HRP20010161B9 - PIRIMIDINI KOJI INHIBIRAJU REPLIKACIJU HIV-a - Google Patents

PIRIMIDINI KOJI INHIBIRAJU REPLIKACIJU HIV-a

Info

Publication number
HRP20010161B9
HRP20010161B9 HRP20010161AA HRP20010161A HRP20010161B9 HR P20010161 B9 HRP20010161 B9 HR P20010161B9 HR P20010161A A HRP20010161A A HR P20010161AA HR P20010161 A HRP20010161 A HR P20010161A HR P20010161 B9 HRP20010161 B9 HR P20010161B9
Authority
HR
Croatia
Prior art keywords
alkyl
optionally substituted
alkyloxy
alkynyl
cycloalkyl
Prior art date
Application number
HRP20010161AA
Other languages
English (en)
Croatian (hr)
Inventor
Bart De Corte
Marc Rene De Jonge
Jan Heeres
Chih Yung Ho
Paul Adriaan Jan Janssen
Robert W. Kavash
Lucien Maria Henricus Koymans
Michael Joseph Kukla
Donald William Ludovici
Koen Jeanne Alfons Van Aken
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26805159&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20010161(B9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HRP20010161A2 publication Critical patent/HRP20010161A2/hr
Publication of HRP20010161B1 publication Critical patent/HRP20010161B1/xx
Publication of HRP20010161B9 publication Critical patent/HRP20010161B9/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HRP20010161AA 1998-11-10 1999-09-24 PIRIMIDINI KOJI INHIBIRAJU REPLIKACIJU HIV-a HRP20010161B9 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10779298P 1998-11-10 1998-11-10
US14396299P 1999-07-15 1999-07-15
PCT/EP1999/007417 WO2000027825A1 (en) 1998-11-10 1999-09-24 Hiv replication inhibiting pyrimidines

Publications (3)

Publication Number Publication Date
HRP20010161A2 HRP20010161A2 (en) 2002-02-28
HRP20010161B1 HRP20010161B1 (en) 2009-03-31
HRP20010161B9 true HRP20010161B9 (hr) 2014-10-24

Family

ID=26805159

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20010161AA HRP20010161B9 (hr) 1998-11-10 1999-09-24 PIRIMIDINI KOJI INHIBIRAJU REPLIKACIJU HIV-a
HRP20080359AA HRP20080359B1 (hr) 1998-11-10 1999-09-24 PIRIMIDINI KOJI INHIBIRAJU REPLIKACIJU HIV-a

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20080359AA HRP20080359B1 (hr) 1998-11-10 1999-09-24 PIRIMIDINI KOJI INHIBIRAJU REPLIKACIJU HIV-a

Country Status (41)

