EA200100534A1 - Производные 2,4-дизамещенного триазина - Google Patents
Производные 2,4-дизамещенного триазинаInfo
- Publication number
- EA200100534A1 EA200100534A1 EA200100534A EA200100534A EA200100534A1 EA 200100534 A1 EA200100534 A1 EA 200100534A1 EA 200100534 A EA200100534 A EA 200100534A EA 200100534 A EA200100534 A EA 200100534A EA 200100534 A1 EA200100534 A1 EA 200100534A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- optionally substituted
- alkyloxycarbonyl
- nhc
- pyridazinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Данное изобретение относится к использованию соединений формулы (I)их N-оксидов, фармацевтически приемлемых аддитивных солей, четвертичных аминов и стереохимически изомерных форм, в которой -a=a-a=a- образует фенил, пиридинил, пиримидинил, пиридазинил или пиразинил с присоединенной винильной группой; n равно 0-4 и, когда возможно, 5; Rпредставляет водород, арил, формил, Cалкилкарбонил, Cалкил, Cалкилоксикарбонил или замещенный Cалкил; каждый Rнезависимо представляет гидрокси, галоген, необязательно замещенный Cалкил, Cалкенил или Cалкинил, Cциклоалкил, Cалкилокси, Cалкилоксикарбонил, карбоксил, циано, нитро, амино, моно- или ди(Cалкил)амино, полигалогенметил, полигалогенметилокси, полигалогенметилтио, -S(=O)R, -NH-S(=O)R, -C(=O)R, -NHC(=O)H, -C(=O)NHNH, -NHC(=O)R, -C(=NH)Rили 5-членное гетероциклическое кольцо; р равно 1 или 2; L представляет необязательно замещенный Cалкил, Cалкенил, Cалкинил или Cциклоалкил; или L представляет -X-R, где Rпредставляет необязательно замещенный фенил, пиридинил, пиримидинил, пиразинил или пиридазинил; X представляет -NR-, -NH-NH-, -N=N-, -O-, -C(=O)-, -CHOH-, -S-, -S(=O)- или -S(=O)-; арил представляет необязательно замещенный фенил; для изготовления лекарственных средств для лечения пациентов, страдающих от инфекции ВИЧ (Вирус Иммунодефицита Человека).Отчет о международном поиске был опубликован 2000.09.21.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10779998P | 1998-11-10 | 1998-11-10 | |
EP99203128 | 1999-09-24 | ||
PCT/EP1999/008688 WO2000027828A2 (en) | 1998-11-10 | 1999-11-04 | 2,4-disubstituted triazine derivatives with anti hiv activity |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200100534A1 true EA200100534A1 (ru) | 2001-10-22 |
EA004501B1 EA004501B1 (ru) | 2004-04-29 |
Family
ID=26153374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100534A EA004501B1 (ru) | 1998-11-10 | 1999-11-04 | Производные 2,4-дизамещенного триазина |
Country Status (35)
Country | Link |
---|---|
US (2) | US6638932B1 (ru) |
EP (1) | EP1129079B1 (ru) |
JP (1) | JP2002529457A (ru) |
KR (1) | KR100620402B1 (ru) |
CN (1) | CN1207290C (ru) |
AP (1) | AP1636A (ru) |
AR (1) | AR021137A1 (ru) |
AT (1) | ATE315031T1 (ru) |
AU (1) | AU764472B2 (ru) |
BG (1) | BG65160B1 (ru) |
BR (1) | BR9915176A (ru) |
CA (1) | CA2351203C (ru) |
CY (1) | CY1105596T1 (ru) |
CZ (1) | CZ20011532A3 (ru) |
DE (1) | DE69929354T2 (ru) |
DK (1) | DK1129079T3 (ru) |
EA (1) | EA004501B1 (ru) |
EE (1) | EE200100253A (ru) |
ES (1) | ES2257081T3 (ru) |
HK (1) | HK1038232A1 (ru) |
HR (1) | HRP20010310A2 (ru) |
HU (1) | HUP0104395A3 (ru) |
ID (1) | ID28545A (ru) |
IL (2) | IL143024A0 (ru) |
MY (1) | MY126781A (ru) |
NO (1) | NO319788B1 (ru) |
NZ (1) | NZ510919A (ru) |
OA (1) | OA11675A (ru) |
PL (1) | PL196523B1 (ru) |
PT (1) | PT1129079E (ru) |
SI (1) | SI1129079T1 (ru) |
SK (1) | SK6022001A3 (ru) |
TR (1) | TR200101319T2 (ru) |
TW (1) | TW541305B (ru) |
WO (1) | WO2000027828A2 (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0104395A3 (en) * | 1998-11-10 | 2003-02-28 | Janssen Pharmaceutica Nv | 2,4-disubstituted triazine derivatives with anti hiv activity, process for their preparation and medicaments containing them |
DE19945982A1 (de) | 1999-09-24 | 2001-03-29 | Knoll Ag | Geschwindigkeitsbestimmte Partikel |
WO2001085700A2 (en) | 2000-05-08 | 2001-11-15 | Janssen Pharmaceutica N.V. | Hiv replication inhibiting pyrimidines and triazines |
AR039540A1 (es) * | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | Compuestos microbicidas con contenido de pirimidina o triazina |
