |
| US202063052840P | 2020-07-16 | 2020-07-16 | |
| US202063058188P | 2020-07-29 | 2020-07-29 | |
| PCT/US2020/048194 WO2021041671A1 (en) | 2019-08-29 | 2020-08-27 | Kras g12d inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA202202362B true ZA202202362B (en) | 2022-09-28 |
Family
ID=74683570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2022/02362A ZA202202362B (en) | 2019-08-29 | 2022-02-24 | Kras g12d inhibitors |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11453683B1 (https=) |
| EP (1) | EP4021444A4 (https=) |
| JP (2) | JP7622043B2 (https=) |
| KR (1) | KR20220071193A (https=) |
| CN (1) | CN114615981B (https=) |
| AU (1) | AU2020337938B2 (https=) |
| BR (1) | BR112022003543A2 (https=) |
| CA (1) | CA3148745A1 (https=) |
| CL (1) | CL2022000447A1 (https=) |
| CO (1) | CO2022003782A2 (https=) |
| IL (1) | IL290845B1 (https=) |
| MX (1) | MX2022002465A (https=) |
| PH (1) | PH12022550469A1 (https=) |
| TW (2) | TWI912127B (https=) |
| WO (1) | WO2021041671A1 (https=) |
| ZA (1) | ZA202202362B (https=) |
Families Citing this family (242)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210006356A (ko) | 2018-04-04 | 2021-01-18 | 아비나스 오퍼레이션스, 인코포레이티드 | 단백질분해 조절제 및 연관된 사용 방법 |
| US11932633B2 (en) | 2018-05-07 | 2024-03-19 | Mirati Therapeutics, Inc. | KRas G12C inhibitors |
| JP2022500385A (ja) | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス， インコーポレイテッド | 組み合わせ療法 |
| CA3112043A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| SMT202500028T1 (it) | 2018-09-10 | 2025-03-12 | Mirati Therapeutics Inc | Terapie combinate |
| WO2020055761A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| WO2020085504A1 (ja) | 2018-10-26 | 2020-04-30 | 大鵬薬品工業株式会社 | 光照射ザンドマイヤー反応を用いたクロロアゾールカルボキシレート誘導体の製造方法 |
| CN113164418A (zh) | 2018-12-05 | 2021-07-23 | 米拉蒂治疗股份有限公司 | 组合疗法 |
| WO2020146613A1 (en) | 2019-01-10 | 2020-07-16 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| WO2021041671A1 (en) * | 2019-08-29 | 2021-03-04 | Mirati Therapeutics, Inc. | Kras g12d inhibitors |
| CN114761012B (zh) | 2019-09-24 | 2025-03-21 | 米拉蒂治疗股份有限公司 | 组合疗法 |
| CN114867726B (zh) | 2019-10-28 | 2023-11-28 | 默沙东有限责任公司 | Kras g12c突变体的小分子抑制剂 |
| WO2021106231A1 (en) * | 2019-11-29 | 2021-06-03 | Taiho Pharmaceutical Co., Ltd. | A compound having inhibitory activity against kras g12d mutation |
| US12479834B2 (en) | 2019-11-29 | 2025-11-25 | Taiho Pharmaceutical Co., Ltd. | Phenol compound or salt thereof |
| PH12022551513A1 (en) | 2019-12-20 | 2023-04-24 | Mirati Therapeutics Inc | Sos1 inhibitors |
| WO2023205701A1 (en) | 2022-04-20 | 2023-10-26 | Kumquat Biosciences Inc. | Macrocyclic heterocycles and uses thereof |
| EP4182313A4 (en) * | 2020-07-16 | 2024-10-09 | Mirati Therapeutics, Inc. | KRAS-G12D INHIBITORS |
| EP4192585A4 (en) * | 2020-08-04 | 2024-08-21 | Mirati Therapeutics, Inc. | Kras g12d inhibitors |
| CN115968286A (zh) * | 2020-08-26 | 2023-04-14 | 益方生物科技(上海)股份有限公司 | 杂芳基化合物，其制备方法和用途 |
| CN116368130A (zh) | 2020-08-28 | 2023-06-30 | 金橘生物科技公司 | 杂环化合物及其用途 |
| MX2023002248A (es) | 2020-09-03 | 2023-05-16 | Revolution Medicines Inc | Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2. |
| WO2022056307A1 (en) | 2020-09-11 | 2022-03-17 | Mirati Therapeutics, Inc. | Crystalline forms of a kras g12c inhibitor |
| US20230081426A1 (en) * | 2020-09-18 | 2023-03-16 | Plexxikon Inc. | Compounds and methods for kras modulation and indications therefor |
| US20230365563A1 (en) * | 2020-09-30 | 2023-11-16 | Shanghai Pharmaceuticals Holding Co., Ltd. | Quinazoline compound and application thereof |
| WO2022098625A1 (en) | 2020-11-03 | 2022-05-12 | Mirati Therapeutics, Inc. | Kras g12d inhibitors |
| WO2022132200A1 (en) | 2020-12-15 | 2022-06-23 | Mirati Therapeutics, Inc. | Azaquinazoline pan-kras inhibitors |
| EP4262803A4 (en) | 2020-12-16 | 2025-03-12 | Mirati Therapeutics, Inc. | Tetrahydropyridopyrimidine pan-kras inhibitors |
| US20240109893A1 (en) * | 2020-12-22 | 2024-04-04 | Shanghai Kechow Pharma, Inc. | Preparation and application method of heterocyclic compounds as kras inhibitor |
| EP4269404A4 (en) * | 2020-12-25 | 2024-12-04 | Xizang Haisco Pharmaceutical Co., Ltd. | KETOHEXOKINASE INHIBITORS AND USE THEREOF |
| WO2022170999A1 (zh) * | 2021-02-09 | 2022-08-18 | 南京明德新药研发有限公司 | 吡啶[4，3-d]嘧啶类化合物 |
| KR20230145361A (ko) | 2021-02-15 | 2023-10-17 | 아스텔라스세이야쿠 가부시키가이샤 | G12d 변이 kras 단백의 분해를 유도하기 위한 퀴나졸린화합물 |
| AU2022219651A1 (en) | 2021-02-15 | 2023-09-07 | Astellas Pharma Inc. | 4-aminoquinazoline compound |
| WO2022184178A1 (en) * | 2021-03-05 | 2022-09-09 | Jacobio Pharmaceuticals Co., Ltd. | Kras g12d inhibitors |
| WO2022188729A1 (en) * | 2021-03-07 | 2022-09-15 | Jacobio Pharmaceuticals Co., Ltd. | Fused ring derivatives useful as kras g12d inhibitors |
| JP2024509280A (ja) * | 2021-03-10 | 2024-02-29 | ベータ・ファーマ・インコーポレイテッド | Ｋｒａｓ阻害物質としてのピリドピリミジン誘導体 |
| CN115073450A (zh) * | 2021-03-15 | 2022-09-20 | 药雅科技(上海)有限公司 | Krasg12c突变蛋白抑制剂的制备及其应用 |
| CN116964058A (zh) * | 2021-03-15 | 2023-10-27 | 贝达药业股份有限公司 | Kras g12d抑制剂及其在医药上的应用 |
| TWI810803B (zh) * | 2021-03-15 | 2023-08-01 | 大陸商藥雅科技（上海）有限公司 | 突變蛋白抑制劑的製備及其應用 |
| CN115260214A (zh) * | 2021-04-29 | 2022-11-01 | 药雅科技(上海)有限公司 | 稠环类krasg12d突变蛋白抑制剂的制备及其应用 |
| CN115304603B (zh) * | 2021-05-07 | 2024-04-09 | 药雅科技(上海)有限公司 | 喹唑啉类抑制剂的制备及其应用 |
| CN115490689B (zh) * | 2021-06-17 | 2024-04-09 | 药雅科技(上海)有限公司 | 不可逆krasg12c抑制剂的制备及其应用 |
| CN115073451A (zh) * | 2021-03-15 | 2022-09-20 | 药雅科技(上海)有限公司 | Krasg12d突变蛋白抑制剂的制备及其应用 |
| CN115160309B (zh) * | 2021-04-07 | 2024-04-09 | 药雅科技(上海)有限公司 | Krasg12c突变蛋白杂环类抑制剂的制备及其应用 |
| WO2022194191A1 (en) * | 2021-03-16 | 2022-09-22 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Heterocyclic compounds as inhibitors of kras g12d |
| EP4310091A4 (en) * | 2021-03-17 | 2025-04-16 | Genfleet Therapeutics (Shanghai) Inc. | Pyrimidine-fused cyclic compound, preparation method therefor and use thereof |
| CN115109078A (zh) * | 2021-03-22 | 2022-09-27 | 苏州泽璟生物制药股份有限公司 | 嘧啶并吡啶类抑制剂及其制备方法和应用 |
| CN115124524A (zh) * | 2021-03-26 | 2022-09-30 | 浙江海正药业股份有限公司 | 三环类衍生物及其制备方法和用途 |
| WO2022206724A1 (zh) * | 2021-03-30 | 2022-10-06 | 浙江海正药业股份有限公司 | 杂环类衍生物及其制备方法和用途 |
| CN115141215B (zh) * | 2021-03-30 | 2023-09-15 | 上海德琪医药科技有限公司 | Kras g12d蛋白抑制剂和其用途 |
| WO2022217042A1 (en) * | 2021-04-09 | 2022-10-13 | Ikena Oncology, Inc. | Naphthyl-substituted quinoline-4(1h)-ones and related compounds and their use in treating medical conditions |