Country Link
US (5) US6878717B2 (OSRAM)
EP (2) EP1002795B1 (OSRAM)
JP (1) JP3635238B2 (OSRAM)
KR (1) KR100658489B1 (OSRAM)
CN (1) CN1214013C (OSRAM)
AP (1) AP1683A (OSRAM)
AR (1) AR024227A1 (OSRAM)
AT (2) ATE455107T1 (OSRAM)
AU (2) AU762523C (OSRAM)
BG (1) BG65103B1 (OSRAM)
BR (1) BRPI9915552B8 (OSRAM)
CA (1) CA2350801C (OSRAM)
CY (1) CY2008021I2 (OSRAM)
CZ (1) CZ301367B6 (OSRAM)
DE (3) DE69905683T2 (OSRAM)
DK (1) DK1002795T3 (OSRAM)
EA (1) EA004049B1 (OSRAM)
EE (1) EE05086B1 (OSRAM)
ES (2) ES2193664T3 (OSRAM)
FR (1) FR09C0004I2 (OSRAM)
HK (1) HK1048817B (OSRAM)
HR (2) HRP20010161B9 (OSRAM)
HU (2) HU230394B1 (OSRAM)
ID (1) ID28376A (OSRAM)
IL (2) IL143023A0 (OSRAM)
LT (1) LTC1002795I2 (OSRAM)
LU (1) LU91528I2 (OSRAM)
MY (1) MY121108A (OSRAM)
NL (1) NL300373I2 (OSRAM)
NO (3) NO318801B1 (OSRAM)
NZ (1) NZ511116A (OSRAM)
OA (1) OA11674A (OSRAM)
PL (1) PL204427B1 (OSRAM)
PT (1) PT1002795E (OSRAM)
SI (1) SI1002795T1 (OSRAM)
SK (2) SK287269B6 (OSRAM)
TR (1) TR200101306T2 (OSRAM)
TW (1) TWI238161B (OSRAM)
UA (1) UA70966C2 (OSRAM)
WO (1) WO2000027825A1 (OSRAM)
ZA (1) ZA200103769B (OSRAM)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ511116A (en) * 1998-11-10 2003-08-29 Janssen Pharmaceutica Nv HIV replication inhibiting pyrimidines
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
DE19945982A1 (de) 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
AU775360B2 (en) 1999-09-24 2004-07-29 Janssen Pharmaceutica N.V. Antiviral compositions
ES2306671T3 (es) 1999-10-07 2008-11-16 Amgen Inc. Inhibidores de triazina quinasa.
CN1429222A (zh) 2000-02-17 2003-07-09 安姆根有限公司 激酶抑制剂
EP1282607B1 (en) 2000-05-08 2015-11-11 Janssen Pharmaceutica NV Prodrugs of hiv replication inhibiting pyrimidines
EP1282606B1 (en) 2000-05-08 2015-04-22 Janssen Pharmaceutica NV Hiv replication inhibiting pyrimidines and triazines
WO2002037338A1 (en) * 2000-11-01 2002-05-10 Snapnames.Com, Inc. Registry-integrated internet domain name acquisition system
EP1392662B1 (de) 2001-05-29 2009-01-07 Bayer Schering Pharma Aktiengesellschaft Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel
US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
WO2003032994A2 (de) 2001-10-17 2003-04-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren
EP1438053B1 (de) * 2001-10-17 2008-09-10 Boehringer Ingelheim Pharma GmbH & Co.KG Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung
EA007578B1 (ru) 2001-11-01 2006-12-29 Янссен Фармацевтика Н.В. Производные амидов в качестве ингибиторов гликогенсинтаза-киназы 3-бета
NZ531853A (en) 2001-11-01 2006-02-24 Janssen Pharmaceutica Nv Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors)
SE0104140D0 (sv) 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
AU2003218737B2 (en) 2002-03-13 2008-04-10 Janssen Pharmaceutica N.V. Inhibitors of histone deacetylase
CN1305850C (zh) 2002-03-13 2007-03-21 詹森药业有限公司 作为组蛋白脱乙酰酶新颖抑制剂的磺酰基氨基衍生物
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
AU2003222310B2 (en) * 2002-05-03 2009-04-09 Janssen Pharmaceutica N.V. Polymeric microemulsions
AR039540A1 (es) * 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
TW200409629A (en) 2002-06-27 2004-06-16 Bristol Myers Squibb Co 2,4-disubstituted-pyridine N-oxides useful as HIV reverse transcriptase inhibitors
