ZA200306810B - Method for rapid detection and identification of bioagents. - Google Patents
Method for rapid detection and identification of bioagents. Download PDFInfo
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- ZA200306810B ZA200306810B ZA200306810A ZA200306810A ZA200306810B ZA 200306810 B ZA200306810 B ZA 200306810B ZA 200306810 A ZA200306810 A ZA 200306810A ZA 200306810 A ZA200306810 A ZA 200306810A ZA 200306810 B ZA200306810 B ZA 200306810B
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- South Africa
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- nucleic acid
- base
- mass
- bioagent
- amplification product
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- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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| US20080138808A1 (en) * | 2003-09-11 | 2008-06-12 | Hall Thomas A | Methods for identification of sepsis-causing bacteria |
| US20100129811A1 (en) * | 2003-09-11 | 2010-05-27 | Ibis Biosciences, Inc. | Compositions for use in identification of pseudomonas aeruginosa |
| US20120122101A1 (en) | 2003-09-11 | 2012-05-17 | Rangarajan Sampath | Compositions for use in identification of bacteria |
| US20100035239A1 (en) * | 2003-09-11 | 2010-02-11 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of bacteria |
| US20050142584A1 (en) * | 2003-10-01 | 2005-06-30 | Willson Richard C. | Microbial identification based on the overall composition of characteristic oligonucleotides |
| US7309410B2 (en) | 2003-12-03 | 2007-12-18 | Palo Alto Research Center Incorporated | Traveling wave grids and algorithms for biomolecule separation, transport and focusing |
| US7163611B2 (en) * | 2003-12-03 | 2007-01-16 | Palo Alto Research Center Incorporated | Concentration and focusing of bio-agents and micron-sized particles using traveling wave grids |
| US7666592B2 (en) * | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
| CA2560521C (en) * | 2004-02-18 | 2012-01-03 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of bacteria |
| US8119336B2 (en) * | 2004-03-03 | 2012-02-21 | Ibis Biosciences, Inc. | Compositions for use in identification of alphaviruses |
| US20060057603A1 (en) * | 2004-03-11 | 2006-03-16 | The Regents Of The University Of California | Detecting Bacillus anthracis |
| JP4810533B2 (ja) | 2004-05-24 | 2011-11-09 | アイビス バイオサイエンシズ インコーポレイティッド | ディジタルスレショルド化による選択的イオン濾過作用を用いた質量分光測定法 |
| US20050266411A1 (en) * | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
| US7811753B2 (en) | 2004-07-14 | 2010-10-12 | Ibis Biosciences, Inc. | Methods for repairing degraded DNA |
| WO2006135400A2 (en) | 2004-08-24 | 2006-12-21 | Isis Pharmaceuticals, Inc. | Methods for rapid identification of recombinant organisms |
| US7888011B2 (en) * | 2004-10-18 | 2011-02-15 | U.S. Genomics, Inc. | Methods for isolation of nucleic acids from prokaryotic spores |
| JP2008530555A (ja) * | 2005-02-09 | 2008-08-07 | コレロジック システムズ，インコーポレイテッド | 細菌及び芽胞の同定 |
| US8084207B2 (en) * | 2005-03-03 | 2011-12-27 | Ibis Bioscience, Inc. | Compositions for use in identification of papillomavirus |
| CA2600184A1 (en) | 2005-03-03 | 2006-09-08 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of adventitious viruses |
| DE602006017365D1 (de) * | 2005-04-13 | 2010-11-18 | Ibis Biosciences Inc | Zusammensetzungen für die identifizierung von adenoviren |
| JP2009502137A (ja) * | 2005-07-21 | 2009-01-29 | アイシス ファーマシューティカルズ インコーポレイティッド | 核酸変種の迅速な同定および定量のための方法 |
| US11834720B2 (en) * | 2005-10-11 | 2023-12-05 | Geneohm Sciences, Inc. | Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx |
| GB0601302D0 (en) * | 2006-01-23 | 2006-03-01 | Semikhodskii Andrei | Diagnostic methods and apparatus |
| EP2010679A2 (de) | 2006-04-06 | 2009-01-07 | Ibis Biosciences, Inc. | Zusammensetzungen für die identifizierung von pilzen |
| US8455184B2 (en) * | 2006-04-18 | 2013-06-04 | The United States Of America As Represented By The Secretary Of The Air Force | Differential multiplexing with pattern recognition |
| EP3617321A3 (de) | 2006-05-31 | 2020-04-29 | Sequenom, Inc. | Verfahren und zusammensetzungen zur nukleinsäureextraktion und -verstärkung aus einer probe |
| CN101501251A (zh) * | 2006-06-16 | 2009-08-05 | 塞昆纳姆股份有限公司 | 扩增、检测和定量样品中核酸的方法和组合物 |
| CA2663029C (en) * | 2006-09-14 | 2016-07-19 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
| US7902345B2 (en) | 2006-12-05 | 2011-03-08 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
| US8076104B2 (en) * | 2007-01-25 | 2011-12-13 | Rogan Peter K | Rapid and comprehensive identification of prokaryotic organisms |
| EP2126132B1 (de) * | 2007-02-23 | 2013-03-20 | Ibis Biosciences, Inc. | Verfahren für schnelle forensische dna-analyse |
| US20100204266A1 (en) * | 2007-03-23 | 2010-08-12 | Ibis Biosciences, INC | Compositions for use in identification of mixed populations of bioagents |
| CA2680588A1 (en) | 2007-03-26 | 2008-10-02 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| US7811766B2 (en) * | 2007-03-28 | 2010-10-12 | Thinkvillage, Llc | Genetic identification and validation of Echinacea species |
| US8527207B2 (en) * | 2007-05-15 | 2013-09-03 | Peter K. Rogan | Accurate identification of organisms based on individual information content |
| WO2009023358A2 (en) * | 2007-05-25 | 2009-02-19 | Ibis Biosciences, Inc. | Compositions for use in identification of strains of hepatitis c virus |
| US9598724B2 (en) | 2007-06-01 | 2017-03-21 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
| CN101541979B (zh) | 2007-06-01 | 2014-11-05 | 科学与工业研究委员会 | 同时检测和鉴别眼睛和中枢神经系统的细菌、真菌、寄生虫和病毒感染的方法 |
| US20110045456A1 (en) * | 2007-06-14 | 2011-02-24 | Ibis Biosciences, Inc. | Compositions for use in identification of adventitious contaminant viruses |
| EP2179041A4 (de) * | 2007-06-22 | 2010-12-22 | Ibis Biosciences Inc | Zusammensetzungen und verfahren zur identifikation der eigenschaften von unterarten von mycobacterium tuberculosis |
| US7964843B2 (en) | 2008-07-18 | 2011-06-21 | The George Washington University | Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry |
| US8067730B2 (en) | 2007-07-20 | 2011-11-29 | The George Washington University | Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry |
| US8901487B2 (en) | 2007-07-20 | 2014-12-02 | George Washington University | Subcellular analysis by laser ablation electrospray ionization mass spectrometry |
| EP2195452B1 (de) | 2007-08-29 | 2012-03-14 | Sequenom, Inc. | Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion |
| US20110097704A1 (en) * | 2008-01-29 | 2011-04-28 | Ibis Biosciences, Inc. | Compositions for use in identification of picornaviruses |
| US20090263809A1 (en) * | 2008-03-20 | 2009-10-22 | Zygem Corporation Limited | Methods for Identification of Bioagents |
| EP2276858A4 (de) | 2008-03-26 | 2011-10-05 | Sequenom Inc | Durch restriktionsendonuklease verbesserter nachweis polymorpher sequenzen |
| US20110177515A1 (en) * | 2008-05-30 | 2011-07-21 | Ibis Biosciences, Inc. | Compositions for use in identification of francisella |
| US20110143358A1 (en) * | 2008-05-30 | 2011-06-16 | Ibis Biosciences, Inc. | Compositions for use in identification of tick-borne pathogens |
| WO2009148995A2 (en) * | 2008-06-02 | 2009-12-10 | Ibis Biosciences, Inc. | Compositions for use in identification of adventitious viruses |
| WO2010033627A2 (en) | 2008-09-16 | 2010-03-25 | Ibis Biosciences, Inc. | Sample processing units, systems, and related methods |
| WO2010033625A1 (en) | 2008-09-16 | 2010-03-25 | Ibis Biosciences, Inc. | Microplate handling systems and related computer program products and methods |
| US8550694B2 (en) | 2008-09-16 | 2013-10-08 | Ibis Biosciences, Inc. | Mixing cartridges, mixing stations, and related kits, systems, and methods |
| US20110189687A1 (en) * | 2008-10-02 | 2011-08-04 | Ibis Bioscience, Inc. | Compositions for use in identification of members of the bacterial genus mycoplasma |
| US20110200985A1 (en) * | 2008-10-02 | 2011-08-18 | Rangarajan Sampath | Compositions for use in identification of herpesviruses |
| WO2010039787A1 (en) * | 2008-10-03 | 2010-04-08 | Ibis Biosciences, Inc. | Compositions for use in identification of clostridium difficile |
| US20110183346A1 (en) * | 2008-10-03 | 2011-07-28 | Ibis Biosciences, Inc. | Compositions for use in identification of neisseria, chlamydia, and/or chlamydophila bacteria |
| WO2010039848A2 (en) * | 2008-10-03 | 2010-04-08 | Ibis Biosciences, Inc. | Compositions for use in identification of streptococcus pneumoniae |