| CN115197245A (zh) * | 2021-04-09 | 2022-10-18 | 上海拓界生物医药科技有限公司 | 一种Kras抑制剂及其制备方法 |
| WO2022214102A1 (zh) * | 2021-04-09 | 2022-10-13 | 杭州英创医药科技有限公司 | 作为kras g12d抑制剂的杂环化合物 |
| WO2022221386A1 (en) * | 2021-04-14 | 2022-10-20 | Erasca, Inc. | Selective kras inhibitors |
| WO2022221739A1 (en) * | 2021-04-16 | 2022-10-20 | Merck Sharp & Dohme Corp. | Small molecule inhibitors of kras g12d mutant |
| WO2022227987A1 (zh) * | 2021-04-28 | 2022-11-03 | 浙江海正药业股份有限公司 | 杂环类衍生物及其制备方法和用途 |
| JP2024517695A (ja) * | 2021-04-29 | 2024-04-23 | アムジエン・インコーポレーテツド | 複素環式化合物及び使用方法 |
| JP2024517693A (ja) * | 2021-04-29 | 2024-04-23 | アムジエン・インコーポレーテツド | ２－アミノベンゾチアゾール化合物及びその使用方法 |
| WO2022228576A1 (zh) * | 2021-04-30 | 2022-11-03 | 上海医药集团股份有限公司 | 一种靶向蛋白调节剂的化合物及其应用 |
| CN117222650A (zh) * | 2021-04-30 | 2023-12-12 | 劲方医药科技(上海)有限公司 | 吡啶或嘧啶并环类化合物，其制法与医药上的用途 |
| WO2022228543A1 (zh) * | 2021-04-30 | 2022-11-03 | 江苏恒瑞医药股份有限公司 | 桥环类化合物、其制备方法及其在医药上的应用 |
| WO2022235866A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Covalent ras inhibitors and uses thereof |
| WO2022236578A1 (en) * | 2021-05-10 | 2022-11-17 | Nikang Therapeutics, Inc. | Exocyclic amino quinazoline derivatives as kras inhibitors |
| UY39779A (es) * | 2021-05-21 | 2023-01-31 | Blossomhill Therapeutics Inc | Compuestos macrocíclicos para tratar enfermedades |
| WO2022247760A1 (zh) * | 2021-05-22 | 2022-12-01 | 上海科州药物研发有限公司 | 作为kras抑制剂的杂环化合物，及其制备和治疗用途 |
| JP2024520000A (ja) | 2021-05-24 | 2024-05-21 | 上海瓔黎薬業有限公司 | 含窒素複素環化合物、その製造方法及び使用 |
| CN115385938A (zh) * | 2021-05-25 | 2022-11-25 | 江苏恒瑞医药股份有限公司 | 苯并嘧啶类化合物、其制备方法及其在医药上的应用 |
| CN115385937A (zh) * | 2021-05-25 | 2022-11-25 | 江苏恒瑞医药股份有限公司 | 嘧啶并环烷基类化合物、其制备方法及其在医药上的应用 |
| WO2022247757A1 (zh) * | 2021-05-26 | 2022-12-01 | 南京明德新药研发有限公司 | 氟取代的嘧啶并吡啶类化合物及其应用 |
| WO2022248885A2 (en) | 2021-05-28 | 2022-12-01 | Redx Pharma Plc. | Compounds |
| CN117500799A (zh) | 2021-06-09 | 2024-02-02 | 伊莱利利公司 | 作为kras g12d抑制剂的取代的稠合吖嗪 |
| JP2024520791A (ja) * | 2021-06-10 | 2024-05-24 | レデックス・ファーマ・パブリック・リミテッド・カンパニー | 化合物 |
| CN115466272A (zh) * | 2021-06-11 | 2022-12-13 | 博瑞生物医药（苏州）股份有限公司 | 一种嘧啶并杂环化合物，包含其的药物组合物及其用途 |
| WO2022262686A1 (en) * | 2021-06-13 | 2022-12-22 | Jingrui Biopharma Co., Ltd. | Kras g12d inhibitors |
| US20240383921A1 (en) * | 2021-06-16 | 2024-11-21 | Erasca, Inc. | Amide and urea-containing tricyclic kras inhibitors |
| WO2022266069A1 (en) * | 2021-06-16 | 2022-12-22 | Erasca, Inc. | Tricyclic kras g12d inhibitors |
| WO2022262838A1 (en) * | 2021-06-18 | 2022-12-22 | Silexon Ai Technology Co., Ltd. | Deuterated compounds useful as kras g12d inhibitors |
| CN117255793A (zh) * | 2021-06-21 | 2023-12-19 | 江苏恒瑞医药股份有限公司 | 稠合四环类化合物、其制备方法及其在医药上的应用 |
| WO2022271823A1 (en) * | 2021-06-23 | 2022-12-29 | Newave Pharmaceutical Inc. | Mutant kras modulators and uses thereof |
| WO2023274324A1 (zh) | 2021-06-30 | 2023-01-05 | 上海艾力斯医药科技股份有限公司 | 一种含氮杂环化合物、其制备方法、中间体及应用 |
| KR20240029051A (ko) * | 2021-07-02 | 2024-03-05 | 상하이 드 노보 파마테크 컴퍼니 리미티드 | Kras g12d 억제제 및 이의 용도 |
| CN117460737A (zh) * | 2021-07-05 | 2024-01-26 | 四川科伦博泰生物医药股份有限公司 | 杂芳环化合物、其制备方法及用途 |
| WO2023280280A1 (zh) * | 2021-07-07 | 2023-01-12 | 微境生物医药科技(上海)有限公司 | 作为KRas G12D抑制剂的稠环化合物 |
| WO2023284730A1 (en) * | 2021-07-14 | 2023-01-19 | Nikang Therapeutics, Inc. | Alkylidene derivatives as kras inhibitors |
| WO2023284881A1 (en) * | 2021-07-16 | 2023-01-19 | Silexon Ai Technology Co., Ltd. | Heterocyclic compounds useful as kras g12d inhibitors |
| CN117157292A (zh) * | 2021-07-16 | 2023-12-01 | 苏州赞荣医药科技有限公司 | Kras g12d抑制剂和其用途 |
| WO2023283933A1 (en) * | 2021-07-16 | 2023-01-19 | Silexon Biotech Co., Ltd. | Compounds useful as kras g12d inhibitors |
| WO2023001141A1 (en) * | 2021-07-23 | 2023-01-26 | Shanghai Zion Pharma Co. Limited | Kras g12d inhibitors and uses thereof |
| WO2023018699A1 (en) * | 2021-08-10 | 2023-02-16 | Erasca, Inc. | Selective kras inhibitors |
| WO2023018812A1 (en) * | 2021-08-10 | 2023-02-16 | Amgen Inc. | Heterocyclic compounds and methods of use |
| MX2024001894A (es) * | 2021-08-10 | 2024-02-29 | Amgen Inc | Compuestos heterociclicos y metodos de uso. |
| CN116669740A (zh) * | 2021-08-16 | 2023-08-29 | 华润医药研究院（深圳）有限公司 | 嘧啶并吡啶类化合物及其制备方法和医药用途 |
| WO2023020523A1 (en) * | 2021-08-18 | 2023-02-23 | Jacobio Pharmaceuticals Co., Ltd. | Bicyclic derivatives and use thereof |
| WO2023020521A1 (en) * | 2021-08-18 | 2023-02-23 | Jacobio Pharmaceuticals Co., Ltd. | Pyridine fused pyrimidine derivatives and use thereof |
| TW202328124A (zh) * | 2021-08-18 | 2023-07-16 | 大陸商北京加科思新藥研發有限公司 | 1,4-氧雜氮雜環庚烷衍生物及其用途 |
| WO2023025116A1 (zh) * | 2021-08-25 | 2023-03-02 | 浙江海正药业股份有限公司 | 杂环类衍生物、其制备方法及其医药上的用途 |
| US20250276982A1 (en) * | 2021-09-03 | 2025-09-04 | Ascentage Pharma (Suzhou) Co., Ltd. | Kras inhibitors |
| CN116284055B (zh) * | 2021-09-10 | 2025-09-23 | 润佳（苏州）医药科技有限公司 | 一种kras抑制剂及其用途 |
| CN115785124B (zh) * | 2021-09-10 | 2024-11-08 | 润佳（苏州）医药科技有限公司 | Kras g12d抑制剂及其用途 |
| US20240409558A1 (en) | 2021-09-13 | 2024-12-12 | Biomea Fusion, Inc. | Irreversible inhibitors of kras |
| CN116143805B (zh) * | 2021-09-17 | 2025-10-17 | 上海凌达生物医药有限公司 | 一类含氮杂环联芳基类化合物、制备方法和用途 |
| CN118043330A (zh) * | 2021-09-29 | 2024-05-14 | 海南先声再明医药股份有限公司 | Kras g12d抑制剂化合物及其制备方法和应用 |
| CA3233571A1 (en) | 2021-10-05 | 2023-04-13 | Jill HALLIN | Combinations of kras g12d inhibitors with irinotecan and related methods of treatment |
| IL311859A (en) | 2021-10-05 | 2024-06-01 | Mirati Therapeutics Inc | Combination therapies of kras g12d inhibitors with sos1 inhibitors |
| KR20240073114A (ko) | 2021-10-05 | 2024-05-24 | 미라티 테라퓨틱스, 인크. | Shp-2 억제제와 kras g12d 억제제의 병용 요법 |
| AU2022359282A1 (en) | 2021-10-05 | 2024-04-11 | Mirati Therapeutics, Inc. | Combinations of kras g12d inhibitors with pi3ka inhibitors and related methods of treatment |
| CA3233567A1 (en) | 2021-10-05 | 2023-04-13 | Jill HALLIN | Combination therapies of kras g12d inhibitors with pan erbb family inhibitors |
| WO2023056951A1 (zh) * | 2021-10-08 | 2023-04-13 | 杭州德睿智药科技有限公司 | 芳基取代并杂环化合物 |
| WO2023061294A1 (zh) * | 2021-10-13 | 2023-04-20 | 再鼎医药(上海)有限公司 | 含氮杂环类衍生物调节剂、其制备方法及应用 |
| EP4417606A4 (en) * | 2021-10-15 | 2025-10-22 | Sunshine Lake Pharma Co Ltd | NOVEL PYRIMIDOPYRIDINE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF |
| WO2023072188A1 (zh) * | 2021-10-29 | 2023-05-04 | 贝达药业股份有限公司 | Kras g12d抑制剂及其在医药上的应用 |
| WO2023077441A1 (en) * | 2021-11-05 | 2023-05-11 | Ranok Therapeutics (Hangzhou) Co. Ltd. | Methods and compositions for targeted protein degradation |
| JP2024543879A (ja) * | 2021-11-24 | 2024-11-26 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｋｒａｓ変異型タンパク質の小分子阻害剤 |
| EP4405337A4 (en) * | 2021-11-30 | 2025-11-26 | Beta Pharma Inc | Fused pyrimidine derivatives as kras oncoprotein inhibitors |
| CN117940436A (zh) * | 2021-12-02 | 2024-04-26 | 上海和誉生物医药科技有限公司 | 一种7-(萘-1-基)吡啶并[4,3-d]嘧啶衍生物及其制备和应用 |
| CN116217591A (zh) * | 2021-12-02 | 2023-06-06 | 思路迪生物医药(上海)有限公司 | 一类作为kras g12d突变抑制剂的吡啶并嘧啶类衍生物 |
| JP7779584B2 (ja) * | 2021-12-02 | 2025-12-03 | 上海和誉生物医薬科技有限公司 | Ｋｒａｓ阻害剤とその製造及び薬学における応用 |
| WO2023103906A1 (zh) * | 2021-12-07 | 2023-06-15 | 贝达药业股份有限公司 | Kras g12d抑制剂及其在医药上的应用 |
| WO2023103523A1 (zh) * | 2021-12-09 | 2023-06-15 | 苏州浦合医药科技有限公司 | 取代的双环杂芳基化合物作为kras g12d抑制剂 |
| EP4452974A4 (en) * | 2021-12-21 | 2025-11-19 | Bridgene Biosciences Inc | RAS ONCOPROTEIN INHIBITORS |
| CN116332959A (zh) * | 2021-12-24 | 2023-06-27 | 苏州泽璟生物制药股份有限公司 | Krasg12d蛋白水解调节剂及其制备方法和应用 |
| WO2023119677A1 (en) * | 2021-12-24 | 2023-06-29 | Astellas Pharma Inc. | Pharmaceutical composition comprising a quinazoline compound |
| WO2023125989A1 (zh) * | 2021-12-31 | 2023-07-06 | 上海医药集团股份有限公司 | 一种喹唑啉类化合物及其应用 |
| WO2023134465A1 (zh) * | 2022-01-11 | 2023-07-20 | 上海艾力斯医药科技股份有限公司 | 一种含氮杂环化合物、其制备方法、中间体及应用 |
| WO2023137223A1 (en) * | 2022-01-17 | 2023-07-20 | Newave Pharmaceutical Inc. | Pan-kras inhibitors and uses thereof |
| CN118556063A (zh) * | 2022-01-21 | 2024-08-27 | 上海湃隆生物科技有限公司 | 杂环类化合物、药物组合物及其应用 |
| MX2024008849A (es) | 2022-01-21 | 2024-07-25 | Usynova Pharmaceuticals Ltd | Compuestos de benzopirimidina y uso de estos. |
| WO2023138524A1 (zh) * | 2022-01-24 | 2023-07-27 | 贝达药业股份有限公司 | Kras g12d降解剂及其在医药上的应用 |
| WO2023143312A1 (zh) * | 2022-01-28 | 2023-08-03 | 上海艾力斯医药科技股份有限公司 | 一种含氮杂环化合物、其制备方法及应用 |
| CN116514847A (zh) | 2022-01-30 | 2023-08-01 | 上海医药集团股份有限公司 | 一种喹啉类化合物及其应用 |
| IL314486A (en) * | 2022-02-03 | 2024-09-01 | Mirati Therapeutics Inc | Quinazoline compounds inhibit PAN-KRAS |
| AU2023218370B2 (en) | 2022-02-09 | 2024-11-28 | Quanta Therapeutics, Inc. | Kras modulators and uses thereof |
| WO2023152255A1 (en) | 2022-02-10 | 2023-08-17 | Bayer Aktiengesellschaft | Fused pyrimidines as kras inhibitors |
| WO2023151621A1 (zh) * | 2022-02-11 | 2023-08-17 | 泰励生物科技（上海）有限公司 | 具有抗kras突变肿瘤活性的化合物 |
| CN116891514A (zh) * | 2022-04-06 | 2023-10-17 | 润佳（苏州）医药科技有限公司 | 一种双官能化合物及其用途 |
| WO2023173014A1 (en) * | 2022-03-09 | 2023-09-14 | Blossomhill Therapeutics, Inc. | Kras inhibitors and their use |
| KR20240163107A (ko) | 2022-03-11 | 2024-11-18 | 컴쿼트 바이오사이언시즈 인크. | 헤테로환 화합물 및 이의 용도 |
| AU2023231912A1 (en) | 2022-03-11 | 2024-08-15 | Astellas Pharma Inc. | Heterocyclic compound for inducing degradation of g12d mutant kras protein |
| CN117659049A (zh) * | 2022-08-23 | 2024-03-08 | 苏州泽璟生物制药股份有限公司 | 取代桥环类抑制剂及其制备方法和应用 |
| CN119317628A (zh) * | 2022-03-22 | 2025-01-14 | 苏州泽璟生物制药股份有限公司 | 取代桥环类抑制剂及其制备方法和应用 |
| JP7676677B2 (ja) | 2022-03-25 | 2025-05-14 | イーライ リリー アンド カンパニー | Ｋｒａｓ阻害剤 |
| US20250177406A1 (en) | 2022-03-31 | 2025-06-05 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumors |
| CN116891488B (zh) | 2022-04-11 | 2025-12-12 | 成都海博为药业有限公司 | 稠环化合物、包含其的药物组合物及应用 |
| CN119365459A (zh) * | 2022-04-11 | 2025-01-24 | 杭州英创医药科技有限公司 | 作为kras g12d抑制剂的多环化合物 |
| WO2023198191A1 (zh) * | 2022-04-15 | 2023-10-19 | 杭州多域生物技术有限公司 | 一种六元并六元化合物、制备方法、药物组合物和应用 |
| WO2023205719A1 (en) | 2022-04-21 | 2023-10-26 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| WO2023212549A1 (en) * | 2022-04-26 | 2023-11-02 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
| JP2025514185A (ja) * | 2022-04-26 | 2025-05-02 | エラスカ・インコーポレイテッド | 三環式ピリドン及びピリミドン |
| WO2023213269A1 (en) * | 2022-05-06 | 2023-11-09 | Zai Lab (Shanghai) Co., Ltd. | Amide-substituted heterocyclic compounds as kras g12d modulators and uses thereof |
| CN119585287A (zh) | 2022-05-06 | 2025-03-07 | Paq医疗公司 | Kras g12d蛋白水解靶向嵌合体 |
| WO2023220421A1 (en) * | 2022-05-13 | 2023-11-16 | Ranok Therapeutics (Hangzhou) Co. Ltd. | Inhibitors of kras(g12d) |
| TW202400170A (zh) * | 2022-05-19 | 2024-01-01 | 美商建南德克公司 | 氮雜－四環氧氮呯化合物及其用途 |
| IL317601A (en) | 2022-05-25 | 2025-02-01 | Quanta Therapeutics Inc | Pyrimidine-based modulators and their uses |
| CN114907387B (zh) * | 2022-05-26 | 2023-11-10 | 中山大学 | 嘧啶并吡咯类kras抑制剂及其制备方法与应用 |
| US20240067662A1 (en) | 2022-06-10 | 2024-02-29 | Bristol-Myers Squibb Company | Kras inhibitors |
| EP4540244A1 (en) * | 2022-06-15 | 2025-04-23 | Mirati Therapeutics, Inc. | Prodrugs of pan-kras inhibitors |
| WO2023246903A1 (zh) * | 2022-06-24 | 2023-12-28 | 暨南大学 | 含硒杂环类化合物及其药用组合物和应用 |
| WO2024001839A1 (zh) * | 2022-06-29 | 2024-01-04 | 四川科伦博泰生物医药股份有限公司 | 杂芳环化合物、其制备方法及用途 |
| WO2024008068A1 (en) * | 2022-07-04 | 2024-01-11 | Jacobio Pharmaceuticals Co., Ltd. | K-ras mutant protein inhibitors |
| MA71388A (fr) | 2022-07-05 | 2025-04-30 | Pfizer Inc. | Composés pyrido[4,3-d]pyrimidines |
| JP2025524597A (ja) * | 2022-07-07 | 2025-07-30 | ベイジン スウィッツアランド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 複素環式化合物、その組成物、及びそれによる処置方法 |
| WO2024008178A1 (zh) * | 2022-07-08 | 2024-01-11 | 贝达药业股份有限公司 | Kras g12d抑制剂及其在医药上的应用 |
| TW202409002A (zh) | 2022-07-21 | 2024-03-01 | 日商安斯泰來製藥股份有限公司 | 作用於g12d突變kras蛋白之雜環化合物 |
| KR20250042155A (ko) | 2022-07-27 | 2025-03-26 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 축합 고리계 화합물, 이의 제조 방법 및 이의 의학적 응용 |
| TW202408536A (zh) | 2022-07-29 | 2024-03-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種包含kras g12d抑制劑的醫藥組成物 |
| CA3261681A1 (en) | 2022-08-05 | 2024-02-08 | Kumquat Biosciences Inc. | HETEROCYCLIC COMPOUNDS AND THEIR USES |
| CN119630656A (zh) | 2022-08-05 | 2025-03-14 | 安斯泰来制药株式会社 | 用于诱导突变kras蛋白分解的杂环化合物 |
| CN119585278A (zh) * | 2022-08-05 | 2025-03-07 | 杭州中美华东制药有限公司 | 具有KRas G12D抑制作用的化合物 |
| EP4568952A1 (en) | 2022-08-11 | 2025-06-18 | Bristol-Myers Squibb Company | Kras inhibitors |
| WO2024034123A1 (ja) * | 2022-08-12 | 2024-02-15 | アステラス製薬株式会社 | 複素環化合物を含む医薬組成物 |
| KR20250048579A (ko) * | 2022-08-16 | 2025-04-09 | 브리스톨-마이어스 스큅 컴퍼니 | Kras 억제제 |
| EP4573095A1 (en) | 2022-08-17 | 2025-06-25 | Treeline Biosciences, Inc. | Pyridopyrimidine kras inhibitors |
