ATE233740T1 - Pyrimidineihibitoren der hiv-replikation - Google Patents

Pyrimidineihibitoren der hiv-replikation

Info

Publication number
ATE233740T1
ATE233740T1 AT99203590T AT99203590T ATE233740T1 AT E233740 T1 ATE233740 T1 AT E233740T1 AT 99203590 T AT99203590 T AT 99203590T AT 99203590 T AT99203590 T AT 99203590T AT E233740 T1 ATE233740 T1 AT E233740T1
Authority
AT
Austria
Prior art keywords
hibitors
pyrimidine
hiv replication
hiv
replication
Prior art date
Application number
AT99203590T
Other languages
German (de)
English (en)
Inventor
Bart De Corte
Marc Rene De Jonge
Jan Heeres
Chih Yung Ho
Paul Adriaan Jan Janssen
Robert W Kavash
Lucien Maria Henricus Koymans
Michael Joseph Kukla
Donald William Ludovici
Koen Jeanne Alfons Van Aken
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26805159&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE233740(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE233740T1 publication Critical patent/ATE233740T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT99203590T 1998-11-10 1999-11-01 Pyrimidineihibitoren der hiv-replikation ATE233740T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10779298P 1998-11-10 1998-11-10
US14396299P 1999-07-15 1999-07-15
PCT/EP1999/007417 WO2000027825A1 (en) 1998-11-10 1999-09-24 Hiv replication inhibiting pyrimidines

Publications (1)

Publication Number Publication Date
ATE233740T1 true ATE233740T1 (de) 2003-03-15

Family

ID=26805159

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99203590T ATE233740T1 (de) 1998-11-10 1999-11-01 Pyrimidineihibitoren der hiv-replikation
AT02018455T ATE455107T1 (de) 1998-11-10 1999-11-01 Hiv-replikationshemmende pyrimidine

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02018455T ATE455107T1 (de) 1998-11-10 1999-11-01 Hiv-replikationshemmende pyrimidine

Country Status (41)