| WO2010039775A1 (en) * | 2008-10-03 | 2010-04-08 | Ibis Biosciences, Inc. | Compositions for use in identification of members of the bacterial class alphaproteobacter |
| WO2010039763A2 (en) * | 2008-10-03 | 2010-04-08 | Ibis Biosciences, Inc. | Compositions for use in identification of antibiotic-resistant bacteria |
| WO2010080616A1 (en) * | 2008-12-19 | 2010-07-15 | Abbott Laboratories | Molecular assay for diagnosis of malaria |
| WO2010071821A1 (en) * | 2008-12-19 | 2010-06-24 | Abbott Laboratories | Diagnostic test for mutations in codons 12-13 of human k-ras |
| DE102009007266B4 (de) * | 2009-02-03 | 2012-04-19 | Bruker Daltonik Gmbh | Massenspektrometrische Identifizierung von Mikroorganismen in komplexen Proben |
| GB2510520B (en) * | 2009-02-03 | 2014-11-05 | Bruker Daltonik Gmbh | Mass spectrometric identification of microorganisms in complex samples |
| EP2396803A4 (de) * | 2009-02-12 | 2016-10-26 | Ibis Biosciences Inc | Ionisationssondenanordnungen |
| WO2010104798A1 (en) | 2009-03-08 | 2010-09-16 | Ibis Biosciences, Inc. | Bioagent detection methods |
| CN102428191A (zh) * | 2009-03-18 | 2012-04-25 | 塞昆纳姆股份有限公司 | 热稳定性内切核酸酶在产生报道分子中的应用 |
| WO2010114842A1 (en) | 2009-03-30 | 2010-10-07 | Ibis Biosciences, Inc. | Bioagent detection systems, devices, and methods |
| EP2414545B1 (de) | 2009-04-03 | 2017-01-11 | Sequenom, Inc. | Zusammensetzungen und verfahren für die herstellung von nukleinsäuren |
| EP2454000A4 (de) | 2009-07-17 | 2016-08-10 | Ibis Biosciences Inc | Systeme zur identifizierung von biowirkstoffen |
| WO2011008971A1 (en) * | 2009-07-17 | 2011-01-20 | Ibis Biosciences, Inc. | Lift and mount apparatus |
| WO2011014811A1 (en) | 2009-07-31 | 2011-02-03 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
| US9080209B2 (en) | 2009-08-06 | 2015-07-14 | Ibis Biosciences, Inc. | Non-mass determined base compositions for nucleic acid detection |
| US20110065111A1 (en) * | 2009-08-31 | 2011-03-17 | Ibis Biosciences, Inc. | Compositions For Use In Genotyping Of Klebsiella Pneumoniae |
| WO2011041695A1 (en) * | 2009-10-02 | 2011-04-07 | Ibis Biosciences, Inc. | Determination of methylation status of polynucleotides |
| US9890408B2 (en) * | 2009-10-15 | 2018-02-13 | Ibis Biosciences, Inc. | Multiple displacement amplification |
| EP2545183B1 (de) | 2010-03-10 | 2017-04-19 | Ibis Biosciences, Inc. | Herstellung einer einsträngigen zirkulären nukleinsäure |
| WO2011115840A2 (en) * | 2010-03-14 | 2011-09-22 | Ibis Biosciences, Inc. | Parasite detection via endosymbiont detection |
| US9068017B2 (en) | 2010-04-08 | 2015-06-30 | Ibis Biosciences, Inc. | Compositions and methods for inhibiting terminal transferase activity |
| US8481281B2 (en) | 2010-06-02 | 2013-07-09 | The Johns Hopkins University | Systems and methods for determining drug resistance in microorganisms |
| WO2012159089A1 (en) | 2011-05-19 | 2012-11-22 | Sequenom, Inc. | Products and processes for multiplex nucleic acid identification |
| WO2012174187A2 (en) * | 2011-06-15 | 2012-12-20 | Grifols Therapeutics Inc. | Methods, compositions, and kits for determining human immunodeficiency virus (hiv) |
| CA2841752A1 (en) | 2011-07-14 | 2013-06-13 | The George Washington University | Plume collimation for laser ablation electrospray ionization mass spectrometry |
| EP3170831A1 (de) | 2011-09-06 | 2017-05-24 | Ibis Biosciences, Inc. | Probenvorbereitungsverfahren |
| US20140228455A1 (en) * | 2011-09-07 | 2014-08-14 | Alpha Biotech Ab | Determination of bacterial infections of the genus rickettsia and possibly borrelia, in patients exhibiting symptoms of disease and being blood donors |
| CN103797132A (zh) * | 2011-09-23 | 2014-05-14 | 霍夫曼-拉罗奇有限公司 | G形夹用于改进的等位基因特异性pcr的用途 |
| WO2013096838A2 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids |
| WO2013096799A1 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids from cellular samples |
| US9970061B2 (en) | 2011-12-27 | 2018-05-15 | Ibis Biosciences, Inc. | Bioagent detection oligonucleotides |
| EP2872523B1 (de) | 2011-12-30 | 2018-01-17 | Abbott Molecular Inc. | Mikroorganismus-nukleinsäurereinigung von wirtsproben |
| US9732387B2 (en) | 2012-04-03 | 2017-08-15 | The Regents Of The University Of Michigan | Biomarker associated with irritable bowel syndrome and Crohn's disease |
| US20150241319A1 (en) | 2012-09-26 | 2015-08-27 | Thomas N. Chiesl | Swab interface for a microfluidic device |
| EP2971169A4 (de) | 2013-03-13 | 2016-10-26 | Abbott Molecular Inc | Systeme und verfahren zur isolierung von nukleinsäuren |
| JP2016512437A (ja) | 2013-03-14 | 2016-04-28 | アボツト・モレキユラー・インコーポレイテツド | 多重メチル化特異的増幅システムおよび方法 |
| US9856525B2 (en) | 2013-03-15 | 2018-01-02 | Bio-Rad Laboratories, Inc. | Digital assays with associated targets |
| WO2014186874A1 (en) | 2013-05-23 | 2014-11-27 | Yyz Pharmatech, Inc. | Methods and compositions for enzyme linked immuno and hybridization mass spectrometric assay |
| CN103344695B (zh) * | 2013-06-18 | 2015-06-10 | 中国疾病预防控制中心传染病预防控制所 | 钩端螺旋体快速质谱检测试剂盒 |
| CN103667109B (zh) * | 2013-10-23 | 2016-02-03 | 大连市水产技术推广总站 | 一种荚膜红细菌及其应用 |
| EP3594684A1 (de) | 2014-06-27 | 2020-01-15 | Abbott Laboratories | Zusammensetzungen und verfahren zum nachweis des menschlichen pegivirus 2 (hpgv-2) |
| RU2580412C1 (ru) * | 2015-02-02 | 2016-04-10 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" | Способ количественного определения т-2 токсина методом дифференциальной вольтамперометрии |
| JP2018512881A (ja) | 2015-04-24 | 2018-05-24 | アジーナ バイオサイエンス， インコーポレイテッド | 少数バリアントの検出および定量のための方法マルチプレックス法 |
| US10233489B2 (en) | 2015-04-24 | 2019-03-19 | Agena Bioscience, Inc. | Multiplexed method for the identification and quantitation of minor alleles and polymorphisms |
| WO2018089978A1 (en) * | 2016-11-14 | 2018-05-17 | Wisconsin Alumni Research Foundation | Nucleic acid quantification compositions and methods |
| CN107085034A (zh) * | 2017-04-19 | 2017-08-22 | 中国人民解放军第三〇二医院 | Maldi‑tof‑ms鉴定宋内志贺菌 |
| CN108048540B (zh) * | 2018-01-03 | 2021-06-08 | 北京毅新博创生物科技有限公司 | 制备检测霍乱弧菌分型的指纹图谱库的方法 |
| CN107988341B (zh) * | 2018-01-03 | 2019-04-23 | 北京毅新博创生物科技有限公司 | 质谱鉴定霍乱弧菌分型的方法及产品 |
| JP7378712B2 (ja) * | 2019-08-07 | 2023-11-14 | 学校法人常翔学園 | 異種移植用材料の病原体感染を検査する方法、検査キット及び病原体感染が評価された異種移植用材料製品の作成方法 |
| CN111737674B (zh) * | 2020-08-03 | 2021-02-09 | 德能森智能科技（成都）有限公司 | 一种基于云平台的智慧园区系统 |
| CN113219115A (zh) * | 2021-05-18 | 2021-08-06 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 一种基于maldi-tof ms的蜡样芽胞杆菌和苏云金芽胞杆菌快速鉴定方法 |
| WO2023077489A1 (zh) * | 2021-11-06 | 2023-05-11 | 江汉大学 | 一种鼠疫杆菌的mnp标记组合、引物对组合、试剂盒及其应用 |
Family Cites Families (427)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4075475A (en) | 1976-05-03 | 1978-02-21 | Chemetron Corporation | Programmed thermal degradation-mass spectrometry analysis method facilitating identification of a biological specimen |
| US5641631A (en) * | 1983-01-10 | 1997-06-24 | Gen-Probe Incorporated | Method for detecting, identifying, and quantitating organisms and viruses |
| ATE167524T1 (de) * | 1983-01-10 | 1998-07-15 | Gen Probe Inc | Verfahren zum nachweis, identifizieren und quantifizieren von organismen und viren |
| US5288611A (en) | 1983-01-10 | 1994-02-22 | Gen-Probe Incorporated | Method for detecting, identifying, and quantitating organisms and viruses |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| EP0272009B2 (de) | 1986-11-24 | 2007-10-03 | Gen-Probe Incorporated | Nukleinsäuresonden zum Nachweis und/oder zur Quantifizierung von nicht-viralen Organismen |
| DE3850273T2 (de) | 1987-03-02 | 1994-09-29 | Gen Probe Inc | Polykationische Träger zur Reinigung, Trennung und Hybridisierung von Nukleinsäure. |
| US5188963A (en) | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
| US5270030A (en) | 1988-12-29 | 1993-12-14 | Bio-Technology General Corp. | Fibrin binding domain polypeptide and method of producing |
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| IE81145B1 (en) * | 1989-04-20 | 2000-05-03 | Thomas Gerard Barry | Generation of specific probes for target nucleotide sequences |
| AU5950690A (en) | 1989-05-31 | 1991-01-07 | Gene-Trak Systems | Universal eubacteria nucleic acid probes and methods |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5213961A (en) | 1989-08-31 | 1993-05-25 | Brigham And Women's Hospital | Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction |
| US6001588A (en) | 1990-01-10 | 1999-12-14 | Hsc Research Development Corporation | Introns and exons of the cystic fibrosis gene and mutations thereof |