| CN120018863A (zh) * | 2022-08-24 | 2025-05-16 | 珃诺生物医药科技(杭州)有限公司 | 用于调节kras(g12d)的方法和组合物 |
| WO2024045066A1 (en) * | 2022-08-31 | 2024-03-07 | Nikang Therapeutics, Inc. | Alkylidene carbamate as kras inhibitors |
| KR20250057027A (ko) * | 2022-09-07 | 2025-04-28 | 브리스톨-마이어스 스큅 컴퍼니 | Kras g12d 억제제 |
| WO2024054625A2 (en) * | 2022-09-08 | 2024-03-14 | Nikang Therapeutics, Inc. | Bifunctional compounds for degrading kras g12d via ubiquitin proteasome pathway |
| WO2024051852A1 (zh) * | 2022-09-09 | 2024-03-14 | 上海翰森生物医药科技有限公司 | 含嘧啶多环类生物抑制剂、其制备方法和应用 |
| WO2024055112A1 (en) * | 2022-09-13 | 2024-03-21 | Risen (Suzhou) Pharma Tech Co., Ltd. | Bifunctional compounds and pharmaceutical uses thereof |
| TW202416976A (zh) * | 2022-09-16 | 2024-05-01 | 大陸商南京明德新藥研發有限公司 | 含六氫螺環［環丙烷—１，２＇—吡咯𠯤］的化合物 |
| CN119855815A (zh) * | 2022-09-21 | 2025-04-18 | 甘李药业股份有限公司 | 一种kras突变蛋白抑制剂、及其制备方法和应用 |
| AU2023349002A1 (en) | 2022-09-30 | 2025-05-15 | Trasveda Ltd. | Compounds with anti-kras mutant tumor activity |
| EP4631942A1 (en) | 2022-10-21 | 2025-10-15 | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. | Pan-kras degrading agent, and preparation method therefor and use thereof |
| JP2025536369A (ja) | 2022-10-21 | 2025-11-05 | リーディングタック ファーマシューティカル（シャオシン）カンパニー，リミテッド | Ｋｒａｓ ｇ１２ｄ分解剤及びその製造方法並びに応用 |
| WO2024092420A1 (zh) * | 2022-10-31 | 2024-05-10 | 上海皓元医药股份有限公司 | 一种((2R,7aS)-2-氟六氢-1H-吡咯嗪-7a-基)甲醇的制备方法 |
| EP4598921A1 (en) * | 2022-11-14 | 2025-08-13 | Amgen Inc. | Macrocyclic kras inhibitors and methods of use |
| WO2024112654A1 (en) | 2022-11-21 | 2024-05-30 | Treeline Biosciences, Inc. | Spirocyclic dihydropyranopyrimidine kras inhibitors |
| EP4626888A1 (en) | 2022-11-28 | 2025-10-08 | Redx Pharma Limited | Compounds |
| CN116554208A (zh) * | 2022-12-02 | 2023-08-08 | 苏州浦合医药科技有限公司 | 取代的双环杂芳基化合物作为kras g12d抑制剂 |
| JP2025540246A (ja) * | 2022-12-07 | 2025-12-11 | エスケー バイオファーマシューティカルズ カンパニー リミテッド | Ｋｒａｓ ｇ１２ｄ阻害剤として新規な３環化合物およびその用途 |
| CN120322441A (zh) | 2022-12-20 | 2025-07-15 | 江苏恒瑞医药股份有限公司 | 一种kras g12d抑制剂的结晶形式及制备方法 |
| JP2025541435A (ja) | 2022-12-23 | 2025-12-18 | 上海和誉生物医薬科技有限公司 | Ｋｒａｓ ｇ１２ｄ阻害剤及びその応用 |
| CN115894503B (zh) * | 2022-12-30 | 2025-06-13 | 合肥诺全医药有限公司 | 一种氮杂环戊烷衍生物的制备方法 |
| WO2024158242A1 (ko) * | 2023-01-25 | 2024-08-02 | 주식회사 엔바이오스 | Kras g12d 돌연변이 억제용 화합물 및 이를 유효성분으로 포함하는 암질환 예방 또는 치료용 조성물 |
| CN121419983A (zh) | 2023-01-26 | 2026-01-27 | 阿尔维纳斯运营股份有限公司 | 基于小脑蛋白的kras降解protac及其相关用途 |
| WO2024179546A1 (en) * | 2023-03-01 | 2024-09-06 | Ascentage Pharma (Suzhou) Co., Ltd. | Kras inhibitors |
| WO2024186680A1 (en) * | 2023-03-03 | 2024-09-12 | Frontier Medicines Corporation | Methods for preparing pyrrolizidine compounds |
| WO2024192424A1 (en) * | 2023-03-15 | 2024-09-19 | Quanta Therapeutics, Inc. | Kras modulators and uses thereof |
| WO2024206747A1 (en) | 2023-03-30 | 2024-10-03 | Eli Lilly And Company | Kras inhibitors |
| EP4688792A1 (en) | 2023-03-31 | 2026-02-11 | Eli Lilly and Company | Kras inhibitors |
| JPWO2024209717A1 (https=) | 2023-04-06 | 2024-10-10 | ||
| WO2024213122A1 (zh) | 2023-04-14 | 2024-10-17 | 广东东阳光药业股份有限公司 | Kras抑制剂化合物、其药物组合物及其用途 |
| KR20260009841A (ko) * | 2023-05-12 | 2026-01-20 | 블로썸힐 테라퓨틱스, 인크. | 질병 치료를 위한 융합 고리 kras 억제제 |
| KR20260015208A (ko) | 2023-05-12 | 2026-02-02 | 재즈 파마슈티칼즈 아일랜드 리미티드 | 암 치료에 유용한 g12d 돌연변이체 kras의 조절제로서 피라졸로[4,3-f]퀴나졸린 유도체 |
| KR20260010430A (ko) * | 2023-05-15 | 2026-01-20 | 미라티 테라퓨틱스, 인크. | Kras g12s 및 g12c 억제제 |
| WO2024243186A2 (en) * | 2023-05-22 | 2024-11-28 | Board Of Regents, The University Of Texas System | Heterocyclic compounds as nras inhibitors |
| CN120981456A (zh) | 2023-05-24 | 2025-11-18 | 金橘生物科技公司 | 杂环化合物及其用途 |
| CN121605110A (zh) | 2023-06-06 | 2026-03-03 | 金橘生物科技公司 | 取代杂环化合物及其用途 |
| AR133027A1 (es) | 2023-06-22 | 2025-08-20 | Astellas Pharma Inc | Composición farmacéutica que comprende un compuesto de quinazolina |
| AR133028A1 (es) | 2023-06-22 | 2025-08-20 | Astellas Pharma Inc | Composición farmacéutica que comprende un degradador de todas las kras |
| WO2025011634A1 (zh) * | 2023-07-13 | 2025-01-16 | 上海森辉医药有限公司 | Kras g12d中间体的制备方法 |
| WO2025016899A1 (en) | 2023-07-19 | 2025-01-23 | Bayer Aktiengesellschaft | Spirocyclic compounds for the treatment of cancer |
| WO2025024447A2 (en) * | 2023-07-24 | 2025-01-30 | Mirati Therapeutics, Inc. | Processes and intermediates for synthesis of mrtx1133 |
| WO2025026903A1 (en) | 2023-07-31 | 2025-02-06 | Bayer Aktiengesellschaft | Imidazo pyrimidine compounds for the treatment of cancer |
| AU2024329738A1 (en) | 2023-08-22 | 2026-04-09 | Sanofi | 2-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,3,5-triazine derivatives as kras g12d inhibitors for the treatment of cancer |
| AU2024337913A1 (en) | 2023-09-08 | 2026-03-26 | Gilead Sciences, Inc. | Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds |
| TW202528315A (zh) | 2023-09-21 | 2025-07-16 | 美商樹線生物科學公司 | 螺環二氫哌喃并吡啶ＫＲａｓ抑制劑 |
| WO2025072457A1 (en) | 2023-09-27 | 2025-04-03 | Eli Lilly And Company | Kras inhibitors |
| US12599672B2 (en) * | 2023-10-03 | 2026-04-14 | PAQ Therapeutics Inc. | KRAS proteolysis targeting chimeras |
| TW202523324A (zh) * | 2023-10-08 | 2025-06-16 | 大陸商成都海博為藥業有限公司 | 一種稠環化合物及應用 |
| US20250114339A1 (en) | 2023-10-09 | 2025-04-10 | Incyte Corporation | Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor |
| AU2024357850A1 (en) | 2023-10-09 | 2026-04-23 | Incyte Corporation | Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor |
| WO2025077770A1 (zh) * | 2023-10-10 | 2025-04-17 | 成都海博为药业有限公司 | 一种稠环化合物及在kras抑制剂方面的应用 |
| US20250120981A1 (en) | 2023-10-12 | 2025-04-17 | Mirati Therapeutics, Inc. | Mrtx1133 pharmaceutical compositions |
| WO2025085748A1 (en) | 2023-10-20 | 2025-04-24 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras proteins |
| TW202521531A (zh) * | 2023-11-20 | 2025-06-01 | 大陸商貝達藥業股份有限公司 | 一種靶向泛kras蛋白降解劑的化合物及其應用 |
| CN117683052A (zh) * | 2023-12-07 | 2024-03-12 | 上海相辉医药科技有限公司 | 一种kras g12d抑制剂mrtx1133的制备方法 |
| CN117756640B (zh) * | 2023-12-14 | 2025-09-26 | 江苏宝众宝达药业股份有限公司 | 一种两步升温法制备高纯度3,3'-二氨基联苯胺的方法 |
| WO2025136346A1 (en) * | 2023-12-19 | 2025-06-26 | Amgen Inc. | Indazole containing compounds and methods of use |
| KR102738924B1 (ko) * | 2023-12-26 | 2024-12-06 | 주식회사 베노바이오 | Kras g12d 변이가 존재하는 암 치료를 위한 신규한 화합물 및 이를 이용한 암의 예방 또는 치료용 조성물 |
| WO2025145207A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg-depleting agent |
