AR110676A1 - Tratamiento del cáncer utilizando receptores de antígenos quiméricos - Google Patents

Tratamiento del cáncer utilizando receptores de antígenos quiméricos

Info

Publication number
AR110676A1
AR110676A1 ARP170102803A ARP170102803A AR110676A1 AR 110676 A1 AR110676 A1 AR 110676A1 AR P170102803 A ARP170102803 A AR P170102803A AR P170102803 A ARP170102803 A AR P170102803A AR 110676 A1 AR110676 A1 AR 110676A1
Authority
AR
Argentina
Prior art keywords
car
chemeric
cancer
treatment
cell
Prior art date
Application number
ARP170102803A
Other languages
English (en)
Spanish (es)
Original Assignee
Novartis Ag
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Pennsylvania filed Critical Novartis Ag
Publication of AR110676A1 publication Critical patent/AR110676A1/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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ARP170102803A 2016-10-07 2017-10-06 Tratamiento del cáncer utilizando receptores de antígenos quiméricos AR110676A1 (es)

Applications Claiming Priority (1)

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US201662405520P 2016-10-07 2016-10-07

Publications (1)

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AR110676A1 true AR110676A1 (es) 2019-04-24

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ARP170102803A AR110676A1 (es) 2016-10-07 2017-10-06 Tratamiento del cáncer utilizando receptores de antígenos quiméricos
ARP220101668A AR126242A2 (es) 2016-10-07 2022-06-24 Tratamiento del cáncer utilizando receptores de antígenos quiméricos

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US (5) US10525083B2 (enExample)
EP (1) EP3523331A1 (enExample)
JP (3) JP7467117B2 (enExample)
KR (2) KR102717188B1 (enExample)
CN (2) CN110225927B (enExample)
AR (2) AR110676A1 (enExample)
AU (2) AU2017341047B2 (enExample)
BR (1) BR112019006781A2 (enExample)
CA (1) CA3039646A1 (enExample)
IL (1) IL265755A (enExample)
MX (2) MX2019003886A (enExample)
MY (1) MY200337A (enExample)
PH (1) PH12019500750A1 (enExample)
SA (1) SA519401494B1 (enExample)
SG (1) SG10201913823VA (enExample)
TW (2) TW202340473A (enExample)
WO (1) WO2018067992A1 (enExample)
ZA (1) ZA201902047B (enExample)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201505896YA (en) 2013-02-20 2015-09-29 Novartis Ag Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
EP3744736A1 (en) 2013-02-20 2020-12-02 Novartis AG Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells
EP2970426B1 (en) 2013-03-15 2019-08-28 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
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