| US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US5143905A (en) | 1990-05-03 | 1992-09-01 | The Regents Of The University Of California | Method and means for extending the host range of insecticidal proteins |
| US5015845A (en) | 1990-06-01 | 1991-05-14 | Vestec Corporation | Electrospray method for mass spectrometry |
| US5712125A (en) | 1990-07-24 | 1998-01-27 | Cemv Bioteknik Ab | Competitive PCR for quantitation of DNA |
| DE4030262A1 (de) | 1990-09-25 | 1992-03-26 | Suedzucker Ag | Verfahren zur herstellung von rhamnose aus rhamnolipiden |
| NL9002259A (nl) * | 1990-10-17 | 1992-05-18 | Eurodiagnostics B V | Werkwijze voor het bepalen van een genotype door het vergelijken van de nucleotidensequentie van leden van een genfamilie, alsmede kit voor het opsporen van genetische variaties. |
| WO1992009703A1 (en) | 1990-11-26 | 1992-06-11 | Cbr Laboratories, Inc. | Testing for spirochetal nucleic acid sequences in samples |
| US5072115A (en) | 1990-12-14 | 1991-12-10 | Finnigan Corporation | Interpretation of mass spectra of multiply charged ions of mixtures |
| WO1992013629A1 (en) | 1991-01-31 | 1992-08-20 | Wayne State University | A method for analyzing an organic sample |
| US5866429A (en) | 1991-04-03 | 1999-02-02 | Bloch; Will | Precision and accuracy of anion-exchange separation of nucleic acids |
| US5472843A (en) | 1991-04-25 | 1995-12-05 | Gen-Probe Incorporated | Nucleic acid probes to Haemophilus influenzae |
| US5213796A (en) | 1991-05-06 | 1993-05-25 | Dana Farber Cancer Institute | Assay for polyomavirus in humans and uses thereof |
| US6055487A (en) | 1991-07-30 | 2000-04-25 | Margery; Keith S. | Interactive remote sample analysis system |
| ES2125268T3 (es) | 1991-07-31 | 1999-03-01 | Hoffmann La Roche | Metodos y reactivos para detectar bacterias en liquido cefalorraquideo. |
| EP0525882B1 (de) | 1991-08-02 | 2004-01-14 | bioMerieux B.V. | Quantifikation von Nukleinsäuren |
| DE69233083T2 (de) | 1991-08-27 | 2003-12-18 | Hoffmann La Roche | Primers und Sondern zum Nachweis von Hepatitis C |
| WO1993005182A1 (en) | 1991-09-05 | 1993-03-18 | Isis Pharmaceuticals, Inc. | Determination of oligonucleotides for therapeutics, diagnostics and research reagents |
| DK0610396T3 (da) | 1991-10-23 | 2001-01-29 | Baylor College Medicine | Fingeraftryksidentifikation af bakteriestammer med anvendelse af repetitiv DNA-sekvensamplifikation |
| FR2683827B1 (fr) | 1991-11-15 | 1994-03-04 | Institut Nal Sante Recherc Medic | Procede de determination de la quantite d'un fragment d'adn d'interet par une methode d'amplification enzymatique. |
| TW393513B (en) * | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US5484908A (en) * | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| WO1993010820A1 (en) * | 1991-11-26 | 1993-06-10 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US6235887B1 (en) | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
| IL103935A0 (en) | 1991-12-04 | 1993-05-13 | Du Pont | Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification |
| EP0746857A4 (de) | 1992-03-13 | 2001-01-03 | Thermomicroscopes Corp | Rasterabtastmikroskop |
| US5981176A (en) * | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
| US6303297B1 (en) | 1992-07-17 | 2001-10-16 | Incyte Pharmaceuticals, Inc. | Database for storage and analysis of full-length sequences |
| FR2694754B1 (fr) | 1992-08-12 | 1994-09-16 | Bio Merieux | Fragments d'ADN de mycobactéries, amorces d'amplification, sondes d'hybridation, réactifs et procédé de détection de détection de mycobactéries. |
| EP0618813B1 (de) | 1992-09-16 | 2002-01-09 | The University Of Tennessee Research Corporation | Antigene des hybriden m-proteins und träger für gruppe a streptokokkenimpfstoff |
| WO1994009156A1 (en) | 1992-10-08 | 1994-04-28 | The Regents Of The University Of California | Pcr assays to determine the presence and concentration of a target |
| US5503980A (en) * | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US6436635B1 (en) * | 1992-11-06 | 2002-08-20 | Boston University | Solid phase sequencing of double-stranded nucleic acids |
| US6372424B1 (en) * | 1995-08-30 | 2002-04-16 | Third Wave Technologies, Inc | Rapid detection and identification of pathogens |
| EP1262564A3 (de) * | 1993-01-07 | 2004-03-31 | Sequenom, Inc. | Dns-Sequenzierung durch Massenspektrometrie |
| US6194144B1 (en) * | 1993-01-07 | 2001-02-27 | Sequenom, Inc. | DNA sequencing by mass spectrometry |
| US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| FR2701961B1 (fr) | 1993-02-24 | 1995-04-21 | Bio Merieux | Procédé de destabilisation d'une structure secondaire intracaténaire d'un polynucléotide simple brin, et de capture dudit nucléotide. |
| WO1994021822A1 (en) | 1993-03-19 | 1994-09-29 | Sequenom, Inc. | Dna sequencing by mass spectrometry via exonuclease degradation |
| US6074823A (en) * | 1993-03-19 | 2000-06-13 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US6323041B1 (en) | 1993-06-11 | 2001-11-27 | Pfizer Inc. | Screening novel human phosphodiesterase IV isozymes for compounds which modify their enzymatic activity |
| JPH0775585A (ja) | 1993-06-14 | 1995-03-20 | Immuno Japan:Kk | Ｃ型肝炎ウイルス関連オリゴヌクレオチドならびにｃ型肝炎 ウイルス遺伝子型判定方法 |
| US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| US6001584A (en) | 1993-07-19 | 1999-12-14 | The Regents Of The University Of California | Oncoprotein protein kinase |
| WO1995004161A1 (en) | 1993-07-29 | 1995-02-09 | Sergio Danilo Junho Pena | Method for recognition of the nucleotide sequence of a purified dna segment |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| US5527675A (en) * | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| AU7679394A (en) | 1993-09-03 | 1995-03-22 | Duke University | A method of nucleic acid sequencing |
| US6376178B1 (en) * | 1993-09-03 | 2002-04-23 | Duke University | Method of nucleic acid sequencing |
| US5484909A (en) * | 1993-09-10 | 1996-01-16 | Amoco Corporation | Nucleic acid probes for the detection of bacteria of the genera Pediococcus and Lactobacillus and methods for the detection of the bacterial agents causing spoilage of beer |
| US5502177A (en) | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| WO1995011996A1 (en) | 1993-10-27 | 1995-05-04 | Cornell Research Foundation, Inc. | Detection assay for listeria and erwinia microorganisms |
| US5504327A (en) | 1993-11-04 | 1996-04-02 | Hv Ops, Inc. (H-Nu) | Electrospray ionization source and method for mass spectrometric analysis |
| DE4338119A1 (de) | 1993-11-08 | 1995-05-11 | Bayer Ag | Spezifische Gensonden und Verfahren zum quantitativen Nachweis von methicillinresistenten Staphylococcen |
| NL9301957A (nl) | 1993-11-11 | 1995-06-01 | U Gene Research Bv | Werkwijze voor het identificeren van micro-organismen, en daarvoor bruikbare hulpmiddelen. |
| US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
| JP3396942B2 (ja) | 1994-02-21 | 2003-04-14 | 三菱化学株式会社 | 芳香族ポリカーボネートの製造方法 |
| US5849492A (en) | 1994-02-28 | 1998-12-15 | Phylogenetix Laboratories, Inc. | Method for rapid identification of prokaryotic and eukaryotic organisms |
| US5608217A (en) | 1994-03-10 | 1997-03-04 | Bruker-Franzen Analytik Gmbh | Electrospraying method for mass spectrometric analysis |
| DE4444229C2 (de) | 1994-03-10 | 1996-07-25 | Bruker Franzen Analytik Gmbh | Verfahren und Vorrichtungen zur Elektrosprüh-Ionisierung für speichernde Massenspektometer |
| US5976798A (en) | 1994-03-30 | 1999-11-02 | Mitokor | Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid |
| AU7242994A (en) | 1994-05-20 | 1995-12-18 | United States Of America, As Represented By The Secretary Of The Army, The | Model for testing immunogenicity of peptides |
| US5814442A (en) | 1994-06-10 | 1998-09-29 | Georgetown University | Internally controlled virion nucleic acid amplification reaction for quantitation of virion and virion nucleic acid |
| DE4421901A1 (de) | 1994-06-23 | 1996-01-04 | Bayer Ag | Ein DNA-Schnelltest zum Nachweis von chinolonresistenten Staphylococcus aureus Erregern in klinischem Probenmaterial |
| US5541405A (en) | 1994-07-27 | 1996-07-30 | Parker-Hannifin Corporation | Method and device for continuous pattern sensing using fiber optics |
| GB9417211D0 (en) | 1994-08-25 | 1994-10-12 | Solicitor For The Affairs Of H | Nucleotide sequencing method |
| US6001564A (en) | 1994-09-12 | 1999-12-14 | Infectio Diagnostic, Inc. | Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US20020055101A1 (en) | 1995-09-11 | 2002-05-09 | Michel G. Bergeron | Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| CA2118048C (en) | 1994-09-30 | 2003-04-08 | James W. Schumm | Multiplex amplification of short tandem repeat loci |