| CN119661556B (zh) * | 2024-01-26 | 2025-12-09 | 苏州盛迪亚生物医药有限公司 | 一种稠环类化合物的可药用盐、其结晶形式及用途 |
| WO2025163494A1 (en) | 2024-01-29 | 2025-08-07 | Jazz Pharmaceuticals Ireland Ltd. | Condensed azines for the treatment of cancer |
| WO2025170938A1 (en) * | 2024-02-06 | 2025-08-14 | Windermere Therapeutics, Inc. | Kras(g12d) inhibitors |
| TW202602882A (zh) * | 2024-03-14 | 2026-01-16 | 美商安進公司 | 作為ｋｒａｓ調節劑的大環化合物及其用途 |
| WO2025194054A1 (en) * | 2024-03-14 | 2025-09-18 | Amgen Inc. | Spirocyclic compounds as modulators of kras and uses thereof |
| US20250312343A1 (en) | 2024-04-08 | 2025-10-09 | Mirati Therapeutics, Inc. | Combination therapies using prmt5 inhibitors and kras g12d inhibitors for the treatment of cancer |
| US20250339436A1 (en) | 2024-05-03 | 2025-11-06 | Mirati Therapeutics, Inc. | Crystalline forms of mrtx1133 |
| WO2025245127A1 (en) | 2024-05-21 | 2025-11-27 | Treeline Biosciences, Inc. | Spirocyclic dihydropyranopyrimidine kras inhibitors |
| WO2025253326A1 (ko) * | 2024-06-05 | 2025-12-11 | 에스케이바이오팜 주식회사 | Kras 저해제로서 신규한 3환 화합물 및 이의 용도 |
| WO2026059955A1 (en) | 2024-09-11 | 2026-03-19 | Eli Lilly And Company | (3-((6-(2-amino-benzo[d]thiazol-4-yl)-3-(pyrrolidin-1-yl)-7,9-dihydrofuro[3,4-f]quinazolin-1-yl)amino)- piperidin-2-one derivatives as kras inhibitors for the treatment of cancer |
| WO2026075942A1 (en) | 2024-10-01 | 2026-04-09 | Eli Lilly And Company | Kras inhibitors |
| US12600733B2 (en) | 2024-10-01 | 2026-04-14 | Eli Lilly And Company | KRAS inhibitors |
| WO2026080796A1 (en) | 2024-10-11 | 2026-04-16 | Mirati Therapeutics, Inc. | Mrtx1133 capsule pharmaceutical compositions |
Family Cites Families (207)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2432578C (en) | 2001-01-02 | 2008-04-01 | F. Hoffmann-La Roche Ag | Quinazolone derivatives as alpha 1a/b adrenergic receptor antagonists |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| US7105667B2 (en) | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
| US20080051387A1 (en) | 2006-06-09 | 2008-02-28 | Yuelian Xu | Tetrahydropyrido[3,4-d]pyrimidines and related analogues |
| US9259426B2 (en) | 2006-07-20 | 2016-02-16 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| CA2673299C (en) | 2006-12-21 | 2016-04-12 | Sloan-Kettering Institute For Cancer Research | Pyridazinone compounds for the treatment of proliferative diseases |
| WO2008103470A2 (en) | 2007-02-21 | 2008-08-28 | Trustees Of Columbia University In The City Of New York | Oncogenic-ras-signal dependent lethal compounds |
| EP2209775A1 (en) | 2007-10-09 | 2010-07-28 | UCB Pharma, S.A. | Heterobicyclic compounds as histamine h4-receptor antagonists |
| AR073354A1 (es) | 2008-07-31 | 2010-11-03 | Genentech Inc | Compuestos de pirimidina, composiciones farmaceuticas y su uso en el tratamiento del cancer. |
| WO2010120996A1 (en) | 2009-04-17 | 2010-10-21 | Wyeth Llc | 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| US8455476B2 (en) | 2009-04-22 | 2013-06-04 | Janssen Pharmaceutica, Nv | Azetidinyl diamides as monoacylglycerol lipase inhibitors |
| EP2518064A1 (en) | 2009-12-25 | 2012-10-31 | Mochida Pharmaceutical Co., Ltd. | Novel aryl urea derivative |
| EP2519664A4 (en) | 2009-12-30 | 2014-03-12 | Avila Therapeutics Inc | LIGAND-RELATED COVALENTS MODIFYING A PROTEIN |
| EP2836482B1 (en) | 2012-04-10 | 2019-12-25 | The Regents of The University of California | Compositions and methods for treating cancer |
| EP3378476A1 (en) | 2012-06-08 | 2018-09-26 | Sensorion | H4 receptor inhibitors for treating tinnitus |
| WO2014011973A2 (en) | 2012-07-13 | 2014-01-16 | The Trustees Of Columbia University In The City Of New York | Quinazolinone-based oncogenic-ras-selective lethal compounds and their use |
| UY35464A (es) | 2013-03-15 | 2014-10-31 | Araxes Pharma Llc | Inhibidores covalentes de kras g12c. |
| US9745319B2 (en) | 2013-03-15 | 2017-08-29 | Araxes Pharma Llc | Irreversible covalent inhibitors of the GTPase K-Ras G12C |
| JP6473133B2 (ja) | 2013-03-15 | 2019-02-20 | アラクセス ファーマ エルエルシー | Ｋｒａｓｇ１２ｃの共有結合性阻害剤 |
| TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Ｋｒａｓ ｇ１２ｃ之抑制劑 |
| AU2014331794C1 (en) | 2013-10-10 | 2019-09-12 | Araxes Pharma Llc | Inhibitors of KRAS G12C |
| MA40074A (fr) | 2014-05-30 | 2015-12-03 | Univ Columbia | Composés liant ras multivalents |
| WO2016025650A1 (en) | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Combinations of an erk inhibitor and a cdk4/6 inhibitor and related methods |
| JO3556B1 (ar) | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | علاجات مدمجة لمعالجة السرطان |
| ES2826443T3 (es) | 2014-09-25 | 2021-05-18 | Araxes Pharma Llc | Inhibidores de proteínas mutantes KRAS G12C |
| US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
| WO2016049565A1 (en) | 2014-09-25 | 2016-03-31 | Araxes Pharma Llc | Compositions and methods for inhibition of ras |
| US10017540B2 (en) | 2015-03-11 | 2018-07-10 | California Institute Of Technology | Cyclic peptide binder against oncogenic K-Ras |
| JP2018513853A (ja) | 2015-04-10 | 2018-05-31 | アラクセス ファーマ エルエルシー | 置換キナゾリン化合物およびその使用方法 |
| JP6789239B2 (ja) | 2015-04-15 | 2020-11-25 | アラクセス ファーマ エルエルシー | Ｋｒａｓの縮合三環系インヒビターおよびその使用の方法 |
| WO2016172692A1 (en) | 2015-04-24 | 2016-10-27 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Mutant kras inhibitors |
| BR112017023821A2 (pt) | 2015-05-06 | 2018-07-31 | Leidos Biomedical Res Inc | moduladores de k-ras |
| US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| JP6877414B2 (ja) | 2015-09-24 | 2021-05-26 | アイオニス・ファーマシューティカルズ・インコーポレイテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Ｋｒａｓ発現のモジュレーター |
| WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| US10647703B2 (en) | 2015-09-28 | 2020-05-12 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| WO2017058807A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| EP3356353A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| EP3356354A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| US10882847B2 (en) | 2015-09-28 | 2021-01-05 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| WO2017058902A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| JP2018533939A (ja) | 2015-10-19 | 2018-11-22 | アラクセス ファーマ エルエルシー | Ｒａｓの阻害剤をスクリーニングするための方法 |
| JP6953400B2 (ja) | 2015-10-22 | 2021-10-27 | ザ スクリプス リサーチ インスティテュート | システイン反応性プローブとその使用 |
