AR064476A1 - Derivados de 1h-pirrolo[2, 3-b]piridina sustituidos, composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por a-raf, b-raf y/o por c-raf-1. - Google Patents
Derivados de 1h-pirrolo[2, 3-b]piridina sustituidos, composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por a-raf, b-raf y/o por c-raf-1.Info
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- AR064476A1 AR064476A1 ARP070105759A ARP070105759A AR064476A1 AR 064476 A1 AR064476 A1 AR 064476A1 AR P070105759 A ARP070105759 A AR P070105759A AR P070105759 A ARP070105759 A AR P070105759A AR 064476 A1 AR064476 A1 AR 064476A1
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- Argentina
- Prior art keywords
- lower alkyl
- nr8c
- fluorine
- nr8r7
- group
- Prior art date
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract
Se describen compuestos activos en proteína quinasa, así como el uso de dichos compuestos para tratar enfermedades y condiciones asociadas con actividad aberrante de proteínas quinasas. Reivindicacion 1: Un compuesto que tiene la estructura química de formula 1, todas las sales, pro-drogas, tautomeros e isomeros de la misma, en donde: R1 se selecciona del grupo que consiste de hidrogeno, halogeno, alquilo inferior, alquenilo inferior, alquinilo inferior, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, -OH, -NH2, -CN, -NO2, -C(O)OH, -S(O)2NH2, -C(O)NH2, -C(S)NH2, -NHC(O)NH2, -NHC(S)NH2, -NHS(O)2NH2, -OR7, -SR7, -NR8R7, -C(O)R7, -C(S)R7, -C(O)OR7, -C(O)NR8R7, -C(S)NR8R7, -S(O)2NR8R7, -NR8C(O)R7, -NR8C(S)R7, - NR8S(O)2R7, -NR8C(O)NH2, -NR8C(O)NR8R7, -NR8C(S)NH2, -NR8C(S)NR8R7, -NR8S(O)2NH2, -NR8S(O)2NR8R7, -S(O)R7, y -S(O)2R7, en donde el alquilo inferior, alquenilo inferior o alquinilo inferior son opcionalmente sustituidos con uno o más sustituyentes seleccionados de fluor, -OH, -NH2, C(O)OH, -C(O)NH2, -OR7, -NR8R7, -C(O)OR7, -C(O)NR8R7, cicloalquilo, heterocicloalquilo, arilo y heteroarilo, en donde el cicloalquilo, heterocicloalquilo, arilo y heteroarilo como R1 o como sustituyentes de alquilo inferior, alquenilo inferior o alquinilo inferior son opcionalmente sustituidos con uno o más sustituyentes seleccionados del grupo que consiste de -OH, -NH2, -CN, -NO2, -S(O)2NH2, -C(O)NH2, -OR9, -SR9, -NHR9, -NR8R9, -NR8C(O)R9, -NR8S(O)2R9, - S(O)2R9, -S(O)2NR8R9, -C(O)R9, -C(O)NR8R9, halogeno, alquilo inferior, alquilo inferior sustituido con fluor y cicloalquilamino; R2 se selecciona del grupo que consiste de halogeno, alquilo inferior, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, -OH, -NH2, -CN, -NO2, -C(O)OH, -S(O)2NH2, -C(O)NH2, -C(S)NH2, -NHC(O)NH2, -NHC(S)NH2, -NHS(O)2NH2, -OR7, -SR7, -NR8R7, -C(O)R7, -C(S)R7, -C(O)OR7, -C(O)NR8R7, -C(S)NR8R7, -S(O)2NR8R7, -NR8C(O)R7, -NR8C(S)R7, -NR8S(O)2R7, -NR8C(O)NH2, - NR8C(O)NR8R7, -NR8C(S)NH2, -NR8C(S)NR8R7, -NR8S(O)2NH2, -NR8S(O)2NR8R7, -S(O)R7, y -S(O)2R7, en donde el alquilo inferior es opcionalmente sustituido con uno o más sustituyentes seleccionados de fluor, -OR7, -NR8R7, cicloalquilo, heterocicloalquilo, arilo y heteroarilo, en donde el cicloalquilo, heterocicloalquilo, arilo y heteroarilo como R2 o como sustituyentes de alquilo inferior son opcionalmente sustituidos con uno o más sustituyentes seleccionados del grupo que consiste de -OH, -NH2, -CN, -NO2, -S(O)2NH2, -C(O)NH2, -OR9, -SR9, -NHR9, -NR8R9, -NR8C(O)R9, -NR8S(O)2R9, -S(O)2R9, -S(O)2NR8R9, -C(O)R9, -C(O)NR8R9, halogeno, alquilo inferior, alquilo inferior sustituido con fluor y cicloalquilamino; R3 se selecciona del grupo que consiste de hidrogeno, fluor y cloro; R7 se selecciona del grupo que consiste de alquilo inferior, cicloalquilo, heterocicloalquilo, arilo y heteroarilo, en donde el alquilo inferior es opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consiste de fluor, alcoxi inferior, alcoxi inferior sustituido con fluor, alquiltio inferior, alquiltio inferior sustituido con fluor, mono-alquilamino, di-alquilamino, cicloalquilo, heterocicloalquilo, arilo