SG11202108281UA - Claudin 6 antibodies and uses thereof - Google Patents

Claudin 6 antibodies and uses thereof

Info

Publication number
SG11202108281UA
SG11202108281UA SG11202108281UA SG11202108281UA SG11202108281UA SG 11202108281U A SG11202108281U A SG 11202108281UA SG 11202108281U A SG11202108281U A SG 11202108281UA SG 11202108281U A SG11202108281U A SG 11202108281UA SG 11202108281U A SG11202108281U A SG 11202108281UA
Authority
SG
Singapore
Prior art keywords
claudin
antibodies
Prior art date
Application number
SG11202108281UA
Inventor
Ross Chambers
Joseph Rucker
Thomas Charpentier
Lewis J Stafford
Brad Screnci
Trevor Barnes
Benjamin Doranz
Original Assignee
Integral Molecular Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Integral Molecular Inc filed Critical Integral Molecular Inc
Publication of SG11202108281UA publication Critical patent/SG11202108281UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11202108281UA 2019-02-15 2020-02-13 Claudin 6 antibodies and uses thereof SG11202108281UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962806048P 2019-02-15 2019-02-15
PCT/US2020/018087 WO2020168059A1 (en) 2019-02-15 2020-02-13 Claudin 6 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
SG11202108281UA true SG11202108281UA (en) 2021-08-30

Family

ID=72043303

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202108281UA SG11202108281UA (en) 2019-02-15 2020-02-13 Claudin 6 antibodies and uses thereof

Country Status (19)

Country Link
US (2) US11248046B2 (en)
EP (1) EP3924389A4 (en)
JP (1) JP2022521723A (en)
KR (1) KR20210128443A (en)
CN (1) CN113767113A (en)
AU (1) AU2020223293A1 (en)
BR (1) BR112021016056A2 (en)
CA (1) CA3129834A1 (en)
CL (1) CL2021002141A1 (en)
CO (1) CO2021011906A2 (en)
CR (1) CR20210471A (en)
EA (1) EA202192146A1 (en)
EC (1) ECSP21068097A (en)
IL (1) IL285626A (en)
MA (1) MA54955A (en)
MX (1) MX2021009831A (en)
SG (1) SG11202108281UA (en)
WO (1) WO2020168059A1 (en)
ZA (1) ZA202106602B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022520632A (en) 2019-02-15 2022-03-31 インテグラル・モレキュラー・インコーポレイテッド Antibodies containing a common light chain and their use
CN113767113A (en) 2019-02-15 2021-12-07 因特格尔莫来库乐有限公司 Encapsulated protein 6 antibodies and uses thereof
AU2022229356A1 (en) * 2021-03-02 2023-08-10 Novarock Biotherapeutics, Ltd. Antibodies against claudin-6 and uses thereof
JPWO2023053282A1 (en) * 2021-09-29 2023-04-06
WO2023230624A2 (en) * 2022-05-27 2023-11-30 Taipei Medical University Epha2-targeting antibodies and their applications in cancer treatment
US20240174751A1 (en) * 2022-11-30 2024-05-30 Integral Molecular, Inc. Antibodies directed to claudin 6, including bispecific formats thereof