| WO2017080980A1 (en) | 2015-11-09 | 2017-05-18 | Astrazeneca Ab | Dihydropyrrolopyrazinone derivatives useful in the treatment of cancer |
| WO2017079864A1 (en) | 2015-11-12 | 2017-05-18 | Hangzhou Yier Biotech Co., Ltd. | Treatment of cancers related to chronically active ras |
| KR20180081596A (ko) | 2015-11-16 | 2018-07-16 | 아락세스 파마 엘엘씨 | 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법 |
| WO2017100546A1 (en) | 2015-12-09 | 2017-06-15 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
| US20170283445A1 (en) | 2016-04-05 | 2017-10-05 | University Of South Carolina | Small Molecule Inhibitors Selective For Polo-Like Kinase Proteins |
| JP7039489B2 (ja) * | 2016-05-18 | 2022-03-22 | ミラティ セラピューティクス， インコーポレイテッド | Ｋｒａｓ ｇ１２ｃ阻害剤 |
| US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
| US10280172B2 (en) * | 2016-09-29 | 2019-05-07 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| EP3523289A1 (en) | 2016-10-07 | 2019-08-14 | Araxes Pharma LLC | Heterocyclic compounds as inhibitors of ras and methods of use thereof |
| AU2017366901B2 (en) | 2016-11-30 | 2022-09-29 | Bantam Pharmaceutical, Llc | Substituted pyrazole compounds and methods of using them for treatment of hyperproliferative diseases |
| MX2019006296A (es) | 2016-11-30 | 2019-11-12 | Bantam Pharmaceutical Llc | Métodos de uso de compuestos de pirazol y pirazol sustituido y para el tratamiento de enfermedades hiperproliferativas. |
| BR112019012263A2 (pt) | 2016-12-15 | 2020-01-28 | The Regents Of The University Of California | composições e métodos para tratar câncer |
| WO2018119183A2 (en) | 2016-12-22 | 2018-06-28 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| JP7219218B2 (ja) | 2016-12-22 | 2023-02-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のベンジルアミノ置換キナゾリンおよびｓｏｓ１阻害剤としての誘導体 |
| US10344026B2 (en) | 2017-01-18 | 2019-07-09 | Nantbio, Inc. | Compositions and methods of targeting mutant K-ras |
| WO2018140514A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
| CN110382482A (zh) | 2017-01-26 | 2019-10-25 | 亚瑞克西斯制药公司 | 稠合的杂-杂二环化合物及其使用方法 |
| WO2018140513A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| EP3573954A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| US20200385364A1 (en) | 2017-01-26 | 2020-12-10 | Araxes Pharma Llc | Fused n-heterocyclic compounds and methods of use thereof |
| JOP20190186A1 (ar) | 2017-02-02 | 2019-08-01 | Astellas Pharma Inc | مركب كينازولين |
| BR112019021899A2 (pt) | 2017-04-20 | 2020-08-18 | The Regents Of The University Of California | moduladores de k-ras |
| MA50077A (fr) | 2017-09-08 | 2020-07-15 | Amgen Inc | Inhibiteurs de kras g12c et leurs procédés d'utilisation |
| US11545829B2 (en) | 2018-07-31 | 2023-01-03 | Honda Motor Co., Ltd. | Power prediction system, power prediction device, power prediction method, program, and storage medium |
| CN113038342B (zh) | 2018-09-30 | 2022-10-14 | 荣耀终端有限公司 | 音频播放电路和终端 |
| CN111193490B (zh) | 2018-11-14 | 2025-05-13 | 天津大学 | 散热结构、带散热结构的体声波谐振器、滤波器和电子设备 |
| WO2020146613A1 (en) | 2019-01-10 | 2020-07-16 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| US20220193242A1 (en) | 2019-02-07 | 2022-06-23 | The Regents Of The University Of California | Immunophilin-dependent inhibitors and uses thereof |
| EP3924687A4 (en) | 2019-02-11 | 2022-11-02 | Mesomat Inc. | SENSING FIBERS FOR STRUCTURAL STRESS MONITORING |
| KR102747104B1 (ko) | 2019-02-18 | 2024-12-27 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리도[3,4-d]피리미딘-8-온 유도체 및 이를 포함하는 암의 예방, 개선 또는 치료용 약학 조성물 |
| WO2020172332A1 (en) | 2019-02-20 | 2020-08-27 | Fred Hutchinson Cancer Research Center | Binding proteins specific for ras neoantigens and uses thereof |
| GB201902392D0 (en) | 2019-02-21 | 2019-04-10 | Cambridge Entpr Ltd | Modular binding proteins |
| EP3931564A4 (en) | 2019-02-26 | 2023-04-26 | Cell Response, Inc. | Methods for treating map3k8 positive cancers |
| WO2020177629A1 (zh) | 2019-03-01 | 2020-09-10 | 劲方医药科技(上海)有限公司 | 螺环取代的嘧啶并环类化合物，其制法与医药上的用途 |
| AU2019432235B2 (en) | 2019-03-05 | 2024-02-01 | Questor Technology Inc. | Gas incinerator system |
| ES3010507T3 (en) | 2019-03-05 | 2025-04-03 | Astrazeneca Ab | Fused tricyclic compounds useful as anticancer agents |
| US12448429B2 (en) | 2019-03-06 | 2025-10-21 | Dana-Farber Cancer Institute, Inc. | T cell receptors specific to b-cell maturation antigen for treatment of cancer |
| US20220160714A1 (en) | 2019-03-22 | 2022-05-26 | Icahn School Of Medicine At Mount Sinai | Methods for treating colorectal cancer |
| AU2020254492A1 (en) | 2019-03-29 | 2021-11-11 | Kura Oncology, Inc. | Methods of treating Squamous Cell Carcinomas with farnesyltransferase inhibitors |
| WO2020205473A1 (en) | 2019-03-29 | 2020-10-08 | Decerna Pharmaceuticals, Inc. | Compositions and methods for the treatment of kras associated diseases or disorders |
| KR102222693B1 (ko) | 2019-04-04 | 2021-03-04 | 금정제약 주식회사 | H-rev107 유래 펩타이드의 신규한 용도 |
| US12528796B2 (en) | 2019-04-15 | 2026-01-20 | Tosk, Inc. | Modulators of RAS GTPase |
| US20200335182A1 (en) | 2019-04-16 | 2020-10-22 | Uratim Ltd. | Method and apparatus for facilitating the binding of biological macromolecules with the use of gluing molecular agents with applications in RAS mutations and related conditions |
| US20220251109A1 (en) | 2019-04-28 | 2022-08-11 | Genfleet Therapeutics (Shanghai) Inc. | Oxaazaquinazoline-7(8h)-ketone compound, preparation method therefor and pharmaceutical application thereof |
| MX2021013662A (es) | 2019-05-10 | 2022-03-11 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de heteroarilaminopirimidina amida y metodos de uso de estos. |
| EP3966207B1 (en) | 2019-05-10 | 2023-11-01 | Deciphera Pharmaceuticals, LLC | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| ES3025633T3 (en) | 2019-05-13 | 2025-06-09 | Novartis Ag | New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer |
| WO2020230091A1 (en) | 2019-05-14 | 2020-11-19 | Janssen Biotech, Inc. | Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors |
| EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
| CN114096544B (zh) | 2019-05-20 | 2025-08-12 | 加州理工学院 | Kras g12c抑制剂及其用途 |
| CN118359609A (zh) | 2019-05-21 | 2024-07-19 | 益方生物科技(上海)股份有限公司 | 杂环化合物，其制备方法和用途 |
| NZ782284A (en) | 2019-05-21 | 2024-11-29 | Amgen Inc | Solid state forms |
| WO2020234103A1 (en) | 2019-05-21 | 2020-11-26 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