Country Link
US (5) US6878717B2 (OSRAM)
EP (2) EP1270560B1 (OSRAM)
JP (1) JP3635238B2 (OSRAM)
KR (1) KR100658489B1 (OSRAM)
CN (1) CN1214013C (OSRAM)
AP (1) AP1683A (OSRAM)
AR (1) AR024227A1 (OSRAM)
AT (2) ATE233740T1 (OSRAM)
AU (2) AU762523C (OSRAM)
BG (1) BG65103B1 (OSRAM)
BR (1) BRPI9915552B8 (OSRAM)
CA (1) CA2350801C (OSRAM)
CY (1) CY2008021I1 (OSRAM)
CZ (1) CZ301367B6 (OSRAM)
DE (3) DE122009000003I1 (OSRAM)
DK (1) DK1002795T3 (OSRAM)
EA (1) EA004049B1 (OSRAM)
EE (1) EE05086B1 (OSRAM)
ES (2) ES2338760T3 (OSRAM)
FR (1) FR09C0004I2 (OSRAM)
HK (1) HK1048817B (OSRAM)
HR (2) HRP20080359B1 (OSRAM)
HU (2) HU230394B1 (OSRAM)
ID (1) ID28376A (OSRAM)
IL (2) IL143023A0 (OSRAM)
LT (1) LTC1002795I2 (OSRAM)
LU (1) LU91528I2 (OSRAM)
MY (1) MY121108A (OSRAM)
NL (1) NL300373I2 (OSRAM)
NO (3) NO318801B1 (OSRAM)
NZ (1) NZ511116A (OSRAM)
OA (1) OA11674A (OSRAM)
PL (1) PL204427B1 (OSRAM)
PT (1) PT1002795E (OSRAM)
SI (1) SI1002795T1 (OSRAM)
SK (2) SK287270B6 (OSRAM)
TR (1) TR200101306T2 (OSRAM)
TW (1) TWI238161B (OSRAM)
UA (1) UA70966C2 (OSRAM)
WO (1) WO2000027825A1 (OSRAM)
ZA (1) ZA200103769B (OSRAM)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA11674A (en) * 1998-11-10 2005-01-12 Janssen Pharmaceutica Nv HIV Replication inhibiting pyrimidines.
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
SK285240B6 (sk) 1999-09-24 2006-09-07 Janssen Pharmaceutica N. V. Antivírusové prostriedky
DE19945982A1 (de) 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
AU770600B2 (en) 1999-10-07 2004-02-26 Amgen, Inc. Triazine kinase inhibitors
CA2400447C (en) 2000-02-17 2008-04-22 Amgen Inc. Kinase inhibitors
AU783981C (en) * 2000-05-08 2007-05-03 Janssen Pharmaceutica N.V. HIV replication inhibitors
JP4969010B2 (ja) 2000-05-08 2012-07-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｈｉｖ複製阻害性ピリミジンのプロドラッグ
US7418471B2 (en) * 2000-11-01 2008-08-26 Snapnames.Com, Inc. Domain name acquisition and management system and method
MEP13408A (en) 2001-05-29 2010-06-10 Bayer Schering Pharma Ag Cdk inhibiting pyrimidines, production thereof and their use as medicaments
US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
JP4460292B2 (ja) 2001-10-17 2010-05-12 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト ピリミジン誘導体、これらの化合物を含む医薬組成物、その使用及びその調製方法
EP1453516A2 (de) 2001-10-17 2004-09-08 Boehringer Ingelheim Pharma GmbH & Co.KG 5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren
IL161662A0 (en) 2001-11-01 2004-09-27 Janssen Pharmaceutica Nv Heteroaryl amines as glycogen synthase kinase 3 beta inhibitors (gsk3 inhibitors)
BR0213791A (pt) 2001-11-01 2004-12-07 Janssen Pharmaceutica Nv Derivados de amida como inibidores de glicogênio sintase quinase 3-beta
SE0104140D0 (sv) 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
EP1485354B1 (en) 2002-03-13 2008-05-28 Janssen Pharmaceutica N.V. Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
JP4725944B2 (ja) 2002-03-13 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの阻害剤
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
EA008244B1 (ru) * 2002-05-03 2007-04-27 Янссен Фармацевтика Н.В. Полимерные микроэмульсии
AR039540A1 (es) 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