WO2004014382A1 (en) 2002-07-29 2004-02-19 Rigel Pharmaceuticals Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
EA007953B1 (ru) * 2002-08-09 2007-02-27 Янссен Фармацевтика Н.В. Способы получения 4-[[4-[[4-(2-цианоэтенил)-2,6-диметилфенил]амино]-2-пиримидинил]амино]бензонитрила
PT1551372T (pt) 2002-09-20 2018-07-23 Alpharma Pharmaceuticals Llc Subunidade de sequestração e composições e métodos relacionados
EA200500721A1 (ru) * 2002-11-28 2005-12-29 Шеринг Акциенгезельшафт Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств
ATE374766T1 (de) 2003-01-14 2007-10-15 Arena Pharm Inc 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie
CN102503903A (zh) * 2003-02-07 2012-06-20 詹森药业有限公司 抑制hiv的1,2,4-三嗪
HRP20050688B1 (hr) 2003-02-07 2017-03-24 Janssen Pharmaceutica N.V. Derivati pirimidina za sprječavanje hiv infekcije
CL2004000306A1 (es) * 2003-02-20 2005-04-08 Tibotec Pharm Ltd Compuestos derivados de pirimidina sustituidas con indano; proceso para su preparacion; composicion farmaceutica que lo comprende; combinacion farmaceutica; y su uso para el tratamiento o profilaxis de una enfermedad infecciosa.
JP4634367B2 (ja) 2003-02-20 2011-02-16 スミスクライン ビーチャム コーポレーション ピリミジン化合物
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
DK1648467T3 (en) * 2003-07-17 2018-06-25 Janssen Sciences Ireland Uc PROCEDURE FOR MANUFACTURING PARTICLES CONTAINING AN ANTIVIRUS AGENT
JP4886511B2 (ja) 2003-07-30 2012-02-29 ライジェル ファーマシューティカルズ， インコーポレイテッド ２，４−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法
US8026245B2 (en) * 2003-09-25 2011-09-27 Janssen Pharmaceutica N.V. HIV replication inhibiting purine derivatives
CA2557790A1 (en) 2004-03-02 2005-09-15 Virco Bvba Estimation of clinical cut-offs
EP1598343A1 (de) * 2004-05-19 2005-11-23 Boehringer Ingelheim International GmbH 2-Arylaminopyrimidine als PLK Inhibitoren
EP1781639B1 (en) 2004-07-28 2012-01-25 Janssen Pharmaceutica NV Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
US7923554B2 (en) 2004-08-10 2011-04-12 Janssen Pharmaceutica N.V. HIV inhibiting 1,2,4-triazin-6-one derivatives
CA2573976C (en) * 2004-09-30 2014-04-29 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-carbo- or heterocyclic substituted pyrimidines
ES2371923T3 (es) * 2004-09-30 2012-01-11 Tibotec Pharmaceuticals 5-heterociclil-pirimidinas que inhiben el vih.
ATE542802T1 (de) * 2004-09-30 2012-02-15 Tibotec Pharm Ltd Hiv-inhibierende 5-substituierte pyrimidine
ES2508766T3 (es) * 2004-10-29 2014-10-16 Janssen R&D Ireland Derivados de pirimidina bicíclicos que inhiben el VIH
CA2583187A1 (en) * 2004-11-08 2006-05-18 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and etravirine
ATE540035T1 (de) 2004-11-24 2012-01-15 Rigel Pharmaceuticals Inc Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen
NZ555947A (en) 2005-01-19 2010-11-26 Rigel Pharmaceuticals Inc Prodrugs of 2,4-pyrimidinediamine compounds and their uses
RU2403245C2 (ru) 2005-01-27 2010-11-10 Тиботек Фармасьютикалз Лтд. Ингибирующие вич производные 2-(4-цианофениламино)пиримидина
ATE398613T1 (de) 2005-02-16 2008-07-15 Astrazeneca Ab Chemische verbindungen
RU2398768C2 (ru) * 2005-02-18 2010-09-10 Тиботек Фармасьютикалз Лтд. Ингибирующие вич производные 2-(4-цианофениламино)-пиримидин-оксида
PT1858861E (pt) * 2005-03-04 2010-09-16 Tibotec Pharm Ltd 2-(4-cianofenil)-6-hidroxilaminopirimidinas inibidoras do hiv