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (en) 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US4699880A (en) 1984-09-25 1987-10-13 Immunomedics, Inc. Method of producing monoclonal anti-idiotype antibody
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
EP0247091B1 (en) 1985-11-01 1993-09-29 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
EP0281604B1 (en) 1986-09-02 1993-03-31 Enzon Labs Inc. Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
DE3920358A1 (en) 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
ES2259800T3 (en) 1990-06-11 2006-10-16 Gilead Sciences, Inc. PROCEDURES FOR THE USE OF NUCLEIC ACID LINKS.
DK1136556T3 (en) 1991-11-25 2005-10-03 Enzon Inc Process for the preparation of multivalent antigen-binding proteins
US6005079A (en) 1992-08-21 1999-12-21 Vrije Universiteit Brussels Immunoglobulins devoid of light chains
WO1994004678A1 (en) 1992-08-21 1994-03-03 Casterman Cecile Immunoglobulins devoid of light chains
ES2162863T3 (en) 1993-04-29 2002-01-16 Unilever Nv PRODUCTION OF ANTIBODIES OR FRAGMENTS (FUNCTIONALIZED) OF THE SAME DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF CAMELIDAE.
SE9400088D0 (en) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
DK0773952T3 (en) 1994-07-20 2004-03-22 Inst Genetics Llc Interaction trap systems for detecting protein interactions
US7763258B2 (en) 1997-05-20 2010-07-27 The Trustees Of The University Of Pennsylvania Virus-like particles (VLPs) comprising heterologous multiple membrane spanning proteins
DE19742706B4 (en) 1997-09-26 2013-07-25 Pieris Proteolab Ag lipocalin muteins
AUPP221098A0 (en) 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
US6955807B1 (en) 1998-05-15 2005-10-18 Bayer Pharmaceuticals Corporation IL-2 selective agonists and antagonists
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
EP2230303B1 (en) 1999-05-05 2013-01-16 Phylogica Limited Isolating biological modulators from biodiverse gene fragment libraries
JP2003500080A (en) 1999-05-26 2003-01-07 リセンチア エルテーデー Methods and materials for producing SH3 domains with designed binding capacity
SE0001877D0 (en) 2000-05-22 2000-05-22 Klaus Mosbach Molecular imprinting
WO2002020565A2 (en) 2000-09-08 2002-03-14 Universität Zürich Collections of repeat proteins comprising repeat modules
DE10053224A1 (en) 2000-10-26 2002-05-08 Univ Goettingen Georg August Procedure for the exposure of peptides and polypeptides to the cell surface of bacteria
EP2284270A3 (en) 2000-12-13 2012-07-25 Anaphore, Inc. Method for the identification and isolation of binding polypeptides from combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains
AUPR546801A0 (en) * 2001-06-05 2001-06-28 Commonwealth Scientific And Industrial Research Organisation Recombinant antibodies
US20040023334A1 (en) 2001-08-30 2004-02-05 Biorexis Pharmaceutical Corporation Modified transferrin fusion proteins
EP1608947A4 (en) 2002-10-02 2009-06-17 Catalyst Biosciences Inc Methods of generating and screening for proteases with altered specificity
EP1587907B1 (en) 2003-01-07 2011-03-02 Dyax Corporation Kunitz domain library
US8574590B2 (en) 2003-07-30 2013-11-05 Integral Molecular, Inc. Lipoparticles comprising proteins, methods of making, and using the same
US20060234205A1 (en) 2004-03-05 2006-10-19 Chiron Corporation In vitro test system for predicting patient tolerability of therapeutic agents
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
DE102004049479A1 (en) 2004-10-11 2006-04-13 Scil Proteins Gmbh Protein conjugates for use in therapy, diagnosis and chromatography
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
US8377691B2 (en) 2006-01-26 2013-02-19 Integral Molecular, Inc. Lipoparticles comprising ion channels, methods of making and using the same
EP1892248A1 (en) 2006-08-21 2008-02-27 Eidgenössische Technische Hochschule Zürich Specific and high affinity binding proteins comprising modified SH3 domains of FYN kinase
GB0624500D0 (en) * 2006-12-07 2007-01-17 Istituto Superiore Di Sanito A novel passive vaccine for candida infections
WO2008151088A2 (en) 2007-06-01 2008-12-11 University Of Maryland, Baltimore Immunoglobulin constant region fc receptor binding agents
WO2009025759A1 (en) 2007-08-17 2009-02-26 Progenics Pharmaceuticals (Nevada), Inc. Tight junction proteins associated with infection and entry of hepatitis c virus (hcv), methods and uses thereof
EP2241578B1 (en) 2008-01-11 2016-04-20 The University of Tokyo Anti-cldn6 antibody
WO2010085495A1 (en) 2009-01-21 2010-07-29 Amgen Inc. Compositions and methods of treating inflammatory and autoimmune diseases
US9074002B2 (en) * 2009-04-27 2015-07-07 Cold Spring Harbor Laboratory PTP1B inhibitors
BR112012011143B1 (en) 2009-11-11 2020-05-19 Ganymed Pharmaceuticals Ag "antibodies specific for claudin 6 (cldn6)".
EP2322555A1 (en) * 2009-11-11 2011-05-18 Ganymed Pharmaceuticals AG Antibodies specific for claudin 6 (CLDN6)
JP5742714B2 (en) 2010-02-04 2015-07-01 東レ株式会社 Pharmaceutical composition for treatment and / or prevention of cancer
EP2404936A1 (en) * 2010-07-06 2012-01-11 Ganymed Pharmaceuticals AG Cancer therapy using CLDN6 target-directed antibodies in vivo
WO2012088446A1 (en) 2010-12-22 2012-06-28 Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
MX341147B (en) 2011-05-13 2016-08-09 Ganymed Pharmaceuticals Ag Antibodies for treatment of cancer expressing claudin 6.
EP2766785B1 (en) 2011-10-14 2019-03-13 Ergotron, Inc. Tablet mounting arm systems and methods
EP2804620A4 (en) 2012-01-18 2016-04-13 Neumedicines Inc Il-12 for radiation protection and radiation-induced toxicity mitigation
WO2014016737A1 (en) * 2012-07-24 2014-01-30 Pfizer Inc. Novel chicken monoclonal antibodies against human phosphorylated tau and uses thereof
US9546203B2 (en) 2013-03-14 2017-01-17 Amgen Inc. Aglycosylated Fc-containing polypeptides with cysteine substitutions
WO2015014376A1 (en) 2013-07-31 2015-02-05 Biontech Ag Diagnosis and therapy of cancer involving cancer stem cells
CN103483449A (en) 2013-08-20 2014-01-01 东北农业大学 Two ScFv (Single Chain Variable Fragment ) antibodies, encoding genes and application thereof for preparing preparation for treating or preventing infectious bursal disease of chicken
PE20160870A1 (en) 2013-11-06 2016-09-09 Abbvie Stemcentrx Llc NOVEL ANTI-CLAUDIN ANTIBODIES AND METHODS OF USE
RS59789B1 (en) 2014-07-21 2020-02-28 Delinia Inc Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
WO2016025385A1 (en) 2014-08-11 2016-02-18 Delinia, Inc. Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases
CA2874083C (en) * 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
EP4223786A3 (en) 2015-03-06 2023-08-16 Public University Corporation Yokohama City University Novel anti-pad4 antibodies
GB201607534D0 (en) 2016-04-29 2016-06-15 Immunocore Ltd & Adaptimmune Ltd Peptides
PE20181302A1 (en) * 2015-12-04 2018-08-09 Abbvie Stemcentrx Llc NEW ANTI-CLAUDIN ANTIBODIES AND THEIR METHODS OF USE
CN109862907A (en) 2016-05-02 2019-06-07 泰特拉基因股份有限公司 Anti- Kv1.3 antibody and its production method and purposes
CN109071623B (en) 2016-05-04 2022-05-27 美国安进公司 Interleukin-2 muteins for expansion of T regulatory cells
WO2018054484A1 (en) 2016-09-23 2018-03-29 Biontech Ag Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
WO2018067198A1 (en) 2016-10-03 2018-04-12 The Regents Of The University Of California Inhibitory antibodies and methods of use thereof
WO2019048040A1 (en) 2017-09-06 2019-03-14 Ganymed Pharmaceuticals Gmbh Antibodies useful in cancer diagnosis
GB202103867D0 (en) 2017-09-18 2021-05-05 Univ California Claudin6 antibodies and methods of treating cancer
WO2020075325A1 (en) 2018-10-09 2020-04-16 公立大学法人福島県立医科大学 Biomarker for predicting prognosis of endometrial cancer patient
JP2022520632A (en) 2019-02-15 2022-03-31 インテグラル・モレキュラー・インコーポレイテッド Antibodies containing a common light chain and their use
CN113767113A (en) 2019-02-15 2021-12-07 因特格尔莫来库乐有限公司 Encapsulated protein 6 antibodies and uses thereof
MX2021011330A (en) 2019-03-20 2021-12-10 Univ California Claudin-6 antibodies and drug conjugates.
CN113950485A (en) 2019-07-10 2022-01-18 中外制药株式会社 Claudin-6 binding molecules and uses thereof

