BRPI0722088A2 - derivados de pirrolo[2,3-b]piridina como moduladores de cinase - Google Patents

derivados de pirrolo[2,3-b]piridina como moduladores de cinase

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Publication number
BRPI0722088A2
BRPI0722088A2 BRPI0722088A BRPI0722088A BRPI0722088A2 BR PI0722088 A2 BRPI0722088 A2 BR PI0722088A2 BR PI0722088 A BRPI0722088 A BR PI0722088A BR PI0722088 A BRPI0722088 A BR PI0722088A BR PI0722088 A2 BRPI0722088 A2 BR PI0722088A2
Authority
BR
Brazil
Prior art keywords
pyrrolo
pyridine derivatives
kinase modulators
modulators
kinase
Prior art date
Application number
BRPI0722088A
Other languages
English (en)
Inventor
Hanna Cho
Hongyao Zhu
Prabha N Ibrahim
Sam Gillette
Shenghua Shi
Shumeye Mamo
Wayne Spevak
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39281754&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0722088(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of BRPI0722088A2 publication Critical patent/BRPI0722088A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
BRPI0722088A 2006-12-21 2007-12-19 derivados de pirrolo[2,3-b]piridina como moduladores de cinase BRPI0722088A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87695306P 2006-12-21 2006-12-21
PCT/US2007/088237 WO2008079906A1 (en) 2006-12-21 2007-12-19 Pyrrolo [2, 3-b] pyridine derivatives as kinase modulators

Publications (1)

Publication Number Publication Date
BRPI0722088A2 true BRPI0722088A2 (pt) 2016-03-22

Family

ID=39281754

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0722088A BRPI0722088A2 (pt) 2006-12-21 2007-12-19 derivados de pirrolo[2,3-b]piridina como moduladores de cinase

Country Status (24)

Country Link
US (2) US7863289B2 (pt)
EP (1) EP2097414A1 (pt)
JP (1) JP2010514687A (pt)
KR (1) KR20090095654A (pt)
CN (1) CN101668757A (pt)
AR (1) AR064476A1 (pt)
AU (1) AU2007336906A1 (pt)
BR (1) BRPI0722088A2 (pt)
CA (1) CA2673000A1 (pt)
CL (1) CL2007003797A1 (pt)
CO (1) CO6190519A2 (pt)
CR (1) CR10860A (pt)
EC (1) ECSP099444A (pt)
HN (1) HN2009001202A (pt)
MA (1) MA31153B1 (pt)
MX (1) MX2009006162A (pt)
MY (1) MY148468A (pt)
NO (1) NO20092251L (pt)
PE (2) PE20121126A1 (pt)
RU (1) RU2009122436A (pt)
TW (1) TW200845975A (pt)
UA (1) UA98629C2 (pt)
UY (1) UY30816A1 (pt)
WO (2) WO2008079906A1 (pt)

Families Citing this family (172)

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US20090118139A1 (en) * 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
CA2550361C (en) 2003-12-19 2014-04-29 Prabha Ibrahim Compounds and methods for development of ret modulators
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
MX2007014377A (es) * 2005-05-17 2008-02-06 Plexxikon Inc Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina.
BRPI0611863B1 (pt) * 2005-06-22 2021-11-23 Plexxikon, Inc Composto, bem como composição e kit compreendendo o mesmo, composto intermediário na preparação do mesmo, método para tratamento e uso do mesmo
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
RU2009122670A (ru) 2006-12-21 2011-01-27 Плекссикон, Инк. (Us) Соединения и способы для модуляции киназ и показания к их применению
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
EP2170830B1 (en) * 2007-07-17 2014-10-15 Plexxikon, Inc. 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS
WO2009099982A1 (en) * 2008-02-04 2009-08-13 Osi Pharmaceuticals, Inc. 2-aminopyridine kinase inhibitors
AR070317A1 (es) * 2008-02-06 2010-03-31 Osi Pharm Inc Furo (3,2-c) piridina y tieno (3,2-c) piridinas
ES2372908T3 (es) 2008-02-25 2012-01-27 F. Hoffmann-La Roche Ag Inhibidores de la pirrolopirazina quinasa.
WO2009106445A1 (en) * 2008-02-25 2009-09-03 F. Hoffmann-La Roche Ag Pyrrolopyrazine kinase inhibitors
EP2250172B1 (en) 2008-02-25 2011-08-31 F. Hoffmann-La Roche AG Pyrrolopyrazine kinase inhibitors
PT2247592E (pt) * 2008-02-25 2011-11-03 Hoffmann La Roche Inibidores de pirrolpirazina-cinase
BRPI0907928A2 (pt) 2008-02-25 2015-07-28 Hoffmann La Roche Inibidores de pirrolopirazina quinase.
CA2716947A1 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. Imidazo [4,5-b] pyridine derivatives used as raf inhibitors
JP2011513332A (ja) * 2008-02-29 2011-04-28 アレイ バイオファーマ、インコーポレイテッド 癌の治療のためのｒａｆ阻害剤としてのｎ−（６−アミノピリジン−３−イル）−３−（スルホンアミド）ベンズアミド誘導体
KR20100117686A (ko) * 2008-02-29 2010-11-03 어레이 바이오파마 인크. 피라졸[3,4-ｂ]피리딘 ｒａｆ 저해물질
EP2265608A2 (en) * 2008-02-29 2010-12-29 Array Biopharma, Inc. Raf inhibitor compounds and methods of use thereof
US8158636B2 (en) 2008-05-19 2012-04-17 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2010019480A1 (en) * 2008-08-11 2010-02-18 The University Of Chicago Attenuated herpesviruses encoding a mek pathway polypeptide
CA2738026C (en) 2008-09-22 2017-01-24 Array Biopharma Inc. Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
RU2011123647A (ru) 2008-11-10 2012-12-20 Вертекс Фармасьютикалз Инкорпорейтед Соединения, полезные в качестве ингибиторов atr киназы
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