WO2006123113A2 (en) 2005-05-16 2006-11-23 Astrazeneca Ab Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
PT1888537E (pt) 2005-05-26 2013-11-26 Janssen R & D Ireland Processo para preparar 4-[(1,6-dihidro-6-oxo-2-pirimidinil)amino benzonitrilo
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
ES2651349T3 (es) 2005-06-08 2018-01-25 Rigel Pharmaceuticals, Inc. Composiciones y métodos para la inhibición de la ruta JAK
EP1945208A4 (en) * 2005-10-06 2011-08-03 Univ Massachusetts Composition and synthesis of new reagents for inhibition of hiv replication
US20080287475A1 (en) 2005-10-28 2008-11-20 Astrazeneca Ab 4-(3-Aminopyrazole) Pyrimidine Derivatives for Use as Tyrosine Kinase Inhibitors in the Treatment of Cancer
DK1979326T3 (da) 2006-01-19 2013-01-07 Janssen Pharmaceutica Nv Pyridin- og pyrimidinderivater som inhibitorer af histondeacetylase
US7834025B2 (en) 2006-01-19 2010-11-16 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
PL1981874T3 (pl) 2006-01-19 2009-10-30 Janssen Pharmaceutica Nv Pochodne aminofenylowe jako nowe inhibitory deacetylazy histonowej
US8962643B2 (en) 2006-02-24 2015-02-24 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
RU2480464C2 (ru) 2006-03-30 2013-04-27 Тиботек Фармасьютикалз Лтд. 5-амидо-замещенные пиримидины, ингибирующие вич
WO2007113256A1 (en) 2006-03-30 2007-10-11 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-(hydroxymethylene and aminomethylene) substituted pyrimidines
PE20120006A1 (es) 2006-05-15 2012-02-02 Boehringer Ingelheim Int Compuestos derivados de pirimidina como inhibidores de la quinasa aurora
HRP20110883T1 (hr) * 2006-06-06 2012-01-31 Tibotec Pharmaceuticals Postupak za pripremanje raspršivanjem osušenih formulacija tmc125
CA2655835C (en) 2006-06-19 2015-07-21 Alpharma, Inc. Abuse-resistant pharmaceutical compositions of opioid agonists
AU2007322269A1 (en) * 2006-10-11 2008-05-29 Alpharma Pharmaceuticals, Llc Pharmaceutical compositions
JP5464584B2 (ja) * 2006-12-06 2014-04-09 ヤンセン・アールアンドデイ・アイルランド 抗ｈｉｖ化合物の臭化水素酸塩
CN101573343B (zh) * 2006-12-29 2016-02-24 爱尔兰詹森科学公司 抑制人免疫缺陷病毒的6-取代的嘧啶
ES2618057T3 (es) 2006-12-29 2017-06-20 Janssen Sciences Ireland Uc Pirimidinas 5,6-sustituidas inhibidoras del VIH
UA99459C2 (en) 2007-05-04 2012-08-27 Астразенека Аб 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
US8410124B2 (en) 2007-10-18 2013-04-02 Concert Pharmaceuticals Inc. Deuterated etravirine
US20100151014A1 (en) * 2008-12-16 2010-06-17 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
WO2009079521A1 (en) * 2007-12-17 2009-06-25 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
CA2723961C (en) 2008-05-21 2017-03-21 Ariad Pharmaceuticals, Inc. Phosphorous derivatives as kinase inhibitors
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
TWI546290B (zh) 2008-06-27 2016-08-21 賽基艾維洛米斯研究股份有限公司 雜芳基化合物及其用途
UY32158A (es) * 2008-10-03 2010-04-30 Astrazeneca Ab Derivados heterociclicos y metodos de uso de los mismos
US20110071158A1 (en) * 2009-03-18 2011-03-24 Boehringer Ingelheim International Gmbh New compounds
EA024299B1 (ru) 2009-03-30 2016-09-30 Янссен Сайенсиз Айрлэнд Юси Сокристалл этравирина и никотинамида, способ его получения и применение
EP2440559B1 (en) 2009-05-05 2018-01-10 Dana-Farber Cancer Institute, Inc. Egfr inhibitors and methods of treating disorders