AR040456A1 (es) 2002-06-27 2005-04-06 Bristol Myers Squibb Co Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana
DK1534286T3 (da) 2002-07-29 2010-04-26 Rigel Pharmaceuticals Inc Fremgangsmåder til behandling eller forebyggelse af autoimmune sygdomme med 2,4-pyrimidindiamin-forbindelser
MY144894A (en) 2002-08-09 2011-11-30 Janssen Pharmaceutica Nv Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2, 6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
EP1551372B8 (en) * 2002-09-20 2018-08-01 Alpharma Pharmaceuticals LLC Sequestering subunit and related compositions and methods
MXPA05005547A (es) * 2002-11-28 2005-07-26 Schering Ag Pirimidinas inhibidoras de chk, pdk y akt, su produccion y uso como agentes farmaceuticos.
CN102558155A (zh) 2003-01-14 2012-07-11 阿伦纳药品公司 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
DE602004015254D1 (de) * 2003-02-07 2008-09-04 Janssen Pharmaceutica Nv Hiv-inhibierende1,2,4-triazine
HRP20050688B1 (hr) 2003-02-07 2017-03-24 Janssen Pharmaceutica N.V. Derivati pirimidina za sprječavanje hiv infekcije
CL2004000306A1 (es) * 2003-02-20 2005-04-08 Tibotec Pharm Ltd Compuestos derivados de pirimidina sustituidas con indano; proceso para su preparacion; composicion farmaceutica que lo comprende; combinacion farmaceutica; y su uso para el tratamiento o profilaxis de una enfermedad infecciosa.
ATE433447T1 (de) 2003-02-20 2009-06-15 Smithkline Beecham Corp Pyrimiidinverbindungen
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
BRPI0412734A (pt) 2003-07-17 2006-09-26 Tibotec Pharm Ltd processo para preparação de partìculas que contêm um antiviral
NZ545270A (en) 2003-07-30 2010-04-30 Rigel Pharmaceuticals Inc 2,4-Pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
CA2535313C (en) * 2003-09-25 2012-07-17 Janssen Pharmaceutica N.V. Hiv replication inhibiting purine derivatives
EP1728186A2 (en) 2004-03-02 2006-12-06 Virco Bvba Estimation of clinical cut-offs
EP1598343A1 (de) * 2004-05-19 2005-11-23 Boehringer Ingelheim International GmbH 2-Arylaminopyrimidine als PLK Inhibitoren
EA010652B1 (ru) 2004-07-28 2008-10-30 Янссен Фармацевтика Н.В. Замещенные индолильные алкиламинопроизводные в качестве новых ингибиторов гистондеацетилазы
AU2005271161B2 (en) 2004-08-10 2011-05-12 Janssen Pharmaceutica N.V. HIV inhibiting 1,2,4-triazin-6-one derivatives
RU2405778C2 (ru) 2004-09-30 2010-12-10 Тиботек Фармасьютикалз Лтд. 5-гетероциклилпиримидины, ингибирующие вич
AU2005288866B2 (en) * 2004-09-30 2012-07-26 Janssen Sciences Ireland Uc HIV inhibiting 5-substituted pyrimidines
BRPI0515935B8 (pt) 2004-09-30 2021-05-25 Janssen Sciences Ireland Uc pirimidinas heterociclil- ou 5-carbo substituídas para inibição de hiv, e composição farmacêutica
US8153640B2 (en) 2004-10-29 2012-04-10 Tibotec Pharmaceuticals Ltd. HIV inhibiting bicyclic pyrimdine derivatives
EP1812069A2 (en) * 2004-11-08 2007-08-01 Boehringer Ingelheim International GmbH Method for treating hiv infection through co-administration of tipranavir and etravirine
ATE540035T1 (de) 2004-11-24 2012-01-15 Rigel Pharmaceuticals Inc Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen
ES2337496T3 (es) 2005-01-19 2010-04-26 Rigel Pharmaceuticals, Inc. Profarmacos de compuestos de 2,4-pirimidindiamina y sus usos.