Also Published As

Publication number Publication date
MX2021009831A (en) 2021-09-10
EP3924389A4 (en) 2023-06-14
CL2021002141A1 (en) 2022-04-01
US11248046B2 (en) 2022-02-15
EP3924389A1 (en) 2021-12-22
EA202192146A1 (en) 2021-11-09
AU2020223293A1 (en) 2021-08-19
IL285626A (en) 2021-09-30
US20220127355A1 (en) 2022-04-28
CN113767113A (en) 2021-12-07
CR20210471A (en) 2021-12-08
KR20210128443A (en) 2021-10-26
US20200262915A1 (en) 2020-08-20
JP2022521723A (en) 2022-04-12
CA3129834A1 (en) 2020-08-20
MA54955A (en) 2021-12-22
WO2020168059A1 (en) 2020-08-20
CO2021011906A2 (en) 2021-09-30
BR112021016056A2 (en) 2021-12-14
ECSP21068097A (en) 2021-11-18
ZA202106602B (en) 2023-12-20

Similar Documents

Publication Publication Date Title
IL276830A (en) Anti-claudin 18.2 antibodies and uses thereof
SG10202111141WA (en) Anti-claudin 18.2 antibodies and uses thereof
IL276950A (en) Anti-cd73 antibodies and uses thereof
IL282968A (en) Anti-nkg2a antibodies and uses thereof
IL285626A (en) Claudin 6 antibodies and uses thereof
ZA202106880B (en) Anti-claudin 18.2 antibody and application thereof
IL289585A (en) Dll3-targeting antibodies and uses thereof
EP4063386A4 (en) Anti-human claudin 18.2 antibody and application thereof
EP3971208A4 (en) Antibody against claudin 18a2 and use thereof
IL275826A (en) Anti-mct1 antibodies and uses thereof
IL285746A (en) High-affinity anti-mertk antibodies and uses thereof
SG11202009772PA (en) Anti-dll3 antibodies and uses thereof
IL290141A (en) Anti-pvrig antibodies formulations and uses thereof
IL289269A (en) Anti-cd24 antibody and uses thereof
IL281297A (en) Anti-npr1 antibodies and uses thereof
SG11202112112UA (en) Anti-galectin-9 antibodies and uses thereof
IL277330A (en) Anti-il-27 antibodies and uses thereof
SG11202009625WA (en) Anti-trem-1 antibodies and uses thereof
IL287690A (en) Anti-hvem antibodies and use thereof
IL291027A (en) Anti-steap1 antibodies and uses thereof
IL280321A (en) Anti-cxcr2 antibodies and uses thereof
IL289656A (en) Anti-tigit antibodies and application thereof
IL283875A (en) Anti-il-27 antibodies and uses thereof
IL281202A (en) Anti-tnfrsf9 antibodies and uses thereof
IL277075A (en) Anti-phf-tau antibodies and uses thereof