WO2010131118A2 (en) * 2009-05-12 2010-11-18 Pliva Hrvatska D.O.O. Polymorphs of etravirine and processes for preparation thereof
US20110196156A1 (en) * 2009-06-22 2011-08-11 Mukund Keshav Gurjar Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor
US8153790B2 (en) 2009-07-27 2012-04-10 Krizmanic Irena Process for the preparation and purification of etravirine and intermediates thereof
GR1007010B (el) 2009-10-08 2010-10-07 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Ινσουλινοειδη πεπτιδια
MA34299B1 (fr) 2010-06-04 2013-06-01 Hoffmann La Roche Dérivés d'aminopyrimidine au titre de modulateurs de lrrk2
US8598341B2 (en) 2010-06-28 2013-12-03 Hetero Research Foundation Process for etravirine intermediate and polymorphs of etravirine
WO2012021444A1 (en) 2010-08-10 2012-02-16 Avila Therapeutics, Inc. Besylate salt of a btk inhibitor
BR112013008100A2 (pt) 2010-09-22 2016-08-09 Arena Pharm Inc "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles."
MY181898A (en) 2010-11-01 2021-01-12 Celgene Car Llc Heterocyclic compounds and uses thereof
EP2635285B1 (en) 2010-11-01 2017-05-03 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EP2637502B1 (en) 2010-11-10 2018-01-10 Celgene CAR LLC Mutant-selective egfr inhibitors and uses thereof
NO2638031T3 (OSRAM) 2010-11-10 2018-03-10
ES2655525T3 (es) 2011-04-26 2018-02-20 Mylan Laboratories Ltd. Proceso novedoso para la preparación de Etravirina
CN103501612B (zh) 2011-05-04 2017-03-29 阿里亚德医药股份有限公司 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物
WO2012170647A1 (en) * 2011-06-09 2012-12-13 Assia Chemical Industriew Ltd. Process for the preparation of etravirine and intermediates in the synthesis thereof
EP3392252B1 (en) 2011-08-23 2023-10-04 Libertas Bio, Inc. Pyrimido- pyridazinone compounds and use thereof
WO2013059572A1 (en) 2011-10-19 2013-04-25 Assia Chemical Industries Ltd. Process for the preparation of etravirine and intermediates in the synthesis thereof
US9364476B2 (en) 2011-10-28 2016-06-14 Celgene Avilomics Research, Inc. Methods of treating a Bruton's Tyrosine Kinase disease or disorder
WO2013109354A2 (en) * 2011-12-07 2013-07-25 Texas Southern University Etravirine formulations and uses thereof
MX356753B (es) 2012-03-15 2018-06-12 Celgene Avilomics Res Inc Formas solidas de un inhibidor de cinasa del receptor del factor de crecimiento epidermico.
SG10201700799WA (en) 2012-03-15 2017-02-27 Celgene Avilomics Res Inc Salts of an epidermal growth factor receptor kinase inhibitor
WO2013169401A1 (en) 2012-05-05 2013-11-14 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
WO2014068588A2 (en) * 2012-10-29 2014-05-08 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of etravirine and its intermediates
WO2014072419A1 (en) 2012-11-08 2014-05-15 Universiteit Antwerpen Novel anti-hiv compounds
US9126950B2 (en) 2012-12-21 2015-09-08 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
JP6370801B2 (ja) 2012-12-21 2018-08-08 ベルリクス・ファーマ・インコーポレイテッド 肝疾患または肝障害の治療のための使用および方法
EA201591051A1 (ru) 2013-02-08 2016-06-30 Селджен Авиломикс Рисерч, Инк. Ингибиторы erk и варианты их применения
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
US10005760B2 (en) 2014-08-13 2018-06-26 Celgene Car Llc Forms and compositions of an ERK inhibitor