| AU2020277398B2 (en) | 2019-05-21 | 2026-01-29 | Amgen Inc. | Solid state forms |
| AU2020289484A1 (en) | 2019-06-07 | 2021-12-23 | Emory University | KRAS G12V mutant binds to JAK1, inhibitors, pharmaceutical compositions, and methods related thereto |
| US20220304984A1 (en) | 2019-06-12 | 2022-09-29 | Vanderbilt University | Amino acid transport inhibitors and the uses thereof |
| AU2020291936A1 (en) | 2019-06-12 | 2022-02-03 | Vanderbilt University | Dibenzylamines as amino acid transport inhibitors |
| TW202115089A (zh) | 2019-07-01 | 2021-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 喹唑啉酮類衍生物、其製備方法及其在醫藥上的應用 |
| MX2022001421A (es) | 2019-08-02 | 2022-06-08 | Shanghai Jemincare Pharmaceuticals Co Ltd | Compuesto tetracíclico, método de preparación y uso del mismo. |
| TWI752580B (zh) | 2019-08-07 | 2022-01-11 | 大陸商北京加科思新藥研發有限公司 | Kras突變蛋白抑制劑 |
| WO2021027943A1 (zh) | 2019-08-14 | 2021-02-18 | 正大天晴药业集团南京顺欣制药有限公司 | 哒嗪酮并嘧啶类衍生物及其医药用途 |
| CN112390797A (zh) | 2019-08-15 | 2021-02-23 | 微境生物医药科技(上海)有限公司 | 新型螺环类K-Ras G12C抑制剂 |
| US20220363681A1 (en) | 2019-08-16 | 2022-11-17 | Genfleet Therapeutics (Shanghai) Inc. | Oxo six-membered cyclopyrimidine compound, preparation method and medical use thereof |
| CN114286676A (zh) | 2019-08-22 | 2022-04-05 | 密歇根大学董事会 | 治疗kras相关癌症的方法 |
| CN114269735B (zh) | 2019-08-26 | 2024-02-23 | 南京创济生物医药有限公司 | 二氢或四氢喹唑啉类化合物及其中间体、制备方法和应用 |
| WO2021041671A1 (en) * | 2019-08-29 | 2021-03-04 | Mirati Therapeutics, Inc. | Kras g12d inhibitors |
| CN112771053A (zh) | 2019-09-06 | 2021-05-07 | 伟迈可生物有限公司 | 基于生物标志物的治疗组合物 |
| WO2021043322A1 (zh) | 2019-09-06 | 2021-03-11 | 正大天晴药业集团南京顺欣制药有限公司 | 氮杂环庚烷并嘧啶类衍生物及其医药用途 |
| EP4028044A4 (en) | 2019-09-10 | 2023-09-27 | The Board of Trustees of the Leland Stanford Junior University | Methods of treating kras mutant cancers |
| TW202124374A (zh) | 2019-09-13 | 2021-07-01 | 美商拜歐斯瑞克斯公司 | Ras蛋白降解劑、其醫藥組合物及其治療應用 |
| EP4031542B1 (en) | 2019-09-18 | 2025-10-15 | Merck Sharp & Dohme LLC | Small molecule inhibitors of kras g12c mutant |
| CA3155066A1 (en) | 2019-09-20 | 2021-03-25 | Shanghai Jemincare Pharmaceuticals Co., Ltd | Fused pyridone compound, and preparation method therefor and use thereof |
| US20230010886A1 (en) | 2019-09-23 | 2023-01-12 | Suzhou Puhe BioPharma Co., Ltd. | Shp2 inhibitors and uses thereof |
| CN114761012B (zh) | 2019-09-24 | 2025-03-21 | 米拉蒂治疗股份有限公司 | 组合疗法 |
| US20210094919A1 (en) | 2019-09-25 | 2021-04-01 | Jacobio Pharmaceuticals Co., Ltd. | Kras mutant protein inhibitors |
| WO2021058018A1 (en) | 2019-09-29 | 2021-04-01 | Beigene, Ltd. | Inhibitors of kras g12c |
| WO2021063346A1 (zh) | 2019-09-30 | 2021-04-08 | 上海迪诺医药科技有限公司 | Kras g12c抑制剂及其应用 |
| CN114555586B (zh) | 2019-10-10 | 2023-06-23 | 信达生物制药(苏州)有限公司 | Krasg12c蛋白抑制剂及其制备方法和用途 |
| JP6754125B1 (ja) | 2019-10-15 | 2020-09-09 | 学校法人東京理科大学 | Ｂｒａｐ２作用増強剤 |
| WO2021076655A1 (en) | 2019-10-15 | 2021-04-22 | Amgen Inc. | Combination therapy of kras inhibitor and shp2 inhibitor for treatment of cancers |
| CN112694475B (zh) | 2019-10-23 | 2025-09-23 | 苏州泽璟生物制药股份有限公司 | 环烷基类和杂环烷基类抑制剂及其制备方法和应用 |
| WO2021080359A1 (ko) | 2019-10-23 | 2021-04-29 | 에스케이바이오팜 주식회사 | 바이사이클릭 화합물 및 이의 용도 |
| EP4684786A3 (en) | 2019-10-24 | 2026-04-08 | Amgen Inc. | Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer |
| CN114867726B (zh) | 2019-10-28 | 2023-11-28 | 默沙东有限责任公司 | Kras g12c突变体的小分子抑制剂 |
| PT4053118T (pt) | 2019-10-30 | 2024-12-05 | Genfleet Therapeutics Shanghai Inc | Composto cíclico fundido heterocíclico substituído, método de preparação deste e utilização farmacêutica deste |
| WO2021085653A1 (en) | 2019-10-31 | 2021-05-06 | Taiho Pharmaceutical Co., Ltd. | 4-aminobut-2-enamide derivatives and salts thereof |
| WO2021084765A1 (en) | 2019-10-31 | 2021-05-06 | Taiho Pharmaceutical Co., Ltd | 4-aminobut-2-enamide derivatives and salts thereof |
| MX2022005359A (es) | 2019-11-04 | 2022-06-02 | Revolution Medicines Inc | Inhibidores de ras. |
| CN120699039A (zh) | 2019-11-04 | 2025-09-26 | 锐新医药公司 | Ras抑制剂 |
| WO2021091956A1 (en) | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2021088458A1 (en) | 2019-11-04 | 2021-05-14 | Jacobio Pharmaceuticals Co., Ltd. | Kras mutant protein inhibitor |
| PE20221323A1 (es) | 2019-11-07 | 2022-09-09 | Chugai Pharmaceutical Co Ltd | Compuesto de peptidos ciclicos que tiene accion inhibidora de kras |
| CN112778301A (zh) | 2019-11-07 | 2021-05-11 | 苏州泽璟生物制药股份有限公司 | 四氢吡啶并嘧啶类抑制剂及其制备方法和应用 |
| WO2021093758A1 (zh) | 2019-11-15 | 2021-05-20 | 四川海思科制药有限公司 | 一种嘧啶并环衍生物及其在医药上的应用 |
| EP4065231A1 (en) | 2019-11-27 | 2022-10-05 | Revolution Medicines, Inc. | Covalent ras inhibitors and uses thereof |
| US20230061083A1 (en) | 2019-11-29 | 2023-03-02 | Evopoint Biosciences Co., Ltd. | Kras g12c inhibitor compound and use thereof |
| US12479834B2 (en) | 2019-11-29 | 2025-11-25 | Taiho Pharmaceutical Co., Ltd. | Phenol compound or salt thereof |
| WO2021106231A1 (en) | 2019-11-29 | 2021-06-03 | Taiho Pharmaceutical Co., Ltd. | A compound having inhibitory activity against kras g12d mutation |
| BR112022010254A2 (pt) | 2019-12-02 | 2022-09-06 | Shanghai Yingli Pharm Co Ltd | Composto heterocíclico contendo oxigênio representado pela fórmula i, método para preparar o composto heterocíclico contendo oxigênio, composto, composição farmacêutica e uso composto heterocíclico contendo oxigênio |
| WO2021113595A1 (en) | 2019-12-06 | 2021-06-10 | Beta Pharma, Inc. | Phosphorus derivatives as kras inhibitors |
| WO2021120045A1 (en) | 2019-12-18 | 2021-06-24 | InventisBio Co., Ltd. | Heterocyclic compounds, preparation methods and uses thereof |
| WO2021126799A1 (en) | 2019-12-18 | 2021-06-24 | Merck Sharp & Dohme Corp. | Macrocyclic peptides as potent inhibitors of k-ras g12d mutant |
| CA3165238A1 (en) | 2019-12-19 | 2021-06-24 | Jacobio Pharmaceuticals Co., Ltd. | Kras mutant protein inhibitors |
| WO2021121397A1 (zh) | 2019-12-19 | 2021-06-24 | 首药控股(北京)股份有限公司 | 取代的炔基杂环化合物 |
| WO2021121371A1 (zh) | 2019-12-19 | 2021-06-24 | 贝达药业股份有限公司 | Kras g12c抑制剂及其在医药上的应用 |
| EP4076667A1 (en) | 2019-12-20 | 2022-10-26 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
| TR201920922A2 (tr) | 2019-12-20 | 2020-06-22 | Ankara Ueniversitesi | 3/4-((2E,6E)-3,7,11-Trimetildodeka-2,6,10-trieniltiyo)benzamid Türevi Bileşikler |
| CN114929704B (zh) | 2019-12-27 | 2024-07-23 | 微境生物医药科技(上海)有限公司 | 含螺环的喹唑啉化合物 |
