AU2004282491C1 - Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates - Google Patents

Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates Download PDF

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Publication number
AU2004282491C1
AU2004282491C1 AU2004282491A AU2004282491A AU2004282491C1 AU 2004282491 C1 AU2004282491 C1 AU 2004282491C1 AU 2004282491 A AU2004282491 A AU 2004282491A AU 2004282491 A AU2004282491 A AU 2004282491A AU 2004282491 C1 AU2004282491 C1 AU 2004282491C1
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Australia
Prior art keywords
cell
binding agent
antibody
cells
maytansinoid
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AU2004282491A
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AU2004282491A1 (en
AU2004282491B2 (en
Inventor
Ravi Chari
Yelena Kovtun
Robert Lutz
Rita Steeves
Hongsheng Xie
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Immunogen Inc
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Immunogen Inc
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Priority claimed from AU2004247015A external-priority patent/AU2004247015B2/en
Application filed by Immunogen Inc filed Critical Immunogen Inc
Priority to AU2004282491A priority Critical patent/AU2004282491C1/en
Publication of AU2004282491A1 publication Critical patent/AU2004282491A1/en
Assigned to IMMUNOGEN, INC. reassignment IMMUNOGEN, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: IMMUNOGEN, INC.
Priority to AU2010212291A priority patent/AU2010212291C1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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AU2004282491A 2003-05-14 2004-10-12 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates Active 2028-09-03 AU2004282491C1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2004282491A AU2004282491C1 (en) 2003-05-14 2004-10-12 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
AU2010212291A AU2010212291C1 (en) 2003-05-14 2010-08-12 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US60/470,550 2003-05-14
US50990103P 2003-10-10 2003-10-10
US60/509,901 2003-10-10
AU2004247015A AU2004247015B2 (en) 2003-05-14 2004-05-14 Drug conjugate composition
US10/960,602 US8088387B2 (en) 2003-10-10 2004-10-08 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US10/960,602 2004-10-08
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