| US5753489A (en) | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
| US5654141A (en) | 1994-11-18 | 1997-08-05 | Thomas Jefferson University | Amplification based detection of bacterial infection |
| KR100399813B1 (ko) | 1994-12-14 | 2004-06-09 | 가부시키가이샤 니콘 | 노광장치 |
| US6180339B1 (en) | 1995-01-13 | 2001-01-30 | Bayer Corporation | Nucleic acid probes for the detection and identification of fungi |
| US5763169A (en) | 1995-01-13 | 1998-06-09 | Chiron Diagnostics Corporation | Nucleic acid probes for the detection and identification of fungi |
| US5707802A (en) | 1995-01-13 | 1998-01-13 | Ciba Corning Diagnostics Corp. | Nucleic acid probes for the detection and identification of fungi |
| US5702895A (en) | 1995-01-19 | 1997-12-30 | Wakunaga Seiyaku Kabushiki Kaisha | Method and kit for detecting methicillin-resistant Staphylococcus aureus |
| US5484808A (en) | 1995-02-09 | 1996-01-16 | Eli Lilly And Company | Methods of inhibiting cell-cell adhesion |
| GB9504598D0 (en) * | 1995-03-03 | 1995-04-26 | Imp Cancer Res Tech | Method of nucleic acid analysis |
| US6428955B1 (en) * | 1995-03-17 | 2002-08-06 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
| CA2218188A1 (en) | 1995-04-11 | 1996-10-17 | Trustees Of Boston University | Solid phase sequencing of biopolymers |
| US5932220A (en) | 1995-05-08 | 1999-08-03 | Board Of Regents University Of Texas System | Diagnostic tests for a new spirochete, Borrelia lonestari sp. nov. |
| US5625184A (en) * | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
| US5830655A (en) * | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
| US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
| US5630653A (en) * | 1995-06-02 | 1997-05-20 | Polka; John G. | Wheel cover mounting bracket |
| NZ308970A (en) | 1995-06-07 | 1999-10-28 | Commw Scient Ind Res Org | Optimized minizymes and miniribozymes and uses thereof |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US6218529B1 (en) | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| US6146854A (en) | 1995-08-31 | 2000-11-14 | Sequenom, Inc. | Filtration processes, kits and devices for isolating plasmids |
| US5994066A (en) | 1995-09-11 | 1999-11-30 | Infectio Diagnostic, Inc. | Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US5869242A (en) * | 1995-09-18 | 1999-02-09 | Myriad Genetics, Inc. | Mass spectrometry to assess DNA sequence polymorphisms |
| US5727202A (en) | 1995-10-18 | 1998-03-10 | Palm Computing, Inc. | Method and apparatus for synchronizing information on two different computer systems |
| US5871697A (en) * | 1995-10-24 | 1999-02-16 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5972693A (en) | 1995-10-24 | 1999-10-26 | Curagen Corporation | Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5716825A (en) * | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
| US6312893B1 (en) * | 1996-01-23 | 2001-11-06 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
| GB9602028D0 (en) | 1996-02-01 | 1996-04-03 | Amersham Int Plc | Nucleoside analogues |
| US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| EP0886681A1 (de) | 1996-03-04 | 1998-12-30 | Genetrace Systems, Inc. | Verfahren zur suche von nukleinsäuren mit massenspektroskopie |
| WO1997037041A2 (en) | 1996-03-18 | 1997-10-09 | Sequenom, Inc. | Dna sequencing by mass spectrometry |
| US6737235B1 (en) | 1996-03-20 | 2004-05-18 | Bio Merieux | Nucleic acid isolation |
| JP3365198B2 (ja) | 1996-03-21 | 2003-01-08 | ミノルタ株式会社 | 画像形成装置 |
| US5745751A (en) | 1996-04-12 | 1998-04-28 | Nelson; Robert W. | Civil site information system |
| US6214555B1 (en) | 1996-05-01 | 2001-04-10 | Visible Genetics Inc. | Method compositions and kit for detection |
| US5928906A (en) * | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| CA2257866A1 (en) * | 1996-06-10 | 1997-12-18 | University Of Utah Research Foundation | Rapid, accurate identification of dna sequence variants by electrospray mass spectrometry |
| WO1998003684A1 (en) | 1996-07-19 | 1998-01-29 | Hybridon, Inc. | Method for sequencing nucleic acids using matrix-assisted laser desorption ionization time-of-flight mass spectrometry |
| US6563025B1 (en) | 1996-07-26 | 2003-05-13 | Board Of Trustees Of The University Of Illinois | Nucleotide sequences encoding anthranilate synthase |
| US5831046A (en) | 1996-08-05 | 1998-11-03 | Prolinx, Incorporated | Boronic acid-contaning nucleic acid monomers |
| DE19633436A1 (de) * | 1996-08-20 | 1998-02-26 | Boehringer Mannheim Gmbh | Verfahren zum Nachweis von Nukleinsäuren unter Ermittlung der Masse |
| US5777324A (en) * | 1996-09-19 | 1998-07-07 | Sequenom, Inc. | Method and apparatus for maldi analysis |
| US5965363A (en) * | 1996-09-19 | 1999-10-12 | Genetrace Systems Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
| WO1998012355A1 (en) | 1996-09-19 | 1998-03-26 | Genetrace Systems | Methods of preparing nucleic acids for mass spectrometric analysis |
| US6361940B1 (en) * | 1996-09-24 | 2002-03-26 | Qiagen Genomics, Inc. | Compositions and methods for enhancing hybridization and priming specificity |
| US5864137A (en) * | 1996-10-01 | 1999-01-26 | Genetrace Systems, Inc. | Mass spectrometer |
| US5885775A (en) | 1996-10-04 | 1999-03-23 | Perseptive Biosystems, Inc. | Methods for determining sequences information in polynucleotides using mass spectrometry |
| GB9620769D0 (en) | 1996-10-04 | 1996-11-20 | Brax Genomics Ltd | Nucleic acid sequencing |
| US6110710A (en) | 1996-10-15 | 2000-08-29 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Sequence modification of oligonucleotide primers to manipulate non-templated nucleotide addition |
| US6024925A (en) | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
| US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
| EP0937096B1 (de) | 1996-11-06 | 2004-02-04 | Sequenom, Inc. | Verfahren zur massenspektrometrie |
| US7285422B1 (en) | 1997-01-23 | 2007-10-23 | Sequenom, Inc. | Systems and methods for preparing and analyzing low volume analyte array elements |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| EP0954612A2 (de) * | 1996-11-06 | 1999-11-10 | Sequenom, Inc. | Dna-diagnostik mittels massenspektrometrie |
| US6140053A (en) * | 1996-11-06 | 2000-10-31 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| WO1998021066A1 (de) | 1996-11-12 | 1998-05-22 | Hp-Chemie Pelzer Research And Development Ltd. | Wiederverwertbares teppichbodenformteil |
| US6060246A (en) | 1996-11-15 | 2000-05-09 | Avi Biopharma, Inc. | Reagent and method for isolation and detection of selected nucleic acid sequences |
| DE69726309T2 (de) | 1996-11-28 | 2004-09-16 | New Japan Chemical Co., Ltd. | Zuckerderivate, geliermittel, geliermittelzubereitungen, verfahren zu ihrer herstellung und gelzubereitungen |
| US5822824A (en) | 1996-12-03 | 1998-10-20 | Dion; William D. | Mountable washing device |
| WO1998026095A1 (en) | 1996-12-10 | 1998-06-18 | Genetrace Systems Inc. | Releasable nonvolatile mass-label molecules |
| US5981190A (en) | 1997-01-08 | 1999-11-09 | Ontogeny, Inc. | Analysis of gene expression, methods and reagents therefor |
| US6046005A (en) * | 1997-01-15 | 2000-04-04 | Incyte Pharmaceuticals, Inc. | Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group |
| ATE374836T1 (de) | 1997-01-15 | 2007-10-15 | Xzillion Gmbh & Co Kg | Massenmarkierte hybridisierungssonden |
| US5876936A (en) * | 1997-01-15 | 1999-03-02 | Incyte Pharmaceuticals, Inc. | Nucleic acid sequencing with solid phase capturable terminators |
| WO1998035057A1 (en) | 1997-02-06 | 1998-08-13 | The National University Of Singapore | Diagnosis of plasmodium infection by analysis of extrachromosomal genetic material |
| US5858062A (en) * | 1997-02-10 | 1999-01-12 | Litton Systems, Inc. | Oxygen concentrator |
| US6727061B2 (en) | 1997-02-20 | 2004-04-27 | Cabtec, Inc. | Methods for identifying species or Shigella and E. coli using operon sequence analysis |
| US5828062A (en) | 1997-03-03 | 1998-10-27 | Waters Investments Limited | Ionization electrospray apparatus for mass spectrometry |
| US6553317B1 (en) | 1997-03-05 | 2003-04-22 | Incyte Pharmaceuticals, Inc. | Relational database and system for storing information relating to biomolecular sequences and reagents |
| DE19710166C1 (de) | 1997-03-12 | 1998-12-10 | Bruker Franzen Analytik Gmbh | Zwei-Schritt-Verfahren der DNA-Amplifikation für MALDI-TOF-Messungen |
| WO1998040520A1 (en) | 1997-03-14 | 1998-09-17 | Hybridon, Inc. | Method for sequencing of modified nucleic acids using electrospray ionization-fourier transform mass spectrometry |