HUE069888T2 (hu) 2015-01-06 2025-04-28 Arena Pharm Inc Vegyületek az S1P1 receptorral összefüggõ állapotok kezelésében történõ alkalmazásra
CN104926829A (zh) * 2015-06-08 2015-09-23 山东大学 一种噻吩并嘧啶类衍生物及其制备方法和应用
KR102883123B1 (ko) 2015-06-22 2025-11-10 아레나 파마슈티칼스, 인크. Ｓ1ｐ1 수용체-관련 장애에서의 사용을 위한 (ｒ)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[ｂ]인돌-3-일)아세트산 (화합물 1)의 결정성 ｌ-아르기닌 염
CA3060316A1 (en) 2017-04-28 2018-11-01 Asana Biosciences, Llc Formulations, methods, kits, and dosage forms for treating atopic dermatitis and for improved stability of an active pharmaceutical ingredient
CN112601516A (zh) 2018-06-06 2021-04-02 艾尼纳制药公司 治疗与s1p1受体相关的病况的方法
CN110066273A (zh) * 2019-06-05 2019-07-30 山东大学 一种含三氮唑环的单芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
WO2021003417A1 (en) 2019-07-03 2021-01-07 Sumitomo Dainippon Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof
CN111217833B (zh) * 2020-02-21 2021-03-16 山东大学 噻吩并[2,3-d]嘧啶类HIV-1非核苷类逆转录酶抑制剂及其制备方法和应用
CN111875548A (zh) * 2020-07-16 2020-11-03 山东大学 一种5位芳环取代的二芳基嘧啶类衍生物及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041512A1 (en) * 1997-03-14 1998-09-24 Celltech Therapeutics Limited Substituted 2-anilinopyrimidines useful as protein kinase inhibitors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
US4659363A (en) 1983-07-25 1987-04-21 Ciba-Geigy Corporation N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
EP0172786B1 (de) * 1984-06-25 1991-01-30 Ciba-Geigy Ag Pyrimidinderivate wirksam als Schädlingsbekämpfungsmittel
ATE112767T1 (de) 1988-03-31 1994-10-15 Mitsubishi Chem Ind Acyclische 6-substituierte pyrimidin nukleosid- abkömmlinge und antivirale mittel, die dieselben als aktive mittel enthalten.
JPH02308248A (ja) 1989-05-24 1990-12-21 Fuji Photo Film Co Ltd アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料
JP2895680B2 (ja) * 1992-07-08 1999-05-24 シャープ株式会社 磁気ヘッドおよびその製造方法
US5516775A (en) 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
JP3398152B2 (ja) 1993-10-12 2003-04-21 ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
US5691364A (en) * 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
GB9523675D0 (en) * 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
HUP9900730A3 (en) 1995-11-23 2001-04-28 Janssen Pharmaceutica Nv Solid mixtures of cyclodextrins prepared via melt-extrusion
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
NO311614B1 (no) * 1996-10-01 2001-12-17 Janssen Pharmaceutica Nv Substituerte diamino-1,3,5-triazinderivater
DE29704863U1 (de) * 1997-03-17 1997-05-22 Gesellschaft für Innenhochdruckverfahren mbH & Co. KG, 73441 Bopfingen Achsschwinge
IL137922A0 (en) 1998-02-17 2001-10-31 Tularik Inc Anti-viral pyrimidine derivatives
KR100643419B1 (ko) * 1998-03-27 2006-11-10 얀센 파마슈티카 엔.브이. Ｈｉｖ를 억제하는 피리미딘 유도체
KR100699514B1 (ko) * 1998-03-27 2007-03-26 얀센 파마슈티카 엔.브이. Ｈｉｖ를 억제하는 피리미딘 유도체
EP0945442A1 (en) 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituted pyrimidine derivatives
NZ511116A (en) * 1998-11-10 2003-08-29 Janssen Pharmaceutica Nv HIV replication inhibiting pyrimidines
EP1282607B1 (en) * 2000-05-08 2015-11-11 Janssen Pharmaceutica NV Prodrugs of hiv replication inhibiting pyrimidines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041512A1 (en) * 1997-03-14 1998-09-24 Celltech Therapeutics Limited Substituted 2-anilinopyrimidines useful as protein kinase inhibitors