| CN113045565A (zh) | 2019-12-27 | 2021-06-29 | 微境生物医药科技(上海)有限公司 | 新型K-Ras G12C抑制剂 |
| WO2021139678A1 (zh) | 2020-01-07 | 2021-07-15 | 广州百霆医药科技有限公司 | 吡啶并嘧啶类kras g12c突变蛋白抑制剂 |
| TWI770760B (zh) | 2020-01-08 | 2022-07-11 | 大陸商蘇州亞盛藥業有限公司 | 螺環四氫喹唑啉 |
| US20210269434A1 (en) | 2020-01-10 | 2021-09-02 | Incyte Corporation | Tricyclic compounds as inhibitors of kras |
| CN115175908B (zh) | 2020-01-13 | 2024-07-23 | 苏州泽璟生物制药股份有限公司 | 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用 |
| KR102382613B1 (ko) | 2020-01-15 | 2022-04-06 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 7-아미노-3,4-디히드로피리미도피리미딘-2-온 유도체 및 이를 포함하는 치료용 약학 조성물 |
| KR102396930B1 (ko) | 2020-01-15 | 2022-05-12 | 한국과학기술연구원 | 피리도[3,4-d]피리미딘 유도체 및 이를 포함하는 치료용 약학 조성물 |
| WO2021150613A1 (en) | 2020-01-20 | 2021-07-29 | Incyte Corporation | Spiro compounds as inhibitors of kras |
| WO2021147965A1 (zh) | 2020-01-21 | 2021-07-29 | 南京明德新药研发有限公司 | 作为kras抑制剂的大环类化合物 |
| GB202001344D0 (en) | 2020-01-31 | 2020-03-18 | Redx Pharma Plc | Ras Inhibitors |
| EP4077328A4 (en) | 2020-02-20 | 2023-11-29 | Beta Pharma, Inc. | PYRIDOPYRIMIDE DERIVATIVES AS KRAS INHIBITORS |
| TW202140450A (zh) | 2020-02-24 | 2021-11-01 | 大陸商泰勵生物科技（上海）有限公司 | 用於癌症治療的ｋｒａｓ抑制劑 |
| CN114845997B (zh) | 2020-02-24 | 2024-03-29 | 上海喆邺生物科技有限公司 | 芳香类化合物及其在制备抗肿瘤药物中的应用 |
| US20210292330A1 (en) | 2020-02-28 | 2021-09-23 | Erasca, Inc. | Pyrrolidine-fused heterocycles |
| WO2021175199A1 (zh) | 2020-03-02 | 2021-09-10 | 上海喆邺生物科技有限公司 | 一类芳香杂环类化合物及其在药物中的应用 |
| KR20210111711A (ko) | 2020-03-03 | 2021-09-13 | 웰마커바이오 주식회사 | Kras 돌연변이 및 활성화된 ron이 존재하는 암의 예방 또는 치료용 약학 조성물 |
| CA3172812A1 (en) | 2020-03-05 | 2021-09-10 | The Regents Of The University Of Michigan | Inhibitors of egfr, kras, braf, and other targets and use of the same |
| MX2022010977A (es) | 2020-03-05 | 2022-12-02 | Univ Michigan Regents | Inhibidores de egfr, kras, braf y otros objetivos y uso de los mismos. |
| KR102822517B1 (ko) | 2020-03-12 | 2025-06-19 | 디3 바이오 (우씨) 컴퍼니, 리미티드 | 피리미도헤테로사이클릭 화합물 및 이의 응용 |
| WO2021185233A1 (en) | 2020-03-17 | 2021-09-23 | Jacobio Pharmaceuticals Co., Ltd. | Kras mutant protein inhibitors |
| CA3170068A1 (en) | 2020-03-25 | 2021-09-30 | Yuli Xie | Spiro ring-containing quinazoline compound |
| AU2021248363B2 (en) | 2020-04-03 | 2024-02-15 | Medshine Discovery Inc. | Octahydropyrazinodiazanaphthyridine dione compounds |
| US20220370416A1 (en) | 2020-04-06 | 2022-11-24 | Arvinas Operations, Inc. | Compounds and methods for targeted degradation of kras |
| WO2021203768A1 (zh) | 2020-04-08 | 2021-10-14 | 江苏恒瑞医药股份有限公司 | 嘧啶并二环类衍生物、其制备方法及其在医药上的应用 |
| CA3179692A1 (en) | 2020-04-16 | 2021-10-21 | Incyte Corporation | Fused tricyclic kras inhibitors |
| WO2021216770A1 (en) | 2020-04-22 | 2021-10-28 | Accutar Biotechnology Inc. | Substituted tetrahydroquinazoline compounds as kras inhibitors |
| EP4138875A4 (en) | 2020-04-23 | 2024-08-28 | The Regents of the University of California | RAS INHIBITORS AND USES THEREOF |
| WO2021215544A1 (en) | 2020-04-24 | 2021-10-28 | Taiho Pharmaceutical Co., Ltd. | Kras g12d protein inhibitors |
| WO2021218110A1 (zh) | 2020-04-29 | 2021-11-04 | 上海凌达生物医药有限公司 | 一类苯并噻唑基联芳基类化合物、制备方法和用途 |
| CN115135636B (zh) | 2020-04-29 | 2024-08-23 | 北京泰德制药股份有限公司 | 喹喔啉酮衍生物作为kras g12c突变蛋白的不可逆抑制剂 |
| CN116194456B (zh) | 2020-04-30 | 2025-08-29 | 上海科州药物股份有限公司 | 作为kras抑制剂的杂环化合物的制备及其应用方法 |
| US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
| CN113666923A (zh) | 2020-05-15 | 2021-11-19 | 苏州泽璟生物制药股份有限公司 | 烷氧基烷基取代杂环基类抑制剂及其制备方法和应用 |
| WO2021236475A1 (en) | 2020-05-18 | 2021-11-25 | Asinex Corporation | Compounds that inhibit asparagine synthetase and their methods of use |
| TWI799871B (zh) | 2020-05-27 | 2023-04-21 | 大陸商勁方醫藥科技(上海)有限公司 | 三環并環類化合物，其製法與醫藥上的用途 |
| US20230210852A1 (en) | 2020-05-29 | 2023-07-06 | Syros Pharmaceuticals, Inc. | Methods of treating cancer in patients with an anomalous kras gene or deletions within chromosome 9 |
| WO2021245055A1 (en) | 2020-06-02 | 2021-12-09 | Boehringer Ingelheim International Gmbh | Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer |
| EP4161934A1 (en) | 2020-06-04 | 2023-04-12 | Antengene Discovery Limited | Inhibitors of kras g12c protein and uses thereof |
| MX2022015253A (es) | 2020-06-04 | 2023-03-14 | Pillai Universal Llc | Moleculas peque?as novedosas para la degradacion dirigida de kras no dirigibles en la terapia contra el cancer. |
| WO2021248079A1 (en) | 2020-06-05 | 2021-12-09 | Sparcbio Llc | Heterocyclic compounds and methods of use thereof |
| WO2021248083A1 (en) | 2020-06-05 | 2021-12-09 | Sparcbio Llc | Heterocyclic compounds and methods of use thereof |
| WO2021248082A1 (en) | 2020-06-05 | 2021-12-09 | Sparcbio Llc | Heterocyclic compounds and methods of use thereof |
| US20230026856A1 (en) | 2020-06-05 | 2023-01-26 | Sparcbio Llc | Heterocyclic compounds and methods of use thereof |
| US20230023009A1 (en) | 2020-06-05 | 2023-01-26 | Sparcbio Llc | Heterocyclic compounds and methods of use thereof |
| WO2021252339A1 (en) | 2020-06-08 | 2021-12-16 | Accutar Biotechnology, Inc. | Substituted purine-2,6-dione compounds as kras inhibitors |
| WO2021249563A1 (zh) | 2020-06-12 | 2021-12-16 | 苏州泽璟生物制药股份有限公司 | 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用 |
| EP4168414A1 (en) | 2020-06-18 | 2023-04-26 | Shy Therapeutics LLC | Substituted thienopyrimidines that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| WO2021259331A1 (zh) | 2020-06-24 | 2021-12-30 | 南京明德新药研发有限公司 | 八元含n杂环类化合物 |
| WO2022002102A1 (en) | 2020-06-30 | 2022-01-06 | InventisBio Co., Ltd. | Quinazoline compounds, preparation methods and uses thereof |
| EP4182313A4 (en) | 2020-07-16 | 2024-10-09 | Mirati Therapeutics, Inc. | KRAS-G12D INHIBITORS |
| TW202214608A (zh) | 2020-07-20 | 2022-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合噠嗪類衍生物、其製備方法及其在醫藥上的應用 |
| CN115052870B (zh) | 2020-08-02 | 2024-02-20 | 上海喆邺生物科技有限公司 | 一种芳香类化合物及其在抗肿瘤药物中的应用 |
| EP4192585A4 (en) | 2020-08-04 | 2024-08-21 | Mirati Therapeutics, Inc. | Kras g12d inhibitors |
| WO2022028492A1 (en) | 2020-08-05 | 2022-02-10 | Beigene, Ltd. | Imidazotriazine and pyrrolopyrimidine derivatives as kras g12c inhibitors |
| WO2022036176A1 (en) | 2020-08-13 | 2022-02-17 | Albert Einstein College Of Medicine | N-cyclyl-sulfonamides useful for inhibiting raf |
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