y heteroarilo, en donde el cicloalquilo, heterocicloalquilo, arilo y heteroarilo como R7 o como sustituyentes de alquilo inferior son opcionalmente sustituidos con uno o más sustituyentes seleccionados del grupo que consiste de -OH, -NH2, -CN, -NO2, -S(O)2NH2, -C(O)NH2, -OR9, -SR9, -NHR9, -NR8R9, -NR8C(O)R9, -NR8S(O)2R9, -S(O)2R9, -S(O)2NR8R9, -C(O)R9, -C(O)NR8R9, halogeno, alquilo inferior, alquilo inferior sustituido con fluor y cicloalquilamino; R8 en cada ocurrencia es independientemente hidrogeno o alquilo inferior y R9 en cada ocurrencia es independientemente seleccionado del grupo que consiste de alquilo inferior, heterocicloalquilo y heteroarilo, en donde el alquilo inferior es opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consiste de fluor, alcoxi inferior, alcoxi inferior sustituido con fluor, alquiltio inferior, alquiltio inferior sustituido con fluor, monoalquilamino, di-alquilamino y cicloalquilamino y en donde el heterocicloalquilo y heteroarilo son opcionalmente sustituidos con uno o más sustituyentes seleccionados del grupo que consiste de halogeno, -CN, alquilo inferior, alquilo inferior sustituido con fluor, alcoxi inferior y alcoxi inferior sustituido con fluor, siempre que, sin embargo, el compuesto no sea ninguno de los del grupo de formulas (2).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US87695306P | 2006-12-21 | 2006-12-21 |
Publications (1)
Publication Number | Publication Date |
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AR064476A1 true AR064476A1 (es) | 2009-04-01 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP070105759A AR064476A1 (es) | 2006-12-21 | 2007-12-20 | Derivados de 1h-pirrolo[2, 3-b]piridina sustituidos, composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por a-raf, b-raf y/o por c-raf-1. |
Country Status (24)
Country | Link |
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US (2) | US7863289B2 (es) |
EP (1) | EP2097414A1 (es) |
JP (1) | JP2010514687A (es) |
KR (1) | KR20090095654A (es) |
CN (1) | CN101668757A (es) |
AR (1) | AR064476A1 (es) |
AU (1) | AU2007336906A1 (es) |
BR (1) | BRPI0722088A2 (es) |
CA (1) | CA2673000A1 (es) |
CL (1) | CL2007003797A1 (es) |
CO (1) | CO6190519A2 (es) |
CR (1) | CR10860A (es) |
EC (1) | ECSP099444A (es) |
HN (1) | HN2009001202A (es) |
MA (1) | MA31153B1 (es) |
MX (1) | MX2009006162A (es) |
MY (1) | MY148468A (es) |
NO (1) | NO20092251L (es) |
PE (2) | PE20121126A1 (es) |
RU (1) | RU2009122436A (es) |
TW (1) | TW200845975A (es) |
UA (1) | UA98629C2 (es) |
UY (1) | UY30816A1 (es) |
WO (2) | WO2008079906A1 (es) |
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- 2007-12-19 BR BRPI0722088A patent/BRPI0722088A2/pt not_active IP Right Cessation
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- 2007-12-19 WO PCT/US2007/088231 patent/WO2008079903A1/en active Application Filing
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-
2010
- 2010-12-29 US US12/981,427 patent/US20110092538A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MY148468A (en) | 2013-04-30 |
US20110092538A1 (en) | 2011-04-21 |
PE20121126A1 (es) | 2012-08-24 |
HN2009001202A (es) | 2012-06-04 |
MA31153B1 (fr) | 2010-02-01 |
RU2009122436A (ru) | 2011-01-27 |
CN101668757A (zh) | 2010-03-10 |
US7863289B2 (en) | 2011-01-04 |
PE20081581A1 (es) | 2008-11-12 |
CA2673000A1 (en) | 2008-07-03 |
TW200845975A (en) | 2008-12-01 |
BRPI0722088A2 (pt) | 2016-03-22 |
MX2009006162A (es) | 2009-06-19 |
KR20090095654A (ko) | 2009-09-09 |
UY30816A1 (es) | 2008-07-31 |
WO2008079903A1 (en) | 2008-07-03 |
JP2010514687A (ja) | 2010-05-06 |
EP2097414A1 (en) | 2009-09-09 |
CO6190519A2 (es) | 2010-08-19 |
NO20092251L (no) | 2009-07-15 |
CR10860A (es) | 2009-06-30 |
ECSP099444A (es) | 2009-07-31 |
UA98629C2 (ru) | 2012-06-11 |
CL2007003797A1 (es) | 2008-07-18 |
US20080167338A1 (en) | 2008-07-10 |
AU2007336906A1 (en) | 2008-07-03 |
WO2008079906A1 (en) | 2008-07-03 |
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