| US5849497A (en) | 1997-04-03 | 1998-12-15 | The Research Foundation Of State University Of New York | Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker |
| US6018713A (en) | 1997-04-09 | 2000-01-25 | Coli; Robert D. | Integrated system and method for ordering and cumulative results reporting of medical tests |
| DE19717085C2 (de) | 1997-04-23 | 1999-06-17 | Bruker Daltonik Gmbh | Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR) |
| US20010039263A1 (en) | 1997-05-02 | 2001-11-08 | Max-Delbruck-Centrum Fur Molekulare Medizin | Chimeric oligonucleotides and the use thereof |
| US6054278A (en) * | 1997-05-05 | 2000-04-25 | The Perkin-Elmer Corporation | Ribosomal RNA gene polymorphism based microorganism identification |
| WO1998054571A1 (en) | 1997-05-28 | 1998-12-03 | The Walter And Eliza Hall Institute Of Medical Research | Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage |
| US6159681A (en) | 1997-05-28 | 2000-12-12 | Syntrix Biochip, Inc. | Light-mediated method and apparatus for the regional analysis of biologic material |
| AU7804098A (en) | 1997-05-30 | 1998-12-30 | Genetrace Systems, Inc. | Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry |
| US6061686A (en) | 1997-06-26 | 2000-05-09 | Digital Equipment Corporation | Updating a copy of a remote document stored in a local computer system |
| AU738237B2 (en) | 1997-07-22 | 2001-09-13 | Qiagen Genomics, Inc. | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques |
| DE19732086C2 (de) | 1997-07-25 | 2002-11-21 | Univ Leipzig | Verfahren zur quantitativen Bestimmung von Eubakterien |
| US6207370B1 (en) | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
| GB9719044D0 (en) | 1997-09-08 | 1997-11-12 | Inst Of Ophthalmology | Assay |
| AU9400398A (en) | 1997-09-19 | 1999-04-05 | Genetrace Systems, Inc. | Dna typing by mass spectrometry with polymorphic dna repeat markers |
| US6063031A (en) | 1997-10-14 | 2000-05-16 | Assurance Medical, Inc. | Diagnosis and treatment of tissue with instruments |
| US6111096A (en) | 1997-10-31 | 2000-08-29 | Bbi Bioseq, Inc. | Nucleic acid isolation and purification |
| JP3423597B2 (ja) | 1997-11-05 | 2003-07-07 | 三井農林株式会社 | 細菌の同定方法 |
| US6007992A (en) | 1997-11-10 | 1999-12-28 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| US6028183A (en) | 1997-11-07 | 2000-02-22 | Gilead Sciences, Inc. | Pyrimidine derivatives and oligonucleotides containing same |
| DK1036202T3 (da) | 1997-12-05 | 2002-08-12 | Max Planck Gesellschaft | Fremgangsmåde til identifikation af nucleinsyrer ved matriksassisteret laserdesorptions/ionisationsmassespektrometri |
| US6914137B2 (en) | 1997-12-06 | 2005-07-05 | Dna Research Innovations Limited | Isolation of nucleic acids |
| US6268131B1 (en) * | 1997-12-15 | 2001-07-31 | Sequenom, Inc. | Mass spectrometric methods for sequencing nucleic acids |
| GB9815166D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds for mass spectrometry |
| US6458533B1 (en) * | 1997-12-19 | 2002-10-01 | High Throughput Genomics, Inc. | High throughput assay system for monitoring ESTs |
| US20030096232A1 (en) | 1997-12-19 | 2003-05-22 | Kris Richard M. | High throughput assay system |
| JP3793342B2 (ja) | 1997-12-26 | 2006-07-05 | ソニーケミカル株式会社 | アクリル系エマルジョン、及び粘着テープ |
| DE19802905C2 (de) | 1998-01-27 | 2001-11-08 | Bruker Daltonik Gmbh | Verfahren zur bevorzugten Herstellung nur eines Stranges selektierten Genmaterials für massenspektrometrische Messungen |
| US6428956B1 (en) | 1998-03-02 | 2002-08-06 | Isis Pharmaceuticals, Inc. | Mass spectrometric methods for biomolecular screening |
| WO1999046047A2 (en) * | 1998-03-10 | 1999-09-16 | Large Scale Proteomics Corporation | Detection and characterization of microorganisms |
| US6270974B1 (en) * | 1998-03-13 | 2001-08-07 | Promega Corporation | Exogenous nucleic acid detection |
| US6268146B1 (en) * | 1998-03-13 | 2001-07-31 | Promega Corporation | Analytical methods and materials for nucleic acid detection |
| US6277578B1 (en) * | 1998-03-13 | 2001-08-21 | Promega Corporation | Deploymerization method for nucleic acid detection of an amplified nucleic acid target |
| US6270973B1 (en) * | 1998-03-13 | 2001-08-07 | Promega Corporation | Multiplex method for nucleic acid detection |
| US6235480B1 (en) * | 1998-03-13 | 2001-05-22 | Promega Corporation | Detection of nucleic acid hybrids |
| US6391551B1 (en) * | 1998-03-13 | 2002-05-21 | Promega Corporation | Detection of nucleic acid hybrids |
| US6312902B1 (en) * | 1998-03-13 | 2001-11-06 | Promega Corporation | Nucleic acid detection |
| US6261769B1 (en) | 1998-03-31 | 2001-07-17 | The United States Of America As Represented By The Secretary Of Agriculture | Intergenic spacer target sequence for detecting and distinguishing Chlamydial species or strains |
| US20030228597A1 (en) | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| US7321828B2 (en) | 1998-04-13 | 2008-01-22 | Isis Pharmaceuticals, Inc. | System of components for preparing oligonucleotides |
| US6223186B1 (en) | 1998-05-04 | 2001-04-24 | Incyte Pharmaceuticals, Inc. | System and method for a precompiled database for biomolecular sequence information |
| US6723564B2 (en) | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
| DE19822108A1 (de) | 1998-05-12 | 2000-02-03 | Schering Ag | Verfahren zur Detektion von Mikroorganismen in Produkten, insbesondere in Arzneimitteln und Kosmetika |
| US6221587B1 (en) | 1998-05-12 | 2001-04-24 | Isis Pharmceuticals, Inc. | Identification of molecular interaction sites in RNA for novel drug discovery |
| US6468743B1 (en) | 1998-05-18 | 2002-10-22 | Conagra Grocery Products Company | PCR techniques for detecting microbial contaminants in foodstuffs |
| DE19922161A1 (de) | 1998-05-18 | 1999-12-09 | Fraunhofer Ges Forschung | Anti-Haft-Beschichtung und Verfahren zu ihrer Herstellung |
| DE19824280B4 (de) | 1998-05-29 | 2004-08-19 | Bruker Daltonik Gmbh | Mutationsanalyse mittels Massenspektrometrie |
| US6104028A (en) * | 1998-05-29 | 2000-08-15 | Genetrace Systems Inc. | Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry |
| GB2339905A (en) | 1998-06-24 | 2000-02-09 | Bruker Daltonik Gmbh | Use of mass-specrometry for detection of mutations |
| ATE440963T1 (de) | 1998-07-02 | 2009-09-15 | Gen Probe Inc | Molekulare fackeln |
| US6074831A (en) | 1998-07-09 | 2000-06-13 | Agilent Technologies, Inc. | Partitioning of polymorphic DNAs |
| US6218118B1 (en) * | 1998-07-09 | 2001-04-17 | Agilent Technologies, Inc. | Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry |
| US6432651B1 (en) * | 1998-07-10 | 2002-08-13 | Cetek Corporation | Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry |
| US6605433B1 (en) | 1998-08-20 | 2003-08-12 | The Johns Hopkins University | Mitochondrial dosimeter |
| US6146144A (en) | 1998-09-29 | 2000-11-14 | Fowler; Ernest R. | Rug hooking kit and method for handicapped |
| US6610492B1 (en) | 1998-10-01 | 2003-08-26 | Variagenics, Inc. | Base-modified nucleotides and cleavage of polynucleotides incorporating them |
| AU6412799A (en) * | 1998-10-05 | 2000-04-26 | Mosaic Technologies | Reverse displacement assay for detection of nucleic acid sequences |
| IT1303330B1 (it) | 1998-11-05 | 2000-11-06 | Ilpea Ind Spa | Guarnizione per frogoriferi con controporta sagomata. |
| DE19852167C2 (de) | 1998-11-12 | 2000-12-14 | Bruker Saxonia Analytik Gmbh | Einfache SNP-Analyse mittels Massenspektrometrie |
| CA2351671A1 (en) | 1998-11-24 | 2000-06-08 | Regents Of The University Of Minnesota | Transgenic circulating endothelial cells |
| US6994962B1 (en) | 1998-12-09 | 2006-02-07 | Massachusetts Institute Of Technology | Methods of identifying point mutations in a genome |
| DE19859723A1 (de) | 1998-12-23 | 2000-06-29 | Henkel Kgaa | Mittel zum Färben von keratinhaltigen Fasern |
| US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
| US6638714B1 (en) | 1999-02-03 | 2003-10-28 | Ortho-Clinical Diagnostics, Inc. | Oligonucleotide primers for efficient detection of hepatitis C virus (HCV) and methods of use thereof |
| US6153389A (en) * | 1999-02-22 | 2000-11-28 | Haarer; Brian K. | DNA additives as a mechanism for unambiguously marking biological samples |
| EP1035219A1 (de) | 1999-02-25 | 2000-09-13 | Universiteit Gent | Gastrische Helicobacter 16S-rDNA Sequenzen von Rind und Schwein und ihre Anwendung zur Detektion and Typisierung von Helicobacter Stämmen |
| DE19910592A1 (de) | 1999-03-10 | 2000-09-14 | Volkswagen Ag | Rückhaltevorrichtung |