RU2403245C2 (ru) * 2005-01-27 2010-11-10 Тиботек Фармасьютикалз Лтд. Ингибирующие вич производные 2-(4-цианофениламино)пиримидина
AU2006215386B2 (en) 2005-02-16 2009-06-11 Astrazeneca Ab Chemical compounds
US7935711B2 (en) 2005-02-18 2011-05-03 Tibotec Pharmaceuticals Ltd. HIV inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives
RS51435B (sr) * 2005-03-04 2011-04-30 Tibotec Pharmaceuticals 2-(4-cijanofenil)-6-hidroksilaminopirimidini koji inhibiraju hiv
WO2006123113A2 (en) 2005-05-16 2006-11-23 Astrazeneca Ab Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
AU2006251163C1 (en) 2005-05-26 2012-07-12 Janssen Sciences Ireland Uc Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US7491732B2 (en) 2005-06-08 2009-02-17 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
EA200801025A1 (ru) * 2005-10-06 2008-12-30 Юниверсити Оф Массачусетс Композиция и синтез новых реагентов для ингибирования репликации вич
CA2626375A1 (en) 2005-10-28 2007-05-03 Astrazeneca Ab 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer
CA2630717C (en) 2006-01-19 2015-02-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
RS51191B (sr) 2006-01-19 2010-10-31 Janssen Pharmaceutica N.V. Derivati aminofenila kao novi inhibitori histon deacetilaze
US7834025B2 (en) 2006-01-19 2010-11-16 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
JP2009528295A (ja) 2006-02-24 2009-08-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ｊａｋ経路の阻害のための組成物および方法
SI2004641T1 (sl) 2006-03-30 2011-02-28 Tibotec Pharm Ltd HIV inhibirajoči 5-(hidroksimetilen in aminometilen) substituirani pirimidini
RU2480464C2 (ru) 2006-03-30 2013-04-27 Тиботек Фармасьютикалз Лтд. 5-амидо-замещенные пиримидины, ингибирующие вич
PE20080068A1 (es) 2006-05-15 2008-03-17 Boehringer Ingelheim Int Compuestos derivados de pirimidina como inhibidores de la quinasa aurora
HRP20110883T1 (hr) 2006-06-06 2012-01-31 Tibotec Pharmaceuticals Postupak za pripremanje raspršivanjem osušenih formulacija tmc125
CA2655835C (en) 2006-06-19 2015-07-21 Alpharma, Inc. Abuse-resistant pharmaceutical compositions of opioid agonists
AU2007322269A1 (en) * 2006-10-11 2008-05-29 Alpharma Pharmaceuticals, Llc Pharmaceutical compositions
EP2104491B1 (en) * 2006-12-06 2017-02-22 Janssen Sciences Ireland UC Hydrobromide salt of an anti-hiv compound
US8318736B2 (en) 2006-12-29 2012-11-27 Janssen R&D Ireland HIV inhibiting 5,6-substituted pyrimidines
KR20090094073A (ko) * 2006-12-29 2009-09-03 티보텍 파마슈티칼즈 리미티드 Ｈｉｖ를 억제하는 6-치환된 피리미딘
UA99459C2 (en) 2007-05-04 2012-08-27 Астразенека Аб 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
EP2212298B1 (en) * 2007-10-18 2013-03-27 Concert Pharmaceuticals Inc. Deuterated etravirine
US20100151014A1 (en) * 2008-12-16 2010-06-17 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
WO2009079521A1 (en) * 2007-12-17 2009-06-25 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
ES2645689T5 (en) 2008-05-21 2025-06-24 Takeda Pharmaceuticals Co Phosphorous derivatives as kinase inhibitors
TWI546290B (zh) 2008-06-27 2016-08-21 賽基艾維洛米斯研究股份有限公司 雜芳基化合物及其用途
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
AR073760A1 (es) * 2008-10-03 2010-12-01 Astrazeneca Ab Derivados heterociclicos y metodos de uso de los mismos
