YU46151B - Postupak za dobijanje 7-/2-(5-amino-1, 2,4-tiadiazol-3-il)-2-(supstituisani)iminoacetamido/3-/3-(kvaternerni amonio)-1-propen-1-il/-3-cefem-4-karboksilata - Google Patents

Postupak za dobijanje 7-/2-(5-amino-1, 2,4-tiadiazol-3-il)-2-(supstituisani)iminoacetamido/3-/3-(kvaternerni amonio)-1-propen-1-il/-3-cefem-4-karboksilata

Info

Publication number
YU46151B
YU46151B YU60085A YU60085A YU46151B YU 46151 B YU46151 B YU 46151B YU 60085 A YU60085 A YU 60085A YU 60085 A YU60085 A YU 60085A YU 46151 B YU46151 B YU 46151B
Authority
YU
Yugoslavia
Prior art keywords
formula
hydrogen
amino
group
protecting group
Prior art date
Application number
YU60085A
Other languages
English (en)
Serbo-Croatian (sh)
Other versions
YU60085A (en
Inventor
H. Yamashita
M. Oka
J. Okumura
T. Naito
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Priority to YU118987A priority Critical patent/YU46213B/sh
Publication of YU60085A publication Critical patent/YU60085A/xx
Publication of YU46151B publication Critical patent/YU46151B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
YU60085A 1984-04-09 1985-04-09 Postupak za dobijanje 7-/2-(5-amino-1, 2,4-tiadiazol-3-il)-2-(supstituisani)iminoacetamido/3-/3-(kvaternerni amonio)-1-propen-1-il/-3-cefem-4-karboksilata YU46151B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YU118987A YU46213B (sh) 1984-04-09 1987-06-25 Postupak za dobijanje 7-/2-(5-amino-1,2,4-tiadiazol-3-il)-2-(supstituisani)iminoacetamido/-3 -/3-(kvaternerni amonio)-1-propen-1-il/-3-cefem-4-karboksilata

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59794184A 1984-04-09 1984-04-09

Publications (2)

Publication Number Publication Date
YU60085A YU60085A (en) 1987-12-31
YU46151B true YU46151B (sh) 1993-05-28

Family

ID=24393575

Family Applications (2)

Application Number Title Priority Date Filing Date
YU60085A YU46151B (sh) 1984-04-09 1985-04-09 Postupak za dobijanje 7-/2-(5-amino-1, 2,4-tiadiazol-3-il)-2-(supstituisani)iminoacetamido/3-/3-(kvaternerni amonio)-1-propen-1-il/-3-cefem-4-karboksilata
YU118987A YU46213B (sh) 1984-04-09 1987-06-25 Postupak za dobijanje 7-/2-(5-amino-1,2,4-tiadiazol-3-il)-2-(supstituisani)iminoacetamido/-3 -/3-(kvaternerni amonio)-1-propen-1-il/-3-cefem-4-karboksilata

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU118987A YU46213B (sh) 1984-04-09 1987-06-25 Postupak za dobijanje 7-/2-(5-amino-1,2,4-tiadiazol-3-il)-2-(supstituisani)iminoacetamido/-3 -/3-(kvaternerni amonio)-1-propen-1-il/-3-cefem-4-karboksilata

Country Status (31)

Country Link
JP (4) JPS615084A (https=)
KR (1) KR870002166B1 (https=)
AR (1) AR244694A1 (https=)
AT (1) AT388735B (https=)
AU (2) AU580990B2 (https=)
BE (1) BE902148A (https=)
CA (3) CA1276929C (https=)
CH (1) CH669197A5 (https=)
DD (3) DD249024A5 (https=)
DE (1) DE3512225A1 (https=)
DK (1) DK155985A (https=)
ES (4) ES8607318A1 (https=)
FI (1) FI84830C (https=)
FR (1) FR2563832B1 (https=)
GB (3) GB2157293B (https=)
GR (1) GR850883B (https=)
HU (2) HU193750B (https=)
IE (2) IE58408B1 (https=)
IL (1) IL74826A (https=)
IT (1) IT1190353B (https=)
LU (1) LU85840A1 (https=)
MY (1) MY101940A (https=)
NL (1) NL192925C (https=)
NZ (1) NZ211659A (https=)
OA (1) OA07985A (https=)
PT (1) PT80246B (https=)
RU (1) RU2056425C1 (https=)
SE (4) SE466205B (https=)
SU (4) SU1367858A3 (https=)
YU (2) YU46151B (https=)
ZA (1) ZA852236B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61145186A (ja) * 1984-12-20 1986-07-02 Meiji Seika Kaisha Ltd 新規セフエム化合物及びその製造法
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
EP0329785B1 (en) * 1985-12-26 1994-11-30 Eisai Co., Ltd. Cephalosporin derivatives
AU614723B2 (en) * 1986-10-13 1991-09-12 Eisai Co. Ltd. 3-propenylcephem derivative
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
JPH085897B2 (ja) * 1986-11-06 1996-01-24 エーザイ株式会社 ３−プロペニルセフェム誘導体
FR2622585B1 (fr) * 1987-11-03 1991-04-19 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical vinyle substitue, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
DE68929368T2 (de) * 1988-03-16 2002-08-14 Eisai Co., Ltd. Cephemderivate und Verfahren zu ihrer Herstellung
JPH0699449B2 (ja) * 1988-03-16 1994-12-07 エーザイ株式会社 セフェム誘導体の合成中間体
FR2655042B1 (fr) * 1989-11-29 1994-01-21 Adir Cie Nouvelles benzothiazolinones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2663332B1 (fr) * 1990-06-15 1997-11-07 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical propenyle substitue par un ammonium quaternaire, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus.
US5126336A (en) * 1990-08-23 1992-06-30 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
AT396108B (de) * 1991-08-21 1993-06-25 Biochemie Gmbh Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten
JPH0741484A (ja) * 1993-07-29 1995-02-10 Katayama Seiyakushiyo:Kk セフェム化合物及び抗菌剤
WO1996005205A1 (en) * 1994-08-16 1996-02-22 Meiji Seika Kabushiki Kaisha Novel cephem derivative
HUP0102350A2 (hu) 1998-06-22 2001-11-28 F.Hoffmann-La Roche Ag. Propenil-cefalosporin-származékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek
CN100398547C (zh) 2003-09-09 2008-07-02 日本化学工业株式会社 3-氯甲基-3-头孢烯衍生物的制造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
US4390534A (en) * 1978-12-29 1983-06-28 Fujisawa Pharmaceutical Co., Ltd. Cephem and cepham compounds
EP0025017A1 (de) * 1979-08-28 1981-03-11 Ciba-Geigy Ag Polyazathiaverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend solche Verbindungen und Verwendung von letzteren
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
GR75644B (https=) * 1980-06-18 1984-08-02 Fujisawa Pharmaceutical Co
GR78245B (https=) * 1980-09-12 1984-09-26 Ciba Geigy Ag
US4521413A (en) * 1981-09-14 1985-06-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4486586A (en) * 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives

Also Published As

Publication number Publication date
GB8508846D0 (en) 1985-05-09
ES8607318A1 (es) 1986-06-16
GB2194789B (en) 1988-10-12
JPS61143387A (ja) 1986-07-01
CH669197A5 (de) 1989-02-28
DD249024A5 (de) 1987-08-26
SE8901226L (sv) 1989-04-06
HU204277B (en) 1991-12-30
DD236735A5 (de) 1986-06-18
SU1487814A3 (ru) 1989-06-15
DD251752A5 (de) 1987-11-25
DE3512225C2 (https=) 1990-02-22
FI84830C (fi) 1992-01-27
HUT37622A (en) 1986-01-23
SE8901226D0 (sv) 1989-04-06
FI84830B (fi) 1991-10-15
SU1375140A3 (ru) 1988-02-15
AU4086285A (en) 1985-10-17
MY101940A (en) 1992-02-15
DE3512225A1 (de) 1985-10-17
DK155985A (da) 1985-10-10
LU85840A1 (fr) 1985-12-16
SE8901225L (sv) 1989-04-06
AU610278B2 (en) 1991-05-16
SE8501680L (sv) 1985-10-10
PT80246A (en) 1985-05-01
JPS615084A (ja) 1986-01-10
ES542013A0 (es) 1986-06-16
GB8721346D0 (en) 1987-10-14
IE58403B1 (en) 1993-09-22
SE470259B (sv) 1993-12-20
FI851379A0 (fi) 1985-04-04
ATA103985A (de) 1989-01-15
CA1340638C (en) 1999-07-06
ES551551A0 (es) 1987-07-01
FR2563832A1 (fr) 1985-11-08
IE850866L (en) 1985-10-09
CA1276929C (en) 1990-11-27
AU2504188A (en) 1989-03-02
SE505256C2 (sv) 1997-07-21
SU1436882A3 (ru) 1988-11-07
KR850007424A (ko) 1985-12-04
IT8520267A0 (it) 1985-04-05
JPS61143390A (ja) 1986-07-01
ZA852236B (en) 1985-11-27
CA1340672C (en) 1999-07-20
FI851379L (fi) 1985-10-10
GB8721347D0 (en) 1987-10-14
ES557060A0 (es) 1987-12-01
IT1190353B (it) 1988-02-16
SE8901224L (sv) 1989-04-06
AU580990B2 (en) 1989-02-09
IL74826A (en) 1990-01-18
YU60085A (en) 1987-12-31
ES8706155A1 (es) 1987-06-01
GB2157293B (en) 1988-10-05
SE466205B (sv) 1992-01-13
OA07985A (fr) 1987-01-31
BE902148A (fr) 1985-10-09
KR870002166B1 (ko) 1987-12-14
ES8800949A1 (es) 1987-12-01
FR2563832B1 (fr) 1989-08-18
AT388735B (de) 1989-08-25
ES551550A0 (es) 1987-06-01
DK155985D0 (da) 1985-04-03
IL74826A0 (en) 1985-07-31
JPH0350754B2 (https=) 1991-08-02
YU46213B (sh) 1993-05-28
GB2194789A (en) 1988-03-16
SE8901224D0 (sv) 1989-04-06
HU193750B (en) 1987-11-30
YU118987A (en) 1988-10-31
RU2056425C1 (ru) 1996-03-20
SU1367858A3 (ru) 1988-01-15
AR244694A1 (es) 1993-11-30
NL192925C (nl) 1998-05-07
SE8901225D0 (sv) 1989-04-06
NL8501002A (nl) 1985-11-01
JPS61143391A (ja) 1986-07-01
PT80246B (pt) 1987-10-20
GB2157293A (en) 1985-10-23
IE58408B1 (en) 1993-09-22
SE8501680D0 (sv) 1985-04-03
JPH0357106B2 (https=) 1991-08-30
JPH0351716B2 (https=) 1991-08-07
NL192925B (nl) 1998-01-05
NZ211659A (en) 1988-11-29
GB2194790A (en) 1988-03-16
JPH0262557B2 (https=) 1990-12-26
GB2194790B (en) 1988-10-05
GR850883B (https=) 1985-11-25
SE470260B (sv) 1993-12-20
ES8706694A1 (es) 1987-07-01

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