| US6436640B1 (en) * | 1999-03-18 | 2002-08-20 | Exiqon A/S | Use of LNA in mass spectrometry |
| US6613509B1 (en) * | 1999-03-22 | 2003-09-02 | Regents Of The University Of California | Determination of base (nucleotide) composition in DNA oligomers by mass spectrometry |
| AU4367500A (en) | 1999-04-21 | 2000-11-02 | Annovis, Inc. | Magnetic dna extraction kit for plants |
| US6649351B2 (en) * | 1999-04-30 | 2003-11-18 | Aclara Biosciences, Inc. | Methods for detecting a plurality of analytes by mass spectrometry |
| US6140067A (en) | 1999-04-30 | 2000-10-31 | Mitokor | Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus |
| ATE437242T1 (de) | 1999-05-03 | 2009-08-15 | Gen Probe Inc | Polynukleotidmatrix-basiertes verfahren zur identifizierung von mikroorganismen |
| US20020086289A1 (en) | 1999-06-15 | 2002-07-04 | Don Straus | Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms |
| WO2001000828A2 (en) | 1999-06-30 | 2001-01-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| EP1198597A1 (de) | 1999-07-22 | 2002-04-24 | Artus Gesellschaft Für Molekularbiologische Diagnostik und Entwicklung MbH. | Verfahren zum speziesspezifischen nachweis von organismen |
| US6723505B1 (en) | 1999-08-13 | 2004-04-20 | Nye Colifast As | Method for identification of the indicators of contamination in liquid samples |
| US6266144B1 (en) | 1999-08-26 | 2001-07-24 | Taiwan Semiconductor Manufacturing Company | Stepper and scanner new exposure sequence with intra-field correction |
| DE19943374A1 (de) | 1999-09-10 | 2001-03-29 | Max Planck Gesellschaft | Verfahren zum Anbinden von Nukleinsäuren an eine Festphase |
| US7005274B1 (en) | 1999-09-15 | 2006-02-28 | Migenix Corp. | Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass |
| WO2001023608A2 (en) | 1999-09-27 | 2001-04-05 | Merck Sharp & Dohme De Espana, S.A.E. | Hybridization probes which specifically detect strains of the genera microbispora, microtetraspora, nonomuria and planobispora |
| CA2388461C (en) | 1999-09-28 | 2013-06-11 | Infectio Diagnostic (I.D.I.) Inc. | Highly conserved genes and their use to generate probes and primers for the detection of microorganisms |
| US6296188B1 (en) | 1999-10-01 | 2001-10-02 | Perfect Plastic Printing Corporation | Transparent/translucent financial transaction card including an infrared light filter |
| JP2003519829A (ja) * | 1999-10-13 | 2003-06-24 | シークエノム・インコーポレーテツド | データベースを作成する方法および多型遺伝的マーカーを同定するためのデータベース |
| US6787302B2 (en) | 1999-10-25 | 2004-09-07 | Genprime, Inc. | Method and apparatus for prokaryotic and eukaryotic cell quantitation |
| EP1228244A4 (de) | 1999-11-04 | 2005-02-09 | California Inst Of Techn | Verfahren und apparate zur analyse von polynukleotidsequenzen |
| US6286146B1 (en) | 1999-11-15 | 2001-09-11 | Debra Rocker | Method of wearing weighted training vest while listening to audio equipment |
| US6856914B1 (en) | 1999-11-19 | 2005-02-15 | The University Of British Columbia | Method, apparatus, media and signals for identifying associated cell signaling proteins |
| AU781961B2 (en) | 1999-11-29 | 2005-06-23 | Aventis Pharma S.A. | Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds |
| US6608190B1 (en) * | 1999-12-16 | 2003-08-19 | E. I. Du Pont De Nemours And Company | Nucleic acid fragments for the identification of bacteria in industrial wastewater bioreactors |
| US6936414B2 (en) | 1999-12-22 | 2005-08-30 | Abbott Laboratories | Nucleic acid isolation method and kit |
| AU3246601A (en) * | 1999-12-29 | 2001-07-16 | Keygene N.V. | Method for generating oligonucleotides, in particular for the detection of amplified restriction fragments obtained using AFLP |
| SE0000061D0 (sv) | 2000-01-10 | 2000-01-10 | Bjoern Herrmann | A method for detection of pathogenic organisms |
| EP1276901A2 (de) | 2000-01-13 | 2003-01-22 | Amsterdam Support Diagnostics B.V. | Ein universelles nukleinsäure-amplifikationssystem für nukleinsäuren in einer probe |
| WO2001053917A2 (en) | 2000-01-24 | 2001-07-26 | Sanjay Chadha | Hand-held personal computing device with microdisplay |
| US20020009727A1 (en) | 2000-02-02 | 2002-01-24 | Schultz Gary A. | Detection of single nucleotide polymorphisms |
| CA2298181C (en) | 2000-02-02 | 2006-09-19 | Dayan Burke Goodnough | Non-targeted complex sample analysis |
| US6453244B1 (en) | 2000-02-10 | 2002-09-17 | Stanford University | Detection of polymorphisms by denaturing high-performance liquid chromatography |
| UA73967C2 (en) | 2000-02-14 | 2005-10-17 | First Opinion Corp | Structure-based automatic processing for diagnostics (variants) |
| US6393367B1 (en) | 2000-02-19 | 2002-05-21 | Proteometrics, Llc | Method for evaluating the quality of comparisons between experimental and theoretical mass data |
| DE10015797B4 (de) | 2000-03-26 | 2006-02-02 | Bruker Daltonik Gmbh | Multiplex-Analyse von DNA-Gemischen mittels photolytisch ablesbarer DNA-Chips |
| DE10015262A1 (de) | 2000-03-28 | 2001-10-04 | Basf Ag | Papierstreichmassen, enthaltend Bindemittel mit Makromonomeren |
| NZ521626A (en) | 2000-03-29 | 2005-09-30 | Cambia | Methods for genotyping by hybridization analysis |
| AU2001253310A1 (en) | 2000-04-10 | 2001-10-23 | Matthew Ashby | Methods for the survey and genetic analysis of populations |
| US6475736B1 (en) * | 2000-05-23 | 2002-11-05 | Variagenics, Inc. | Methods for genetic analysis of DNA using biased amplification of polymorphic sites |
| US6716634B1 (en) | 2000-05-31 | 2004-04-06 | Agilent Technologies, Inc. | Increasing ionization efficiency in mass spectrometry |
| US6507837B1 (en) | 2000-06-08 | 2003-01-14 | Hyperphrase Technologies, Llc | Tiered and content based database searching |
| WO2001096388A2 (en) | 2000-06-09 | 2001-12-20 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| WO2001096607A2 (en) * | 2000-06-13 | 2001-12-20 | The Trustees Of Boston University | Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing |
| EP1170379A1 (de) * | 2000-06-30 | 2002-01-09 | Centre National de Genotypage | Erstellung von Proben zur Genotypisierung mittels Massenspektroskopie |
| FR2811321A1 (fr) | 2000-07-04 | 2002-01-11 | Bio Merieux | Amplificateur d'une region ribonucleique cible d'un arn ribosomal 16s ou adn pour un tel arn d'une espece eubacterienne et detection de telles especes |
| US6504021B2 (en) | 2000-07-05 | 2003-01-07 | Edge Biosystems, Inc. | Ion exchange method for DNA purification |
| US20040072239A1 (en) | 2000-07-06 | 2004-04-15 | Patricia Renaud | Method for controlling the microbiological quality of an aqueous medium and kit therefor |
| US6783939B2 (en) | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| WO2002010186A1 (en) | 2000-07-27 | 2002-02-07 | California Institute Of Technology | A rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping |
| AUPQ909000A0 (en) | 2000-07-28 | 2000-08-24 | University Of Sydney, The | A method of detecting microorganisms |
| US20030190635A1 (en) | 2002-02-20 | 2003-10-09 | Mcswiggen James A. | RNA interference mediated treatment of Alzheimer's disease using short interfering RNA |
| GB0021286D0 (en) | 2000-08-30 | 2000-10-18 | Gemini Genomics Ab | Identification of drug metabolic capacity |
| US20040005555A1 (en) * | 2000-08-31 | 2004-01-08 | Rothman Richard E. | Molecular diagnosis of bactermia |
| US6813615B1 (en) | 2000-09-06 | 2004-11-02 | Cellomics, Inc. | Method and system for interpreting and validating experimental data with automated reasoning |
| US20020120408A1 (en) * | 2000-09-06 | 2002-08-29 | Kreiswirth Barry N. | System and method for tracking and controlling infections |
| US7349808B1 (en) | 2000-09-06 | 2008-03-25 | Egenomics, Inc. | System and method for tracking and controlling infections |
| AU2001288762A1 (en) | 2000-09-08 | 2002-03-22 | Large Scale Proteomics Corporation | Detection and characterization of microorganisms |
| SE0003286D0 (sv) | 2000-09-15 | 2000-09-15 | Ulf Gyllensten | Method and kit for human identification |
| US7494659B2 (en) | 2000-09-25 | 2009-02-24 | Polymun Scientific Immunbiologische Forschung Gmbh | Live attenuated influenza vaccine |
| WO2002028901A2 (en) | 2000-10-05 | 2002-04-11 | Millennium Pharmaceuticals, Inc. | Seven-transmembrane (7tm) receptors and uses thereof |
| US6996472B2 (en) | 2000-10-10 | 2006-02-07 | The United States Of America As Represented By The Department Of Health And Human Services | Drift compensation method for fingerprint spectra |
| GB2384309B8 (en) | 2000-10-13 | 2016-03-02 | Irm Llc | High throughput processing system and method of using |
| ATE380883T1 (de) | 2000-10-24 | 2007-12-15 | Univ Leland Stanford Junior | Direkte multiplex charakterisierung von genomischer dna |