US20110071158A1 (en) * 2009-03-18 2011-03-24 Boehringer Ingelheim International Gmbh New compounds
WO2010112411A1 (en) 2009-03-30 2010-10-07 Tibotec Pharmaceuticals Co-crystal of etravirine and nicotinamide
CN102482277B (zh) 2009-05-05 2017-09-19 达纳-法伯癌症研究所有限公司 表皮生长因子受体抑制剂及治疗障碍的方法
WO2010131118A2 (en) * 2009-05-12 2010-11-18 Pliva Hrvatska D.O.O. Polymorphs of etravirine and processes for preparation thereof
BRPI1004934A2 (pt) 2009-06-22 2016-11-29 Emcure Pharmaceuticals Ltd processo para a síntese de inibidor não nucleosídico de transcriptase reversa diarilpirimidínico
WO2011017079A1 (en) 2009-07-27 2011-02-10 Teva Pharmaceutical Industries Ltd. Process for the preparation and purification of etravirine and intermediates thereof
GR1007010B (el) 2009-10-08 2010-10-07 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Ινσουλινοειδη πεπτιδια
PT2576541T (pt) 2010-06-04 2016-07-08 Hoffmann La Roche Derivados de aminopirimidina como moduladores de lrrk2
CA2803848A1 (en) 2010-06-28 2012-01-05 Hetero Research Foundation A process for etravirine intermediate and polymorphs of etravirine
JP6068340B2 (ja) 2010-08-10 2017-01-25 セルジーン アヴィロミクス リサーチ， インコーポレイテッド Ｂｔｋ阻害剤のベシル酸塩
EP3323818A1 (en) 2010-09-22 2018-05-23 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
JP5956999B2 (ja) 2010-11-01 2016-07-27 セルジーン アヴィロミクス リサーチ， インコーポレイテッド ヘテロアリール化合物およびその使用
BR112013010564B1 (pt) 2010-11-01 2021-09-21 Celgene Car Llc Compostos heterocíclicos e composições compreendendo os mesmos
SG189043A1 (en) 2010-11-10 2013-05-31 Hoffmann La Roche Pyrazole aminopyrimidine derivatives as lrrk2 modulators
EP2637502B1 (en) 2010-11-10 2018-01-10 Celgene CAR LLC Mutant-selective egfr inhibitors and uses thereof
ES2655525T3 (es) 2011-04-26 2018-02-20 Mylan Laboratories Ltd. Proceso novedoso para la preparación de Etravirina
KR101884010B1 (ko) 2011-05-04 2018-07-31 어리어드 파마슈티칼스, 인코포레이티드 Egfr-유도된 암의 세포 증식을 억제하는 화합물
WO2012170647A1 (en) * 2011-06-09 2012-12-13 Assia Chemical Industriew Ltd. Process for the preparation of etravirine and intermediates in the synthesis thereof
EP3404029A3 (en) 2011-08-23 2018-12-12 Asana BioSciences, LLC Pyrimido-pyridazinone compounds and methods and use thereof
US20130123498A1 (en) 2011-10-19 2013-05-16 Maja Sepelj MAJER Process for the preparation of etravirine and intermediates in the synthesis thereof
JP2014532658A (ja) 2011-10-28 2014-12-08 セルジーン アヴィロミクス リサーチ， インコーポレイテッド ブルトン型チロシンキナーゼ疾患または障害を治療する方法
WO2013109354A2 (en) * 2011-12-07 2013-07-25 Texas Southern University Etravirine formulations and uses thereof
CN104302178B (zh) 2012-03-15 2018-07-13 西建卡尔有限责任公司 表皮生长因子受体激酶抑制剂的固体形式
SG10201700799WA (en) 2012-03-15 2017-02-27 Celgene Avilomics Res Inc Salts of an epidermal growth factor receptor kinase inhibitor
JP6469567B2 (ja) 2012-05-05 2019-02-13 アリアド・ファーマシューティカルズ・インコーポレイテッド Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物
WO2014068588A2 (en) * 2012-10-29 2014-05-08 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of etravirine and its intermediates
WO2014072419A1 (en) 2012-11-08 2014-05-15 Universiteit Antwerpen Novel anti-hiv compounds
WO2014094176A1 (en) 2012-12-21 2014-06-26 Oncozyme Pharma Inc. Uses and methods for the treatment of liver diseases or conditions