Also Published As

Publication number Publication date
HK1048817B (en) 2010-04-09
AU6200899A (en) 2000-05-29
HUP0104177A2 (hu) 2002-03-28
HRP20080359B1 (hr) 2016-01-01
NO318801B1 (no) 2005-05-09
LU91528I2 (fr) 2009-04-20
FR09C0004I1 (OSRAM) 2009-02-27
IL169949A (en) 2011-02-28
NO2021015I1 (no) 2021-03-29
US20040039005A1 (en) 2004-02-26
FR09C0004I2 (fr) 2010-06-11
UA70966C2 (uk) 2004-11-15
DE69905683T2 (de) 2004-03-18
EE05086B1 (et) 2008-10-15
ES2338760T3 (es) 2010-05-12
US20050288278A1 (en) 2005-12-29
NO20011696L (no) 2001-04-04
CA2350801C (en) 2008-05-20
AU2011200708A1 (en) 2011-03-10
SK287270B6 (sk) 2010-05-07
US20030114472A1 (en) 2003-06-19
US8530655B2 (en) 2013-09-10
HRP20010161A2 (en) 2002-02-28
CN1322198A (zh) 2001-11-14
ATE233740T1 (de) 2003-03-15
US8003789B2 (en) 2011-08-23
JP3635238B2 (ja) 2005-04-06
KR100658489B1 (ko) 2006-12-18
US6878717B2 (en) 2005-04-12
NO2009003I2 (no) 2010-06-07
ES2193664T3 (es) 2003-11-01
EP1002795B1 (en) 2003-03-05
NO20011696D0 (no) 2001-04-04
EA200100536A1 (ru) 2002-02-28
HU230394B1 (hu) 2016-04-28
DE69941934D1 (de) 2010-03-04
LTC1002795I2 (lt) 2021-06-10
NO2009003I1 (no) 2009-03-09
JP2002529456A (ja) 2002-09-10
HK1048817A1 (en) 2003-04-17
PL204427B1 (pl) 2010-01-29
SK287269B6 (sk) 2010-05-07
NL300373I1 (nl) 2009-03-02
LTPA2008016I1 (lt) 2021-04-26
PT1002795E (pt) 2003-07-31
CZ20011533A3 (cs) 2001-10-17
EA004049B1 (ru) 2003-12-25
AP1683A (en) 2006-11-29
BRPI9915552B8 (pt) 2021-05-25
EP1270560B1 (en) 2010-01-13
DE122009000003I1 (de) 2009-05-20
US7037917B2 (en) 2006-05-02
DE69905683D1 (de) 2003-04-10
DK1002795T3 (da) 2003-06-30
ID28376A (id) 2001-05-17
ATE455107T1 (de) 2010-01-15
ZA200103769B (en) 2002-08-12
HK1025330A1 (en) 2000-11-10
NZ511116A (en) 2003-08-29
AU762523C (en) 2004-02-12
BR9915552B1 (pt) 2013-11-19
WO2000027825A1 (en) 2000-05-18
SI1002795T1 (en) 2003-10-31
CZ301367B6 (cs) 2010-02-03
BG65103B1 (bg) 2007-02-28
CN1214013C (zh) 2005-08-10
KR20010075235A (ko) 2001-08-09
BG105418A (en) 2001-11-30
EP1270560A1 (en) 2003-01-02
HUP0104177A3 (en) 2003-01-28
EP1002795A1 (en) 2000-05-24
TWI238161B (en) 2005-08-21
US20080176880A1 (en) 2008-07-24
US20110263625A1 (en) 2011-10-27
IL143023A0 (en) 2002-04-21
HRP20080359A2 (en) 2008-12-31
CY2008021I1 (el) 2010-07-28
CY2008021I2 (el) 2010-07-28
EE200100252A (et) 2002-10-15
AR024227A1 (es) 2002-09-25
BR9915552A (pt) 2001-08-14
OA11674A (en) 2005-01-12
PL347586A1 (en) 2002-04-08
SK6032001A3 (en) 2002-01-07
NL300373I2 (nl) 2009-04-01
HU227453B1 (en) 2011-06-28
TR200101306T2 (tr) 2001-10-22
HRP20010161B1 (en) 2009-03-31
CA2350801A1 (en) 2000-05-18
LU91528I9 (OSRAM) 2019-01-02
AU762523B2 (en) 2003-06-26
MY121108A (en) 2005-12-30