| US6906316B2 (en) | 2000-10-27 | 2005-06-14 | Fuji Electric Co., Ltd. | Semiconductor device module |
| US6682889B1 (en) * | 2000-11-08 | 2004-01-27 | Becton, Dickinson And Company | Amplification and detection of organisms of the Chlamydiaceae family |
| JPWO2002050307A1 (ja) | 2000-12-12 | 2004-04-22 | 中外製薬株式会社 | 質量分析を利用してｄｎａの多型を検出する方法 |
| US6800289B2 (en) | 2000-12-21 | 2004-10-05 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence | Strain of the western equine encephalitis virus |
| US6586584B2 (en) | 2001-01-29 | 2003-07-01 | Becton, Dickinson And Company | Sequences and methods for detection of Hepatitis C virus |
| DE10108453B4 (de) | 2001-02-22 | 2005-10-20 | Bruker Daltonik Gmbh | Massenspektrometrische Mutationsanalyse mit photolytisch spaltbaren Primern |
| CA2439504A1 (en) | 2001-02-28 | 2002-09-12 | Chondrogene Inc. | Compositions and methods relating to osteoarthritis |
| CA2478020C (en) | 2001-03-01 | 2006-12-19 | The Johns Hopkins University | Quantitative assay for the simultaneous detection and speciation of bacterial infections |
| US7718354B2 (en) | 2001-03-02 | 2010-05-18 | Ibis Biosciences, Inc. | Methods for rapid identification of pathogens in humans and animals |
| US20040121314A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in containers |
| US20040121310A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in forensic studies |
| US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
| AU2003298030B2 (en) | 2001-03-02 | 2009-12-10 | Ibis Biosciences, Inc. | Methods for rapid identification of pathogens in humans and animals |
| US20040121309A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues |
| US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
| US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
| US20040038206A1 (en) * | 2001-03-14 | 2004-02-26 | Jia Zhang | Method for high throughput assay of genetic analysis |
| US20030104410A1 (en) | 2001-03-16 | 2003-06-05 | Affymetrix, Inc. | Human microarray |
| AU2002306777C1 (en) | 2001-03-19 | 2008-04-24 | President And Fellows Of Harvard College | Evolving new molecular function |
| CN1316034C (zh) | 2001-03-28 | 2007-05-16 | 科学与工业研究会 | 用于野生生物鉴定的通用引物 |
| US7630836B2 (en) | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| CA2348042A1 (en) | 2001-06-04 | 2002-12-04 | Ann Huletsky | Sequences for detection and identification of methicillin-resistant staphylococcus aureus |
| CN1630718A (zh) | 2001-06-06 | 2005-06-22 | Dsmip资产公司 | 改进的类异戊二烯生产 |
| US20020187477A1 (en) * | 2001-06-06 | 2002-12-12 | Hong Xue | Method for detecting single nucleotide polymorphisms (SNPs) and point mutations |
| GB0113907D0 (en) | 2001-06-07 | 2001-08-01 | Univ London | Virus detection using degenerate PCR primers |
| GB0113908D0 (en) | 2001-06-07 | 2001-08-01 | Univ London | Designing degenerate PCR primers |
| US20020187490A1 (en) | 2001-06-07 | 2002-12-12 | Michigan State University | Microbial identification chip based on DNA-DNA hybridization |
| US8073627B2 (en) | 2001-06-26 | 2011-12-06 | Ibis Biosciences, Inc. | System for indentification of pathogens |
| US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
| DE10132147B4 (de) | 2001-07-03 | 2004-04-15 | Universität Leipzig | Verfahren zur schnellen quantitativen Bestimmung von Eu-Bakterien |
| GB0117054D0 (en) | 2001-07-12 | 2001-09-05 | Plant Bioscience Ltd | Methods and means for modification of plant characteristics |
| ATE323182T1 (de) | 2001-07-19 | 2006-04-15 | Infectio Diagnostic Inc | Universelle methode und zusammensetzung zur schnellen lysierung von zellen zur freisetzung von nukleinsäuren und ihre detektion |
| US20040191769A1 (en) | 2001-07-24 | 2004-09-30 | Transgenomic, Inc. | Methods, compositions, and kits for mutation detection in mitochondrial DNA |
| AU2002325197A1 (en) | 2001-07-30 | 2003-02-17 | Den Kgl. Veterinaer- Og Landbohojskole | Bacterial strains belonging to lactobacillus species and their use in food and feed industry |
| US7115385B2 (en) | 2001-08-02 | 2006-10-03 | North Carolina State University | Media and methods for cultivation of microorganisms |
| AT411174B (de) | 2001-08-09 | 2003-10-27 | Lambda Labor Fuer Molekularbio | Verfahren und chip zur analyse von nukleinsäuren |
| US20030039976A1 (en) * | 2001-08-14 | 2003-02-27 | Haff Lawrence A. | Methods for base counting |
| US20040175715A1 (en) | 2001-08-21 | 2004-09-09 | Burgoyne Leigh A. | Method and device for simultaneously molecularly cloning and polylocus profiling of genomes or genomes mixtures |
| US7105296B2 (en) | 2001-08-29 | 2006-09-12 | E. I. Du Pont De Nemours And Company | Genes encoding Baeyer-Villiger monooxygenases |
| US7049286B2 (en) | 2001-08-30 | 2006-05-23 | Diatos, S.A. | Insulin conjugates and methods of use thereof |
| US7060809B2 (en) | 2001-09-04 | 2006-06-13 | Exiqon A/S | LNA compositions and uses thereof |
| US20040101809A1 (en) | 2001-09-21 | 2004-05-27 | Weiss Ervin I | Device, method and materials for mobilizing substances into dentinal tubules in root canal treatment |
| DE10150121B4 (de) | 2001-10-11 | 2005-12-01 | Bernhard-Nocht-Institut für Tropenmedizin | Echtzeitdetektion von DNA-Amplifikationsprodukten |
| US6977148B2 (en) | 2001-10-15 | 2005-12-20 | Qiagen Gmbh | Multiple displacement amplification |
| US7297485B2 (en) | 2001-10-15 | 2007-11-20 | Qiagen Gmbh | Method for nucleic acid amplification that results in low amplification bias |
| US20040029129A1 (en) | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| DE10152821B4 (de) | 2001-10-25 | 2006-11-16 | Bruker Daltonik Gmbh | Massenspektren ohne elektronisches Rauschen |
| EP1308506A1 (de) | 2001-11-06 | 2003-05-07 | Eidgenössische Technische Hochschule Zürich | Mischungen von Propionibakterium jensenii und Lactobacillus sp. mit antimikrobieller Aktivität zur Verwendung als natürliches Konservierungsmittel |
| CA2945734C (en) | 2001-11-13 | 2020-02-25 | The Trustees Of The University Of Pennsylvania | A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby |
| BR0206488A (pt) * | 2001-11-15 | 2008-08-05 | Whatman Inc | dispositivo, método e kit para armazenamento e análise de uma porção contendo ácido nucleico em uma amostra biológica |
| US20040023209A1 (en) | 2001-11-28 | 2004-02-05 | Jon Jonasson | Method for identifying microorganisms based on sequencing gene fragments |
| JP3692067B2 (ja) | 2001-11-30 | 2005-09-07 | 株式会社東芝 | 銅のｃｍｐ用研磨スラリーおよびそれを用いた半導体装置の製造方法 |
| US20030148284A1 (en) * | 2001-12-17 | 2003-08-07 | Vision Todd J. | Solid phase detection of nucleic acid molecules |
| TW509116U (en) | 2001-12-18 | 2002-11-01 | Ind Tech Res Inst | Device for clipping and tightening spindle of honing and milling machine |
| US20030175709A1 (en) | 2001-12-20 | 2003-09-18 | Murphy George L. | Method and system for depleting rRNA populations |
| US7468185B2 (en) | 2001-12-21 | 2008-12-23 | Pfizer Inc. | Vaccine for periodontal disease |
| KR100444230B1 (ko) | 2001-12-27 | 2004-08-16 | 삼성전기주식회사 | 내환원성 유전체 자기 조성물 |
| US20060088826A1 (en) | 2001-12-28 | 2006-04-27 | Van Eijk Michael Josephus Ther | Discrimination and detection of target nucleotide sequences using mass spectrometry |
| ATE358185T1 (de) | 2002-02-01 | 2007-04-15 | Bruker Daltonik Gmbh | Mutationsanalyse mittels pcr und massenspektrometrie |
| CN1202204C (zh) | 2002-02-27 | 2005-05-18 | 财团法人工业技术研究院 | 红光有机电激发光化合物及用其制成的组件和装置 |
| KR100600988B1 (ko) | 2002-03-13 | 2006-07-13 | 주식회사 엘지생명과학 | Ｄｎａ 면역화에서 인플루엔자 ｎｐ 유전자 ｄｎａ를 함께투여하여 면역반응을 증가시키는 방법 |
| US7024370B2 (en) | 2002-03-26 | 2006-04-04 | P) Cis, Inc. | Methods and apparatus for early detection of health-related events in a population |
| US6897027B2 (en) | 2002-03-27 | 2005-05-24 | Decode Genetics Ehf. | Method for desalting nucleic acids |
| WO2003100035A2 (en) | 2002-04-01 | 2003-12-04 | Isis Pharmaceuticals, Inc. | Method for rapid detection and identification of viral bioagents |
| AU2003224897A1 (en) | 2002-04-09 | 2003-10-27 | Kenneth L. Beattie | Oligonucleotide probes for genosensor chips |
| JP2004000200A (ja) | 2002-04-19 | 2004-01-08 | Menicon Co Ltd | 微生物の検出方法 |
| FR2838740A1 (fr) | 2002-04-22 | 2003-10-24 | Centre Nat Rech Scient | Oligonucleotides issus des sequences codant pour la composante de surface des proteines d'enveloppe des ptlv et leurs utilisations |
| GB0209812D0 (en) | 2002-04-30 | 2002-06-05 | Renovo Ltd | Genetic testing |
| US6906319B2 (en) | 2002-05-17 | 2005-06-14 | Micromass Uk Limited | Mass spectrometer |