US9126950B2 (en) 2012-12-21 2015-09-08 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
US9145387B2 (en) 2013-02-08 2015-09-29 Celgene Avilomics Research, Inc. ERK inhibitors and uses thereof
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
TW201613892A (en) 2014-08-13 2016-04-16 Celgene Avilomics Res Inc Forms and compositions of an ERK inhibitor
EP4445956A3 (en) 2015-01-06 2024-12-04 Arena Pharmaceuticals, Inc. Compound for use in treating conditions related to the s1p1 receptor
CN104926829A (zh) * 2015-06-08 2015-09-23 山东大学 一种噻吩并嘧啶类衍生物及其制备方法和应用
EP3310760B8 (en) 2015-06-22 2022-10-19 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in s1p1 receptor-associated disorders
CN117503775A (zh) 2017-04-28 2024-02-06 自由生物有限公司 治疗特应性皮炎以及提高活性药物成分稳定性的制剂、方法、试剂盒和剂型
KR102859841B1 (ko) 2018-06-06 2025-09-12 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 병태의 치료 방법
CN110066273A (zh) * 2019-06-05 2019-07-30 山东大学 一种含三氮唑环的单芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
WO2021003417A1 (en) 2019-07-03 2021-01-07 Sumitomo Dainippon Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof
CN111217833B (zh) * 2020-02-21 2021-03-16 山东大学 噻吩并[2,3-d]嘧啶类HIV-1非核苷类逆转录酶抑制剂及其制备方法和应用
CN111875548A (zh) * 2020-07-16 2020-11-03 山东大学 一种5位芳环取代的二芳基嘧啶类衍生物及其制备方法与应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
US4659363A (en) * 1983-07-25 1987-04-21 Ciba-Geigy Corporation N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
ATE60591T1 (de) * 1984-06-25 1991-02-15 Ciba Geigy Ag Pyrimidinderivate wirksam als schaedlingsbekaempfungsmittel.
CH676712A5 (OSRAM) 1988-03-31 1991-02-28 Mitsubishi Chem Ind
JPH02308248A (ja) 1989-05-24 1990-12-21 Fuji Photo Film Co Ltd アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料
JP2895680B2 (ja) * 1992-07-08 1999-05-24 シャープ株式会社 磁気ヘッドおよびその製造方法
US5516775A (en) 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
RU2153494C2 (ru) 1993-10-12 2000-07-27 Дзе Дюпон Мерк Фармасьютикал Компани 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция
US5691364A (en) * 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
GB9523675D0 (en) * 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
WO1997018839A1 (en) 1995-11-23 1997-05-29 Janssen Pharmaceutica N.V. Solid mixtures of cyclodextrins prepared via melt-extrusion
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
NO311614B1 (no) * 1996-10-01 2001-12-17 Janssen Pharmaceutica Nv Substituerte diamino-1,3,5-triazinderivater
GB9705361D0 (en) * 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
DE29704863U1 (de) * 1997-03-17 1997-05-22 Gesellschaft für Innenhochdruckverfahren mbH & Co. KG, 73441 Bopfingen Achsschwinge
CN1297447A (zh) 1998-02-17 2001-05-30 图拉列克股份有限公司 抗病毒嘧啶衍生物
KR100643419B1 (ko) * 1998-03-27 2006-11-10 얀센 파마슈티카 엔.브이. Ｈｉｖ를 억제하는 피리미딘 유도체
EP0945443B9 (en) * 1998-03-27 2003-08-13 Janssen Pharmaceutica N.V. HIV inhibiting pyrimidine derivatives
EP0945442A1 (en) 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituted pyrimidine derivatives
OA11674A (en) * 1998-11-10 2005-01-12 Janssen Pharmaceutica Nv HIV Replication inhibiting pyrimidines.
JP4969010B2 (ja) * 2000-05-08 2012-07-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｈｉｖ複製阻害性ピリミジンのプロドラッグ

