ATE346160T1 - Proteingerüste für antikörper-mimetika und andere bindungsproteine - Google Patents

Proteingerüste für antikörper-mimetika und andere bindungsproteine

Info

Publication number
ATE346160T1
ATE346160T1 AT01913159T AT01913159T ATE346160T1 AT E346160 T1 ATE346160 T1 AT E346160T1 AT 01913159 T AT01913159 T AT 01913159T AT 01913159 T AT01913159 T AT 01913159T AT E346160 T1 ATE346160 T1 AT E346160T1
Authority
AT
Austria
Prior art keywords
antibod
mimetics
binding proteins
protein scaffolds
proteins
Prior art date
Application number
AT01913159T
Other languages
English (en)
Inventor
Dasa Lipovsek
Richard W Wagner
Robert G Kuimelis
Original Assignee
Adnexus Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adnexus Therapeutics Inc filed Critical Adnexus Therapeutics Inc
Application granted granted Critical
Publication of ATE346160T1 publication Critical patent/ATE346160T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT01913159T 2000-02-29 2001-02-28 Proteingerüste für antikörper-mimetika und andere bindungsproteine ATE346160T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/515,260 US6818418B1 (en) 1998-12-10 2000-02-29 Protein scaffolds for antibody mimics and other binding proteins

Publications (1)

Publication Number Publication Date
ATE346160T1 true ATE346160T1 (de) 2006-12-15

Family

ID=24050620

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01913159T ATE346160T1 (de) 2000-02-29 2001-02-28 Proteingerüste für antikörper-mimetika und andere bindungsproteine

Country Status (11)

Country Link
US (2) US6818418B1 (de)
EP (1) EP1266025B1 (de)
JP (1) JP4829457B2 (de)
AT (1) ATE346160T1 (de)
AU (2) AU2001241850B2 (de)
CA (1) CA2400058A1 (de)
DE (1) DE60124678T2 (de)
DK (1) DK1266025T3 (de)
ES (1) ES2276770T3 (de)
PT (1) PT1266025E (de)
WO (1) WO2001064942A1 (de)

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CA2412664A1 (en) * 2000-06-15 2001-12-20 Board Of Regents The University Of Texas System Regulatable, catalytically active nucleic acids
EP2141243A3 (de) * 2000-10-16 2010-01-27 Brystol-Myers Squibb Company Proteingerüste für Antikörpermimetika und andere Bindungsproteine

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CA2400058A1 (en) 2001-09-07
US6818418B1 (en) 2004-11-16
WO2001064942A1 (en) 2001-09-07
PT1266025E (pt) 2007-02-28
EP1266025A1 (de) 2002-12-18
JP2003525487A (ja) 2003-08-26
AU4185001A (en) 2001-09-12
DE60124678T2 (de) 2007-09-13
AU2001241850B2 (en) 2006-09-07
ES2276770T3 (es) 2007-07-01
US20050255548A1 (en) 2005-11-17
EP1266025B1 (de) 2006-11-22
DE60124678D1 (de) 2007-01-04
JP4829457B2 (ja) 2011-12-07
EP1266025A4 (de) 2005-02-02
DK1266025T3 (da) 2007-03-19

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