| DE10222632B4 (de) | 2002-05-17 | 2006-03-09 | Con Cipio Gmbh | Mikrosatellitenmarker für genetische Analysen und zur Unterscheidung von Rosen |
| EP1365031A1 (de) | 2002-05-21 | 2003-11-26 | MTM Laboratories AG | Verfahren zur Detektierung von somatischen Mutationen mittels Massenspektrometrie |
| AU2003237249A1 (en) | 2002-05-24 | 2003-12-12 | Isis Pharmaceuticals, Inc. | Oligonucleotides having modified nucleoside units |
| US20030220844A1 (en) * | 2002-05-24 | 2003-11-27 | Marnellos Georgios E. | Method and system for purchasing genetic data |
| CN1656228A (zh) | 2002-05-29 | 2005-08-17 | 阿雷萨生物检测公司 | 用于植物的报告系统 |
| GB0212666D0 (en) | 2002-05-31 | 2002-07-10 | Secr Defence | Immunogenic sequences |
| WO2003104410A2 (en) | 2002-06-07 | 2003-12-18 | Incyte Corporation | Enzymes |
| AU2003245488A1 (en) | 2002-06-13 | 2003-12-31 | Regulome Corporation | Functional sites |
| KR100484144B1 (ko) | 2002-06-20 | 2005-04-18 | 삼성전자주식회사 | 원격 관리 서버 및 원격 관리 방법 |
| EP1539944A4 (de) | 2002-07-01 | 2005-12-28 | Univ Wayne State | Verfahren und zusammensetzungen zur identifizierung von gegenüber antibiotikaresistenz unempfindlichen antibiotika |
| AU2003254093A1 (en) | 2002-07-19 | 2004-02-09 | Isis Pharmaceuticals, Inc. | Methods for mass spectrometry analysis utilizing an integrated microfluidics sample platform |
| US6916483B2 (en) * | 2002-07-22 | 2005-07-12 | Biodynamics, Llc | Bioabsorbable plugs containing drugs |
| GB0217434D0 (en) | 2002-07-27 | 2002-09-04 | Royal Vetinary College | Biological material |
| US20040022764A1 (en) | 2002-07-31 | 2004-02-05 | Hanan Polansky | Inhibition of microcompetition with a foreign polynucleotide as treatment of chronic disease |
| US7172868B2 (en) | 2002-08-01 | 2007-02-06 | The Regents Of The University Of California | Nucleotide sequences specific to Francisella tularensis and methods for the detection of Francisella tularensis |
| US20040038385A1 (en) * | 2002-08-26 | 2004-02-26 | Langlois Richard G. | System for autonomous monitoring of bioagents |
| CN1703521B (zh) | 2002-09-06 | 2011-11-16 | 波士顿大学信托人 | 基因表达的定量 |
| US20040110138A1 (en) | 2002-11-01 | 2004-06-10 | University Of Ottawa | Method for the detection of multiple genetic targets |
| AU2003276634A1 (en) | 2002-11-12 | 2004-06-03 | Genolife | One step real-time rt pcr kits for the universal detection of organisms in industrial products |
| US7250496B2 (en) | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| ATE459727T1 (de) | 2002-11-15 | 2010-03-15 | Gen Probe Inc | Test und zusammensetzungen zum nachweis von bacillus-anthracis-nukleinsäure |
| US6680476B1 (en) | 2002-11-22 | 2004-01-20 | Agilent Technologies, Inc. | Summed time-of-flight mass spectrometry utilizing thresholding to reduce noise |
| JP2006516193A (ja) | 2002-12-06 | 2006-06-29 | アイシス・ファーマシューティカルス・インコーポレーテッド | ヒトおよび動物における病原体の迅速な同定方法 |
| JP2004201679A (ja) | 2002-12-10 | 2004-07-22 | Kao Corp | Ｐｃｒ法によるフゾバクテリウム・ニュークレタム菌の検出用プライマー及びその検出方法 |
| US20040117354A1 (en) | 2002-12-16 | 2004-06-17 | Azzaro Steven Hector | Process for tagging and measuring quality |
| US20040122857A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in forensic studies thereby |
| US20040121329A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in blood, bodily fluids, and bodily tissues thereby |
| US20040121315A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in containers thereby |
| US20040121340A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent associated with host versus graft and graft versus host rejections thereby |
| US20040122598A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in food products and cosmetics thereby |
| US20040121312A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of the absence of bioagents |
| US9487823B2 (en) | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
| JP2004201641A (ja) | 2002-12-26 | 2004-07-22 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | 真菌検出方法 |
| US20040170981A1 (en) | 2003-02-10 | 2004-09-02 | Mckenney Keith | Real-time polymerase chain reaction using large target amplicons |
| US20040170954A1 (en) | 2003-02-10 | 2004-09-02 | Mckenney Keith | Pathogen inactivation assay |
| US20040185438A1 (en) | 2003-03-10 | 2004-09-23 | Ecker David J. | Methods of detection and notification of bioagent contamination |
| US20050065813A1 (en) | 2003-03-11 | 2005-03-24 | Mishelevich David J. | Online medical evaluation system |
| US8046171B2 (en) | 2003-04-18 | 2011-10-25 | Ibis Biosciences, Inc. | Methods and apparatus for genetic evaluation |
| EP1618216A2 (de) * | 2003-04-25 | 2006-01-25 | Sequenom, Inc. | Auf fragmentierung beruhende verfahren und systeme zur de-novo-sequenzierung |
| US8057993B2 (en) | 2003-04-26 | 2011-11-15 | Ibis Biosciences, Inc. | Methods for identification of coronaviruses |
| WO2005009202A2 (en) | 2003-05-12 | 2005-02-03 | Isis Pharmaceuticals, Inc. | Automatic identification of bioagents |
| US7964343B2 (en) | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| US8158354B2 (en) | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| WO2005003384A1 (en) | 2003-07-03 | 2005-01-13 | Danmarks Og Grønlands Geologiske Undersøgelse | Method for selective detection of a target nucleic acid |
| AU2003257013A1 (en) | 2003-07-29 | 2005-03-07 | Sigma Aldrich Co. | Methods and compositions for amplification of dna |
| JP4304292B2 (ja) | 2003-07-30 | 2009-07-29 | 日本電気株式会社 | 移動通信システム、移動通信端末及びそれに用いるパワーコントロール方法並びにそのプログラム |
| KR100632429B1 (ko) | 2003-08-01 | 2006-10-09 | 프로테온 주식회사 | 프라이머 특이성 유무에 의한 멀티플렉스 역전사 중합효소연쇄반응을 이용한 재조합 독감 바이러스의 스크리닝 방법 |
| US20120122101A1 (en) | 2003-09-11 | 2012-05-17 | Rangarajan Sampath | Compositions for use in identification of bacteria |
| US20060240412A1 (en) | 2003-09-11 | 2006-10-26 | Hall Thomas A | Compositions for use in identification of adenoviruses |
| US20050142584A1 (en) | 2003-10-01 | 2005-06-30 | Willson Richard C. | Microbial identification based on the overall composition of characteristic oligonucleotides |
| WO2005036369A2 (en) | 2003-10-09 | 2005-04-21 | Isis Pharmaceuticals, Inc. | Database for microbial investigations |
| FR2861743B1 (fr) | 2003-11-04 | 2007-10-19 | Univ Aix Marseille Ii | Identification moleculaire des bacteries du genre corynebacterium |
| JP3861871B2 (ja) | 2003-11-26 | 2006-12-27 | サンケン電気株式会社 | スイッチング電源装置 |
| WO2005062770A2 (en) | 2003-12-19 | 2005-07-14 | Novakoff James L | Method for conducting pharmacogenomics-based studies |
| JP4619368B2 (ja) | 2004-02-10 | 2011-01-26 | エフ．ホフマン−ラ ロシュ アーゲー | パルボウイルスｂ１９の検出のための新規なプライマーおよびプローブ |
| US7666592B2 (en) | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
| CA2560521C (en) | 2004-02-18 | 2012-01-03 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of bacteria |
| US8119336B2 (en) | 2004-03-03 | 2012-02-21 | Ibis Biosciences, Inc. | Compositions for use in identification of alphaviruses |
| US7312036B2 (en) | 2004-03-22 | 2007-12-25 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of viral hemorrhagic fever viruses |
| US20050266411A1 (en) | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
| WO2006135400A2 (en) | 2004-08-24 | 2006-12-21 | Isis Pharmaceuticals, Inc. | Methods for rapid identification of recombinant organisms |
| US7627437B2 (en) | 2005-01-14 | 2009-12-01 | Idaho Research Foundation | Categorization of microbial communities |
| DE102005008583B4 (de) | 2005-02-24 | 2007-10-25 | Johannes-Gutenberg-Universität Mainz | Verfahren zur Typisierung eines Individuums mittels short tandem repeat (STR)-Loci der genomischen DNA |
| CA2600184A1 (en) | 2005-03-03 | 2006-09-08 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of adventitious viruses |
| DE602006017365D1 (de) | 2005-04-13 | 2010-11-18 | Ibis Biosciences Inc | Zusammensetzungen für die identifizierung von adenoviren |
| EP1882045B1 (de) | 2005-04-21 | 2012-08-29 | Ibis Biosciences, Inc. | ZUSAMMENSETZUNG ZUR IDENTIFIZIERUNG VON Staphylococcus aureus |
| JP2009502137A (ja) | 2005-07-21 | 2009-01-29 | アイシス ファーマシューティカルズ インコーポレイティッド | 核酸変種の迅速な同定および定量のための方法 |
| US20070026435A1 (en) | 2005-07-28 | 2007-02-01 | Polysciences, Inc. | Hydroxysilane functionalized magnetic particles and nucleic acid separation method |
| EP2126132B1 (de) | 2007-02-23 | 2013-03-20 | Ibis Biosciences, Inc. | Verfahren für schnelle forensische dna-analyse |
| US20100204266A1 (en) | 2007-03-23 | 2010-08-12 | Ibis Biosciences, INC | Compositions for use in identification of mixed populations of bioagents |
| JP5067239B2 (ja) | 2008-03-28 | 2012-11-07 | 富士通株式会社 | ケーブルマネージメント装置および電子機器装置 |
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