Also Published As

Publication number Publication date
AU6200899A (en) 2000-05-29
US8003789B2 (en) 2011-08-23
NL300373I2 (nl) 2009-04-01
NL300373I1 (nl) 2009-03-02
EA004049B1 (ru) 2003-12-25
DE122009000003I1 (de) 2009-05-20
JP3635238B2 (ja) 2005-04-06
ES2338760T3 (es) 2010-05-12
HU227453B1 (en) 2011-06-28
EP1002795B1 (en) 2003-03-05
IL143023A0 (en) 2002-04-21
FR09C0004I1 (OSRAM) 2009-02-27
US6878717B2 (en) 2005-04-12
LTC1002795I2 (lt) 2021-06-10
US20080176880A1 (en) 2008-07-24
CY2008021I2 (el) 2010-07-28
CA2350801A1 (en) 2000-05-18
US7037917B2 (en) 2006-05-02
AU762523B2 (en) 2003-06-26
US20050288278A1 (en) 2005-12-29
ATE455107T1 (de) 2010-01-15
MY121108A (en) 2005-12-30
DE69905683D1 (de) 2003-04-10
DK1002795T3 (da) 2003-06-30
ID28376A (id) 2001-05-17
JP2002529456A (ja) 2002-09-10
AR024227A1 (es) 2002-09-25
NO2009003I2 (no) 2010-06-07
HRP20080359A2 (en) 2008-12-31
NO318801B1 (no) 2005-05-09
CA2350801C (en) 2008-05-20
SI1002795T1 (en) 2003-10-31
CZ301367B6 (cs) 2010-02-03
AU2011200708A1 (en) 2011-03-10
PT1002795E (pt) 2003-07-31
TWI238161B (en) 2005-08-21
HUP0104177A2 (hu) 2002-03-28
BR9915552A (pt) 2001-08-14
SK287270B6 (sk) 2010-05-07
US20030114472A1 (en) 2003-06-19
HRP20010161B9 (hr) 2014-10-24
HUP0104177A3 (en) 2003-01-28
PL204427B1 (pl) 2010-01-29
DE69905683T2 (de) 2004-03-18
DE69941934D1 (de) 2010-03-04
LU91528I2 (fr) 2009-04-20
NO2021015I1 (no) 2021-03-29
OA11674A (en) 2005-01-12
ZA200103769B (en) 2002-08-12
HRP20010161A2 (en) 2002-02-28
HK1048817B (en) 2010-04-09
LTPA2008016I1 (lt) 2021-04-26
HK1025330A1 (en) 2000-11-10
NO20011696L (no) 2001-04-04
EE05086B1 (et) 2008-10-15
NZ511116A (en) 2003-08-29
NO2009003I1 (no) 2009-03-09
BG105418A (en) 2001-11-30
HRP20080359B1 (hr) 2016-01-01
EE200100252A (et) 2002-10-15
PL347586A1 (en) 2002-04-08
ES2193664T3 (es) 2003-11-01
CY2008021I1 (el) 2010-07-28
NO20011696D0 (no) 2001-04-04
UA70966C2 (uk) 2004-11-15
SK6032001A3 (en) 2002-01-07
AU762523C (en) 2004-02-12
BR9915552B1 (pt) 2013-11-19
CN1214013C (zh) 2005-08-10
KR100658489B1 (ko) 2006-12-18
LU91528I9 (OSRAM) 2019-01-02
US20110263625A1 (en) 2011-10-27
EP1270560B1 (en) 2010-01-13
TR200101306T2 (tr) 2001-10-22
HK1048817A1 (en) 2003-04-17
EA200100536A1 (ru) 2002-02-28
HRP20010161B1 (en) 2009-03-31
WO2000027825A1 (en) 2000-05-18
EP1002795A1 (en) 2000-05-24
CN1322198A (zh) 2001-11-14
US20040039005A1 (en) 2004-02-26
EP1270560A1 (en) 2003-01-02
BRPI9915552B8 (pt) 2021-05-25
HU230394B1 (hu) 2016-04-28
SK287269B6 (sk) 2010-05-07
US8530655B2 (en) 2013-09-10
BG65103B1 (bg) 2007-02-28
AP1683A (en) 2006-11-29
KR20010075235A (ko) 2001-08-09
CZ20011533A3 (cs) 2001-10-17
IL169949A (en) 2011-02-28
FR09C0004I2 (fr) 2010-06-11

Similar Documents

Publication Publication Date Title
ATE233740T1 (de) Pyrimidineihibitoren der hiv-replikation
PT945443E (pt) Derivados de pirimidina inibidores de hiv
DE69943247D1 (de) HIV hemmende Pyrimidin Derivate
SG80631A1 (en) Inhibitors of hiv reverse transcriptase
CY2012012I1 (el) Παραγωγα πυριμιδινης που αναστελλουν τον hiv
DK0986309T3 (da) Anvendelse af olielegemer
DE69936008D1 (de) Keramischer Kondensator
ATE256123T1 (de) Pyrimidonderivate
DK1042307T3 (da) Aminothiazolinhibitorer af cyclinafhængige kinaser
DK1064298T3 (da) Inhibitorer af caspaser
DE69942085D1 (de) Monolithischer keramischer Kondensator
IT1295072B1 (it) Procedimento per la produzione di stirene
IT1296985B1 (it) Derivati benzazinici inibitori della fosfodiesterasi 4
BR9507666A (pt) Novos derivados de pirimidina
FR2776660B1 (fr) Diazepino-indoles de phosphodiesterases iv
IT1302677B1 (it) Derivati benzazinici inibitori della fosfodiesterasi 4
DK1137632T3 (da) Thiourinstofinhibitorer af herpesvira
IS5426A (is) Fjölbrigðaform af dófetilíði
FI980902A7 (fi) Levosimendaanin stabiileja koostumuksia
DK0908690T3 (da) Brændingsunderlag til brænding af tegsten af forskellige former
ES1036506Y (es) Pieza modular para formacion de estructuras.
DE69931763D1 (de) Nachweis von produkten von apoptosis
IT237972Y1 (it) Elemento modulare per la realizzazione di transenne
IT1292354B1 (it) Procedimento per la fabbricazione di piastrelle di klinker ceramico.
ID17477A (id) Turunan-turunan pirimidina nukleosida