Similar Documents

Publication Publication Date Title
HRP20010161B9 (hr) PIRIMIDINI KOJI INHIBIRAJU REPLIKACIJU HIV-a
EA200400304A1 (ru) Производные пиримидина, ингибирующие вич
EP0117082A3 (en) Thiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
HRP20050688A2 (en) Pyrimidine derivatives for the prevention of hiv infection
CY1109756T1 (el) Φαρμακευτικες συνθεσεις που περιεχουν κρυσταλλικα αλατα 7-[4-(4-φθοροφαινυλ)-6-ισοπροπυλ-2- [μεθυλ(μεθυλσουλφονυλ)αμινο] πυριμιδιν-5-υλ]-(3r,5s)-3,5-διυδροξυεπτ-6-ενοϊκου οξεος
HRP20040097B1 (hr) 2-amino-4,5-trisupstituirani derivati tiazolila
FI964815A0 (fi) Piperatsiinijohdoksia 5-HT1A antagonisteina
MY129224A (en) 4-phenyl-pyridine derivatives
BG100069A (bg) Амидинови производни,съдържащи хетероциклични групи,получаване и приложението им
ATE21900T1 (de) Pyrimidinonderivate und diese enthaltende pharmazeutische zusammenstellungen.
MEP15708A (en) Lithium complexes of n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, production and use thereof
AR038824A1 (es) Composiciones de medicamentos que, junto a agentes colinergicos, contienen compuestos heterociclicos
CO5160261A1 (es) Derivados de bifenilo sustituidos que son antagonistas nk-1, su procedimiento de sintesis y composiciones farmaceuticas que los contienen
EA200100534A1 (ru) Производные 2,4-дизамещенного триазина
ES8802310A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridinas
EP0180542A3 (en) alkyl substituted pyridazinones, processes for producing them, pharmaceutical preparations containing these compounds, and the use thereof
NO20000114D0 (no) 2,4,4-trisubstituerte-1,3-diokolan-antifungale midler
ME00081B (me) Derivati 3-heteroaril-3,5-dihidro-4-okso-4h-piridazino (4,5-b)- indol-1-acetamida, njihovo dobijanje i primjena u terapiji
MEP22408A (en) 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-carboxamide derivatives, their preparation and therapeutic use
CY1125571T1 (el) Πυριμιδινες που αναστελλουν τον πολλαπλασιασμο toy hiv
TH76074A (th) อะมิโน-เฮทเทอโรไซเคิลที่มีหกสมาชิกซึ่งมีไนโตรเจนที่ถูกแทนที่ซึ่งเป็นวานิลลอยด์-1 รีเซพเตอร์ แอนทาโกนิสต์สำหรับการทรีตอาการปวด

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
B9IS Complete republication of an hr-b document
ODRP Renewal fee for the maintenance of a patent

Payment date: 20180814

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20190924