ATE402152T1 (de) * | 2003-02-07 | 2008-08-15 | Janssen Pharmaceutica Nv | Hiv-inhibierende1,2,4-triazine |
CN101035773B (zh) | 2004-08-10 | 2012-06-06 | 詹森药业有限公司 | 抑制hiv的1,2,4-三嗪-6-酮衍生物 |
GB201204756D0 (en) * | 2012-03-19 | 2012-05-02 | Lewi Paulus J | Triazines with suitable spacers for treatment and/or prevention of HIV infections |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4927592B1 (ru) * | 1970-05-13 | 1974-07-18 | ||
BE754242A (fr) | 1970-07-15 | 1971-02-01 | Geigy Ag J R | Diamino-s-triazines et dinitro-s-triazines |
US4650867A (en) * | 1985-03-26 | 1987-03-17 | Ciba-Geigy Corporation | Process for the preparation of 2,4,6-tris(aminophenylamino)triazines |
JPH02308248A (ja) | 1989-05-24 | 1990-12-21 | Fuji Photo Film Co Ltd | アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料 |
EP0723533A1 (en) | 1993-10-12 | 1996-07-31 | The Du Pont Merck Pharmaceutical Company | 1n-alkyl-n-arylpyrimidinamines and derivatives thereof |
US5691364A (en) * | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
ATE245641T1 (de) | 1998-02-17 | 2003-08-15 | Tularik Inc | Antivirale pyrimidinderivate |
HUP0104395A3 (en) * | 1998-11-10 | 2003-02-28 | Janssen Pharmaceutica Nv | 2,4-disubstituted triazine derivatives with anti hiv activity, process for their preparation and medicaments containing them |
-
1999
- 1999-11-04 HU HU0104395A patent/HUP0104395A3/hu unknown
- 1999-11-04 NZ NZ510919A patent/NZ510919A/en unknown
- 1999-11-04 CN CNB998130478A patent/CN1207290C/zh not_active Expired - Fee Related
- 1999-11-04 EP EP99953980A patent/EP1129079B1/en not_active Expired - Lifetime
- 1999-11-04 US US09/831,808 patent/US6638932B1/en not_active Expired - Fee Related
- 1999-11-04 AP APAP/P/2001/002155A patent/AP1636A/en active
- 1999-11-04 EA EA200100534A patent/EA004501B1/ru not_active IP Right Cessation
- 1999-11-04 CZ CZ20011532A patent/CZ20011532A3/cs unknown
- 1999-11-04 AT AT99953980T patent/ATE315031T1/de not_active IP Right Cessation
- 1999-11-04 IL IL14302499A patent/IL143024A0/xx active IP Right Grant
- 1999-11-04 SI SI9930886T patent/SI1129079T1/sl unknown
- 1999-11-04 DK DK99953980T patent/DK1129079T3/da active
- 1999-11-04 PT PT99953980T patent/PT1129079E/pt unknown
- 1999-11-04 AU AU10462/00A patent/AU764472B2/en not_active Ceased
- 1999-11-04 OA OA1200100114A patent/OA11675A/en unknown
- 1999-11-04 PL PL348145A patent/PL196523B1/pl not_active IP Right Cessation
- 1999-11-04 ID IDW00200101017A patent/ID28545A/id unknown
- 1999-11-04 EE EEP200100253A patent/EE200100253A/xx unknown
- 1999-11-04 JP JP2000581008A patent/JP2002529457A/ja active Pending
- 1999-11-04 ES ES99953980T patent/ES2257081T3/es not_active Expired - Lifetime
- 1999-11-04 DE DE69929354T patent/DE69929354T2/de not_active Expired - Fee Related
- 1999-11-04 BR BR9915176-6A patent/BR9915176A/pt not_active IP Right Cessation
- 1999-11-04 SK SK602-2001A patent/SK6022001A3/sk unknown
- 1999-11-04 CA CA002351203A patent/CA2351203C/en not_active Expired - Fee Related
- 1999-11-04 TR TR2001/01319T patent/TR200101319T2/xx unknown
- 1999-11-04 WO PCT/EP1999/008688 patent/WO2000027828A2/en active IP Right Grant
- 1999-11-04 KR KR1020017003574A patent/KR100620402B1/ko not_active IP Right Cessation
- 1999-11-05 MY MYPI99004801A patent/MY126781A/en unknown
- 1999-11-09 AR ARP990105681A patent/AR021137A1/es active IP Right Grant
- 1999-12-23 TW TW088119615A patent/TW541305B/zh not_active IP Right Cessation
-
2001
- 2001-04-06 BG BG105419A patent/BG65160B1/bg unknown
- 2001-04-19 NO NO20011934A patent/NO319788B1/no unknown
- 2001-05-02 HR HR20010310A patent/HRP20010310A2/hr not_active Application Discontinuation
- 2001-05-07 IL IL143024A patent/IL143024A/en not_active IP Right Cessation
- 2001-12-10 HK HK01108632A patent/HK1038232A1/xx not_active IP Right Cessation
-
2003
- 2003-08-27 US US10/649,017 patent/US7015221B2/en not_active Expired - Fee Related
-
2006
- 2006-03-31 CY CY20061100457T patent/CY1105596T1/el unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |